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Management and outcome of hepatocellular adenoma with massive bleeding at presentation

World Journal of Gastroenterology 2017年第25期23卷 4579-4586页

作者： Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan nm Ijzermans Department of Surgery Department of Gastroenterology and Hepatology Department of Radiology

To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma (HCA). METHODSThis retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage (grade II or III) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrast-enhanced magnetic resonance imaging (MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short- and long-term complications and patient and lesion follow-up. RESULTSAll patients were female (n = 23). Treatment in the acute phase consisted of embolization (n = 9, 39.1%), conservative therapy (n = 13, 56.5%), and other intervention (n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively (0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe short-term complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in non-surgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary (elective) treatment (i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented (4.3%). None of the patients experienced long-term complication (mean follow-up time: 36 mo). CONCLUSIONWith a 4.3% risk of rebleeding, secondary (elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm.

关键词： Hepatocellular adenoma Management Bleeding Outcome Hemorrhage

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The role of human papillomaviruses in cancer progression

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 201-213页

作者： pinar Tulay Nedime Serakinci Department of Medical Genetics Faculty of MedicineNear East University999058 NicosiaCyprus

The importance of human papillomavirus(HPV)infection and its role in the progress of cancer have been widely *** understanding of HPV association with certain cancers,such as cervical cancer,is very well established.A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been *** the last decade,development of HPV vaccination has reduced the number of cases in HPV infections and infection induced *** this report,we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.

关键词： Human papillomavirus cancer immune response human papillomavirus vaccine

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Machine perfusion in abdominal organ transplantation: Current use in the Netherlands

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World Journal of Transplantation 2020年第1期10卷 15-28页

作者： Elsaline Rijkse Jan nm IJzermans Robert C Minnee Division of HPB and Transplant Surgery Department of Surgery Erasmus MC University Medical Center

Scarcity of donor organs and the increment in patients awaiting a transplant increased the use of organs from expanded criteria donors or donation after circulatory *** to the suboptimal outcomes of these donor organs,there is an increased interest in better preservation methods,such as ex vivo machine perfusion or abdominal regional perfusion to improve *** state-ofthe-art review aims to discuss the available types of perfusion techniques,its potential benefits and the available evidence in kidney,liver and pancreas ***,translational steps from animal models towards clinical studies will be described,as well as its application to clinical practice,with the focus on the *** the lack of evidence from randomized controlled trials,currently available data suggest especially beneficial effects of normothermic regional perfusion on biliary complications and ischemic cholangiopathy after liver *** ex vivo machine perfusion in kidney transplantation,hypothermic machine perfusion has proven to be beneficial over static cold storage in a randomized controlled trial,while normothermic machine perfusion is currently under *** ex vivo machine perfusion in liver transplantation,normothermic machine perfusion has proven to reduce discard rates and early allograft *** response to clinical studies,hypothermic machine perfusion for deceased donor kidneys has already been implemented as standard of care in the Netherlands.

关键词： Machine perfusion Review Kidney transplantation Liver transplantation Pancreas transplantation

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Intrapulmonary calcifying fibrous pseudotumour of the lung

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Chinese Medical Journal 2012年第21期125卷 3918-3919页

作者： pinar Bicakcioglu Serpil Dizbay Sak Riza Dogan Department of Thoracic Surgery Ataturk Training and Research Hospital for Chest Disease and Thoracic SurgeryKecioren 06280AnkaraTurkey Department of Pathology Ankara University Medical FacultyAnkaraTurkey Department of Thoracic and Cardiovascular Surgery I lacetlepe University Medical FacultyAnkaraTurkey

Lalcifying fibrous pseudotumor （CFP） is one of the most unusual benign lesions and its histopathological appearance defined only during the last 15 years. It is characterized by dense, hyalinised collagenous tissue interspersed with benign spindle cells,lymphoplasmocytic psammomatous and/or infiltrate and particularly, dystrophic *** exhaustive search has shown that only 70 cases of this rare entity have been recorded in English：

关键词： calc!fying fibrous pseudotumour pulmonary nodule benign

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Spatio-temporal variation of cyclone intensity over the coastal region of Bangladesh using 134 years track analysis

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Tropical Cyclone Research and Review 2022年第1期11卷 16-25页

作者： nm Refat Nasher Kh Razimul Karim Md Yachin Islam Department of Geography and Environment Jagannath UniversityBangladesh Graduate School of Human Development and Environment Kobe UniversityJapan Center for Environmental and Geographic Information Services(CEGIS) DhakaBangladesh

