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宁晋超深盐穴储气库盐系地层地应力测定分析

盐科学与化工 2024年第4期53卷 5-8,13页

作者：侯秉仁牛耀辉上官拴通苏野王续学杨哲河北燃气有限公司河北石家庄050000 河北省煤田地质局第二地质队(河北省干热岩研究中心) 河北邢台054000 河北省煤田地质局煤田地质勘查院河北邢台054000

地应力是盐穴储气库钻完井设计、运行压力设计等方面的重要基础数据,同时在储气库安全运行、经营管理等方面具有非常重要的意义。宁晋石盐田盐岩平均埋深超过2700 m,而国际上基于超深盐岩地应力的研究鲜有报道,这使宁晋盐穴储气库造腔... 详细信息

地应力是盐穴储气库钻完井设计、运行压力设计等方面的重要基础数据,同时在储气库安全运行、经营管理等方面具有非常重要的意义。宁晋石盐田盐岩平均埋深超过2700 m,而国际上基于超深盐岩地应力的研究鲜有报道,这使宁晋盐穴储气库造腔层段地应力的测定面临很大的技术挑战。文章主要以水压致裂法(HF)和声发射试验(AE)两种测试方法为主,对比已有的区域构造应力测试结果,基于Z1资料井对研究区盐系地层地应力分布特征进行综合分析,研究表明:(1)Z1井盐系地层水平最大主应力方向总体表现为近东西向;(2)Z1井盐系地层地应力整体上随深度增大,水平最大主应力为51.9~60.0 MPa,水平最小主应力为43.2~53.7 MPa,垂向最大应力为65.7 MPa;(3)Z1井盐系地层地应结构总体表现为S_(V)>S_(H)>S_(h),垂向应力为最大主应力,区域应力状态属于正断层应力环境。

关键词：盐穴储气库超深盐岩地应力测量

超深地层盐岩蠕变试验及储气库长期稳定性研究

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盐科学与化工 2024年第6期53卷 1-5,9页

作者：于长富宋鹤上官拴通高亮牛耀辉李志强李江雄康思佳姚伟杰河北燃气有限公司河北石家庄050000 河北省煤田地质局第二地质队(河北省干热岩研究中心) 河北邢台054000

为了研究宁晋超深地层盐岩的蠕变特性和长期稳定性,采用岩石伺服三轴流变试验机对盐岩进行三轴蠕变试验分析,分析围压、偏应力、时间对蠕变的影响;通过FLAC3D软件对不同循环内压下运行30 a后腔周塑性区范围、腔周位移进行长期稳定性分... 详细信息

为了研究宁晋超深地层盐岩的蠕变特性和长期稳定性,采用岩石伺服三轴流变试验机对盐岩进行三轴蠕变试验分析,分析围压、偏应力、时间对蠕变的影响;通过FLAC3D软件对不同循环内压下运行30 a后腔周塑性区范围、腔周位移进行长期稳定性分析。通过三轴蠕变试验表明:围压的变化能够使蠕变三阶段重新发生;随着偏应力的增大,稳态蠕变率增加;偏应力对蠕变的影响要大于围压对蠕变的影响;宁晋超深储气库石盐矿层蠕变参数为:A=1.55×10-10,n=3.961。长期稳定性模拟研究表明:塑性区位置、最大腔周位移都出现在腔体中部位置;随着流变时间的增加,塑性区范围、腔周位移都逐渐变大;内压越高,塑性区范围、腔周位移越小,运行过程中要避免低压长期运行。

关键词：盐穴储气库盐岩蠕变特性稳定性模拟超深

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制导光纤高速释放中姿态与受力情况分析

弹箭与制导学报 2024年第3期44卷 1-10,21页

作者：李明航张卓唐峰薛耀辉王嘉欣牛大山西安现代控制技术研究所陕西西安710065

光纤作为制导武器的信号传输介质,若发生断裂,导弹则失去控制无法飞行。由于实弹飞行成本高、周期长,为高效评价光纤的可靠性与抗拉强度等指标,光纤的地面模拟释放实验对检验光纤释放可靠性具有重要意义。针对制导光纤地面释放中的断线... 详细信息

