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Treatment Outcome of Pharmacokinetics-Based Dosing of Docetaxel and Fluorouracil in Advanced Head and Neck Cancer Patients

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Journal of Cancer Therapy 2018年第12期9卷 998-1010页

作者： Abdelhamid M. Fouad Magdy M. saber Yahia M. Ismail Yasser A. Sallam Tarek M. Shouman Reham A. A. Elshimy Ahmed Abo Gabal Department of Medical Oncology National Cancer Institute Cairo University Cairo Egypt Department of Radiation Oncology National Cancer Institute Cairo University Cairo Egypt Department of Clinical and Chemical Pathology National Cancer Institute Cairo University Cairo Egypt

Introduction: Docetaxel, Cisplatin and 5-Fluorouracil (DPF) became the standard induction chemotherapy in advanced Head and Neck Cancer (HNC) but associated with high toxicity rate. Several studies reported higher response rates with better tolerability when chemotherapy dose is calculated based on Pharmacokinetics (PK) versus conventional Body Surface Area (BSA). Patients and Methods: Thirty nine patients with stage III and IV HNC who received induction DPF were included in the study. Dose of cycle 1 was BSA-based then Docetaxel and 5-FU doses were PK-adjusted starting from cycle 2 whereas Cisplatin dose was BSA-based throughout the study. Results: After median follow up period of 14 months the median overall survival (OS) and progression free survival (PFS) were 15.1 and 10.6 months respectively. Twenty nine patients were available for response assessment. Seven patients (24.1%) achieved complete response while partial response encountered in 19 patients (65.5%) with and Overall response rate of 89.6%. Both treatment related side effects and mortality significantly decreased after the application of PK dose adjustments (p-value 0.007 and 0.01 respectively). Conclusion: PK-guided dose adjustments of 5-FU and Docetaxel in DPF regimen can significantly decrease the treatment related side effects and mortality without compromising the tumor response rate. A randomized clinical trial is needed to compare the PK-guided dose adjustment with the standard BSA based protocol.

关键词： Head and Neck Cancer DPF Docetaxel Fluorouracil Pharmacokinetics Dose Adjustment

A Hybrid Genetic Algorithm to Interpolate and Predict Average Reservoir Pressure

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材料科学与工程（中英文A版） 2012年第9期2卷 661-667页

作者： saber Elmabrouk Ezeddin Shirif Faculty of Engineering University of Regina Regina SK Canada S4S OA2 University of Tripoli Tripoli Libya

Insight into average reservoir pressure and its change in time, plays a critical role in reservoir development and management, economic evaluation, obtaining a hydrocarbon in place, computing rock and fluid characteristics, reservoir material balance calculations, pressure maintenance projects, surface and subsurface facility designs and predicting reservoir behavior. In particular, almost every well intervention requires insight with respect to average reservoir pressure. Traditionally, average reservoir pressure is obtained via a pressure build-up test which measures long-term built-up pressure when the producing wells are shut in. It is worth noting that the average reservoir pressure measurements should be updated periodically because reservoir pressure changes as fluids (oil, gas and water) are released from the reservoir. However, a significant economic impact is caused by shutting in the producing wells during the entire build-up test. The purpose of the work is to introduce a neural network model as an alternative tool to interpolate and predict average reservoir pressure without closing the producing wells.

关键词：地层压力预测平均地层压力混合遗传算法插值物料平衡计算油气藏开发管理储层压力神经网络模型

MicroRNA-34a targets EMT-TFs and inhibits breast cancer cell migration and invasion

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MicroRNA-34a targets EMT-TFs and inhibits breast cancer cell...

