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Epidemic management in a measles outbreak in 2023,the return of vaccine-preventable diseases:A single center,retrospective observational study

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 110-118页

作者： Sevgi Aslan Tuncay Gulsen Akkoc Seyhan Yilmaz Burcu Parlak pinar Canizci Erdemli Aylin Dizi Isik Didem Buyuktas Aytac Meryem Cagla Abaci Capar Eda Kepenekli Kadayifci Marmara University Faculty of Medicine Department of Pediatric Infectious DiseaseIstanbulTurkey

Objective:To investigate the importance of immunization in preventing measles infection and to determine the most useful laboratory tests for confirmation of ***:This study included pediatric cases evaluated with a presumed diagnosis of measles between December 2022 and June 2023,at Marmara University Pendik Training and Research *** effects of vaccination status and underlying disease on the clinical course,treatments,and complications were ***:In total,117 patients were enrolled in the study with a median age of 80 months(IQR:32.5-125.0).Twelve patients with contact history were asymptomatic and had an underlying disorder,and intravenous immunoglobulin was given to them for post-exposure ***-one patients had confirmed measles *** treatment was given to three patients(a newborn,a girl with rhabdomyosarcoma,and a healthy boy)with respiratory ***-eight percent of confirmed measles cases were unvaccinated,and all hospitalized cases were unvaccinated or *** full-vaccinated children had confirmed measles *** PCR from nasopharyngeal swabs was negative in all of them,and their diagnosis was established with anti-measles IgM ***:The measles vaccine is the most effective way to protect from measles and measles-related *** measles can also occur in fully vaccinated patients,the disease is milder than in unvaccinated *** ELISA and RT-PCR tests together may be beneficial in patients with high clinical suspicion for early diagnosis.

关键词： Measles Outbreak Vaccination Vitamin A Ribavirin

Slender reinforced concrete shear walls with high-strength concrete boundary elements

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Frontiers of Structural and Civil Engineering 2023年第1期17卷 138-151页

作者： Mohammad SYED pinar OKUMUS Department of Civil Structural and Environmental EngineeringUniversity at BuffaloBuffaloNY 14260USA

Reinforced concrete structural walls are commonly used for resisting lateral forces in buildings. Owing to the advancements in the field of concrete materials over the past few decades, concrete mixes of high compressive strength, commonly referred to as high-strength concrete (HSC), have been developed. In this study, the effects of strategic placement of HSC on the performance of slender walls were examined. The finite-element model of a conventional normal-strength concrete (NSC) prototype wall was validated using test data available in extant studies. HSC was incorporated in the boundary elements of the wall to compare its performance with that of the conventional wall at different axial loads. Potential reductions in the reinforcement area and size of the boundary elements were investigated. The HSC wall exhibited improved strength and stiffness, and thereby, allowed reduction in the longitudinal reinforcement area and size of the boundary elements for the same strength of the conventional wall. Cold joints resulting from dissimilar concrete pours in the web and boundary elements of the HSC wall were modeled and their impact on behavior of the wall was examined.

关键词： slender walls high-strength concrete rectangular and barbell-shaped walls cold joints

Mucosa-associated microbiota alterations in primary sclerosing cholangitis(PSC)before and after liver transplantation-who is calling the shots?

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 795-797页

作者： Münevver Demir Michael Sigal Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharitéUniversitätsmedizin BerlinBerlinGermany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular MedicineBerlinGermany

Primary sclerosing cholangitis(PSC)is an immune-related chronic cholangiopathy associated with high rates of progression to liver cirrhosis and the need for liver *** PSC is frequently associated with inflammatory bowel disease(IBD),several studies have investigated the role of the gut-liver axis in PSC and emerging evidence indicates that gut and bile microbiota are associated with the onset and progression of PSC[reviewed in(1)].

关键词： Primary sclerosing cholangitis(PSC) liver transplantation Klebsiella microbiota mucosal microbiota

Potential impact of autonomous vehicles in mixed traffic from simulation using real traffic flow

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Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2023年第1期6卷 1-15页

作者： Eleonora Andreotti Selpi pinar Boyraz Department of Mechanics and Maritime Sciences Chalmers University of TechnologySE-41296 GöteborgSweden CINECA Supercomputing Inter-University Consortium40033 BolognaItaly Department of Computer Science and Engineering Chalmers University of TechnologySE-41296 GöteborgSweden

