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Management of extramedullary plasmacytoma: Role of radiotherapy and prognostic factor analysis in 55 patients

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Chinese Journal of Cancer Research 2017年第5期29卷 438-446页

作者： Ge Wen Weihu Wang Yujing Zhang Shaoqing niu Qiwen Li Yexiong Li Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Radiation Oncology Peking University Cancer Hospital & Institute Department of Radiation Oncology the Third Affiliated Hospital of Guangzhou Medical University Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Department of Radiation Oncology the First Affiliated Hospital of Sun Yat-sen University Department of Radiation Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Science & Peking Union Medical College

Objective： To investigate potential prognostic factors affecting patient outcomes and to evaluate the optimal methods and effects of radiotherapy（RT） in the management of extramedullary plasmacytoma（EMP）.Methods： Data from 55 patients with EMP between November 1999 and August 2015 were collected. The median age was 51（range, 22–77） years. The median tumor size was 3.5（range, 1.0–15.0） cm. The median applied dose was 50.0（range, 30.0–70.0） Gy. Thirty-nine patients（70.9%） presented with disease in the head or neck region. Twelve patients received RT alone, 9 received surgery（S） alone, 3 received chemotherapy（CT） alone, and 3 patients did not receive any treatment. Combination therapies were applied in 28 ***：The median follow-up duration was 56 *** 5-year local recurrence-free survival（LRFS）,multiple myeloma-free survival（MMFS）,progression-free survival（PFS）and overall survival（OS）rates were 79.8%,78.6%,65.2% and 76.0%,*** analysis revealed that RT was a favourable factor for all examined ***,head and neck EMPs were associated with superior LRFS,MMFS and *** size〈4 cm was associated with superior MMFS,PFS and OS;serum M protein negativity was associated with superior MMFS and PFS;age≥50 years and local recurrence were associated with poor *** dose≥45 Gy group exhibited superior 5-year LRFS,MMFS and PFS rates（94.7%,94.4%,90.0%,respectively）,while the corresponding values for the dose〈45 Gy group were 62.5%（P=0.008）,53.3%（P=0.036）and 41.7%（P〈0.001）.Conclusions：Involved-site RT of at least 45 Gy should be considered for ***,patients with head and neck EMP,tumor size〈4 cm,age〈50 years and serum M protein negativity had better outcomes.

关键词： Extramedullary plasmacytoma prognostic factors radiotherapy multiple myeloma

基于双给体三元体异质结的高性能倍增型有机光电探测器

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光子学报 2024年第3期53卷 251-261页

作者：李尧王奋强王爱玲蓝俊刘虎刘良朋张鹏杰吴回州牛瑞霞张栩莹兰州交通大学电子与信息工程学院兰州730070

为了拓展光谱响应范围至近红外,采用双给体单受体的三元体异质结策略,基于溶液法制备了以ITO/PEDOT∶PSS/活性层/Al为基本结构的倍增型有机光电探测器,活性层由P3HT∶PTB7-Th∶IEICO-4F(100-x∶x∶1,wt/wt/wt)组成,研究了不同质量比的PT... 详细信息

为了拓展光谱响应范围至近红外,采用双给体单受体的三元体异质结策略,基于溶液法制备了以ITO/PEDOT∶PSS/活性层/Al为基本结构的倍增型有机光电探测器,活性层由P3HT∶PTB7-Th∶IEICO-4F(100-x∶x∶1,wt/wt/wt)组成,研究了不同质量比的PTB7-Th对器件光电特性的影响。优化后的三元倍增型有机光电探测器以P3HT∶PTB7-Th∶IEICO-4F(60∶40∶1,wt/wt/wt)为活性层,在-15 V偏压下,在450、520、655和850 nm处的外量子效率分别为2 666.40%、1 752.11%、1 894.26%和938.22%,响应度分别为965.80、733.35、998.68和641.91 A/W,比探测率均超过10^(13)Jones,在850 nm处的响应度与比探测率分别是相同条件下二元器件P3HT∶IEICO-4F(100∶1,wt/wt)的2.23倍和7.08倍。结果表明,在二元体系P3HT∶IEICO-4F中掺入适量的PTB7-Th,不仅能拓展光谱响应范围至近红外,还能改变活性层中激子解离界面、电子陷阱类型和空穴注入势垒高度,优化器件的电学性能。

关键词：倍增型有机光电探测器三元体异质结溶液法近红外激子解离

Hydrothermal Synthesis and Crystal Structure of a New 2D Layer Compound [{Ni(en)_2}_2Sb_8V_(14)O_(42)]·5.5H_2O

