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Open Journal of Endocrine and Metabolic Diseases 2017年第3期7卷 97-110页

作者： Meral Mert Gonca Tamer Nahide Ekici Gunay Ilkay Kartal Hamide Piskinpasa pinar Karakaya Yildiz Okuturlar Clinic of Endocrinology and Metabolism Bakirkoy Dr. Sadi Konuk Education and Research Hospital Istanbul Turkey Clinic of Endocrinology and Metabolism Istanbul Medeniyet University Goztepe Education and Research Hospital Istanbul Turkey Central Laboratory Kayseri Education and Research Hospital Kayseri Turkey Clinic of Internal Medicine Bakirkoy Dr. Sadi Konuk Education and Research Hospital Istanbul Turkey

Objective: To evaluate vitamin D status in relation to serum levels for parathyroid hormone (PTH) and corrected calcium among endocrine outpatients. Methods: A total of 760 patients (mean(SD) age: 40.0(12.6) years, 94.6% were females) admitted to our endocrinology outpatient clinic were included and evaluated with respect to patient demographics, serum levels for 25-hydroxyvitamin D (25(OH) D, ng/mL), PTH (pg/mL) and corrected calcium (mg/dL) as well as the vitamin D status. Results: Vitamin D deficiency was determined in 65.0% and elevated PTH levels in 20.3% of patients. iPTH levels were significantly higher in females than in males (58.9(40.4) vs. 45.1(26.2) pg/mL, p = 0.031) and in summer than in winter cases (63.9(47.7) vs. 54.2(32.8) pg/mL, p = 0.002), whereas no difference was found in serum levels for 25(OH) D, corrected calcium and phosphate with respect to gender and season. Significantly higher levels for iPTH were noted in vitamin D deficient patients (60.7(43.9) pg/mL) than in normal (51.1(33.4) pg/mL) and vitamin D insufficient (57.1(26.0) pg/mL) cases (p = 0.03). iPTH levels were correlated positively with age (r = 0.116, p = 0.001) and negatively with corrected calcium (r = −0.097, p = 0.008), P (r = −0.224, p = 0.000) and 25(OH) D (r = −0.134, p = 0.000), whereas no correlation was noted between 25(OH) D and corrected calcium levels. Conclusion: Our findings indicated that vitamin D deficiency in 65.0%, whereas PTH elevation only in 20.3% of endocrine outpatients, despite the significantly negative correlation of PTH to 25(OH) D and significantly higher levels of PTH among vitamin D deficient cases than in vitamin D insufficient and sufficient cases. Gender’s and seasonal differences had influence on serum levels for PTH but not on either 25(OH) D or corrected calcium, and no correlation was evident between 25(OH) D and corrected calcium levels.

关键词： Vitamin D Deficiency Parathyroid Hormone Calcium 25(OH) D Testing

Study of the Possibility of Predicting Earthquakes

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International Journal of Geosciences 2018年第12期9卷 688-706页

作者： Strachimir Cht Mavrodiev Lazo Pekevski Emil Botev Ali pinar Giorgi Kikuashvili Alexader Vol Arie Gilat INRNE-BAS Sofia Bulgaria Skopje Seismological Observatory Skopje Macedonia NIGGG BAS Sofia Bulgaria Department of Earthquake Engineering Bogazi&ccedil i University Istanbul Turkey Tbilisi Giorgia OSHADI Drug Administration Ltd. Rehovot Israel Geological Survey of Israel Jerusalem (ret.) Israel

It is already well known that the “when, where and how strong” earthquake prediction problem cannot be solved by only analyzing the database from former earthquakes. A possible solution to this problem is proposed herein based on the analysis of the physicochemical processes as participants in earthquake preparation and on the characteristic rate of reflection of these processes on the Earth’s surface. The proposed procedure includes monitoring of correlation of electromagnetic fields variations with tidal waves.?This solution provides a way of selecting a complex of reliable earthquake precursors using the Inverse Problem Method for earthquakes which will occur in the region around the monitoring point (radial distance ≈ 700 km) in the next seven-day period [1].