The cyclone tracks from 1877 to 2020 were analyzed to detect the spatial and temporal *** tracks were gathered from previously published *** previous articles’tracks were digitized and converted to shape files for analysis in Arc-GIS.A total 126 cyclone tracks were used to detect monthly and seasonal cyclone intensity and spatial *** fluctuations were examined over a 30-year period,which is believed to be the climate of a particular *** cyclones hit the Bay of Bengal’s coast starting in May and lasting until *** May and October,the number of cyclones is at its peak(26 nos in each month).From June through September,the number of cyclones *** October and November,the number of cyclones increased *** number of cyclones substantially fell in December,and no cyclones were observed from January through *** 1939 through 1969,the highest number of cyclones(36)was *** the mid-and latetwentieth century,there were a higher number of *** coastal region of Bangladesh suffered the fewest cyclones in history over the recent era(2001–2020).The western shore was particularly vulnerable from 1877 to 1907,and the entire coastal region was dangerous from 1908 to *** the Post-monsoon(October to December)season,the number of cyclones is lower than in the Monsoon period(May to September).In the pre-monsoon season,71 cyclones strike,while in the Monsoon season,53 cyclones strike.

关键词： Digitize Tropical Seasonal Monthly Strike Coastal

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A Comparative Analysis of Owner-Contractor Agreements in the Turkish and US Construction Industry

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Journal of Civil Engineering and Architecture 2014年第4期8卷 492-498页

作者： pinar Irlayici Cakmak Elcin Tas Department of Architecture lstanbul Technical University Istanbu134743 Turkey

Successful and cost-effective construction relies upon appropriate communication of the participants of the construction project. Hence, it is important to define the rights and responsibilities of the parties, and relationships among them. In this context, well-designed and complete agreement is essential and necessary for the successfully completion of a construction project within the desired time, quality and budget. In this paper, it is aimed to analyze and compare the owner-contractor agreements in the Turkish and the US construction industry. First, the importance of construction contracts and contractual elements of an agreement is determined, and then, the standard owner-contractor agreement which is used in the Turkish construction industry is analyzed and compared with the US standard owner-contractor agreement. Finally, the differences between these agreements are put forward, the lack and deficiencies of Turkish standard agreement form are determined, and appropriate suggestions are improved.

关键词： AIA (American Institute of Architects) construction contracts KIK (Kamu lhale Kurumu) owner-contractor agreement,standard forms.

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Potential impact of autonomous vehicles in mixed traffic from simulation using real traffic flow

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2023年第1期6卷 1-15页

作者： Eleonora Andreotti Selpi pinar Boyraz Department of Mechanics and Maritime Sciences Chalmers University of TechnologySE-41296 GöteborgSweden CINECA Supercomputing Inter-University Consortium40033 BolognaItaly Department of Computer Science and Engineering Chalmers University of TechnologySE-41296 GöteborgSweden

This work focuses on the potential impacts of the autonomous vehicles in a mixed traffic condition represented in traffic simulator Simulation of Urban MObility(SUMO)with real traffic ***,real traffic flow and speed data collected in 2002 and 2019 in Gothenburg were used to simulate daily flow variation in *** order to predict the most likely drawbacks during the transition from a traffic consisting only manually driven vehicles to a traffic consisting only fully-autonomous vehicles,this study focuses on mixed traffic with different percentages of autonomous and manually driven *** realize this aim,several parameters of the car following and lane change models of autonomous vehicles are investigated in this *** with the fundamental diagram,the number of lane changes and the number of conflicts are analyzed and studied as measures for improving road safety and *** study highlights that the autonomous vehicles’features that improve safety and efficiency in 100%autonomous and mixed traffic are different,and the ability of autonomous vehicles to switch between mixed and autonomous driving styles,and vice versa depending on the scenario,is necessary.

关键词： automated driving autonomous vehicles(AVs) mixed-traffic traffic simulations driving style realistic conditions

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Hypochlorous Acid Induces Caspase Dependent Apoptosis in <i>Saccharomyces cerevisiae</i>

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Journal of Biosciences and Medicines 2021年第4期9卷 42-53页

作者： Nur Kaluç pinar B. Thomas Department of Medical Biology and Genetics Faculty of Medicine Maltepe University Istanbul Turkey

