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The Fifth China-Japan Seminar on Advanced Engineering Plastics, Polymer Alloys and Composites

作者： noboru yamaguchi Takasni SAKURAI Tatsuya KASAHARA Petrochemicals Research Laboratory Sumitomo Chemical Co. Ltd.2-1 Kitasode Sodegaura City Chiba 299-0295 JAPAN

Mechanical property and structural evolution process of isotactic polypropylene (iPP) film with different molecular weight distribution (MWD) and isotacticity has been investigated by carrying out the in-situ time-resolved measurements of synchrotron wide-angle X-ray diffraction (WAXD) and small-angle X-ray scattering (SAXS).In the uniaxial hot drawing process the stress was found to increase with an increment of drawing ratio,which was more remarkable for the sample with narrower MWD and higher isotacticity.The SAXS and WAXD patterns were found to change remarkably in this process,from which the deformation of lamellar stacking structure and crystallites were derived concretely.The sample with narrower MWD and higher isotacticity showed the homogeneous lamellar stacking structure and lamellar deformation behavior.On the other hand the sample with wider MWD and isotacticity showed heterogeneous lamellar stacking structure and deformation behavior.The mechanical property and the deformation behavior of crystalline lamellae in the hot drawing process were found to be affected significantly and sensitively by MWD and isotacticity distribution of iPP samples.

关键词： isotactic polypropylene synchrotron WAXD SAXS drawing

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Raman spectroscopy for the diagnosis of unlabeled and unstained histopathological tissue specimens

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 439-448页

作者： Haruo Ikeda Hiroaki Ito Muneaki Hikita Noriko yamaguchi Naoyuki Uragami noboru Yokoyama Yuko Hirota Miki Kushima Yoichi Ajioka Haruhiro Inoue Digestive Disease Center Showa University Koto Toyosu Hospital Department of Surgery Digestive Disease Center Showa University Koto Toyosu Hospital Stem Cell Business Development Department Nikon Corporation Sakae-ku Department of Pathology Showa University Koto Toyosu Hospital Division of Cellular and Molecular Pathology Niigata University Graduate School of Medical and Dental Sciences

AIM To investigate the possibility of diagnosing gastric cancer from an unstained pathological tissue using Raman spectroscopy, and to compare the findings to those obtained with conventional histopathology. METHODS We produced two consecutive tissue specimens from areas with and without cancer lesions in the surgically resected stomach of a patient with gastric cancer. One of the two tissue specimens was stained with hematoxylin and eosin and used as a reference for laser irradiation positioning by the spectroscopic method. The other specimen was left unstained and used for Raman spectroscopy analysis. RESULTS A significant Raman scattering spectrum could be obtained at all measurement points. Raman scattering spectrum intensities of 725 cm^(-1) and 782 cm^(-1), are associated with the nucleotides adenine and cytosine, respectively. The Raman scattering spectrum intensity ratios of 782 cm^(-1)/620 cm^(-1), 782 cm^(-1)/756 cm^(-1), 782 cm^(-1)/1250 cm^(-1), and 782 cm^(-1)/1263 cm^(-1) in the gastric adenocarcinoma tissue were significantly higher than those in the normal stomach tissue.CONCLUSION The results of this preliminary experiment suggest the feasibility of our spectroscopic method as a diagnostic tool for gastric cancer using unstained pathological specimens.

关键词： Label-free analysis Raman spectroscopy Histopathological examination Gastric cancer

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Review of novel therapeutic medicines targeting androgen signaling in castration-resistant prostate cancer

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World Journal of Clinical Urology 2014年第3期3卷 264-271页

作者： Daisuke Obinata Kyoko Fujiwara Kenya yamaguchi Ken-ichi Takayama Tomohiko Urano Hiroki Nagase Satoshi Inoue Satoru Takahashi noboru Fukuda Department of Urology Nihon University School of MedicineTokyo 173-8610 Japan Division of General Medicine Department of Medicine Nihon University School of MedicineTokyo 173-8610 Japan Department of Anti-Aging Medicine Graduate School of Medicine The University of TokyoTokyo 113-8655 Japan Chiba Cancer Center Research Institute Chiba 260-8717 Japan Division of Life Science Advanced Research Institute of Sciences and Humanities Nihon UniversityTokyo 173-8610 Japan

Prostate cancer is the most common male malignant neoplasm.Androgens and the androgen receptor(AR)play a key role in the onset and progression of prostate cancer.The expression of the AR is still preserved in the majority of patients with castration-resistant prostate cancer(CRPC).CRPC is considered to be induced by the following mechanisms:(1)sustained AR activation by enhancing intracellular conversion of adrenal androgens to dehydrotestosterone via a de novo route;(2)AR hypersensitivity;(3)promiscuous activation of AR signaling;and(4)outlaw pathways.Recent advances in the treatment of CRPC include novel medicinestargeting AR signaling pathways.In addition,functional molecular studies have shown that some of the ARregulated genes and AR coregulators are prognostic markers and potential therapeutic targets for prostate cancer,particularly in the castration-resistant state.Therefore,identification of the AR signaling pathways responsible for establishment of CRPC is critical for developing new strategies for the treatment of CRPC.

