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Stir-Fried Semen Armeniacae Amarum Suppresses Aristolochic AcidⅠ-Induced Nephrotoxicity and DNA Adducts

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Chinese Journal of Integrative Medicine 2025年第2期31卷 142-152页

作者： LI Cheng-xian XIAO Xiao-he LI Xin-yu XIAO Da-ke WANG Yin-kang WANG Xian-ling ZHANG Ping LI Yu-rong niu Ming BAI Zhao-fang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing(100102)China Department of Hepatology Military Institute of Chinese Materiathe Fifth Medical CentreGeneral Hospital of PLABeijing(100039)China National Key Laboratory of Kidney Beijing(100039)China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu(610075)China School of Traditional Chinese Medicine Capital Medical UniversityBeijing(100069)China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing(100039)China Department of Military Patient Management the Fifth Medical Center of PLA General HospitalBeijing(100039)China Department of Hematology the Fifth Medical Center of Chinese PLA General HospitalBeijing(100071)China

Objective:To investigate the protective effects of stir-fried Semen Armeniacae Amarum(SAA)against aristolochic acidⅠ(AAⅠ)-induced nephrotoxicity and DNA adducts and elucidate the underlying mechanism involved for ensuring the safe use of Asari Radix et ***:In vitro,HEK293T cells overexpressing Flag-tagged multidrug resistance-associated protein 3(MRP3)were constructed by Lentiviral transduction,and inhibitory effect of top 10 common pairs of medicinal herbs with Asari Radix et Rhizoma in clinic on MRP3 activity was verified using a self-constructed fluorescence screening *** m RNA,protein expressions,and enzyme activity levels of NAD(P)H quinone dehydrogenase 1(NQO1)and cytochrome P4501A2(CYP1A2)were measured in differentiated Hepa RG *** toxicity after inhibition of AAⅠmetabolite transport was detected using cell counting kit-8 *** vivo,C57BL/6 mice were randomly divided into 5 groups according to a random number table,including:control(1%sodium bicarbonate),AAⅠ(10 mg/kg),stir-fried SAA(1.75 g/kg)and AAⅠ+stir-fried SAA(1.75 and 8.75 g/kg)groups,6 mice in each *** 7 days of continuous gavage administration,liver and kidney damages were assessed,and the protein expressions and enzyme activity of liver metabolic enzymes NQO1 and CYP1A2 were determined ***:In vivo,combination of 1.75 g/kg SAA and 10 mg/kg AAⅠsuppressed AAⅠ-induced nephrotoxicity and reduced d A-ALI formation by 26.7%,and these detoxification effects in a dose-dependent manner(P<0.01).Mechanistically,SAA inhibited MRP3 transport in vitro,downregulated NQO1 expression in vivo,increased CYP1A2 expression and enzymatic activity in vitro and in vivo,respectively(P<0.05 or P<0.01).Notably,SAA also reduced AAⅠ-induced hepatotoxicity throughout the detoxification process,as indicated by a 41.3%reduction in the number of liver adducts(P<0.01).Conclusions:Stirfried SAA is a novel drug candidate for the suppression of AAⅠ-induced liver and kidney dam

关键词： aristolochic acidⅠ stir-fried Semen Armeniacae Amarum detoxification principles of compatibility metabolic enzymes transporters

Model and Data Hybrid Driven Approach for Quantifying the Meteorology-Dependent Demand Flexibility of Building Thermal Loads

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 394-405页

作者： Bo Hu Xin Cheng Changzheng Shao Tao niu Chunyan Li Yue Sun Wei Huang Kaigui Xie State Key Laboratory of Power Transmission Equipment and System Security Chongqing UniversityChongqing400030China

