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Adipose tissue derived stromal cells in a gelatin-based 3D matrix with exclusive ascorbic acid signalling emerged as a novel neural tissue engineering construct:an innovative prototype for soft tissue

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Regenerative Biomaterials 2022年第1期9卷 444-459页

作者： Catherine Ann Martin Subathra Radhakrishnan Jose Luis Gòmez Ribelles Omana Anna Trentz nivethaa eak Mettu Srinivas Reddy Mohamed Rela Narayana Kalkura Subbaraya Crystal Growth Centre Anna UniversityGuindyChennai-600025India Cell Laboratory National Foundation for Liver ResearchNo.7CLC works RoadChennai-600044India Center for Biomaterials and Tissue Engineering(CBIT) Universitat Politècnica de Vale`nciaValencia 46022Spain Biomedical Research Networking Centre in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Valencia 46022Spain MIOT Institute of Research MIOT Hospitals4/112Mount Poonamallee RoadChennai-600089India

The current study investigated a triad,which comprises of adipose tissue derived stem cells isolated from infrapatellar fat pad and gelatin/polyvinyl alcohol(PVA)-based matrix with exclusive ascorbic acid ***,the bio-mechanical properties of the gelatin–PVA blended scaffolds in wet condition are equivalent to the ECM of soft tissues in general,in this study,the triad was tested as a model for neural tissue *** from being cytocompatible and biocompatible,the porosity of the scaffold has been designed in such a manner that it facilitates the cell signalling and enables the exchange of nutrients and *** highly proliferative stem cells from Passage 2 were characterized using both,mesenchymal and embryonic stem cell *** an initial exploration the mesenchymal stem cells at Passage 4 were exposed to ascorbic acid and basic fibroblast growth factor signalling for neuronal differentiation in 2D environment *** MSCs successfully differentiated and acquired neuron specific markers related to cytoskeleton and ***,three phases of experiments have been conducted on the 3D gelatin/PVA matrix to prove their efficacy,the growth of stem cells,growth of differentiated neurons and the in situ growth and differentiation of *** scaffold was conducive and directed MSCs to neuronal lineage under specific ***,this organotypic model triad could open a new avenue in the field of soft tissue engineering as a simple and effective tissue construct.

关键词： adipose derived stem cells(ASCs) ascorbic acid soft tissue engineering triad neuronal differentiation

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