This work focuses on the potential impacts of the autonomous vehicles in a mixed traffic condition represented in traffic simulator Simulation of Urban MObility(SUMO)with real traffic ***,real traffic flow and speed data collected in 2002 and 2019 in Gothenburg were used to simulate daily flow variation in *** order to predict the most likely drawbacks during the transition from a traffic consisting only manually driven vehicles to a traffic consisting only fully-autonomous vehicles,this study focuses on mixed traffic with different percentages of autonomous and manually driven *** realize this aim,several parameters of the car following and lane change models of autonomous vehicles are investigated in this *** with the fundamental diagram,the number of lane changes and the number of conflicts are analyzed and studied as measures for improving road safety and *** study highlights that the autonomous vehicles’features that improve safety and efficiency in 100%autonomous and mixed traffic are different,and the ability of autonomous vehicles to switch between mixed and autonomous driving styles,and vice versa depending on the scenario,is necessary.

关键词： automated driving autonomous vehicles(AVs) mixed-traffic traffic simulations driving style realistic conditions

Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence

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World Journal of Clinical Cases 2022年第31期10卷 11226-11239页

作者： Niyazi Emre Kurşunoğlu Banu pinar Sarer Yurekli School of Medicine Ege Universityİzmir 35100Turkey Department of Endocrinology Ege University School of Medicineİzmir 35100Turkey

Obesity is becoming an inevitable pandemic all over the *** World Obesity Federation predicts in the 2022 World Obesity Atlas that one billion people worldwide,including 1 in 5 women and 1 in 7 men,will be living with obesity by ***,the prevalence of diabetes is increasing worldwide,and diabetes is becoming more of a public health *** insulin resistance due to obesity and deficiency in insulin secretion are the two main causes of type 2 diabetes mellitus(T2DM).An exogenous chemical or mixture of chemicals that interferes with any aspect of hormone action was defined as endocrine-disrupting chemicals(EDCs).Bisphenol A(BPA),the first known EDC,was synthesized and was considered to be *** production of BPA has increased progressively from 5 to 8 million tons(MT)between 2010 and ***,researchers estimated that the production should reach 10.2 MT by *** human population is exposed to EDCs in daily life in such forms as pesticides/herbicides,industrial and household products,plastics,detergents,and personal care *** term obesogen was used for chemicals that promote weight gain and obesity by increasing the number of adipocytes and fat storage in existing adipocytes,changing the energy balance,and finally regulating appetite and *** the obesogenic effect,EDCs can cause T2DM through alteration inßcell function and morphology and insulin *** this review,we provide clinical and mechanistic evidence regarding EDCs as obesogen and ***,those studies are not enough methodologically to indicate *** this respect,randomized clinical trials are needed to investigate the association between obesogen,diabetogen and the related metabolic clinical picture.

关键词： Endocrine disruptors Adipogenesis Obesity Diabetes mellitus

Free fatty acids, glucose, and insulin in type 2 diabetes mellitus

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World Journal of Diabetes 2022年第3期13卷 275-277页

作者： Rob nm Weijers Teaching Hospital OLVGAmsterdam 95500Netherlands

Xu et al used the HOMA2 model to estimate theβ-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin *** method is based on the assumption that the glucose-insulin axis is central for the metabolic activities,which led to type 2 ***,significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids(FFAs)into the blood circulation,which leads to a marked reduction in membrane *** data favor a FFA-glucose-insulin *** authors are invited to extend their study with the introduction of the saturation index(number of carbon-carbon double bonds per 100 fatty-acyl chains),as observed in erythrocytes.

关键词： Free fatty acids Membrane flexibility NKX2-1 gene RNA sequencing Type 2 diabetes TPD52L-3 gene Unsaturation index

Thermodynamic Performance Analysis of a Low-Cost,Recycled and Energy-Efficient Solar Air Heater with Waste Beverage Cans:An Experimental Research

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Journal of Thermal Science 2023年第4期32卷 1657-1670页

作者： pinar Mert CUCE Abhishek SAXENA Erdem CUCE Yusuf Nadir YILMAZ Saboor SHAIK GUO Shaopeng Department of Architecture Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey Pinar Mert Cuce Low/Zero Carbon Energy Technologies Laboratory Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey Mechanical Engineering Department School of EngineeringDev Bhoomi Uttarakhand UniversityDehradunIndia Solar Energy Research Lab PandharpurMaharashtraIndia Department of Mechanical Engineering Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey School of Mechanical Engineering Vellore Institute of Technology VelloreVelloreTamil Nadu632014India School of Energy and Environment Inner Mongolia University of Science and TechnologyBaotou014010China