Recently, the heat and electricity integrated energy system (HE-IES) has become a hot topic in both industry and academia. In the HE- IES, the potential flexibility of the buildings' thermal loads can be exploited to relax the heat power balance constraints and consequently allow a more flexible operation of the combined heat and power units. In this paper, model-driven and data-driven techniques are combined to quantify the demand flexibility of the buildings' thermal loads in a non-instructive way. First, the explicit analytical equivalent thermal parameter (ETP) model of the aggregated buildings is developed. The heat transfer coefficient (k) and thermal inertia coefficient (C) of the ETP model are designated to measure the potential demand flexibility. Second, the Particle Swarm Optimization optimized Radial Basis Function neural network (PSO-RBF) is used to identify the relationship between the values of k and C and the meteorological factors. To obtain the training data, an innovative two-stage regression method based on the adaptive temporal resolution is proposed to extract k and C values from the historical thermal load data. Finally, a flexible thermal load model is built based on the predictions of the meteorological factors, which can be conveniently incorporated into the online dispatch of the HE-IES. A comprehensive simulation environment is designed to verify the accuracy and availability of the proposed technique.

关键词： Flexibility of buildings'thermal loads heat and electricity integrated energy system meteorological factors model and data hybrid driven.

Modular access toπ-conjugated planar chiral diradicaloids using redox-active pillar[5]arenes

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Science China Chemistry 2025年

作者： Yuting Xue Yi Zeng Yafei Shi Yu Tian Cuiping Sun niu Zhang Xiaoyan Zheng Pangkuan Chen Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science of the Ministry of Education Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering of the Ministry of Industry and Information Technology School of Chemistry and Chemical Engineering Beijing Institute of Technology Analysis & Testing Centre Beijing Institute of Technology

Open-shell chiral diradicals that feature both the unique chiroptical properties and tunable spin states have kindled numerous interests in organic synthesis and material *** present a new class of such model systems based on theπ-extended planar chiral pillar[5]arene derivatives P5Flu and P5Cz,where the pillar[5]arene-based chiral scaffolds are coupled with sterically encumbered fluorenyl and carbazolyl moieties as highly luminescent redox-active emitters,*** molecules in neutral states can readily undergo chemical oxidations leading toπ-conjugated chiral diradicals of the dehydrogenated P5Flu2·and a positively charged dication P5Cz2+2·.Characterization of the resulting Müller’s open-shell species by variable-temperature electron spin resonance （VT-ESR）,UV-vis-NIR absorption,VT-NMR and by computational studies revealed a singlet (ΔES-T=?1.63 kcal mol-1) and a nearly degenerate singlet-triplet ground state (ΔES-T=0.05 kcal mol-1,with a diradical character index y0=0.89) for P5Cz2+2·and P5Flu2·,*** particularly show in this work a new journey for pillar[5]arenes from the conventionally available closed-shell structures to different open-shell spin states with potential applications in chirospintronics and NIR-active chiroptoelectronic materials.

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Differential expression of plasma extracellular vesicle miRNAs as biomarkers for distinguishing psoriatic arthritis from psoriasis

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中华医学杂志(英文版) 2025年第2期138卷 219-221页

作者： Yan Kexiang Zhu Jie Zhang Mengmeng Zhang Fuxin Wang Bing Han Ling Huang Qiong Tang Yulong Li Yuan Yawalkar Nikhil Zhang Zhenghua niu Zhenmin Department of Dermatology Huashan Hospital Fudan University Shanghai China State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and Development School of Life Sciences Human Phenome Institute Fudan University Shanghai China Department of Dermatology Inselspital Bern University Hospital University of Bern Bern CH-Bern Switzerland Department of Genetics Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science &amp Technology (SAST) Shanghai China

Dyssynchronous heart failure models in canines:New insights into electrocardiographic,echocardiographic and histological features

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Animal Models and Experimental Medicine 2025年第1期8卷 142-153页

