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山东中医杂志 2024年第12期43卷 1380-1386页

作者：游晓阳马巧琳胡斌孙春阳宋甲奇李明哲张琳赵蓉蓉牛骏崴南阳医学高等专科学校河南南阳473061 河南中医药大学河南郑州450046 河南中医药大学第三附属医院河南郑州450008

目的:观察五神针联合眠安汤治疗复合证型不寐的临床疗效。方法:将90例复合证型(心脾两虚证、痰热扰心证)不寐患者随机分为五神针组(30例,完成研究者27例)、眠安汤组(30例,完成研究者28例)和针药联合组(30例,完成研究者27例),分别采用针... 详细信息

目的:观察五神针联合眠安汤治疗复合证型不寐的临床疗效。方法:将90例复合证型(心脾两虚证、痰热扰心证)不寐患者随机分为五神针组(30例,完成研究者27例)、眠安汤组(30例,完成研究者28例)和针药联合组(30例,完成研究者27例),分别采用针刺、中药、针药联合治疗,3组均治疗2周。比较3组治疗前、治疗1周后、治疗2周后的匹兹堡睡眠质量指数量表(PSQI)和阿森斯失眠量表(AIS)评分以评价疗效。结果:经治疗后,针药联合组的总有效率(96.30%)高于五神针组(74.07%)和眠安汤组(75.00%)(P<0.05),且针药联合组的PSQI、AIS评分均低于同期其他两组(P<0.05)。组内比较发现,3组患者治疗后的PSQI、AIS评分均低于治疗前(P<0.05)。结论:五神针、眠安汤、五神针联合眠安汤对于复合证型不寐均有治疗效果,且五神针联合眠安汤治疗效果更好。

关键词：复合证型不寐五神针眠安汤心脾两虚针药联合

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Chemerin/ChemR23在早期糖尿病肾病中的作用及其与炎症因子表达关系的研究

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中华生物医学工程杂志 2018年第4期24卷 235-241页

作者：王晓阳牛聪吴秋杰李肖肖王聪宫亚楠张晓雪程根阳刘栋肖静赵占正郑州大学第一附属医院肾脏病医院肾内科 450052

目的观察糖尿病肾损伤早期Chemerin/ChemR23的表达水平及与炎症因子的关系。方法80只SD大鼠,随机分为正常对照组(NC组,n=40)和糖尿病组(DM组,n=40)。DM组大鼠单次腹腔注射75 mg/kg链脲佐菌素(streptozotocin,STZ)建立早期糖尿病肾病模... 详细信息

目的观察糖尿病肾损伤早期Chemerin/ChemR23的表达水平及与炎症因子的关系。方法80只SD大鼠,随机分为正常对照组(NC组,n=40)和糖尿病组(DM组,n=40)。DM组大鼠单次腹腔注射75 mg/kg链脲佐菌素(streptozotocin,STZ)建立早期糖尿病肾病模型。分别于注射后1、2、3、4和12周,检测每只大鼠的体重、血糖、肾重指数(肾脏重量/体重)、尿白蛋白/肌酐比值(urinary albumin creatinine ratio,UACR)、血肌酐(SCr)水平和肾脏病理结构的变化,并检测肾组织中Chemerin、ChemR23的表达水平,血清中Chemerin的表达水平,分析Chemerin与ChemR23与肿瘤坏死因子⁃α(TNF⁃α)、白介素⁃6(IL⁃6)、C反应蛋白(CRP)的相关关系。结果注射STZ 72 h后,糖尿病模型建立成功。造模后4周,大鼠出现微量白蛋白尿,尿白蛋白/肌酐比值从(0.36±0.22)mg/mmol升高至(1.46±0.49)mg/mmol。肾脏病理学也显示早期肾损伤。12周DM组大鼠出现大量白蛋白尿,尿白蛋白/肌酐比值升高至(2.64±1.11)mg/mmol,血肌酐水平明显升高,肾脏病理学显示糖尿病肾损伤进一步加重。4周时,肾组织中Chemerin和ChemR23的表达水平明显升高。采用Spearman相关分析发现,DM组血清和肾组织中Chemerin的蛋白表达水平与TNF⁃α、IL⁃6和CRP(P<0.01)呈正相关。结论Chemerin、ChemR23与糖尿病肾病炎症反应及肾病进展相关。

关键词：糖尿病肾病炎症炎症趋化因子类

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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