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To scope or not-the challenges of managing patients with positive fecal occult blood test after recent colonoscopy

World Journal of Gastrointestinal Oncology 2022年第9期14卷 1798-1807页

作者： nivedita Rattan Laura Willmann Diana Aston Shani George Milan Bassan David Abi-Hanna Sulakchanan Anandabaskaran George Ermerak Watson Ng Jenn Hian Koo Gastroenterology and Liver Services Liverpool HospitalLiverpool 2170New South WalesAustralia Faculty of Medicine University of New South WalesSydney 2052New South WalesAustralia

BACKGROUND Colorectal cancer(CRC) is a major health problem. There is minimal consensus of the appropriate approach to manage patients with positive immunochemical fecal occult blood test(iFOBT), following a recent *** To determine the prevalence of advanced neoplasia in patients with a positive iFOBT after a recent colonoscopy, and clinical and endoscopic predictors for advanced *** The study recruited i FOBT positive patients who underwent colonoscopy between July 2015 to March 2020. Data collected included demographics, clinical characteristics, previous and current colonoscopy findings. Primary outcome was the prevalence of CRC and advanced neoplasia in a patient with positive iFOBT and previous colonoscopy. Secondary outcomes included identifying any clinical and endoscopic predictors for advanced *** The study included 1051 patients(male 53.6%;median age 63). Forty-two(4.0%) patients were diagnosed with CRC, 513(48.8%) with adenoma/sessile serrated lesion(A-SSL) and 257(24.5%) with advanced A-SSL(AA-SSL). A previous colonoscopy had been performed in 319(30.3%). In this cohort, four(1.3%) were diagnosed with CRC, 146(45.8%) with A-SSL and 56(17.6%) with AA-SSL. Among those who had a colonoscopy within 4 years, none had CRC and 7 had AA-SSL. Of the 732 patients with no prior colonoscopy, there were 38 CRCs(5.2%). Independent predictors for advanced neoplasia were male [odds ratio(OR) = 1.80;95% confidence interval(CI): 1.35-2.40;P < 0.001), age(OR = 1.04;95%CI: 1.02-1.06;P < 0.001) and no previous colonoscopy(OR = 2.07;95%CI: 1.49-2.87;P < 0.001).CONCLUSION A previous colonoscopy, irrespective of its result, was associated with low prevalence of advanced neoplasia, and if performed within four years of a positive iFOBT result, was protective against CRC.

关键词： Colorectal cancer Adenoma Screening Fecal occult blood test Colonoscopy

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Intuitionistic Neuro-Fuzzy Optimization in the Management of Medical Diagnosis

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Applied Mathematics 2021年第11期12卷 993-1020页

作者： nivedita Seema Agrawal Dhanpal Singh Mukesh Kumar Sharma Department of Mathematics S. S. V. (P. G.) College Hapur India Department of Mathematics Keshav Mahavidyalaya University of Delhi New Delhi India Department of Mathematics Chaudhary Charan Singh University Meerut India

Diabetes has become a major concern nowadays and its complications are affecting various organs of a diabetic patient. Therefore, a multi-dimensional technique including all parameters is required to detect the cause, its proper diagnostic procedure and its prevention. In this present work, a technique has been introduced that seeks to build an implementation for the intelligence system based on neural networks. Moreover, it has been described that how the proposed technique can be used to determine the membership together with the non-membership functions in the intuitionistic environment. The dataset has been obtained from Pima Indians Diabetes Database (PIDD). In this work, a complete diagnostic procedure of diabetes has been introduced with seven layered structural frameworks of an Intuitionistic Neuro Sugeno Fuzzy System (INSFS). The first layer is the input, in which six factors have been taken as an input variable. Subsequently, a neural network framework has been developed by constructing IFN for all the six input variables, and then this input has been fuzzified by using triangular intuitionistic fuzzy numbers. In this work, we have introduced a novel optimization technique for the parameters involved in the INSFS. Moreover, an inference system has also been framed for the neural network known as INFS. The results have also been given in the form of tables, which describe each concluding factor.

