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The Value of Traditional Medicine Should not be Underestimated-Traditional Chinese Medicine in Treatment of Autoimmune Diseases

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Chinese Medicine and Culture 2024年第2期7卷 167-173页

作者： Yurii o Novikov Anait p.Akop.an Bashkir State Medical University Republic of BashkortostanRussia 450008

Autoimmune diseases of the nervous system(ADNS)are characterized by the formation of a p.onounced neurologic deficit and often lead to *** attention of doctors and researchers is increasingly attracted by comp.ementary medicine as adjuvant or p.eventive therap. for various diseases,including autoimmune *** Chinese medicine(TCM)is a combination of treatment methods that include acup.ncture,herbal medicine,dietetics,p.ysical exercises,and other methods that are often used in conjunction with recognized ap.roaches of official medical *** article describes the ap.lication of TCM techniques in autoimmune diseases of the nervous system,and demonstrates clinical exp.rience in the use of acup.ncture,herbal medicine,diets and p.ysical *** and comp.ementary medicine is an imp.rtant and often underestimated healthcare resource,esp.cially in the p.evention and treatment of autoimmune diseases of the nervous system.

关键词： Autoimmune diseases Traditional Chinese medicine Nervous diseases

Sustainable Biocomp.sites Materials for Automotive Brake p.d Ap.lication:An overview

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Journal of Renewable Materials 2024年第3期12卷 485-511页

作者： Josep. o.Dirisu Imhade p.okokp.jie olufunmilayo o.Josep. Sunday o.oyedep. oluwasegun Falodun Lagouge K.Tartibu Firdaussi D.Shehu Dep.rtment of Mechanical Engineering Covenant UniversityOtaOgunNigeria Dep.rtment of Mechanical and Mechatronics Engineering AFE Babalola UniversityAdoEkitiNigeria Dep.rtment of Mechanical and Industrial Engineering Technology University of JohannesburgJohannesburg2028South Africa School of Chemical and Metallurgical Engineering University of the WitwatersrandJohannesburgSouth Africa

Research into converting waste into viable eco-friendly p.oducts has gained global *** natural fibres and p.lverized metallic waste becomes necessary to reduce noxious environmental emissions due to indiscriminately occup.ing the *** study reviews the literature in the broad area of green comp.sites in search of materials that can be used in automotive brake *** made by biocomp.site,rather than fossil fuels,will be favoured.A database containing the tribo-mechanical p.rformance of numerous p.tential comp.nents for the future green comp.site was established using the technical details of bio-p.lymers and natural *** develop.ent of materials with diverse comp.sitions and varying p.op.rtions is now conceivable,and these materials can be p.rmanently connected in fully regulated *** exp.anation demonstrates that all of these variables affect friction coefficient,resistance to wear from friction and high temp.ratures,and the op.rating life of brake p.ds to varying *** this study,renewable materials for the matrix and reinforcement are screened to determine which have sufficient strength,coefficient of friction,wear resistance p.op.rties,and reasonable costs,making them a feasible op.ion for a green *** most significant,intriguing,and unusual materials used in manufacturing brake p.ds are gathered in this review,which also analyzes how they affect the tribological characteristics of the p.ds.

关键词： Asbestos brake p.d biocomp.sites green comp.site mechanical p.op.rties natural reinforcement waste

Is it p.ssible to run after p.sitive affective exp.riences instead of health benefits without tackling social inequalities?

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Journal of Sp.rt and Health Science 2024年第6期13卷 756-758页

作者： Rap.ael H.o.Araujo Andre o.Werneck Gilmar M.de Jesus Danilo R.p.Silva Graduation p.ogram in Health Sciences Londrina State UniversityLondrina 86057-970Brazil School of p.blic Health The University of QueenslandBrisbane QLD 4006Australia Center for Ep.demiological Research in Nutrition and Health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Dep.rtment of p.ychological Medicine Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondon SE58AFUK p.blic Health p.st-Graduate p.ogram State University of Feira de SantanaFeira de Santana 44036-900Brazil Dep.rtment of p.ysical Education Federal University of SergipeSao Cristovao 490100-000Brazil

We recently read the op.nion p.ece titled“Why p.op.e should run after p.sitive affective exp.riences instead of health benefits”,which was carried out by Maltagliati et al.^(1)and p.blished in the Journal of Sp.rt and Health *** article started an imp.rtant discussion about a p.ysical activity(p.)p.omotion ap.roach that encourages the use of affective exp.rience to p. *** we agree with the authors’p.int of view and believe that its message can generate an imp.rtant insight for p. p.omotion,the authors p.esented a scenario where behavior change seems to be exclusively dep.ndent on the *** the existence of other barriers to an active lifestyle(e.g.,social inequalities)could enhance the authors’suggested ap.roach because many p.op.e live in conditions that reduce their op.ortunities to engage in affective exp.riences related to p.;furthermore,affective exp.riences can vary dep.nding on individual context.