Solar air heaters are at the centre of interest owing to their widespread use for various *** the study,thermal performance analysis of a solar air heater that can be easily produced from daily waste materials is *** system has a low-cost structure with both waste material use and a simple *** proposed system is tested under different climatic conditions,and the energetic and the exergetic performance figures are obtained for the first time in *** is observed from the experimental tests that the results are stable and coherent as well as in good accordance with the similar attempts in literature with some cost reductions and performance *** performance analyses indicate that the maximum energy efficiency of the system is about 21%,whereas the exergy efficiency is 1.8%.The energetic and exergetic outputs of the system are also determined to be 27 W and 3 W,respectively,which is promising.

关键词： solar air heaters absorber design waste beverage cans energy and exergy efficiency

Global technological advancement and challenges of glazed window,facade system and vertical greenery-based energy savings in buildings:A comprehensive review

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Energy and Built Environment 2023年第2期4卷 206-226页

作者： M.Washim Akram M.Hasannuzaman Erdem Cuce pinar Mert Cuce Department of Mechanical Engineering University of Saskatchewan57 Campus DrSaskatoonSKS7N 5A9Canada UM Power Energy Dedicated Advanced Centre(UMPEDAC) Level 4Wisma R&DHigher Institution Centre of Excellence(HICoE)University of MalayaJalan Pantai BaharuKuala Lumpur 59990Malaysia Department of Mechanical Engineering Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize 53100Turkey Low/Zero Carbon Energy Technologies Laboratory Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize 53100Turkey Department of Architecture Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize 53100Turkey

There are many factors that have a major influence on reducing the energy expenditure in building *** research aims at qualitative and quantitative assessment of those factors such as double glazed windows,ver-tical greenery systems(VGS),integrating of semi-transparent photovoltaic device with architectural design of buildings,energy saving by using heat reflecting coating,passive climate control methods,energy saving by shading,building energy performance enhancement by using optimisation technique,double skin green facade,*** a holistic and thematic *** the aforesaid techniques,VGS is found the most reliable,efficient and sustainable *** VGS can improve the urban environment,increase biodiversity,mit-igate pollution also results economic benefit of the buildings as like as energy savings and decreasing surface *** fundamental energy saving methods are used in VGS which are considered as passive energy saving ***,interception of solar radiation due to the shadow risen by the vegetation;secondly,vegetation also provides thermal insulation;thirdly,plants evapotranspiration helps for evaporative cooling of building;finally,building blockage makes a variation of wind effect on *** peak cooling load of ivy coated green building wall has been reduced by 28%.If a VGS is installed without windows and building fac-ing on west,east,south and north correspondingly,the reduction in the cooling load capacity of the building is observed to be up to 20,18,8 and 5%,*** high thermally resistive glazed areas on building envelope can be secured via thin film PV glazing and vacuum glazing products with an average U-value of 1.1 and 0.4 W/m 2 K,*** use policies are also helpful to improve energy consumption scenario of *** developing more energy-efficient,sustainable and eco-friendly buildings,these techniques might be helpful for the building designers and architect

关键词： Building Energy consumption Energy saving Vertical greenery Green facade

An AI-driven microstructure optimization framework for elastic properties of titanium beyond cubic crystal systems

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npj Computational Materials 2023年第1期9卷 1217-1226页

作者： Yuwei Mao Mahmudul Hasan Arindam Paul Vishu Gupta Kamal Choudhary Francesca Tavazza Wei-keng Liao Alok Choudhary pinar Acar Ankit Agrawal Department of Electrical and Computer Engineering Northwestern UniversityEvanstonILUSA Virginia Tech BlacksburgVAUSA Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Theiss Research La JollaCA 92037USA

Materials design aims to identify the material features that provide optimal properties for various engineering applications,such as aerospace,automotive,and *** of the important but challenging problems for materials design is to discover multiple polycrystalline microstructures with optimal *** paper proposes an end-to-end artificial intelligence(AI)-driven microstructure optimization framework for elastic properties of *** this work,the microstructure is represented by the Orientation Distribution Function(ODF)that determines the volume densities of crystallographic *** framework was evaluated on two crystal systems,cubic and hexagonal,for Titanium(Ti)in Joint Automated Repository for Various Integrated Simulations(JARVIS)database and is expected to be widely applicable for materials with multiple crystal *** proposed framework can discover multiple polycrystalline microstructures without compromising the optimal property values and saving significant computational time.

关键词： microstructure cubic crystal