关键词： Intuitionistic Fuzzy Set Neural Network Neuro-Fuzzy System Intuitionistic Neuro-Fuzzy System Optimization Medical Diagnosis

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Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management

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World Journal of Hepatology 2018年第3期10卷 352-370页

作者： Ranjit Chauhan Shilpa Lingala Chiranjeevi Gadiparthi nivedita Lahiri Smruti R Mohanty Jian Wu Tomasz I Michalak Sanjaya K Satapathy Molecular Virology and Hepatology Research Group Division of Bio Medical SciencesHealth Sciences Centre Memorial University Division of Transplant Surgery Methodist University Hospital Transplant Institute University of Tennessee Health Sciences Center Division of Rheumatology Immunology and Allergy Brigham Women's Hospital Harvard Medical School Division of Gastroenterology and Hepatobiliary Disease New York-Presbyterian Brooklyn Methodist Hospital Department of Medical Microbiology Key Laboratory of Molecular Virology Fudan University School of Basic Medical Sciences

Chronic hepatitis B(CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to complications, such as cirrhosis, liver failure and hepatocellular carcinoma(HCC). Liver transplantation(LT) is considered gold standard for treatment of hepatitis B virus(HBV)-related liver failure and HCC. However, post-transplant viral reactivation can be detrimental to allograft function, leading to poor survival. Prophylaxis with high-dose hepatitis B immunoglobulin(HBIG) and anti-viral drugs have achieved remarkable progress in LT by suppressingviral replication and improving long-term survival. The combination of lamivudine(LAM) plus HBIG has been for many years the most widely used. However, life-long HBIG use is both cumbersome and costly, whereas long-term use of LAM results in resistant virus. Recently, in an effort to develop HBIG-free protocols, high potency nucleos(t)ide analogues, such as Entecavir or Tenofovir, have been tried either as monotherapy or in combination with low-dose HBIG with excellent results. Current focus is on novel antiviral targets, especially for covalently closed circular DNA(ccc DNA), in an effort to eradicate HBV infection instead of viral suppression. However, there are several other molecular mechanisms through which HBV may reactivate and need equal attention. The purpose of this review is to address post-LT HBV reactivation, its risk factors, underlying molecular mechanisms, and recent advancements and future of anti-viral therapy.

关键词： Hepatitis B virus Liver transplantation Reactivation Hepatitis B immunoglobulin Recurrence Prophylaxis Antivirals

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Metachronous bladder metastasis from papillary renal cell carcinoma

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 130-132页

作者： Arun Ramdas Menon nivedita Suresh Prajwal Ravinder Rajeev Thekke Puthalath Department of Urology K S Hegde Medical AcademyMangalore 575018KarnatakaIndia Department of Pathology K S Hegde Medical AcademyMangalore 575018KarnatakaIndia

Renal cell carcinoma(RCC)is well known for its metastatic potential and predilection for unusual sites of *** to the bladder is rare and has been reported predominantly from clear cell *** report a case of a 72-year-old male presenting with a bladder tumor which on histopathological evaluation was found to be a metastasis from papillary RCC,7 years after radical *** case highlights the need to maintain a high index of suspicion to diagnose bladder metastasis in a patient with a history of RCC presenting with a bladder lesion.