关键词： Earthquakes Prediction Earth Degassing Physical Chemistry Explosions Electromagnetic Field Monitoring

计算机控制的Ishihara色觉测试法(英文)

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国际眼科杂志 2007年第5期7卷 1223-1228页

作者： Nimet nay Gündogan Nezih Durmazlar Koray Gümüs pinar Geyik zdemir 土耳其安卡拉Boskent大学医学院生理科土耳其安卡拉Hacettepe大学医学院生理科土耳其安卡拉Hacettepe大学医学院眼科土耳其安卡拉Hacettepe大学医学院生物统计学教研室

目的:研究经计算机控制的Ishihara测试法诊断色盲的可靠性及其与经典Ishihara测试法的一致性,计算机控制的Ishihara测试法的敏感性与特异性;并探讨该测试方法在检测先天性色盲或色弱中的潜在价值。方法:用两种方法测试104名大学生的色觉... 详细信息

目的:研究经计算机控制的Ishihara测试法诊断色盲的可靠性及其与经典Ishihara测试法的一致性,计算机控制的Ishihara测试法的敏感性与特异性;并探讨该测试方法在检测先天性色盲或色弱中的潜在价值。方法:用两种方法测试104名大学生的色觉,年龄20～23岁(中位数21岁)。分别采用经计算机控制的Ishihara色板和经典的Ishihara打印色板显露法对个体色觉进行检查。通过上述两种不同的方法评价每个学生对颜色的感知能力,借此探讨计算机控制的Ishihara测试法的特异性,准确性以及与经典法的一致性。结果:本实验共检测到6位男性色盲患者和1位女性色盲患者。调查该女性学生的家族史,发现其母亲为色盲基因携带者,而其父亲为色盲患者。本实验中男性色盲患病率为13.6%(6/44),女性为1.7%(1/60);整个人群总的患病率为6.7%(7/104)。进行本试验前,这些学生并未意识到自己存在色觉功能缺陷。为探讨这两种方法的一致性,分别对色觉正常和患色盲的学生的测试结果进行比较。结果表明:两种实验方法的特异性及敏感性均为100%,一致性达到100%。结论:计算机控制的Ishihara测试法是数字调控性的,但有关色觉测试的基本概念没有改变。该法总的测试时间和误差计分都已标准化,与手动测试法相比有明显的优势;而且该法与被认为是"金标准"的经典测试法的一致性达到100%。这些特征表明,计算机控制的Ishihara测试法是一种新颖和可靠的方法。

关键词： Ishihara色觉测试法计算机控制的Ishihara色觉测试法色盲

Comparison of myocardial perfusion scintigraphy and computed tomography (CT) angiography based on conventional coronary angiography

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Natural Science 2012年第12期4卷 976-982页

作者： Bekir Tasdemir Tansel Ansal Balci Bedriye Busra Demirel Ilgin Karaca Ayse Murat Aydin Zehra pinar Koc Department of Cardiology Firat University Medical Faculty Elazig Turkey Department of Nuclear Medicine Dicle University Medical Faculty Diyarbakir Turkey Department of Nuclear Medicine Firat University Medical Faculty Elazig Turkey Department of Nuclear Medicine Oncology Hospital Ankara Turkey Department of Radiology Firat University Medical Faculty Elazig Turkey

Coronary artery disease is one of the most common and important health problems in the world. Early diagnosis of this disease is very important to treat before severe myocardial damage occurred. Myocardial perfusion scintigraphy (MPS) and computed tomography coronary angiography (CTCA) which evaluates regional myocardial perfusion and coronary arteries, respectively, are reliable and non-invasive methods in terms of coronary artery disease. In this study we aimed to compare MPS and CTCA based on conventional coronary angiography (CCA). Totally 60 patients were included in the study. CCA and MPS were performed to 30 patients;CCA and CTCA were performed to the rest of the patients (30 patients). Lesions were classified as mild, moderate and severe in these imaging methods. MPS and CTCA were compared with CCA by using chi-square and Fisher’s exact test. MPS and CTCA’s p values were found for left anterior descending artery (LAD) p: 0, p: 0.271;for circumflex artery (Cx) p: 0.256, p: 0.08 and for right coronary artery (RCA) p: 0.033, p: 0.271, respectively. Furthermore MPS and CTCA’s sensitivity, specificity, accuracy, positive predictive value and negative predictive value were calculated 81% to 87%;70% to 49%;73% to 72%;54% to 72%;90% to 71%, respectively. CCA results were found more concordant with MPS for LAD and RCA lesions and more concordant with CTCA for Cx lesions. It was also found that positive predictive value of MPS and negative predictive value of CTCA were significantly higher than the others. As a result, MPS and CTCA were suggested as complementary techniques for the diagnosis of coronary artery disease, not as alternatives to each other.