Diagnostic Utility of Sago-Like Nodules on Gross Thoracoscopic Appearance in Tuberculous Pleural Effusion and Their Correlation with Final Histo-Microbiologic Findings

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Chunli Wei saber Imani Jingliang Cheng Asaduzzaman Khan Shangyi Fu Luquan Yang Mousumi Tania Xianqin Zhang Xiuli Xiao Xianning Zhang Junjiang Fu Key Laboratory of Epigenetics and Oncology Research Center for Precision MedicineSouthwest Medical University State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Chemical Injuries Research Center Baqiyatallah Medical Sciences University (BMSU) Faculty of Applied Sciences Ton Duc Thang University The Honors College University of Houston Pathology Department Southwest Medical University Department of Cell Biology and Medical Genetics Zhejiang University School of Medicine

MicroRNA-34 a(miR-34 a) plays an essential role against tumorigenesis and progression of cancer metastasis. Here, we analyzed the expression, targets and functional effects of miR-34 a on epithelial to mesenchymal transition-inducing transcription factors(EMT-TFs), such as TWIST1, SLUG and ZEB1/2, and an EMT-inducing protein NOTCH1 in breast cancer(BC) cell migration and invasion and its correlation with tumorigenesis and clinical outcomes. Expression of miR-34 a is downregulated in human metastatic breast cancers(MBC) compared to normal breast tissues and is negatively correlated with clinicopathological features of MBC patients. Ectopic expression of miR-34 a in MBC cell-line BT-549 significantly inhibits cell migration and invasion, but exhibits no clear effect on BC cell growth. We found that miR-34 a is able to inactivate EMT signaling pathway with mediatory of NOTCH1, TWIST1, and ZEB1 upon 3′-UTR activity in MBC cell lines, but has no inhibitory effects on SLUG and ZEB2. Furthermore, we investigated the synergistic effects of Thymoquinone(TQ) and miR-34 a together on the expression of EMT-associated proteins. Results showed that co-delivery of miR-34 a and TQ is able to inactivate EMT signaling pathway by directly targeting TWIST1 and ZEB1 in BT-549 cell line, indicating that they might be a promising therapeutic combination against breast cancer metastasis. Epigenetic inactivation of the EMT-TFs/miR-34 a pathway can potentially alter the equilibrium of these regulations, facilitating EMT and metastasis in BC. Altogether, our findings suggest that miR-34 a alone could serve as a potential therapeutic agent for MBC, and together with TQ, their therapeutic potential is synergistically enhanced.

关键词： microRNA-34a thymoquinone epithelial-mesenchymal transition metastasis breast cancer

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Journal of Tuberculosis Research 2018年第4期6卷 270-280页

作者： Merlin Thomas Wanis H. Ibrahim Tasleem Raza Kamran Mushtaq Adeel Arshad Mushtaq Ahmed Salma Taha Shireen Omer saber Al Sarafandi Omer Rabadi Hisham A. Abdul-Sattar Department of Chest Hamad General Hospital Doha Qatar Department of Medicine Hamad General Hospital Doha Qatar

Background: Distinguishing tuberculous pleural effusion (TPE) from other causes of exudative effusion is often challenging. Delay in treatment initiation can occur while awaiting histo-microbiologic confirmation owing to the paucibacillary nature of the disease. Sago-like nodules are the most common visual finding on gross thoracoscopic appearance. The primary objective was to determine the diagnostic utility of the presence of sago-like nodules on gross thoracoscopic appearance in TPE to help justify early initiation of tuberculosis (TB) treatment based on their finding while awaiting final histo-microbiologic confirmation. Secondary objective was to study the correlation between the presence of sago-like nodules and the final histo-microbiologic findings in pleural biopsy specimens. Methods: This was a retrospective-descriptive study of all patients with exudative pleural effusion who underwent diagnostic medical thoracoscopy (MT) at Hamad General Hospital during an eight-year period (from January, 2008 to December, 2015). Results: The presence of sago-like nodules on gross thoracoscopic appearance of the pleural surface had a sensitivity of 58%, a specificity of 89% and a positive predictive value of 97% for TPE with a diagnostic accuracy of 62%. There is significant association between the presence of sago-like nodules and demonstration of granulomatous inflammation in pleural biopsy specimens (P = 0.000). There is no.association between sago-like nodules and positive TB smear and culture in biopsy specimens. Conclusion: The presence of sago-like nodules on gross thoracoscopic appearance has a high specificity and positive predictive value for TPE and significantly correlates with the presence of granulomatous inflammation. Patients from TB prevalent areas with exudative pleural effusion and sago-like nodules on gross thoracoscopic appearance may be commenced on TB chemotherapy while awaiting final histologic confirmation.