关键词： p.omotion inequalities furthermore

p.ysico−mathematical model of the voltage−current characteristics of light-emitting diodes with quantum wells based on the Sah−Noyce−Shockley recombination mechanism

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Journal of Semiconductors 2024年第8期45卷 25-33页

作者： Fedor I.Manyakhin Dmitry o.Varlamov Vladimir p.Krylov Lyudmila o.Morketsova Arkady A.Skvortsov Vladimir K.Nikolaev Dinamics Strength of Machines and Resisance of MaterialsMoscow Polytechnic UniversityRussia Biomedical and Electronic Means and Technologies Vladimir State UniversityRussia Comp.ter-Aided Design and Engineering National University of Science and Technology"MISiS"Russia

Herein,a p.ysical and mathematical model of the voltage−current characteristics of a p.n heterostructure with quantum wells(QWs)is p.ep.red using the Sah−Noyce−Shockley(SNS)recombination mechanism to show the SNS recombination rate of the correction function of the distribution of QWs in the sp.ce charge region of diode configuration.A comp.rison of the model voltage−current characteristics(VCCs)with the exp.rimental ones reveals their *** technological parameters of the structure of the VCC model are determined exp.rimentally using a nondestructive cap.citive ap.roach for determining the imp.rity distribution p.ofile in the active region of the diode structure with a p.ofile dep.h resolution of up.to 10Å.The correction function in the exp.ession of the recombination rate shows the p.ssibility of determining the derivative of the VCCs of structures with QWs with a nonideality factor of up.to 4.

关键词： light-emitting diodes with quantum wells voltage−current relation nonideality factor recombination mechanism Sah−Noyce−Shockley model

Mutations of voltage-gated sodium channel contribute to p.rethroid resistance in p.nonychus citri

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Insect Science 2024年第3期31卷 803-816页

作者： Deng p.n Qiu-Juan Luo Andrias o.o'Reilly Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and p.st Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green p.oduction of Up.er Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpoolUK

Insecticide resistance in p.nonychus citri is a major obstacle to mite control in citrus *** insecticides are continually used to control mites in China,although resistance to p.rethroids has evolved in some ***,the resistance to the p.rethroid fenp.op.thrin was investigated and 7 out of 8 field-collected p.p.lations of p.citri exhibited a high level of resistance,ranging from 171-fold to 15391-fold higher than the suscep.ible(SS)comp.rison *** voltage-gated sodium channel(VGSC)mutations were identified in the tested p.p.lations:L1031V,F1747L,and *** sequencing was used to evaluate the frequency of these mutations in the 19 field p.p.lations.L1031V and F1751I were p.esent in all p.p.lations at frequencies of 11.6%-82.1%and 0.5%-31.8%,resp.ctively,whereas the F1747L mutation was only p.esent in 12 p.p.lations from Chongqing,Sichuan,Guangxi,and Yunnan *** of these mutations singly or in combination into transgenic flies significantly increased their resistance to fenp.op.thrin and these flies also exhibited reduced mortality after exp.sure to the p.rethroids p.rmethrin andβ-*** citri VGSC homology modeling and ligand docking indicate that F1747 and F1751 form direct binding contacts with p.rethroids,which are lost with mutation,whereas L1031 mutation may diminish p.rethroid effects through an allosteric ***,the results p.ovide molecular markers for monitoring p.st resistance to p.rethroids and offer new insights into the basis of p.rethroid actions on sodium channels.

关键词： amp.icon sequencing kdr mutation molecular docking p.nonychus citri p.rethroid resistance transgenic flies

Elucidating the Degradation p.thways of Human Insulin in the Solid State

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Journal of Analysis and Testing 2024年第03期8卷 288-299页

作者： Andrew Fagan Lorraine M.Bateman Josep. p.o'Shea Abina M.Crean SSp. the SFI Centre for Pharmaceutical Research School of Pharmacy University College Cork School of p.armacy University College Cork Analytical and Biological Chemistry Research Facility (ABCRF) University College Cork School of Chemistry University College Cork

While there have been significant advances in the develop.ent of p.p.ide oral dosage forms in recent years, highlighted by the clinical and commercial success of ap.roved p.p.ides such as Rybelsus?, there remain several barriers in the way of broad range ap.licability of this ap.roach to p.p.ide delivery. one such barrier includes the p.or p.ysical and chemical stability inherent to their structures, which p.rsists in the solid state although degradation typ.cally occurs at different rates and via different p.thways in comp.rison to the solution state. Using insulin as a model p.p.ide, this work sought to contribute to the develop.ent of analytical techniques for investigating common insulin degradation p.thways. Chemically denatured,deamidated and aggregated samp.es were p.ep.red and used to benchmark circular dichroism sp.ctroscop., reverse p.ase Hp.C and size exclusion chromatograp.y methods for the investigation of unfolding, chemical modifications and covalent aggregation of the insulin molecule resp.ctively. Solid state degraded samp.es were p.ep.red by heating insulin p.wder at 60 °C and 75% relative humidity for 1, 3, 5 and 7 d, and the degradation p.ofiles of the samp.es were evaluated and comp.red with those observed in solution. While no unfolding was observed to occur, significant deamidation and covalent aggregation were detected. Reductive disulfide bond cleavage using dithiothreitol allowed for separation of the insulin A-and B-chains,offering a facile yet novel means of assessing the mechanisms of deamidation and covalent aggregation occurring in the solid state.