作者： Han Jin Shengwen Yang Hao Huang Sijing Cheng Pengkang He Sixian Weng Min Gu Hongxia niu Wei Hua Yiran Hu Hui Li Cardiology Department Peking University First HospitalBeijingChina Department of Heart Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiac Arrhythmia Center Fuwai HospitalState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology and Macrovascular Disease Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Ultrasound State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:We investigated the similarities and differences between two experimental approaches using tachy-pacing technology to induce desynchronized heart failure in ***:A total of eight dogs were included in the experiment,four were tachypaced in right ventricle apex (RVAP) and 4 were paced in right atrium after the ablation of left bundle branch to achieve left bundle branch block (RAP+LBBB).Three weeks of follow-up were conducted to observe the changes in cardiac function and myocardial staining was performed at the end of the ***:Both experimental approaches successfully established heart failure with reduced ejection fraction models,with similar trends in declining cardiac *** RAP+LBBB group exhibited a prolonged overall ventricular activation time, delayed left ventricular activation,and lesser impact on the right *** RVAP approach led to a reduction in overall right ventricular compliance and right ve ntricular *** RAP+LBBB group exhibited significant reductions in left heart compliance (LVGLS,%:RAP+LBBB-12.60±0.12 to-5.93±1.25;RVAP-13.28±0.62to-8.05±0.63, p=0.023;LASct,%:RAP+LBBB-15.75±6.85 to-1.50±1.00;RVAP-15.75±2.87 to-10.05±6.16,p=0.035).Histological examination revealed more pronounced fibrosis in the left ventricular wall and left atrium in the RAP+LBBBgroup while the RVAP group showed more prominent fibrosis in the right ventricular ***:Both approaches establish HFrEF models with comparable *** RVAP group shows impaired right ventricular function,while the RAP+LBBB group exhibits more severe decreased compliance and fibrosis in left ventricle.

关键词： dyssynchrony heart failure tachy-pacing technology

1854~1860年常熟梅雨重建与特征分析

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第四纪研究 2025年第1期45卷 203-212页

作者：牛浪深圳职业技术大学马克思主义学院深圳518055 北京师范大学历史学院北京100875

梅雨是长江中下游地区重要的气候现象,梅雨期长短和梅雨量变化历来受到高度重视。提取《季芝昌日记》中夏季天气记录,重建了1854~1860年江苏常熟夏季降水序列。依据雨日确定梅雨期的方法,得到常熟逐年入梅与出梅时间。在此基础上,对1854... 详细信息

梅雨是长江中下游地区重要的气候现象,梅雨期长短和梅雨量变化历来受到高度重视。提取《季芝昌日记》中夏季天气记录,重建了1854~1860年江苏常熟夏季降水序列。依据雨日确定梅雨期的方法,得到常熟逐年入梅与出梅时间。在此基础上,对1854~1860年常熟梅雨进行分类,再根据地方志、档案等资料旱涝灾害记载,探讨了常熟梅雨与长三角地区旱涝的联系。结果表明:1)1854~1860年常熟平均入梅日期为6月15日,出梅日期为7月1日;2)1854~1860年常熟梅雨与现代梅雨(1981~2010年)有较大差异,表现为入梅时间提前1 d,出梅时间提前9 d,梅雨期少8 d;3)1854~1860年常熟有3个典型梅雨年,4个异常梅雨年。其中,1854年为丰梅年,1856年为空梅年,1858年为晚梅雨年,1859年为早梅雨年;4)常熟梅雨与长三角地区旱涝虽有密切关系,但并非完全对应,个别年份存在较大差别。本研究结果对了解小冰期末期常熟梅雨变化特征及其长三角地区的年际旱涝灾害具有一定参考价值。

关键词：《季芝昌日记》常熟梅雨小冰期旱涝关系

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Spatiotemporal variations of tenebrionid beetles(Coleoptera:Tenebrionidae)in the Gobi desert,Northwest China

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Journal of Arid Land 2025年第1期17卷 112-129页

作者： REN Jialong ZHAO Wenzhi HE Zhibin WANG Yongzhen FENG Yilin niu Yiping XIN Weidong PAN Chengchen LIU Jiliang College of Geographic Sciences Shanxi Normal UniversityTaiyuan 030031China Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Linze Inland River Basin Research StationNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610213China Plant Protection Institute Hebei Academy of Agriculture and Forestry SciencesBaoding 071002China

