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Simple lC Isocratic Methods Development, Validation, and Application in the Analysis of Poor Quality Antimalarial Medicines

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American Journal of Analytical Chemistry 2017年第9期8卷 582-603页

作者： Védaste Habyalimana Jérémie Kindenge Mbinze Achille loconon Yemoa Justin-léonard Kadima Ntokamunda Philippe Hubert Roland Marini Djang’eing’a laboratory of Pharmaceutical Analytical Chemistry CIRM University of Liège (ULg) Liège Belgium Rwanda Biomedical Center/Medical Procurement and Production Division Kigali Rwanda Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa XI Democratic Republic of Congo Faculty of Health Sciences School of Pharmacy University of Abomey Calavi Cotonou Benin School of Medicine and Pharmacy University of Rwanda Butare Rwanda

liquid chromatographic methods in isocratic mode for the analysis of poor quality medicines are privileged due to their simplicity and facility in methods development. They are generally fast;do not need to be re-equilibrated between sample injections;have larger flexibility with acceptable changes on different column dimensions;and are applicable to lC systems equipped with simple or high developed pumps. In this study, we focused on developing simple isocratic methods using classical mobile phase composed by methanol and ammonium formate buffer for the analysis of most common antimalarial medicines marketed in malaria endemic countries and susceptible of being counterfeit/falsified, substandard and degraded. The selected medicines were quinine and related cinchona alkaloids in tablets and injectable forms;artemether/lumefantrine tablets;and artemisinin compounds (arteether, artemether, and artesunate) in injectable forms. The current methods were developed thanks to simple methodological approach consisting in sequential isocratic runs through adjustment or adaptation of existing methods to obtain optimal analytical conditions without complex design of experiments that might be long and costly. Then, the new methods presented shorter analysis time;allowed increase of sample analysis throughput;and obviously consumed little mobile phase solvents on classical analytical columns: 50 - 250 mm of length (l), 4.6 mm of internal diameter (I.D.), and 3.5 - 5.0 μm of particle size (dp).

关键词： Antimalarial Medicines liquid Chromatography Isocratic Mode Validation Poor Quality Medicines

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Utilization of Different Variables for the Visualization of Fluid Flows: Application to Instantaneous Channel Flows

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Journal of Thermal Science 2001年第2期10卷 116-122页

作者： Gerard J. Poitras New Brunswick Cornmunity College, Edmundston (NB), Canada l.-Emmanuel Brizzi laboratoire d’etudes aerodynamiaues, Universite de Poitiers, 86960 Futuroscope, france Yves Gagnon Faculte des studes superieures et de la recherche, Universite New Brunswick Community College Edmundston Canada laboratoire d’études aérodynamiques Université de Poitiers Futuroscope France Faculté des études supérieures et de la recherche Université de Moncton Moncton Canada

The results of different numerical algorithms for the computation of unsteady fluid flows are used to visualize different variables of the flow. In particular, the instantaneous vorticity, velocity and pressure fields, along with streamline plots, are presented as a function of time inside a visualization window of the computational domain. The different forms of visualization are used to analyze the flow inside a two-dimensional channel incorporating an obstacle, which can represent several interesting flows such as the flow over electronic components, heat transfer devices and buildings.

关键词： Vortex methods finite volume method velocity field pressure vorticity.

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Nanoscale image of the drug/metal mono-layer interaction:Tapping A FM-IR investigations

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Nano Research 2020年第4期13卷 1020-1028页

作者： Natalia Piergies Alexandre Dazzi Ariane Deniset-Besseau Jeremie Mathurin Magdalena Ocwieja Czeslawa Paluszkiewicz Wojciech M.Kwiatek Institute of Nuclear Physics Polish Academy of SciencesPL-31342 KrakowPoland laboratoire de Chimie Physique(lCP) CNRS UMR 8000Univ.of Paris-SudUniversite Paris-Saclay91405 OrsayFrance Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences Niezapominajek 8PL-30239 KrakowPoland