关键词： Bladder metastasis metachronous metastasis renal cell carcinoma

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Flexible computational photodetectors for self-powered activity sensing

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npj Flexible Electronics 2022年第1期6卷 45-52页

作者： Dingtian Zhang Canek Fuentes-Hernandez Raaghesh Vijayan Yang Zhang Yunzhi Li Jung Wook Park Yiyang Wang Yuhui Zhao nivedita Arora Ali Mirzazadeh Youngwook Do Tingyu Cheng Saiganesh Swaminathan Thad Starner Trisha L.Andrew Gregory D.Abowd School of Interactive Computing Georgia Institute of TechnologyAtlantaGAUSA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGAUSA Department of Electrical and Computer Engineering Northeastern UniversityBostonMAUSA Department of Chemistry University of Massachusetts AmherstAmherstMAUSA Department of Electrical and Computer Engineering University of CaliforniaLos AngelesCAUSA Human-Computer Interaction Institute Carnegie Mellon UniversityPittsburghPAUSA Departments of Chemistry and Chemical Engineering University of Massachusetts AmherstAmherstMAUSA

Conventional vision-based systems,such as cameras,have demonstrated their enormous versatility in sensing human activities and developing interactive ***,these systems have long been criticized for incurring privacy,power,and latency issues due to their underlying structure of pixel-wise analog signal acquisition,computation,and *** this research,we overcome these limitations by introducing in-sensor analog computation through the distribution of interconnected photodetectors in space,having a weighted responsivity,to create what we call a computational *** photodetectors can be used to extract mid-level vision features as a single continuous analog signal measured via a two-pin *** develop computational photodetectors using thin and flexible low-noise organic photodiode arrays coupled with a self-powered wireless system to demonstrate a set of designs that capture position,orientation,direction,speed,and identification information,in a range of applications from explicit interactions on everyday surfaces to implicit activity detection.

关键词： everyday overcome photodetector

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用聚乙烯亚胺絮凝和在布上粘附实现降解尿素细胞的固定化

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生物技术 1992年第5期2卷 46-46,4331页

作者： nivedita Kamath S.F.D’Souza 江清彦

近年来,排除和控制废水中含氮物质,对保护和维持环境有重大意义.尿素肥料工业的产品是尿素和氨以及丰富的含氮废水.尿素废水能用高压水解塔(气提塔)处理,然而该工艺耗资太大.通常,尿素残水经处理后可进一步利用或贮於泻湖晒干.虽然已提... 详细信息

近年来,排除和控制废水中含氮物质,对保护和维持环境有重大意义.尿素肥料工业的产品是尿素和氨以及丰富的含氮废水.尿素废水能用高压水解塔(气提塔)处理,然而该工艺耗资太大.通常,尿素残水经处理后可进一步利用或贮於泻湖晒干.虽然已提出,尿素残水处理可利用固相酶通过生物降解作用来清除氨,但利用固相酶或固定化尿素降解微生物的有关报告则甚少.

关键词：固相酶尿毒降解

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屏风住宅印度勒克瑙私宅

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室内设计与装修 2020年第7期 80-83页

作者：麦子(编译) 无 Nina Puri Sanjay Puri Ruchika Gupta Jinal Jain nivedita Raverkar Nandita Rebello Akanksha Singh Swati Gadekar Dinesh Mehta(摄影) 不详 Nina&Sanjay Puri Architects

印度勒克瑙城拥有丰富的历史文化遗产,许多建筑都可追溯到18世纪。本文介绍的这幢住宅位于该市繁忙的主干道边,是一片私人住宅地块的边缘部分。项目采用了印度传统四合院的建筑形制,以回应城市特征和炎热的气候条件。业主希望在这个两... 详细信息

印度勒克瑙城拥有丰富的历史文化遗产,许多建筑都可追溯到18世纪。本文介绍的这幢住宅位于该市繁忙的主干道边,是一片私人住宅地块的边缘部分。项目采用了印度传统四合院的建筑形制,以回应城市特征和炎热的气候条件。业主希望在这个两层高的通风庭院中穿插设置一些有遮挡的开放式露台和景观花园。同时,除了6间卧室之外,还需要普伽室、书房、影视室以及多功能区域等,并希望这些空间均能通往露台和景观花园。

关键词：私人住宅建筑形制露台历史文化遗产传统四合院屏风边缘部分勒克瑙

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Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu nivedita Nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

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