光纤作为制导武器的信号传输介质,若发生断裂,导弹则失去控制无法飞行。由于实弹飞行成本高、周期长,为高效评价光纤的可靠性与抗拉强度等指标,光纤的地面模拟释放实验对检验光纤释放可靠性具有重要意义。针对制导光纤地面释放中的断线问题,根据光纤释放的运动特点,在旋转坐标系下推导出了光纤运动的动力学方程。基于光纤释放过程中绝大部分时间处于恒定速度释放这一特点,忽略时间变化项对动力学方程的影响,着重分析光纤“准稳态”情况下的光纤受力以及空间分布情况。通过数值方法求解了简化后的光纤姿态微分方程,利用高速摄影机拍摄了地面模拟释放实验中光纤的运动姿态,并与理论计算结果进行了对比。对比发现,光纤刚挣脱粘结剂进行运动时,理论计算结果与实际光纤运动姿态相差较大。光纤逐渐运动离开线包后,理论计算结果与光纤实际运动姿态逐渐相符。最后,考察了光纤初始方向向量、收线点处张力、释放点与收线点之间的距离以及光纤释放速度对光纤姿态、张力分布的影响。光纤高速释放中姿态与受力情况分析为光纤释放断裂事故分析以及提升光纤释放可靠性提供理论基础。

关键词：制导光纤地面释放张力分布空间姿态

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聚乙醇酸加工技术中助剂的应用进展

中国塑料 2024年第6期38卷 105-110页

作者：牛荷吕明福张宗胤徐耀辉许巍张师军郭鹏中国石化北京化工研究院北京100013

综述了聚乙醇酸(PGA)加工技术中助剂的应用进展,包括抗氧剂、扩链剂、抗水解剂以及无机粒子。

关键词：聚乙醇酸生物可降解聚合物助剂

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy

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Frontiers of Medicine 2023年第4期17卷 699-713页

作者： Zixun Yan Li Li Di Fu Wen Wu niu Qiao yaohui Huang Lu Jiang Depei Wu Yu Hu Huilai Zhang Pengpeng Xu Shu Cheng Li Wang Sahin Lacin Muharrem Muftuoglu Weili Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Hematology The First Affiliated Hospital of Soochow UniversitySuzhou 215000China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Tianjin Medical University Cancer Institute&Hospital Tianjin 300070China University of Texas MD Anderson Cancer Center HoustonTexas 77030USA Laboratory of Molecular Pathology Pôle de Recherches Sino-Français en Science du Vivant et GénomiqueShanghai 200025China

Anti-CD19 chimeric antigen receptor(CAR)-T cell therapy has achieved 40%–50%long-term complete response in relapsed or refractory diffuse large B-cell lymphoma(DLBCL)patients.However,the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cell therapy failure needs further investigation.A multi-center phase I/II trial of anti-CD19 CD28z CAR-T(FKC876,ChiCTR1800019661)was conducted.Among 22 evaluable DLBCL patients,seven achieved complete remission,10 experienced partial remissions,while four had stable disease by day 29.Single-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected from long-term complete remission and early-progressed patients,and compared at different stages of treatment.M2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumor functions of CAR-T cells,leading to CAR-T cell therapy failure and disease progression in DLBCL.Immunosuppressive tumor microenvironments persisted before CAR-T cell therapy,during both cell expansion and disease progression,which could not be altered by infiltrating CAR-T cells.Aberrant metabolism profile of M2-subtype macrophages and those of dysfunctional T cells also contributed to the immunosuppressive tumor microenvironments.Thus,our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming immune cell metabolism as effective therapeutic strategies to prevent lymphoma relapse in future designs of CAR-T cell therapy.

关键词： anti-CD19 chimeric antigen receptor T immunotherapy diffuse large B cell lymphoma tumor microenvironment tumor-associated macrophage metabolism

A mechanical reliability study of 3-dB waveguide hybrid couplers in submillimeter and terahertz bands

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Frontiers of Information Technology & Electronic Engineering 2021年第8期22卷 1104-1113页

作者： Zhongqian niu Bo ZHANG Daotong LI Dongfeng JI Yang LIU Yinian FENG Tianchi ZHOU yaohui ZHANG Yong FAN School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Center of Aerocraft TT&C and Communication Chongqing UniversityChongqing 400044China

This paper presents a mechanical reliability study of 3-dB waveguide hybrid couplers in submillimeter and terahertz bands.To show the necessity of improving the mechanical properties of the coupler’s branch in submillimeter and terahertz bands,a comprehensive study regarding the displacement of hybrid branch variation with varying width-length ratio and height-length ratio has been completed.In addition,a modified 3-dB waveguide hybrid coupler is designed and presented.Compared with the traditional branch structure,the proposed hybrid consists of a modified middle branch with circular cutouts at the top and bottom on both sides instead of the traditional rectangle branch,which increases the branch size and improves its mechanical reliability while achieving the same performance.Simulation results show that the deformation of the modified hybrid branch is 22%less than those of other traditional structure designs under the same stress.In practice,a vibration experiment is set up to verify the mechanical reliability of hybrid couplers.Measurement results show that the experiment deteriorates the coupling performance.Experimental results verify that the performance of the novel structure coupler is better than that of a traditional structure branch hybrid coupler under the same electrical properties.

