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Realizing the purification and grain refinement of Mg-Gd-Y alloy by one-step flux refining

中华口腔医学会第14次全国口腔医学学术会议（2012年会）

作者： nizhou liu shanghai jiao tong university school of medicine

Background: To investigate the suitability of beagles and Labradors as animal models for osteotome sinus floor elevation(OSFE) and dental implants in posterior maxilla subjacent to sinus.

关键词： animal model dog OSFE RBH dental implants

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Journal of Materials Science & Technology 2024年第6期173卷 202-217页

作者： Xin tong Guohua Wu Ming Sun Qiman Wang Liang Zhang Wencai liu National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China school of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China

In the conventional melt preparation of magnesium rare-earth(Mg-RE)alloys,the repeated heating/cooling process involved in grain refinement and flux refining usually prolongs the preparation period and aggravates melt *** this work,the purification and grain refinement of Mg-9Gd-3Y(GW93)alloy was simultaneously realized by one-step refining at 740℃ by using a self-developed compound *** results show that,only after holding for 10 min,the inclusion content of the alloy is reduced by 81%to 0.29%,while the grain size is reduced by 84%to 119μm.A physical model depicting the interactions between compound flux and alloy melt was proposed based on thermodynamic calculation and microstructure *** grain refinement mechanism has been analyzed by considering the presence of Zr particle(Zr_(p))and Zr solute(Zr_(s)).In addition,the generated RECl_(3) was found to be readily absorbed by the flux,decreasing the surface tension and promoting the purification efficacy of the flux,which plays an important role in the promoted elongation of the as-cast Mg-9Gd-3Y-0.5Zr(GW93K)*** work presents a unique prospect in simplifying the melt preparation of Mg-RE alloy with a promoted quality.

关键词： Mg-Gd-Y-Zr alloy Purification Grain refinement Compound flux Settling behavior

Data-driven approach to predict the fatigue properties of ferrous metal materials using the cGAN and machine-learning algorithms

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Advances in Manufacturing 2024年第3期12卷 447-464页

作者： Si-Geng Li Qiu-Ren Chen Li Huang Min Chen Chen-Di Wei Zhong-Jie Yue Ru-Xue liu Chao tong Qing liu school of Advanced Technology Xi’an Jiaotong-Liverpool UniversitySuzhou215123JiangsuPeople’s Republic of China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China Materials Bigdata and Application Division Material Academy JitriSuzhou215131JiangsuPeople’s Republic of China school of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240People’s Republic of China

The stress-life curve(S–N)and low-cycle strain-life curve(E–N)are the two primary representations used to characterize the fatigue behavior of a *** material fatigue curves are essential for structural fatigue ***,conducting material fatigue tests is expensive and *** address the challenge of data limitations on ferrous metal materials,we propose a novel method that utilizes the Random Forest Algorithm and transfer learning to predict the S–N and E–N curves of ferrous *** addition,a data-augmentation framework is introduced using a conditional generative adversarial network(cGAN)to overcome data *** incorporating the cGAN-generated data,the accuracy(R2)of the Random Forest Algorithm-trained model is improved by 0.3–*** is proven that the cGAN can significantly enhance the prediction accuracy of the machine-learning model and balance the cost of obtaining fatigue data from the experiment.

关键词： Fatigue life curve Machine learning Transfer learning Conditional generative adversarial network(cGAN)

Spatial transcriptomics reveals that metabolic characteristics define the tumor immunosuppression microenvironment via iCAF transformation in oral squamous cell carcinoma

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International Journal of Oral Science 2024年第1期16卷 110-121页

作者： Zheqi liu Zhen Zhang Yu Zhang Wenkai Zhou Xu Zhang Canbang Peng tong Ji Xin Zou Zhiyuan Zhang Zhenhu Ren Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghaiChina Department of Oral and Maxillofacial Surgery Zhongshan HospitalFudan UniversityShanghaiChina school and Hospital of Stomatology Kunming Medical UniversityKunmingChina Center for Tumor Diagnosis&Therapy Jinshan HospitalFudan UniversityShanghaiChina Department of Pathology Jinshan HospitalFudan UniversityShanghaiChina Hainan Western Central Hospital Academician Zhang Zhiyuan Team Innovation CenterDanzhouChina