Tenebrionid beetles represent a crucial arthropod taxon in the Gobi desert ecosystems owing to their species richness and high biomass,both of which are essential for maintaining ecosystem health and ***,the spatiotemporal variations of tenebrionid beetle assemblages in the Gobi desert remain poorly *** this study,the monthly dynamics of tenebrionid beetles in the central part of the Hexi Corridor,Northwest China,a representative area of the Gobi desert ecosystems,were monitored using pitfall trapping during *** following results were showed:(1)monthly activity of tenebrionid beetles was observed from March to October,with monthly activity peaking in spring and summer,and monthly activity periods and peak of tenebrionid beetle species exhibited interspecific differences that varied from year to year;(2)spatial distribution of tenebrionid beetle community was influenced by structural ***,at a spatial scale of 24.00 m,tenebrionid beetle community was strongly and positively correlated with the dominant species,with distinct spatial distribution patterns observed for Blaps gobiensis and Microdera kraatzi alashanica;(3)abundance of tenebrionid beetles was positively correlated with monthly mean precipitation and monthly mean temperature,whereas monthly abundance of *** and *** alashanica was positively correlated with monthly mean precipitation;and(4)the cover of Reaumuria soongarica(Pall.)*** Nitraria sphaerocarpa *** a positive influence on the number of tenebrionid beetles *** conclusion,monthly variation in precipitation significantly influences the community dynamic of tenebrionid beetles,with precipitation and shrub cover jointly determining the spatial distribution pattern of these beetles in the Gobi desert ecosystems.

关键词： Gobi desert precipitation change tenebrionid beetles temporal dynamics spatial pattern

YOLO-based lightweight traffic sign detection algorithm and mobile deployment

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Optoelectronics Letters 2025年第4期21卷 249-256页

作者： WU Yaqin ZHANG Tao niu Jianjun CHANG Yan LIU Ganjun Software College Shanxi Agricultural University School of Electrical Automation and Information Engineering Tianjin University

This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO). Firstly, the classification to fusion(C2f) structure is integrated into the backbone network, employing deformable con... 详细信息

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Dynamically self-adjustable liquid-liquid and self-adaptive softcontact solid-solid triboelectric nanogenerator for wave energy harvesting

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Nano Research 2025年第1期18卷 404-414页

作者： Yong Long Bingqi Zhao Jianan niu Yuxiu Liu Wei Sha Jiangwen Wang Zhong Lin Wang Weiguo Hu Guangzhou Institute of Blue Energy Knowledge CityHuangpu DistrictGuangzhou 510555China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Water wave energy exhibits great potential toalleviate the global energy crisis. However, harvesting andutilizing wave energy are challenging due to its irregularity,randomness, and low frequency. Triboelectric nanogenerators(TENGs) have gained significant attention for harvesting waveenergy with high efficiency. This study presents a novelellipsoidal, pendulum-like TENG integrating both liquid-liquid(L-L) and solid-solid (S-S) triboelectricity (LS-TENG). Thisinnovative design enables continuous wave energy harvestingand self-powered marine environment monitoring under variousconditions, including temperature, humidity, and light intensity. The binary immiscible liquids within the LS-TENG’s innersoft balloon create dynamic, and self-adjustable L-L contact interfaces, significantly increasing the L-L contact area andenhancing L-L contact electrification (CE). The unique self-adaptive, soft S-S contact increases the S-S contact areacompared to traditional hard point contact, better adapting to the irregular movements of waves and promoting efficient S-SCE. The LS-TENG achieves highly efficient wave energy harvesting by coupling L-L and S-S CE. Furthermore, the uniquesoft contact design protects the S-S interfaces from mechanical wear and damage during long-term work. The LS-TENG’snovel structure provides an innovative and effective way for water wave energy harvesting.

关键词： self-adaptive soft-contact solid-solid liquid-liquid self-adjustable triboelectric nanogenerator