关键词： Directional coupler 3-dB waveguide hybrid coupler Submillimeter-wave device Terahertz circuit Mechanical reliability

The Research on 220GHz Multicarrier High-Speed Communication System

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China Communications 2020年第3期17卷 131-139页

作者： Zhongqian niu Bo Zhang Jiale Wang Ke Liu Zhi Chen Ke Yang Zhen Zhou Yong Fan yaohui Zhang Dongfeng Ji Yinian Feng Yang Liu School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China Xi’an Institute of Space Radio Technology Xi’an 710000China Nation Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 610054China

This paper presents our investigation into a 220 GHz multicarrier highspeed communication system based on solid state transceivers.The proposed system has eased the demand of high sampling rate analog-to-digital converter(ADC)by providing several signal carriers in microwave band and converting them to 220 GHz channel.The system consists of a set of 220 GHz solid-state transceiver with 2 signal carriers,two basebands for 4 GSPS ADCs.It has achieved 12.8 Gbps rate real-time signal transmission using 16QAM modulation over a distance of 20 m without any other auxiliary equipment or test instruments.The baseband algorithm overcomes the problem of frequency difference generates by non-coherent structure,which guarantees the feasibility of long-distance transmission application.Most importantly,the proposed system has already carried out multi-channel 8K video parallel transmission through switch equipment,which shows the multicarrier high-speed communication system in submillimeter wave has great application prospects.To the best of the authors’knowledge,this is the first all-solid-state electronics multicarrier communication system in submillimeter and terahertz band.

关键词： circuits and systems communication systems submillimeter wave communication solid state circuits

实蝇类昆虫利用视觉和嗅觉定位寄主的分子基础及应用

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华中农业大学学报 2022年第2期41卷 161-167页

作者：高秉丽王浩然王耀辉徐鹏辉牛长缨湖北省昆虫资源利用与害虫可持续治理重点实验室/华中农业大学植物科学技术学院武汉430070

在昆虫与植物协同进化过程中,昆虫成功定位寄主植物决定其食性及生态位。实蝇类昆虫是世界范围内分布的重要果蔬害虫,在定位寄主植物过程中,实蝇视觉和嗅觉发挥重要作用,利用寄主颜色和气味模拟的诱捕装置能够有效诱杀实蝇,但诱杀效果... 详细信息

在昆虫与植物协同进化过程中,昆虫成功定位寄主植物决定其食性及生态位。实蝇类昆虫是世界范围内分布的重要果蔬害虫,在定位寄主植物过程中,实蝇视觉和嗅觉发挥重要作用,利用寄主颜色和气味模拟的诱捕装置能够有效诱杀实蝇,但诱杀效果参差不齐。因此,本文对实蝇类昆虫视觉、嗅觉定位寄主植物的行为和相关分子基础进行了阐述,介绍了有关的应用成果,并对未来的方向进行了展望,以期为建立实蝇类害虫可持续的绿色防控技术奠定基础。

关键词：实蝇寄主定位视觉嗅觉绿色防控

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特利加压素对肝硬化UGIB患者的疗效

菏泽医学专科学校学报 2022年第1期34卷 22-24,39页

作者：牛建朝赵永涛张耀辉郑州中康医院河南郑州452370

目的探究特利加压素治疗肝硬化急性上消化道出血(UGIB)患者的疗效及其对肝静脉压力水平、超敏C反应蛋白(hs-CRP)及血氨(BA)水平的影响。方法选取我院收治的83例肝硬化UGIB患者作为研究对象,随机分为观察组和对照组。对照组41例给予生长... 详细信息

目的探究特利加压素治疗肝硬化急性上消化道出血(UGIB)患者的疗效及其对肝静脉压力水平、超敏C反应蛋白(hs-CRP)及血氨(BA)水平的影响。方法选取我院收治的83例肝硬化UGIB患者作为研究对象,随机分为观察组和对照组。对照组41例给予生长抑素治疗,观察组42例在对照组基础上给予特利加压素治疗,观察两组患者的临床疗效、肝静脉压力水平、实验室指标及并发症情况。结果治疗后对照组临床疗效低于观察组(P0.05。结论特利加压素治疗肝硬化UGIB患者可有效降低肝静脉压力,调节hs-CRP、BA水平,提高临床疗效,且安全性高。

关键词：特利加压素肝硬化肝静脉压力血氨