关键词： Tuberculous Pleural Effusions Medical Thoracoscopy Sago-Like Nodules

MEBT/MEBO治疗5岁以下儿童烧伤疗效评估

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中国烧伤创疡杂志 2017年第4期29卷 229-241页

作者： Hayam Sabry Hussein saber Raouf Gomaa Iman Labib Souad Farid Hassan Kholousy Mahmoud Sakr 埃及卡夫拉谢赫大学医学部外科系埃及卡夫拉谢赫埃及亚历山大大学医学部外科系埃及亚历山大埃及亚历山大大学医学部微生物学系埃及亚历山大

目的评估烧伤再生医疗技术(moist exposed burn therapy/moist exposed burn ointment,MEBT/MEBO)治疗儿童Ⅱ~Ⅲ度烧伤创面的临床疗效和安全性。方法 2015年9月—2016年8月埃及亚历山大大学总医院烧伤科收治的20例5岁以下Ⅱ度和/... 详细信息

目的评估烧伤再生医疗技术(moist exposed burn therapy/moist exposed burn ointment,MEBT/MEBO)治疗儿童Ⅱ~Ⅲ度烧伤创面的临床疗效和安全性。方法 2015年9月—2016年8月埃及亚历山大大学总医院烧伤科收治的20例5岁以下Ⅱ度和/或Ⅲ度烧伤患儿,均于入院后在全身综合治疗的基础上接受MEBT/MEBO治疗局部创面,其中Ⅱ度烧伤创面每天换药3次,直至创面愈合;Ⅲ度烧伤创面每天换药3次,待创面肉芽组织生长良好后,予以植皮术封闭创面。观察肉芽组织形成时间、创面愈合时间、瘢痕增生情况及药物不良反应,并检测治疗过程中创面细菌感染情况。结果肉芽组织的形成时间为10~19 d;浅Ⅱ度烧伤创面愈合时间为6~7 d,愈后皮肤弹性正常,无明显瘢痕增生及色素沉着;深Ⅱ度烧伤创面愈合时间为14~19 d,除2例患儿部分愈后皮肤留有非增生性软瘢痕外,其余患儿愈后皮肤均未见明显瘢痕增生;Ⅲ度烧伤创面均进行了皮肤移植,愈合情况良好;治疗3周后患儿创面感染率由入院时的70%下降至0;治疗过程中所有患儿均未出现药物不良反应;随访6个月,所有四肢烧伤患儿均无四肢功能障碍及畸形。结论MEBT/MEBO治疗儿童Ⅱ~Ⅲ度烧伤,可有效促进Ⅱ度烧伤创面的生理性再生愈合,恢复皮肤的正常组织结构及功能,避免植皮;可显著促进Ⅲ度烧伤创面焦痂的液化脱离以及肉芽组织的早期生长,为皮肤移植做好准备,提高移植皮片的成活率;可有效抑制细菌生长,防治创面感染;操作简便、安全可靠,可有效降低过敏反应及副反应的发生率。

关键词：再生疗法烧伤再生医疗技术湿润环境烧伤感染儿童创面愈合

Developing a Low-cost,smart,handheld electromyography biofeedback system for telerehabilitation with Clinical Evaluation

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Medicine in Novel Technology and Devices 2021年第2期10卷 17-24页

作者： Mazen M.Yassin Abubakr M.saber Mohamed N.Saad Ashraf M.Said Ayman M.Khalifa Biomedical Engineering Department Minia UniversityMinia61111Egypt Department of Biomedical Engineering Helwan UniversityCairo11731Egypt J.Crayton Pruitt Family Department of Biomedical Engineering University of FloridaGainesvilleFL32611USA

Existing telerehabilitation systems require highly experienced personnel to interpret a patient’s muscle activity in a specialized lab,limiting the biofeedback available at the patient’s *** addition,there is no contact between physiotherapists and patients *** study designed and implemented an interactive teleelectromyography(EMG)biofeedback device for facilitating patients’rehabilitation and giving the physiotherapist the ability to develop and monitor personalized treatment for each patient precisely and *** device comprised a device that acquires EMG signals during muscular activity and two cell phone applications,one for the patient and the other for the physiotherapist;traced muscle activity;and enabled the physiotherapist to monitor and control the patients’sessions through a Google Firebase *** signals were acquired from five subjects,and results were compared to a certified *** evaluation process involved two metrics,correlation coefficient and root mean square value(RMSV).The proposed EMG biofeedback device is an integrated solution with numerous features,such as low cost,handheld size,patient-friendly interface,contributions to rapid healing,and secure *** addition,it provides raw EMG signals for applied research applications.