Hypochlorous acid (HOCl) is a strong oxidant produced by activated neutrophils via the myeloperoxidase (MPO) enzyme in order to fight against infections. Because of their antimicrobial and antiviral properties, stabilized HOCl solutions were produced to be used as a disinfectant and became a recommended disinfectant against COVID-19 by the US Environmental Protection Agency. Aberrant MPO enzyme activity results in abundant HOCl production which is related to the development and/or progression of several diseases including atherosclerosis, cardiovascular and neurodegenerative diseases. Previous studies investigating the effect of HOCl on the mode of cell death in different cell types reported that HOCl induces both apoptosis and necrosis depending on its concentration. However, the data on the apoptotic pathway triggered by HOCl is controversial. In this study, we investigated the mode of cell death induced by different concentrations of HOCl in Saccharomyces cerevisiae. Our data revealed that HOCl leads to cell death within 1 minute at 170 μM and above. At 340 μM, HOCl causes a rapid necrosis, while 170 μM HOCl leads to apoptosis. HOCl-induced apoptosis is mostly caspase dependent and Aif1 doesn’t have a significant role.

关键词： Hypochlorous Acid Saccharomyces cerevisiae Viability Apoptosis

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含黄酮的三价铁配合物合成及其药理性质(英文)

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无机化学学报 2010年第10期26卷 1743-1749页

作者： Emel Yildiz Sadet Karabulut Neslihan S.pinar Yusuf Karatas Figen Doran Cukurova大学文理学院化学系 Cukurova大学医学院药理学系 Cukurova大学医学院病理学系

3,3,4,7-四羟基黄酮与1,3-二环己基碳二亚胺在4-二甲胺吡啶存在下反应,得到2,2-双(3,3,4,7-四羟基黄酮)1,3-二环己基碳二亚胺。三价金属离子与上述合成得到的配体螯合,对此四面体结构的双核Fe(Ⅲ)配合物的血液学及病理学数据进行了讨论... 详细信息

3,3,4,7-四羟基黄酮与1,3-二环己基碳二亚胺在4-二甲胺吡啶存在下反应,得到2,2-双(3,3,4,7-四羟基黄酮)1,3-二环己基碳二亚胺。三价金属离子与上述合成得到的配体螯合,对此四面体结构的双核Fe(Ⅲ)配合物的血液学及病理学数据进行了讨论,同时研究了合成的配体作为螯合剂清除鼠肝胰组织中超载的铁的能力。结果表明作为口服药其作为双齿配体的螯合能力与市售用于治疗地中海贫血的药物"去铁敏"相近。

关键词：螯合黄酮铁(Ⅲ)离子药物治疗地中海贫血

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Dependence of microstructural, mechanical and electrical properties on growth rates in directional solidified Zn-Al-Bi eutectic alloy

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Transactions of Nonferrous Metals Society of China 2016年第9期26卷 2320-2335页

作者： Yasin KARAMAZI Umit BAYRAM pinar ATA Sezen AKSOZ Kazim KESLIOGLU Necmettin MARASLI Department of Physics Institute of Science and TechnologyErciyes UniversityKayseri 38039Turkey Department of Physics Faculty of ScienceErciyes UniversityKayseri 38039Turkey Department of Physics Institute of Science and TechnologyNevsehir Hacl Bektas Veli UniversityNevsehir 50300Turkey Department of Physics Faculty of Arts and SciencesNevsehir Haci Bektas Veli UniversityNevsehir 50300Turkey Department of Metallurgical and Materials Engineering Faculty of Chemistry and Metallurgical EngineeringYildiz Technical UniversityDavutpasa-EsenlerIstanbul 34220Turkey

Zn-5%Al-0.2%Bi（mass fraction） alloy was directionally solidified upward at a constant temperature gradient with a wide range of growth rates using a Bridgman-type directional solidification furnace. The eutectic spacings, microhardness, ultimate tensile strength and electrical resistivity for directionally solidified Zn-Al-Bi alloy were measured. Dependence of eutectic spacings, microhardness, ultimate tensile strength and electrical resistivity on growth rates was obtained by linear regression analysis. The results obtained in the present work for low growth rates（smaller than 450.0 μm/s） are in good agreement with experimental results obtained in previous work for directional solidified Zn-Al eutectic alloy with a similar growth rate but differs from the Jackson-Hunt eutectic theory and those obtained in previous experimental works at higher growth rates. The critical growth rate might be 450.0 μm/s for the Zn-Al-Bi eutectic alloy. From the plot of heat flow versus temperature, enthalpy of fusion, specific heat difference between liquid and solid phases and melting temperature for the Zn-Al-Bi alloy are found to be 112.55 J/g, 0.291 J/（g·K） and 660.20 K, respectively.

关键词： directional solidification zinc-aluminum alloy microstructure microhardness tensile strength electrical properties

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