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Chemical Research in Chinese Universities 2009年第4期25卷 426-429页

作者： YU Li LIU Jiang-ping WANG Jing-ping niu Jing-yang Institute of Molecular and Crystal Engineering School of Chemistry and Chemical Engineering Ifenan University Kaifeng 475001 P. R. China

A new compound based on polyoxovanadate [{Ni（en）2}2Sb8V14O42]·5.5H2O（en=ethylenediamine）（1） was synthesised hydrothermally as black rhombus *** 1 crystallized in the monoclinic system with space group P21/n,Z=4,a=1.46953（9） nm,b=1.28623（8） nm,c=1.76008（11） nm,β=105.7230（10）°.In the asymmetric unit,cluster {Sb8V14O42} can be considered as an Sb derivative of the {V18O42} *** {Sb8V14O42} cluster as a building block interconnected to four other neighboring units by {Ni（en）2} bridging groups which are linked through the terminal oxygen atoms of the polyoxoanions,forming a two dimensional network.

关键词： Hydrothermal synthesis Antimony-substituted Polyoxovanadate

Hybrid Tungstocuprate [Cu(2,2′-bpy)_3]_2H_4[CuW_(12)O_(40)]·6H_2O Based on Keggin Polyoxoanion [CuW_(12)O_(40)]^(6-) with Cu~Ⅱas Heteroatom

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Chemical Research in Chinese Universities 2007年第3期23卷 263-267页

作者： WANG Jing-ping MA Peng-tao LI Jie niu Jing-yang Institute of Molecular and Crystal Engineering School of Chemistry and Chemical Engineering Henan University Kaifeng 475001 P. R. China

A novel hybrid tungstocuprate （ Ⅱ ） [ Cu （2,2＇-bpy） 3 ] 2 H4 [ CuW12O40 ] · 6H2O （ 2,2＇-bpy = 2,2＇-bipyfidine） was synthesized via hydrothermal method and characterized using elemental analyses, IR, UV, XPS, TG-DSC, EPR, and X-ray single crystal diffraction. The structural analysis shows that the complex consists of an unusual Keggin-type polyoxoanion [ CuW12O40 ]^6- and a pair of chiral complex cations [ Cu（2,2＇-bpy） 3 ]^＋ together with four protons and six crystallization water molecules, and the Keggin polyoxoanion is connected with [ Cu （2,2＇-bpy）3 ]^＋v/a multiple C-H…O hydrogen bonds resulting in a dimer.

关键词： Hydrothermal synthesis Polyoxometalates Keggin Tungstocuprate

A Dairy Industry Information Cooperative Service System Based on a Production Process Ontology

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Journal of Integrative Agriculture 2012年第5期11卷 839-848页

作者： XU Yong niu Fang-qu Luke Bergmann WANG Zhi-qiang WANG Jian Key Laboratory of Regional Sustainable Development Modeling Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 P.R.China Department of Geography University of Minnesota Minneapolis MN 55455 United States of America Institute of Agricultural Information Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China

Agricultural information cooperative services （AICS） are now becoming an important aspect of agriculture informatization. This study offers an ontological conception of the agricultural production process, establishing operational divisions corresponding to both the stages and the fundamental information requirements of the dairy industry production process in China, yielding a process ontology for the dairy industry as well as a business chain model. A framework for a dairy industry information cooperative service system was established, with service functions realized in a prototype system. The resulting agricultural process ontology built on the basis of biological characteristics has advantages as a classification standard for agricultural information; whereas the business chain model based on this agricultural process ontology allows for an effective distribution of agricultural information cooperative services. This study outlines a concept and demonstrates a prototype of a cooperative service capable of integrating diverse online agricultural information relevant to the dairy industry in China.

关键词： agricultural information ontology dairy industry cooperative service agricultural informatization

Vilsmeier反应在呋虫胺合成中的应用

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广州化工 2024年第10期52卷 60-62页

作者：盛国柱牛家杰刘瑞宾山东康乔生物科技有限公司山东滨州256500

将Vilsmeier反应应用到呋虫胺的合成中,设计一条呋虫胺合成的全新路径。以2,5-二氢呋喃为基础原料,通过Vilsmeier反应、还原氨化、缩合三步反应得到呋虫胺,通过GC对中间体合成追踪和定性鉴定,通过HPLC、熔点和核磁仪对目标产品呋虫胺合... 详细信息

