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The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

Bi-Directional Signal Transmission in EPR Correlation

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Journal of Modern Physics 2014年第14期5卷 1340-1343页

作者： noboru Hokkyo Senjikan Institute Niigata Japan

A solution of nonlocal EPR correlation between counter-propagating pair of polarization entangled photons emitted from a common source at S and detected at points P and Q is sought outside the EPR’s reality criterion of local causality but within the framework of time-symmetric quantum electrodynamics allowing the bi-directional signal transmission P ?S Q on the double-light cone where the future and the past cones share common light paths connecting the photon source S and the detection points P and Q.

关键词： Quantum Theory Time-Symmetry Relativity Causality Locality Correlation Retrocausation Paradox

Outcomes of locally advanced prostate cancer:a single institution study of 209 patients in Japan

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Asian Journal of Andrology 2006年第5期8卷 555-561页

作者： ToshihiroSaito YasuoKitamura ShuichiKomatsubara YasuoMatsumoto TadashiSugita noboru Hara Department of Urology Niigata Cancer Center Hospital Niigata 951-8566Japan Radiotherapy Niigata Cancer Center HospitalNiigata 951-8566Japan Department of Urology Niigata Cancer Center Hospital Niigata 951-8566Japan Division of Urology Department of Regenerative and Transplant MedicineGraduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan

Aim： To investigate the outcomes for Asian populations with locally advanced/clinical stage Ⅲ prostate cancer （PCa） treated with currently prevailing modalities. Methods： We reviewed the record of 209 patients with clinical stage Ⅲ PCa, who were treated at Niigata Cancer Center Hospital between 1992 and 2003. Treatment options included hormone therapy-combined radical prostatectomy （RP＋HT）, hormone therapy-combined external beam irradiation （EBRT＋HT） and primary hormone therapy （PHT）. Results： The 5- and 10-year overall survival rates were 80.3% and 46.1% in all cohorts, respectively. The survival rates were 87.3% and 66.5% in the RP＋HT group, 94.9% and 70.0% in the EBRT＋HT group and 66.1% and 17.2% in the PHT group, respectively. A significant survival advantage was found in the EBRT＋HT group compared with that in the PHT group （P 〈 0.0001）. Also, the RP＋HT group had better survival than the PHT group （P = 0.0107）. The 5- and 10-year disease-specific survival rates for all cases were 92.5% and 80.0%, respectively. They were 93.8% and 71.4% in the RP＋HT group, 96.6% and 93.6% in the EBRT＋HT group and 88.6% and 62.3% in the PHT group, respectively. A survival advantage was found in the EBRT＋HT group compared with the PHT group （P = 0.029）. No significant difference was found in disease-specific survival between the EBRT＋HT and RP＋HT groups or between the RP＋HT and PHT groups. Condusion： Although our findings indicate that radiotherapy plus HT has a survival advantage in this stage of PCa, we recommend therapies that take into account the patients＇ social and medical conditions for Asian men with clinical stage Ⅲ PCa.

关键词： locally advanced prostate cancer radical prostatectomy radiotherapy hormone therapy

BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

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Bone Research 2020年第3期8卷 365-378页

作者： Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono noboru Taniguchi Department of Orthopaedic Surgery Kagoshima UniversityKagoshimaKagoshima 890-8520Japan Department of Medical Joint Materials Kagoshima UniversityKagoshimaKagoshima 890-8520Japan Department of Bone and Joint Medicine Kagoshima UniversityKagoshimaKagoshima 890-8520Japan Department of Molecular Pathology Graduate School of MedicineThe University of TokyoBunkyo-kuTokyo 113-0033Japan Institute for Frontier Life and Medical Sciences Kyoto UniversitySakyo-kuKyoto 606-8507Japan

Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone *** or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,*** morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of ***,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains *** the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in *** vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult *** global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult ***8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow ***8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ***,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression *** results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption.

关键词： Runx2 osteoclast BMP

精细农业机械化作物生产计算机集成技术(英文)

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农业工程学报 2006年第11期22卷 152-159页

作者：何勇张勤 Alan Hansen noboru Noguchi Beom-soo Shin 浙江大学生物系统工程与食品科学学院杭州310029 美国伊利诺依大学农业与生物工程系厄尔巴纳il61801 日本北海道大学农业研究生院韩国江原道大学农业工程系

介绍了一项适用于精细农业机械化的新技术计算机集成作物生产技术(CCP)。该技术融合信息采集、网络通讯、数据处理、过程决策、自动执行等功能,能有效地完成作物生产的精确机械化作业。计算机集成作物生产技术的3个主要功能是先根据需... 详细信息