关键词： Myocardial Perfusion SPECT Scintigraphy CT Coronary Angiography Conventional Coronary Angiography

Abducens nerve palsy during pegvisomant therapy in an acromegalic patient

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Open Journal of Internal Medicine 2013年第2期3卷 66-69页

作者： Esra Hatipoglu Hasan Kepicoglu Emel Basar Nurperi Gazioglu Civan Islak Sabahattin Saip pinar Kadioglu Department of Neurology Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Department of Neurosurgery Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Department of Ophthalmology Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Department of Radiology Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Division of Endocrinology and Metabolism Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey

Pegvisomant is a recent treatment modality of acromegaly, which is most effective in regulating IGF-1 levels. Tumor growth has been reported in 5% of the acromegaly cases treated with pegvisomant. Herein we report a case of acromegaly resistant to surgical treatment, radiotherapy and medical therapy with a somatostatin analogue and cabergolin. Due to presence of pituitary tumor with cavernous sinus invasion and unremitting disease activity pegvisomant therapy was initiated. She developed left abducens nerve palsy after pegvisomant treatment. The objective of this report is to emphasize the value of close follow-up of the acromely cases under pegvisomant therapy, especially if they have cavernous sinus infiltrating tumor. A 44-year-old woman with acromegaly presented with visual defect and diplopia on left lateral gaze. Her complaint developed 3 years after initiation of pegvisomant therapy. Her neurologic examination was consistent with mild abducens nerve palsy on left side. Other causes for abducens nerve palsy were excluded. Pegvisomant was discontinued upon patient request. Although sella MRI did not reveal a tumor growth, even minimal growth within cavernous sinus can cause cranial nerve involvement. Therefore close and careful follow-up of cavernous sinus infiltrating tumors after pegvisomant therapy is crucial to early recognition of complications.

关键词： Acromegaly Pegvisomant Tumor Growth Cavernous Sinus Abduscence Nerve palsy

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双眼眼部缺损合并非综合征性唇腭裂(英文)

国际眼科杂志 2009年第7期9卷 1243-1244页

作者： pinar Saatci A ylin Yaman Mahmut Kaya Handan Cakmakci Salih Kavukeu Ali osman Saatci 大官邸卫生部口腔医院土耳其伊兹密尔 Dokuz Eylul大学眼科教研室 Dokuz Eylul大学放射科教研室 Dokuz Eylul大学儿科教研室

患儿,男,2mo,非综合征性唇腭裂。检查发现患者下方虹膜缺损,玻璃体盖膜,视乳头和脉络膜缺损。核磁共振(MRI)检查显示双侧缺损性小眼球,眼球后囊肿,视神经细。每位唇腭裂患儿需经眼科医师检查以排除可能合并的眼部畸形。

关键词：唇腭裂缺损性小眼球球后囊肿

Drug Resistance Trends and Patterns of Mycobacterium Tuberculosis Isolates from Pulmonary Tuberculosis Patients at a Tertiary Care Hospital in Turkey

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Journal of Tuberculosis Research 2014年第4期2卷 155-159页

作者： Esra Yazar pinar Yildiz Gulsah Gunluoglu Sedat Altin Veysel Yilmaz Derya Gencer Hatice Yazisiz Pulmonary Medicine Department Yedikule Chest Disease Education and Training Hospital Yedikule Istanbul Infection Diseases Department Yedikule Chest Disease Education and Training Hospital Yedikule Istanbul Microbiology Department Yedikule Chest Disease Education and Training Hospital Yedikule Istanbul

Background: We aim to determine the proportions and patterns of resistance to first-line drugs: isoniazid (H), rifampicin (R), ethambutol (E) and streptomycin (S) among pulmonary tuberculosis patients. Methods: Strains were obtained from 1584 culture positive pulmonary tuberculosis patients. All specimens were inoculated into L?wenstein-Jensen media (LJ) and TK selective;drug susceptibility tests (DST) were performed for first-line drugs. Results: Multidrug resistant (MDR) were detected in 146 (9.2%) isolates. Three hundred (18.9%) isolates were resistant to H;220 (13.9%) to R;168 (10.6%) to S;137 (8.6%) to E. Any drug resistance was detected in 442 (27.9%) isolates. MDR rate was higher in male patients than females (P = 0.006). MDR rates were different according to the age groups (P = 0.02). The highest rate was in 35 - 44 years and the lowest rate was in 15 - 24 years. Conclusions: We found an association between middle age and male gender and MDR tuberculosis.