Tumor progression is closely related to tumor tissue metabolism and reshaping of the microenvironment. Oral squamous cell carcinoma (OSCC), a representative hypoxic tumor, has a heterogeneous internal metabolic environment. To clarify the relationship between different metabolic regions and the tumor immune microenvironment (TME) in OSCC, Single cell (SC) and spatial transcriptomics (ST) sequencing of OSCC tissues were performed. The proportion of TME in the ST data was obtained through SPOTlight deconvolution using SC and GSE103322 data. The metabolic activity of each spot was calculated using scMetabolism,and k-means clustering was used to classify all spots into hyper-, normal-, or hypometabolic regions. CD4T cell infiltration and TGF-βexpression is higher in the hypermetabolic regions than in the others. Through CellPhoneDB and NicheNet cell-cell communication analysis, it was found that in the hypermetabolic region, fibroblasts can utilize the lactate produced by glycolysis of epithelial cells to transform into inflammatory cancer-associated fibroblasts (iCAFs), and the increased expression of HIF1A in iCAFs promotes the transcriptional expression of CXCL12. The secretion of CXCL12 recruits regulatory T cells (Tregs), leading to Treg infiltration and increased TGF-β secretion in the microenvironment and promotes the formation of a tumor immunosuppressive microenvironment. This study delineates the coordinate work axis of epithelial cells-iCAFs-Tregs in OSCC using SC, ST and TCGA bulk data, and highlights potential targets for therapy.

关键词： CXCL12 microenvironment squamous

Modeling of human colonic blood flow for a novel artificial anal sphincter system

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2008年第9期9卷 734-738页

作者： Peng ZAN, Guo-zheng YAN, Hua liu (school of Electronics, Information and Electrical Engineering, shanghai jiao tong university, shanghai 200240, China) school of Electronics Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200240 China zanpeng@***.

A novel artificial anal sphincter system has been developed to simulate the normal physiology of the human anorectum. With the goal of engineering a safe and reliable device, the model of human colonic blood flow has been built and the relationship between the colonic blood flow rate and the operating occlusion pressure of the anorectum is achieved. The tissue ischemia is analyzed based on constitutive relations for human anorectum. The results suggest that at the planned operating occlusion pressure of less than 4 kPa the artificial anal sphincter should not risk the vascularity of the human colon.

关键词： Incontinence Artificial anal sphincter Colonic blood flow Tissue ischemia

SIMULATION OF BLOOD FLOW IN INTRACRANIAL ICA-PCOMA ANEURYSM VIA COMPUTATIONAL FLUID DYMAMICS MODELING

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Journal of Hydrodynamics 2009年第5期21卷 583-590页

作者： WANG Qing WANG Wei-zhe FEI Zhi-min liu Ying-zheng CAO Zhao-min school of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 China Renji Hospital Shanghai Jiao Tong University Shanghai 200001 China

In the present study, hemodynamics of the internal carotid artery-posterior communicating artery （ICA-PComA） was numerically modeled with CFD approach. The steady and pulsating blood flow in the ICA-PComA was simulated. The main concern was placed on the influence of aneurysm geometry on the local hemodynamics by changing the sac diameter and Aspect Ratio （AR） of the aneurysm. The numerical results show the significantly weakened Wall Shear Stress （WSS） and the intensified wall pressure in the aneurysm as AR is increased. Two factors, i.e., low WSS and high pressure of the aneurysm, may play important roles in the fragile change of the aneurysm and the final rupture. The distributions of Time-Averaged WSS （TAWSS）, Oscillatory Shear Index （OSI） and spatial WSS Gradients （WSSG）） were determined and discussed in view of their influences on the evolution of ICA-PComA aneurysm.

关键词： CFD intracranial aneurysm hemodynamics

NUMERICAL INVESTIGATION ON THE AEROELASTIC BEHAVIOR OF AN AIRSHIP WITH HULL-FIN CONFIGURATION

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Journal of Hydrodynamics 2010年第2期22卷 207-213页

作者： liu Jian-min LU Chuan-jing - XUE Lei-ping Marine Engineering Institute Jimei University Xiamen 361021 China school of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200030 China

Numerical investigation was conducted on an airship of hull-fin configuration for aerodynamic and aeroelastic characteristics in three-dimensional viscous *** mathematical model was built and the corresponding numerical code was developed for the fluid-structure interaction *** governing equations of the viscous flow with LL-Low Reynolds modified model were solved by the standard SIMPLE algorithm based on the finite volume method.A fluid-structure coupled method was employed to solve the nonlinear aeroelasticity problem for the *** computational results of the viscous flow are in good agreement with the experimental *** simulation on the aeroelastic behavior of the airship in a trimmed flight reveals the effect of structure flexibility on the aerodynamic performance.