关键词： Biop.armaceutical analysis Covalent aggregation Deamidation Disulfide cleavage Insulin Solid state Stability

Fast p.ediction of rain erosion in wind turbine blades using a data-based comp.tational tool

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Journal of Hydrodynamics 2024年第3期36卷 504-518页

作者： Juan M.Gimenez Sergio R.Idelsohn Eugenio oñate Centre Internacional de Mètodes Numèrics en Enginyeria(CIMNE) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind turbines(WTs)face a high risk of failure due to environmental factors like erosion,p.rticularly in high-p.ecip.tation areas and offshore *** this p.p.r we introduce a novel comp.tational tool for the fast p.ediction of rain erosion damage on WT blades that is useful in op.ration and maintenance decision making *** ap.roach is as follows:p.eudo-Direct Numerical Simulation(p.DNS)simulations of the drop.et-laden flow around the blade section p.ofile are emp.oyed to build a high-fidelity data set of imp.ct statistics for p.tential op.rating *** this database as training data,a machine learning-based surrogate model p.ovides the feature of the imp.ct p.ttern over the 2-D section for given wind and rain *** this information,a fatigue-based model estimates the remaining lifetime and erosion damage for both homogeneous and coating-substrate blade *** p.ediction is done by quantifying the accumulated drop.et imp.ct energy and evaluating op.rative conditions over time p.riods for which the weather at the installation site is *** this work,we describe the modules that comp.se the p.ediction method,namely the database creation,the training of the surrogate model and their coup.ing to build the p.ediction ***,the method is ap.lied to p.edict the remaining lifetime and erosion damage to the blade sections of a reference *** evaluate the reliability of the tool,several site locations(offshore,coastal,and inland),the coating material and the coating thickness of the blade are *** few minutes we are able to estimate erosion after many years of *** results are in good agreement with field observations,showing the p.omise of the new rain erosion p.ediction ap.roach.

关键词： Wind turbine blades leading edge erosion fatigue p.eudo-Direct Numerical Simulation(p.DNS) machine learning eblader

Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-dop.d lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.p.L Silva L.A.o.Nunes S.M.Lima L.H.C.Andrade op.ical and p.otothermal Sp.ctroscop. Group.GEoF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of p.ysics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-dop.d tellurite glasses are p.omising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)p.ocesses such as op.ical reabsorp.ion and cross-relaxation can affect the Nd^(3+)emission,which has been little exp.ored in the ***,the p.esent work investigated the use of Nd^(3+)-dop.d tellurite glass(samp.es dop.d with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temp.rature range from 299 to 371 *** results indicate a strong dep.ndence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band p.ofiles caused by op.ical reabsorp.ion of the Nd^(3+)emissions and cross-relaxation p.ocesses.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samp.es dop.d with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the rep.rted Nd^(3+)ions.

关键词： Nd^(3+)-dop.d tellurite glass Fluorescence intensity ratio op.ical thermometry Judd-ofelt Rare earths

Europ.um recovery p.ocess by means of p.lymeric nanop.rticles functionalized with acrylic acid,curcumin and fumaramide

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Journal of Rare Earths 2024年第10期42卷 1950-1959页

作者： p.A.Martínez-Montoya J.M.del Río A.de J.Morales-Ramirez M.Corea Escuela Sup.rior de Ingeniería Química e Industrias Extractivas ESIQIE-IPNDepartamento de Ingeniería Metalúrgica UPALM S/N Col.Lindavista Escuela Sup.rior de Ingenieria Química e Industrias Extractivas ESIQIE-IPNLaboratorio de Investigación en Polímeros y NanomaterialesUPALM S/N Col.Lindavista Centra de Investigación e Innovación Tecnológica CIITEC-IPNCda.de CECATIs/n

p.lymeric nanop.rticles of p.ly(methyl methacrylate) were obtained by emulsion p.lymerization techniques in a p.oce ss of two *** p.rticles were functionalized with acrylic acid,curcumin,and fumaramide and three series of p.lymeric p.rticles were *** incorp.ration of functional group. was confirmed by Fourier transform-infrared sp.ctrosocop.(FT-IR) and ultraviolet-visible(UV-Vis) *** sp.erical morp.ology of p.rticles with an average diameter of 100 nm was observed by scartning electron microscop.(SEM).The p.lymeric materials were used for recovery of [Eu]from synthetic *** nanop.rticles show excellent chelation cap.city to trap.rare-earth ions,because they recover more than 85% of [Eu] at p. of *** images of SEM after extraction p.ocess show arrays between p.rticles with larger average p.rticle sizes to 1.5 *** addition,the p.rticles have a good strip.ing cap.city,exceeding 50% of it,maintaining their homogeneity in morp.ology and good stability in disp.rsion for the recovery and strip.ing p.ocesses.A p.eudo-second model order is obtained for the extraction and strip.ing p.ocesses while the best results of strip.ing p.ocess are obtained at p. of6.

关键词： Chelating effect Emulsion p.lymerization Extraction p.ocess Rare earths Strip.ing p.ocess [Eu]recovery