关键词： Tuberculosis Drug Resistance Patterns Drug Susceptibility Test

Assessment of Interference Effect on Glucose Biosensor

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分析测试学报 1994年第3期 30-45页

作者： Ebtisam Wilkins Rajesh Vaidya Plamen Atanasov (Department of Chemical and Nuclear Engineering,University of New Mexico, Albuquerque, nm 87131, U. S.A.)

ＡｓｓｅｓｓｍｅｎｔｏｆＩｎｔｅｒｆｅｒｅｎｃｅＥｆｆｅｃｔｏｎＧｌｕｃｏｓｅＢｉｏｓｅｎｓｏｒ￥ＥｂｔｉｓａｍＷｉｌｋｉｎｓ；ＲａｊｅｓｈＶａｉｄｙａ；ＰｌａｍｅｎＡｔａｎａｓｏｖ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍ... 详细信息

ＡｓｓｅｓｓｍｅｎｔｏｆＩｎｔｅｒｆｅｒｅｎｃｅＥｆｆｅｃｔｏｎＧｌｕｃｏｓｅＢｉｏｓｅｎｓｏｒ￥ＥｂｔｉｓａｍＷｉｌｋｉｎｓ；ＲａｊｅｓｈＶａｉｄｙａ；ＰｌａｍｅｎＡｔａｎａｓｏｖ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃａｌａｎｄＮｕｃｌｅａｒＥｎｇ...

关键词： Assessment of Interference Effect on Glucose Biosensor

Nilotinib-mediated mucosal healing in a rat model of colitis

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World Journal of Gastroenterology 2013年第37期19卷 6237-6244页

作者： pinar Ataca Mujde Soyturk Meral Karaman Mehtat Unlu Ozgul Sagol Gozde Dervis Hakim Osman Yilmaz Department of Internal Medicine Dokuz Eylul University School of Medicine Department of Gastroenterology Dokuz Eylul University School of Medicine Department of Laboratory Animal Science Dokuz Eylul University School of Medicine Department of Pathology Dokuz Eylul University School of Medicine

AIM:To investigate the effects of nilotinib in a rat model of trinitrobenzene sulfonic acid(TNBS)-induced ***:Twenty-one Wistar albino female rats obtained from Dokuz Eylul University Department of Laboratory Animal Science were categorized into a control(n=7),TNBS(n=7)and nilotinib group(n=7).Saline was administered orally for 14 d to the control and the TNBS *** TNBS group received rectal TNBS on the first day while saline was administered to the control *** nilotinib group received 20mg/kg nilotinib for 14 d in 2 divided doses,starting the same day as TNBS *** 14 d,the rats were fed a standard diet,and their weights were recorded *** sacrifice,colon tissue samples from each group were scored for macroscopic and microscopic *** indices were determined by the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling ***-derived growth factor receptor(PDGFR)alpha and beta levels were assessed through immunohistochemistry staining scores and compared among the *** and serum tumor necrosis factor(TNF)alpha levels were determined by enzyme-linked immunosorbent ***:Between days 1 and 14,the nilotinib group rats lost significantly less weight than the TNBS group rats(-0.7 g vs-14.0 g,P=0.047).The difference in weight between the control and nilotinib groups was also statistically significant(+8.3 gvs-0.7 g,P=0.031).From day 7 to day 14,the weight differences of the control group vs the TNBS group,the TNBS group vs the nilotinib group,and the control group vs the nilotinib group were all statistically significant(+8.0 g vs-11.1 g,P=0.007;-11.1 g vs+2.9 g,P=0.015;+8.0g vs+2.9 g,P=0.042,respectively).Macroscopic and microscopic scores were significantly lower in the nilotinib group than in the TNBS group(0.00±0.00 vs 1.43±0.65,P=0.009;2.86±0.55 vs 7.71±1.48,P=0.030,respectively).However,these scores were similar between the nilotinib and control *** no

关键词： Inflammatory bowel disease Plateletderived growth factor receptor Tumor necrosis factor alpha Tyrosine kinase inhibitor Mucosal healing