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TWO COUNTERMEASURE STRATEGIES TO MITIGATE RANDOM DISRUPTIONS IN CAPACITATED SYSTEMS

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Journal of Systems Science and Systems Engineering 2010年第2期19卷 210-226页

作者： niyazi O.BAKIR Alex SAVACHKIN Andrés Uribe-SANCHEZ Department of Industrial Engineering Bilkent University Department of Industrial and Management Systems Engineering University of South Florida

We examine a capacitated system exposed to random stepwise capacity disruptions with exponentially distributed interarrival times and tmiformly distributed magnitudes. We explore two countermeasure policies for a risk-neutral decision maker who seeks to maximize the long-nm average reward. A one-phase policy considers implementation of countermeasures throughout the entirety of a disruption cycle. The results of this analysis form a basis for a two-phase model which implements countermeasures during only a fraction of a disruption cycle. We present an extensive numerical analysis as well as a sensitivity study on the fluctuations of some system parameter values.

关键词： Capacity analysis capacitated system lean random disruptions countermeasure policy

Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence

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World Journal of Clinical Cases 2022年第31期10卷 11226-11239页

作者： niyazi Emre Kurşunoğlu Banu Pinar Sarer Yurekli School of Medicine Ege Universityİzmir 35100Turkey Department of Endocrinology Ege University School of Medicineİzmir 35100Turkey

Obesity is becoming an inevitable pandemic all over the *** World Obesity Federation predicts in the 2022 World Obesity Atlas that one billion people worldwide,including 1 in 5 women and 1 in 7 men,will be living with obesity by ***,the prevalence of diabetes is increasing worldwide,and diabetes is becoming more of a public health *** insulin resistance due to obesity and deficiency in insulin secretion are the two main causes of type 2 diabetes mellitus(T2DM).An exogenous chemical or mixture of chemicals that interferes with any aspect of hormone action was defined as endocrine-disrupting chemicals(EDCs).Bisphenol A(BPA),the first known EDC,was synthesized and was considered to be *** production of BPA has increased progressively from 5 to 8 million tons(MT)between 2010 and ***,researchers estimated that the production should reach 10.2 MT by *** human population is exposed to EDCs in daily life in such forms as pesticides/herbicides,industrial and household products,plastics,detergents,and personal care *** term obesogen was used for chemicals that promote weight gain and obesity by increasing the number of adipocytes and fat storage in existing adipocytes,changing the energy balance,and finally regulating appetite and *** the obesogenic effect,EDCs can cause T2DM through alteration inßcell function and morphology and insulin *** this review,we provide clinical and mechanistic evidence regarding EDCs as obesogen and ***,those studies are not enough methodologically to indicate *** this respect,randomized clinical trials are needed to investigate the association between obesogen,diabetogen and the related metabolic clinical picture.

关键词： Endocrine disruptors Adipogenesis Obesity Diabetes mellitus

Ethanol shock enhances the recovery of anthocyanin from lowbush blueberry

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3096-3102页

作者： Nueraili Maimaiti niyazi Aili M.Kamran Khan Zhigang Tang Guoqiang Jiang Zheng Liu Key Laboratory of Industrial Biocatalysis Ministry of EducationBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Deactivation of polyphenol oxidase(PPO)in natural products is essential for downstream processing of functional molecules used as food or food additives,particularly those served as *** the present work,we identified two proteins with PPO activity from lowbush blueberry using ammonium sulphate precipitation and chromatography *** of these proteins was studied using aqueous solutions of ethanol of different *** PPO activity was recovered after ethanol removal for the protein samples previously soaked in a lowconcentration ethanol solution.A complete and unrecoverable deactivation of the proteins was achieved using ethanol with concentration over 70%(v/v),as manifested by the significant changes in circular dichroism(CD)and fluorescence spectroscopy *** on these findings,we propose a new extraction process for blueberry anthocyanin,in which an ethanol shock,*** blueberry fruit in a 70%(v/v)ethanol solution for 1 h,is implemented before subsequent *** new process increases the anthocyanin yield by 55%in comparison to that without the ethanol shock.