关键词： Androgen receptor Prostate cancer Pyrrole-imidazole polyamide

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Quantitative Evaluation of Mixing Characteristics of Static Mixers by Visualization Experiments

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Journal of Flow Control, Measurement & Visualization 2018年第1期6卷 27-38页

作者： noboru Mochizuki Aya Kaide Takashi Saeki Business Development Department ISEL Co. Ltd. Osaka Japan Graduate School of Science and Technology for Innovation Yamaguchi University Yamaguchi Japan

We propose a convenient way of evaluating the mixing performance of static mixers used for round pipe by conducting flow visualization experiments under the turbulent region and using water as the main stream. A fluorescent pigment, glycerin, two carboxymethyl cellulose solutions, and rapeseed oil were each injected upstream of the mixer. Three static mixer conditions were tested: 1) no static mixer;2) a Kenics-type static mixer;and 3) a multi-stacked elements (MSE) static mixer. The mixing trend downstream of the mixer in each condition and with each injection fluid was monitored using a laser and high-speed video camera system to obtain cross-sectional images. We propose suitable indexes based on the images obtained for quantitative evaluations of the mixing characteristics of static mixers.

关键词： Line Mixer Stacked Elements Pigment Mixing Performance Visualization Experiment

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过湿条件下大豆不定根的发生及其生理作用研究

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大豆科学 2008年第1期27卷 79-85页

作者：马启林雷慰慈山口武视中田升李阳生武汉大学生命科学学院湖北武汉430072 鸟取大学农学部日本鸟取680-8553 长江大学农学院湖北荆州434103

大豆是实行水旱轮作的重要作物之一,在缺乏良好排水条件的水田中实行水旱轮作时,长期涝渍所致的伤害成为大豆生长不良及产量低的重要原因。通过盆栽和大田试验在大豆生育初期进行过湿处理,调查培土或无培土条件下不定根的发生情况,揭示... 详细信息

大豆是实行水旱轮作的重要作物之一,在缺乏良好排水条件的水田中实行水旱轮作时,长期涝渍所致的伤害成为大豆生长不良及产量低的重要原因。通过盆栽和大田试验在大豆生育初期进行过湿处理,调查培土或无培土条件下不定根的发生情况,揭示不定根对伤流速度,氮素的吸收运转等的影响,讨论了不定根与大豆耐湿性的关系。淹水条件下培土对不定根及根瘤的发生产生较大的影响,淹水条件下发生的不定根的量占总根重的43.1%,这些不定根提供了81.4%的伤流速度。不定根的呼吸速度为2.61mgCO2g-1h-1,是初生根的近3倍。淹水导致全叶位叶片的叶色变淡,不定根的发生改变了伤流液中不同形态氮素的组成和全氮含量,可使下位叶的叶色维持较高水平。淹水条件下大豆的冠根比比对照小。不定根取代了受涝渍伤害而失去功能的初生根的作用,积极地进行养分和水的吸收,确保了涝渍逆境下物质生产的顺利进行。

关键词：大豆涝渍逆境不定根氮的同化吸收伤流速度

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水旱轮作大豆的营养生长与根系活力的关系

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大豆科学 2009年第1期28卷 36-40页

作者：马启林雷慰慈山口武视中田升李阳生武汉大学生命科学学院湖北武汉430072 长江大学农学院湖北荆州434103 鸟取大学农学部日本鸟取680-8553

大豆是实行水旱轮作制度的重要作物之一,水田的排水不良是导致轮作大豆减产的重要原因。通过对水旱轮作大豆幼苗进行过湿处理,分析了不同大豆品种的营养生长特性与根系生理活性的关系。轮作大豆在过湿条件下,所有品种的生育都受到抑制,... 详细信息

大豆是实行水旱轮作制度的重要作物之一,水田的排水不良是导致轮作大豆减产的重要原因。通过对水旱轮作大豆幼苗进行过湿处理,分析了不同大豆品种的营养生长特性与根系生理活性的关系。轮作大豆在过湿条件下,所有品种的生育都受到抑制,干物质生产受抑制程度存在着品种间的差异。营养生长诸性状中,伤流速度受过湿处理影响最大,处理区的伤流速度仅为对照区的64.2%。过湿处理导致伤流液中氮含量几乎减少了一半,伤流中的氮含量与叶片氮素含量之间存在极显著正相关关系,过湿条件下叶片氮含量的减少是由于根的氮素吸收能力的低下所致。遭遇过湿逆境时的植株个体大小与维持物质生产关系密切。过湿处理期间及其后的干物质增加量的大小与以伤流速度为代表的根系活力密切相关,说明从田间管理技术上提高大豆的根系活力以维持水旱轮作大豆的干物质生产是可行的。

关键词：大豆水旱轮作涝渍营养生长性状根系活力氮吸收能

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