The application of metal nanoparticles as an efficient drug delivery system is one of the directions of cancer therapy ***,this strategy requires precise information about how the drug interacts with the applied *** this study,atomic force microscopy combined with infrared spectroscopy(AFM-IR)was used for the first time to investigate the erlotinib adsorption structure on two different types of 15 nm metal nanoparticle mono-layers,namely,silver nanoparticle(AgNP)and gold nanoparticle(AuNP)*** the metal nanoparticles are loosely bound samples,only the tapping AFM-IR mode is suitable for the collection of IR maps and spectra for such a *** obtained results indicated the relevance of the AFM-IR technique for characterizing drug interactions with a metal mono-layer *** investigated drug interacts with the AgNPs mainly through phenyl rings and methoxy moieties,while quinazoline,amino,and ethoxy moieties appear to be farther from the *** the AuNPs,the interaction occurs through both the phenyl ring and the quinazoline ***,the aliphatic groups of erlotinib directly participate in this *** novelty of the present work is also related to the use of the tapping AFM-IR mode to study metal NP mono-layers with a drug adsorbed on *** collected IR maps for the most enhanced erlotinib bands show specific areas with very high signal *** connection between these areas and the"hot spots"typical for the surface plasmon resonance phenomenon of metals is considered.

关键词： metal nanoparticle mono-layer drug's adsorption infrared nanospectroscopy atomic force microscopy erlotinib

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Recent Developments in Cooling Using Blowing

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Tsinghua Science and Technology 2002年第2期7卷 116-134页

作者： F. Bataille, l. Mathelin, A. lallemand Centre de Thermique de lyon, UMR CNRS 5008, INSA de lyon, france Centre de Thermique de lyon UMR CNRS 5008 INSA de Lyon France

Influence of the blowing through a porous flat plate and a circular cylinder has been studied. Experimental and numerical results agree and show a thickening of the boundary layers, both dynamic and thermal. The thermal protection effectiveness has been quantified for the two geometries, and comparisons between discrete injection and blowing, in the case of the flat plate, were carried out, showing a stronger impact of the latter. Finally, the blowing influence on the primary instability properties results in a decrease of the vortex shedding frequency and a modification of the shear layer. 

关键词： blowing cooling flat plate circular cylinder

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Multi-Compartment SCFA Quantification in Human

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American Journal of Analytical Chemistry 2024年第6期15卷 177-200页

作者： Jérémy Monteiro Antoine lefèvre Diane Dufour-Rainfray Adeline Oury Gabrielle Chicheri laurent Galineau Hélène Blasco lydie Nadal-Desbarats Patrick Emond Imaging Brain & Neuropsychiatry iBraiN U1253 Universit de Tours INSERM MetaboHub Tours Tours France CHRU de Tours Service de Mdecine Nuclaire in Vitro Tours France Service de Biochimie et Biologie Molculaire CHRU Tours France

Short-chain fatty acids (SCFA) play an important role in human biochemistry. They originate primarily from the digestive system through carbohydrates microbial fermentation. Most SCFA produced in the colon are absorbed by the intestinal wall and enter the bloodstream to be distributed throughout the body for multiple purposes. At the intestinal level, SCFA play a role in controlling fat storage and fatty acid metabolism. The effects of these beneficial compounds therefore concern overall health. They facilitate energy expenditure and are valuable allies in the fight against obesity and diabetes. SCFA are also involved in the regulation of the levels of several neurotransmitters such as GABA (γ-aminobutyric acid), glutamate, serotonin, dopamine, and norepinephrine. Their role is also highlighted in many inflammatory and neurodegenerative diseases such as Alzheimer’s disease (AD) or Parkinson’s disease (PD). To have a realistic picture of the distribution of SCFA in different biological compartments of the human body, we propose to study SCFA simultaneously in five human biological samples: feces, saliva, serum, cerebrospinal fluid (CSF), and urine, as well as in Dried Blood Spot (DBS). To evaluate their concentration and repeatability, we used 10 aliquots from pooled samples, analyzed by 3-nitrophenylhydrazine (3-NPH) derivation and liquid chromatography coupled with high sensitivity mass spectrometry (lC-QqQ-MS). We also evaluated the SCFA assay on Dried Blood Spot (DBS). In this work, we adapted the pre-analytical parts for each sample to be able to use a common calibration curve, thus facilitating multi-assay quantification studies and so being less time-consuming. Moreover, we proposed new daughter ions from the same neutral loss (43 Da) to quantify SCFAs, thus improving the sensitivity. In conclusion, our methodology, based on a unique calibration curve for all samples for each SCFA, is well-suited to quantified them in a clinical context.