介绍了一项适用于精细农业机械化的新技术计算机集成作物生产技术(CCP)。该技术融合信息采集、网络通讯、数据处理、过程决策、自动执行等功能,能有效地完成作物生产的精确机械化作业。计算机集成作物生产技术的3个主要功能是先根据需要实时采集传感数据,然后根据传感信息构建合理的行动决策,最后将传递上述决策并付诸实施。为了说明CCP的工作原理和结构设计,介绍了由伊利诺依大学机械电子系统实验室设计开发的CCP技术系统的关键功能。研究结果表明,在车辆自动导航,主从机械控制,在线式变量作业等利用农业机械实施田间作物生产作业的领域,有必要在农业机械上集成CCP技术,使机械自动地完成各项最优化项目作业。最后,根据以往工作中的经验,简要讨论了目前CPP技术发展所面临的问题和挑战。

关键词：精细农业计算机集成作物生产机械电子信息采集网络自动化

Fabrication of Porous SiO_2·RO/SUS Composite Body for DPF (Diesel Particulate Filter) and Microwave Heating Behavior

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Journal of Iron and Steel Research International 2012年第S2期19卷 787-791页

作者： LEE Chang Chuan ICHIHASHI Yuma YOSHIKAWA noboru TANIGUCHI Shoji Graduate School of Environmental Studies Tohoku University School of Manufacturing Engineering Universiti Malaysia Perlis Department of Materials Science and Engineering Tohoku University

Glass/stainless steel porous composite body were prepared by the polyurethane sponge replica method using slurries containing mixture of SiO_2-RO/30 vol%*** porous samples were obtained which consists of well-distributed stainless steel particles within the glass *** a microstructure is desired for the purpose as a soot particulate filters(DPF)utilizing microwave rapid heating in cold start *** ability of the fabricated porous composite body was carried out placing the specimen in the maximum H-field of a 2.45 GHz single mode applicator. Heating behavior of the samples was mainly influenced by the volume fraction of stainless *** heating rate was observed for samples with higher stainless steel *** to the different microwave absorbability of the materials, stainless steel particle in the porous matrix structure was firstly heated up by microwave and transferred the heat energy throughout the whole *** of the fraction of the stainless steel particle in the matrix structure led the better heating;however the strength of the samples decreased.

关键词： porous composite polyurethane sponge microwave heating

The Japanese Community Pharmacists’ Perceptions of the Health Support Pharmacy System

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Pharmacology & Pharmacy 2020年第4期11卷 55-70页

作者： Noritake Hirota noboru Okamura Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Mukogawa Women’s University Nishinomiya Japan General Incorporated Association Osaka Pharmaplan Aozora Pharmacy Osaka Japan

A questionnaire survey was conducted employing pharmacists at 350 Japanese Federation of Democratic Medical Institutions (Min-Iren) member pharmacies, evaluating the challenges related to registering as a Health Support Pharmacy (HSP). Completed responses were received from 193 pharmacies (55.1%). Fifty-five (28.5%) of these pharmacies were approved as meeting the HSP criteria. Some difficulties encountered in registering as an HSP included the preparation of the numerous required documents and placing a health support pharmacist. The obstacles that prevented pharmacists from registering were physical, including “placement of two or more health support pharmacists” and “placement of the required over-the-counter drugs (OTCs).” Based on these, 51.8% of supervising pharmacists stated the opinion that the government should “loosen current criteria.” However, a survey conducted among the 724 participant pharmacists, working in a pharmacy, showed no significant difference in their answering tendencies depending on whether or not they worked at an HSP. This could be attributed to the effort that Min- Iren pharmacies have been putting into health support and primary care functions. Overall, 64.5% of pharmacists working at HSPs were proud that the pharmacy they worked had HSP status. The present survey revealed the physical obstacles of HSP registration. Conformity to the criteria of HSP is essential for performing their fundamental functions as pharmacies. The relaxation of the criteria is anticipated.

关键词： Health Support Pharmacy Health Support Function Primary Care Function

Future perspectives for sustainable agricultural production system in Japan

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Future perspectives for sustainable agricultural production ...

A Plus Type CC-Based Current-Mode Universal Biquad

纪念中国农业工程学会成立三十周年暨中国农业工程学会2009年学术年会（CSAE 2009）

作者： noboru NOGUCHI Hokkaido University Science Council of Japan (SCJ) Japan Society of Promotion of Science (JSPS)

Congratulations on the 30th Anniversary of the Chinese Society of Agricultural EngineeringTopics

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Journal of Electrical Engineering 2020年第1期8卷 17-20页

作者： Takao Tsukutani noboru Yabuki National Institute of Technology Matsue CollegeMatsue 690-8518Japan National Institute of Technology Tsuyama CollegeTsuyama 708-8509Japan

This paper introduces a current-mode universal biquad circuit using only plus type CCs(current conveyors)(***(differential voltage current conveyors)and CCIIs(second generation current conveyors)).The circuit enables LP(low-pass),BP(band-pass),HP(high-pass),BS(band-stop)and AP(all-pass)responses by the selection and/or addition of the input and output currents without any component matching *** the circuit parametersω0 and Q can be set orthogonally adjusting the circuit components.A design example is given together with simulation responses by PSPICE.

关键词： Analog circuit biquad responses current conveyors CMOS technology