关键词： Electromyography EMG Biofeedback Physiotherapy Telerehabilitation Home use Rehabilitation

A Markov Model for Production and Maintenance Decision

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Macro Management & Public Policies 2020年第1期2卷 1-5页

作者： Mohammad saber Fallahnezhad Alie Ranjbar Faeze Zahmatkesh Sredorahi Industrial Engineering Yazd UniversityYazdIran

In this paper,we consider a production machine which may fail and it is necessary to repair the machine after each failure and there are two statuses for each repair;in one case,we should replace the machine because of catastrophic failure and in the other case,only small repairs are *** between failures and repair and replace times are random and demands are satisfied by inventory during repairing and replacing the machine;shortage level is *** model described system as a Markov chain and develop an algorithm to compute the expected number of transitions among states.

关键词： Markov chain Cost function Maintenance policy Production process

Evaluation of the effect of neoadjuvant chemotherapy on tumor and axillary lymph nodes in locally advanced breast cancer: a study of 50 patients

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The Chinese-German Journal of Clinical Oncology 2014年第8期13卷 363-369页

作者： Ali H.Meebed Ihab S.Fayek Amany saber Reda H.Tabashy Mona A.Sakr Department of Surgical Oncology National Cancer InstituteCairo Egypt Department of Medical Oncology Minia Cancer Center El Minia Egypt Department of Radiodiagnosis National Cancer Institute Cairo Egypt Department of Surgical Pathology National Cancer Institute Cairo Egypt

Objective： The purpose of the study was to correlate between effect of pre-neoadjuvant chemotherapy （NACT） and post-NACT clinical, sonographic and pathologic features of the tumor and axillary lymph nodes （ALNs） and to raise the possibility of applying the concept of sentinel lymph node biopsy （SLNB） in patients with initially positive ALNs before NACT. Methods： A prospective study of 50 female patients with locally advanced breast cancer （LABC） with clinically *** cytologically （under ultrasonographic guidance） positive ALNs. All patients received NACT and then referred for ultrasono- graphic assessment of the axilla regarding any detectable sonographic criteria of metastatic deposits in ALNs as well as the tumor size in relation to its prechemotherapy size, All patients were then subjected either to modified radical mastectomy or breast conserving surgery. The clinical, sonographic and pathological response of the tumor and the ALNs were documented, classified and correlated with each other. Results： Patients＇ mean age was 47.7±9.1 years. The mean clinical tumor size was 6.7 ± 1.4 cm; stage IliA that was presented in 32 patients （64%） and IIIB was presented in 18 patients （36%）. Chemotherapy was given for a median of 4 cycles, there was reduction of the mean clinical tumor size from 6.7 ± 1.4 cm to 4.3 ± 2.7 cm （P 〈 0.001）. Clinical response was complete in 5 （10%） tumors, complete pathological tumor response （post-neoadjuvant） was detected in 6 （16%） of patients. Complete clinical no.al response （post-neoadjuvant） in 23 （46%） axillae, on sonographic assessment of the axilla, response was complete in 17 （34%） axillae. Complete pathological no.al response occurred in 16 （32%） axillae. Out of 17 axillae that showed complete sonographic response 11 axillae showed complete pathological no.al response （P 〈 0.001）. Conclusion： Formal axillary lymph node dissection can be avoided and replaced by SLNB post NACT in patients with LABC with metastatic ALNs if there

关键词： locally advanced breast cancer (LABC) neoadjuvant chemotherapy (NACT) axUlary nodes

ABCC4基因的突变影响纤毛的发生造成家猪的轴前多趾畸形

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ABCC4基因的突变影响纤毛的发生造成家猪的轴前多趾畸形