关键词： fluid-structure interaction airship aeroelasticity flexibility

Challenges in the diagnosis and treatment of transsexualism in contemporary China

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上海精神医学 2014年第1期26卷 49-50页

作者： Na liu Zheng LU shanghai Mental Health Center, shanghai jiao tong university school of medicine Department of Psychiatry, tongji university, tongji Hospital shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China. shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China Department of Psychiatry Tongji University Tongji Hospital Shanghai China.

According to the International Classification of Diseases10th Edition(ICD-10),[1]transsexualism refers to thecondition where an individual desires to live and to beaccepted as someone of the gender which is oppositetheir biological *** is usually accompanied withdiscomfort or distress about their anatomic *** somecases,individuals with this condition modify their bodyfeatures using laser or plastic surgeries to

关键词：当代中国诊断性欲治疗物理特性整形手术精神障碍生物性

Antibiotic Resistance of Probiotic Strains of Lactic Acid Bacteria Isolated from Marketed Foods and Drugs

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Biomedical and Environmental Sciences 2009年第5期22卷 401-412页

作者： CHANG liu, ZHUO-YANG ZHANG, KE DONG, JIAN-PING YUAN, AND XIAO-KUI GUO P1 P Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences, shanghai jiao tong university school of medicine, shanghai 200025, China [a] Department of Medical Microbiology and Parasitology Institutes of Medical Sciences shanghai jiao tong university school of medicine shanghai 200025 China

Objective To identify the antimicrobial resistance of commercial lactic acid bacteria present in microbial foods and drug additives by analyzing their isolated strains used for fermentation and probiotics. Methods Antimicrobial susceptibility of 41 screened isolates was tested with disc diffusion and E-test methods after species-level identification. Resistant strains were selected and examined for the presence of resistance genes by PCR. Results Distribution of resistance was found in different species. All isolates were susceptible to chloramphenicol, tetracycline, ampicillin, amoxicillin/clavulanic acid, cephalothin, and imipenem. In addition, isolates resistant to vancomycin, rifampicin, streptomycin, bacitracin, and erythromycin were detected, although the incidence of resistance to these antibiotics was relatively low. In contrast, most strains were resistant to ciprofloxacin, amikacin, trimethoprim/sulphamethoxazole, and gentamycin. The genes msrC, vanX, and dfrA were detected in strains of Enterococcus faecium, Lactobacillus plantarum, Streptococcus thermophilus, and Lactococcus lactis. Conclusion Antibiotic resistance is present in different species of probiotic strains, which poses a threat to food safety. Evaluation of the safety of lactic acid bacteria for human consumption should be guided by established criteria, guidelines and regulations.

关键词： Disc diffusion E-test MICs vanX msrC dfrA

Identification of TMEM217 as a novel prognostic biomarker and potential therapeutic target in acute myeloid leukemia

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Genes & Diseases 2024年第4期11卷 90-93页

作者： Yunying Yao Zhizhou Xi Min Wu Bo jiao Jiaming Gao Donghe Li Xi Xie Pengfei Xu jiaoyang Li Lei Yan Ruibao Ren Ping liu shanghai Institute of Hematology State Key Laboratory for Medical GenomicsNational Research Center for Translational MedicineCollaborative Innovation Center of HematologyRuijin Hospital affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China International Center for Aging and Cancer Hainan Medical UniversityHaikouHainan 570102China

Despite remarkable advances in molecular and cell biology of acute myeloid leukemia(AML),AML patients still frequently relapse and have low 5-year overall survival(OS)rates.1 It is worth noting that a recent study from the registry or clinical trial compilation has reported an improvement in the OS of adult AML patients,especially those under 60 years of age.

关键词： acute myeloid leukemia