关键词： Anthocyanin Lowbush blueberry Ethanol shock Polyphenol oxidase Bioseparation Enzyme deactivation

Reciprocal interactions between gut microbiota and autophagy

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World Journal of Gastroenterology 2021年第48期27卷 8283-8301页

作者： Pierre Lapaquette Jean-Baptiste Bizeau niyazi Acar Marie-Agnès Bringer UMR PAM A 02.102 University Bourgogne Franche-ComtéAgrosup DijonDijon 21000France Eye and Nutrition Research Group Centre des Sciences du Goût et de l'AlimentationAgroSup DijonCNRSINRAEUniversitéBourgogne Franche-ComtéDijon 21000France

A symbiotic relationship has set up between the gut microbiota and its host in the course of evolution,forming an interkingdom *** gut offers a favorable ecological niche for microbial communities,with the whole body and external factors(e.g.,diet or medications)contributing to modulating this ***,the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other ***,failure in one or another of these two partners can lead to the breakdown in their symbiotic equilibrium and contribute to disease onset and/or *** microbial and host processes are devoted to facing up the stress that could alter the symbiosis,ensuring the resilience of the *** these processes,autophagy is a host catabolic process integrating a wide range of stress in order to maintain cell survival and *** cytoprotective mechanism,which is ubiquitous and operates at basal level in all tissues,can be rapidly down-or upregulated at the transcriptional,post-transcriptional,or post-translational levels,to respond to various stress *** of its sensitivity to all,metabolic-,immune-,and microbial-derived stimuli,autophagy is at the crossroad of the dialogue between changes occurring in the gut microbiota and the host *** this review,we first delineate the modulation of host autophagy by the gut microbiota locally in the gut and in peripheral ***,we describe the autophagy-related mechanisms affecting the gut *** conclude this review with the current challenges and an outlook toward the future interventions aiming at modulating host autophagy by targeting the gut microbiota.

关键词： Gut microbiota Autophagy Probiotic Brain Liver Muscle

The Public Savings’ Relation With Borrowing Requirement and Financial Balances After Global Crisis in Turkey

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Economics World 2017年第5期5卷 435-443页

作者： niyazi OZKER Bandirma Onyedi Eylul University Bandirma Turkey

In this study, we aim to determine public savings’ structural location in the analysis of effect levels that are related to public borrowing requirement to cope with the deviation of financial balances, especially after 2009 global crisis in Turkey. Public savings as a financial option take up an important place in the scope of expressed government budget balances related to public borrowing requirements which are increasingly located together with budget deficits. This fact especially is pertaining to investments and capital’s transfers that are subject to the public decision making process towards economic growth in the future in developing countries like Turkey. Therefore, increasing public savings’ limits appear on these countries as an inevitable financial phenomenon concerning the desired investments. Turkey, as a developing country, has faced two financial phenomenons that increase borrowing requirement terms that lead to intend financial balances that have generally deviated after 2009 financial crisis. Firstly, it’s increasing foreign debt burden and the public savings’ levels that have not been enough to cover all the proportion of foreign debt payments since 2009. Secondly, the effect level of global crisis on the exchange rates directly causes the deviation of national currency values as a meaningful important negative impact on budget balances that are aimed at together with the macroeconomic financial balances.

关键词： financial crisis foreign debt burden national investments public borrowing requirement public savings

木质素/PVA复合膜的制备及白腐真菌降解特性的探究

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绿色科技 2025年第2期27卷 252-258页

作者：吕翔热孜亚·尼亚孜刘一晓吴雨峰张雯新疆农业大学化学化工学院新疆乌鲁木齐830000

随着环境保护意识的不断提高,可生物降解材料的研究与开发日益受到关注。采用脱碱木质素、白木质素和聚乙烯醇,通过溶液共混法成功构建了木质素/聚乙烯醇复合膜。木质素作为一种天然高分子材料,具有来源广泛、可再生等优点。聚乙烯醇则... 详细信息

随着环境保护意识的不断提高,可生物降解材料的研究与开发日益受到关注。采用脱碱木质素、白木质素和聚乙烯醇,通过溶液共混法成功构建了木质素/聚乙烯醇复合膜。木质素作为一种天然高分子材料,具有来源广泛、可再生等优点。聚乙烯醇则具有良好的成膜性和机械性能。将两者复合,有望获得性能优异的可生物降解材料。对木质素/PVA复合膜进行了白腐菌降解实验,以分析薄膜的降解情况。结果表明,该复合膜在白腐菌的作用下能够发生有效的降解。通过对降解过程的监测和分析,探讨了木质素含量对白腐菌降解木质素/PVA复合膜降解的影响。为开发可生物降解的木质素基复合膜材料提供了理论依据和实验基础。

关键词：木质素/聚乙烯醇复合膜溶液共混法白腐真菌降解特性

Application of Value Engineering in Construction Projects

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Journal of Traffic and Transportation Engineering 2013年第1期1卷 39-48页