关键词： lC-MS 3-Nitrophenylhydrazine Short-Chain Fatty Acids Human Biological Samples Quantification

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Ionization Process of Atoms by Intense Femtosecond Chirped laser Pulses

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Journal of Modern Physics 2013年第10期4卷 20-26页

作者： Stéphane laulan Jérémie Haché Harouna S. Ba Samira Barmaki laboratoire de Physique Computationnelle et Photonique Université de Moncton Campus de Shippagan Shippagan Canada

We numerically investigate the ionization mechanism in a real hydrogen atom under intense fem to second chirped laser pulses. The central carrier frequency of the pulses is chosen to be 6.2 eV (λ = 200 nm), which corresponds to the fourth-harmonic of the Ti:Sapphire laser. Our simulation of the laser-atom interaction consists on numerically solving the three-dimensional time-dependent Schrodinger equation with a spectral method. The unperturbed wave functions and electronic energies of the atomic system were found by using an l2 discretization technique based on the expansion of the wave functions on B-spline functions. The presented results of kinetic energy spectra of the emitted electrons show the sensitivity of the ionization process to the chirp parameter. Particular attention is paid to the important role of the excited bound states involved in the ionization paths.

关键词： Hydrogen Atom Chirped laser Multiphoton Ionization Population Transfer Nonperturbative Approach

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空间冷原子钟技术

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中国激光 2024年第11期51卷 201-222页

作者：项静峰任伟邓思敏达刘亮吕德胜中国科学院上海光学精密机械研究所空天激光技术与系统部上海201800 中国科学院上海光学精密机械研究所量子光学重点实验室上海201800 中国科学院大学材料科学与光电子学技术学院北京100049

空间冷原子钟作为在空间环境运行的高精度原子钟,在导航定位、深空探测和基础物理研究等领域展现出巨大的应用潜力。20世纪90年代以来,随着中性原子激光冷却技术的发展,喷泉冷原子钟得以实现并将频率稳定度和准确度从以往铯束原子钟的10... 详细信息

空间冷原子钟作为在空间环境运行的高精度原子钟,在导航定位、深空探测和基础物理研究等领域展现出巨大的应用潜力。20世纪90年代以来,随着中性原子激光冷却技术的发展,喷泉冷原子钟得以实现并将频率稳定度和准确度从以往铯束原子钟的10^(-14)量级提高到10^(-16)量级。法国、美国和中国均提出了在微重力环境下运行高精度冷原子钟的计划。在中国载人航天工程的支持下,2016年上海光学精密机械研究所研制的天宫二号空间冷原子钟在国际上首次实现了在轨运行。欧盟的空间光钟项目于2007年获得欧洲航天局资助,目前实验室中的冷原子光钟的频率不确定度与稳定度都达到了10-18量级。随着空间光钟技术的不断发展,美国、欧盟和中国分别提出了基于空间光钟的不同实验项目建议。本文首先介绍冷原子微波钟与冷原子光钟的技术基础,然后通过概述国内外空间冷原子钟计划的任务特点、关键技术和项目进展,阐述了空间冷原子钟在基础物理和导航定位中的作用,并展望了未来高精度原子钟技术的发展方向。

关键词：冷原子原子钟光钟频率稳定度频率不确定度空间站

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敦煌册子本缝缀形式初探——以英藏和法藏敦煌文献为中心

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古籍保护研究 2024年第1期 70-103页

作者：吕晓芳北京大学图书馆

文章根据文字和图版资料,对英藏和法藏敦煌文献中涉及缝缀的册子本进行筛查和整理,尝试全貌性地揭示敦煌册子本中缝缀形式的特征、类别和分布。敦煌册子本的缝缀形式可以分为粘叶本的加固缝缀和线订本的独立缝缀两大类。粘叶本的加固缝... 详细信息