将Vilsmeier反应应用到呋虫胺的合成中,设计一条呋虫胺合成的全新路径。以2,5-二氢呋喃为基础原料,通过Vilsmeier反应、还原氨化、缩合三步反应得到呋虫胺,通过GC对中间体合成追踪和定性鉴定,通过HPLC、熔点和核磁仪对目标产品呋虫胺合成追踪、含量测定和结构表征,整体收率为63%。该方法具有合成路线短,工艺成本低,操作简单等优点,对于呋虫胺的合成及工业生产具有重要意义。

关键词： 2,5-二氢呋喃 Vilsmeier反应 3-氨甲基四氢呋喃呋虫胺

Construction of a Nano-rectangular Zn(Ⅱ)-Yb(Ⅲ)Complex with Near-Infrared Luminescent Response towards Metallons

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Chinese Journal of Chemistry 2020年第12期38卷 1585-1588页

作者： Xia Liu Xiaoping Yang Yanan Ma Jieni Liu Dongliang Shi Mengyu niu College of Chemistry and Materials Engineering Wenzhou UniversityWenzhouZhejiang 325035China

of main observation and conclusion One six-metal Zn(Ⅱ)-Yb(Ⅲ)complex[Zn2Yb4L2(OAC).(OH)2(CH3OH)2](1)was constructed from Schiff baseligand bis(3-methoxysalicylidenelethylene-1,2-pherylenediamine(HL4).1 shows a nanoscale rectangular structure with dimensions of approximately 0.8nm×1.1 nm×2.8 *** by lgand-centered absorption bands,1 shows typical near-infrared emission of Yb^3+***,1 exhits lanthanideluminescent response towards metal ions,especially to Cd^2+at ppm level.

关键词： Zn(Ⅱ) rectangular Infrared

A Strategy to Find Novel Candidate DKAs Inhibitors Using Modified QSAR Model with Favorable Druggability Properties

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Chemical Research in Chinese Universities 2019年第6期35卷 1111-1118页

作者： ZHANG Xiaoyi niu Wenling TANG Tang HOU Chengfei GUO Yajie KONG Ren College of Life Science and Bioengineering Beijing University of TechnologyBeijing 100124P.R.China Institute of Bioinfotmatics and Medical Engineering School of Electrical and Information EngineeringJiangsu University of TechnologyChangzhou 213016P.R.China

The study dealed with quantitative structure-activity relationship(QSAR)to explore the important features of diketo acid(DKA)derivatives for exerting potent HIV-1 integrase inhibitors activity.A three-step screening method was proposed to choose ***,additional descriptors were used in the CoMFA and ***,a modified CoMSIA m7 model,constructed by adding Csp^2_03_F descriptor,showed better predictive *** parameters(Q^2 and R^2)for the models were 0.722 and 0.925,*** addition,external validation for the models using a test group revealed R^2pred=*** maps analysis defined favored and disfavored regions of the compounds,and two new compounds with the descriptor structure were designed with better activities than Raltegravir(RAL),well drug-likeness and low *** research provides a base for further DKA development.

关键词： Diketo acid(DKA) Modified quantitative structure-activity relationship(QSAR) Autodock Drug design Descriptor screening

Space-air-ground integrated vehicular network for connected and automated vehicles:Challenges and solutions

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Intelligent and Converged Networks 2020年第2期1卷 142-169页

作者： Zhisheng niu Xuemin S.Shen Qinyu Zhang Yuliang Tang Beijing National Research Center for Information Science and Technology Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Department of Electrical and Computer Engineering University of WaterlooWaterlooN2L 3G1Canada School of Electronic and Information Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Information and Communication Engineering Xiamen UniversityXiamen 361005China

Unlimited and seamless coverage as well as ultra-reliable and low-latency communications are vital for connected vehicles,in particular for new use cases like autonomous driving and vehicle *** this paper,we propose a novel Space-Air-Ground integrated vehicular network(SAGiven)architecture to gracefully integrate the multi-dimensional and multi-scale context-information and network resources from satellites,High-Altitude Platform stations(HAPs),low-altitude Unmanned Aerial Vehicles(UAVs),and terrestrial cellular communication *** of the key features of the SAGiven is the reconfigurability of heterogeneous network functions as well as network *** first give a comprehensive review of the key challenges of this new architecture and then provide some up-to-date solutions on those ***,the solutions will cover the following topics:(1)space-air-ground integrated network reconfiguration under dynamic space resources constraints;(2)multi-dimensional sensing and efficient integration of multi-dimensional context information;(3)real-time,reliable,and secure communications among vehicles and between vehicles and the SAGiven platform;and(4)a holistic integration and demonstration of the ***,it is concluded that the SAGiven can play a key role in future autonomous driving and Internet-of-Vehicles applications.

关键词： space information network vehicular network space-air-ground integrated network autonomous driving context information Internet-of-Vehicles