作者： Senay Atabay and niyazi Galipogullari Department of Civil Engineering Civil Engineering Faculty Yildiz Technical University Istanbu134220 Turkey

The current economic conditions have entailed the use of rational method and techniques and research and application of new techniques by utilizing advancements in technology in the field of production as well as in every field. Excess cost control requires to be maintained throughout the project life of building beginning from the initial stages of design. Scrutinizing the project well and considering all possible alternatives particularly in design stage are important for achieving optimum cost. In this study, how the principles of VE （value engineering） are applied in construction projects is explained, and by covering Bregana-Zagreb-Dubrovnik Motorway construction in Croatia by BECHTEL -ENKA joint venture as the sample project, practices of VE in this project are described. The satisfactory results of time and cost saving are achieved by applying value engineering principles through the VE team during the project preparation phase and project revision phase. Approximately 43,000,0005 and 12 months of time were saved in total thanks to all these VE works. This saving provided builder company with 6% financial saving and 17% work time reduction.

关键词： Value engineering value management motorway construction.

Ultrabright γ-ray emission from the interaction of an intense laser pulse with a near-critical-density plasma

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Chinese Physics B 2021年第11期30卷 419-429页

作者： Aynisa Tursun Mamat Ali Bake Baisong Xie Yasheng niyazi Abuduresuli Abudurexiti School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China Key Laboratory of Beam Technology of the Ministry of Education and College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Physics and Electrical Engineering Kashi UniversityKashgar 844009China

An efficient scheme for generating ultrabright γ-rays from the interaction of an intense laser pulse with a near-criticaldensity plasma is studied by using the two-dimensional particle-in-cell simulation including quantum electrodynamic *** investigate the effects of target shape on γ-ray generation efficiency using three configurations of the solid foils attached behind the near-critical-density plasma:a flat foil without a channel(target 1),a flat foil with a channel(target 2),and a convex foil with a channel(target 3).When an intense laser propagates in a near-critical-density plasma,a large number of electrons are trapped and accelerated to GeV energy,and emit γ-rays via nonlinear betatron oscillation in the first *** the second stage,the accelerated electrons collide with the laser pulse reflected from the foil and emit high-energy,high-density γ-rays via nonlinear Compton *** simulation results show that compared with the other two targets,target 3 affords better focusing of the laser field and electrons,which decreases the divergence angle of ***,denser and brighter γ-rays are emitted when target 3 is ***,a dense γ-ray pulse with a peak brightness of 4.6×10^(26) photons/s/mm2/mrad2/0.1%BW(at 100 MeV)and 1.8×1023 photons/s/mm2/mrad2/0.1%BW(at 2 GeV)are obtained at a laser intensity of 8.5×10^(22) W/cm2 when the plasma density is equal to the critical plasma density *** addition,for target 3,the effects of plasma channel length,foil curvature radius,laser polarization,and laser intensity on the γ-ray emission are discussed,and optimal values based on a series of simulations are proposed.

关键词： electron acceleration γ-ray emission inverse Compton scattering near-critical-density plasma 2D-QED-PIC simulation

强激光与气体-固体复合靶相互作中γ射线产生的研究

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激光杂志 2025年第2期46卷 48-53页

作者：亚生·尼亚孜何洋买买提艾力·巴克喀什大学物理与电气工程学院新疆大学物理科学与技术学院

通过理论和二维等离子体粒子模拟方法，研究了强激光与气体-固体复合靶相互作用中γ射线的产生。研究结果表明，向右传播的入射激光在等离子体中激发尾场并将电子加速到高能，随后被固体靶反射的激光与高能电子相互作用。向前传播的电... 详细信息

通过理论和二维等离子体粒子模拟方法，研究了强激光与气体-固体复合靶相互作用中γ射线的产生。研究结果表明，向右传播的入射激光在等离子体中激发尾场并将电子加速到高能，随后被固体靶反射的激光与高能电子相互作用。向前传播的电子穿过固体靶后再与向左传播的入射激光相互作用。从而，在固体靶前后能产生具有不同长度、能量和延时的两束γ射线。研究激光偏振以及预等离子体密度对γ射线产生的影响并且讨论了其物理机制。研究结果表明，较高密度的预等离子体和圆偏振情况下可以产生更多的γ光子，并且所产生的光子具有小发散角和高通量的优点。

关键词：强激光脉冲激光尾场加速 γ射线产生等离子体粒子模拟