文章根据文字和图版资料,对英藏和法藏敦煌文献中涉及缝缀的册子本进行筛查和整理,尝试全貌性地揭示敦煌册子本中缝缀形式的特征、类别和分布。敦煌册子本的缝缀形式可以分为粘叶本的加固缝缀和线订本的独立缝缀两大类。粘叶本的加固缝缀是在使用过程中补充添加,形式较为随意,相对常见的方法是在天头、地脚处分别贯穿打一到两孔穿线缀订。线订本的独立缝缀则是册子最初制作时采取的缀订形式,呈现显著的共性。绝大多数线订本采用多纸成查、折缝穿线、连查为册的典型折缝锁线订,规整者多四张对叶成查,六孔、八孔或四孔,孔距均匀,原色缝线,开本多呈类似现代书籍的竖方形或类似经折本的竖长形。除此之外还有个别线订本为单查折缝锁线订、侧订等形式。

关键词：敦煌文献册子本缝缀形式书籍装订

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地被菊花Fall Color体细胞胚途径再生、遗传转化及转基因植株的抗寒性检测

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中国农业科学 2006年第7期39卷 1443-1450页

作者：洪波仝征李邱华马超 KASUGA mie YAMAGUCHI-SHINOZA KIKaziko 高俊平中国农业大学观赏园艺与园林系 Biological Resources Division Japan International Research Center for Agricultural Sciences1-1 OhwashiTsukubaIbaraki305-8686 Japan

【目的】培育耐寒性强的地被菊花[Dendranthemagrandiflorum(Ramat.)Kitamura]新材料。【方法】以FallColor品种的幼嫩叶片为外植体,探讨胚状体诱导所需的植物生长调节剂浓度和诱导培养时间等条件。【结果】叶片外植体在添加0.75mg·l-1... 详细信息

【目的】培育耐寒性强的地被菊花[Dendranthemagrandiflorum(Ramat.)Kitamura]新材料。【方法】以FallColor品种的幼嫩叶片为外植体,探讨胚状体诱导所需的植物生长调节剂浓度和诱导培养时间等条件。【结果】叶片外植体在添加0.75mg·l-12,4-D的诱导培养基上诱导15d,再进行分生培养,不仅能够诱导胚性愈伤组织形成,还能够诱导胚状体发生,并进一步诱导芽再生,最终93%的供试外植体通过胚状体途径获得芽的再生。通过根癌农杆菌介导法将35S启动子驱动的逆境诱导转录因子DREB1A基因导入该品种。转化株在低温下的种子发芽率、扦插苗生长以及植株露地越冬生长状况等方面都明显优于对照。【结论】本研究成功地建立了地被菊花FallColor体细胞胚再生途径,并成功地获得了具有越冬耐性的地被菊花转化株系。

关键词：菊花地被菊花体细胞胚遗传转化 AtDREB1A 耐性检测

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滥伐护岸林对潜在土壤侵蚀及渔业的影响

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水土保持科技情报 1998年第3期16卷 4-5页

作者： R.l.france 刘秀菊河南省西峡县水利局

乱砍滥伐护岸林加速土壤侵蚀，大大危害鱼类的生存。加拿大安大略省西北部10个湖滨区，由于过量采伐林木长达4～10a，地面上的枯枝落叶层只有未采区的60％。随着湖滨区地表覆盖物的减少，土壤腐殖质的含量大为下降。通过模拟降雨试验，... 详细信息

乱砍滥伐护岸林加速土壤侵蚀，大大危害鱼类的生存。加拿大安大略省西北部10个湖滨区，由于过量采伐林木长达4～10a，地面上的枯枝落叶层只有未采区的60％。随着湖滨区地表覆盖物的减少，土壤腐殖质的含量大为下降。通过模拟降雨试验，发现裸地侵蚀量为有枯枝落叶覆盖地的2倍。由于林木的滥伐导致土壤侵蚀加剧，有关人士认为，安大略省应该恢复1985年前的政策：禁止在湖滨区采伐树木，为鱼类生存创造环境，确保渔业发展。

关键词：护岸林潜在土壤侵蚀枯枝落叶土壤侵蚀渔业

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