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Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats

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World Journal of Gastroenterology 2005年第31期11卷 4912-4915页

作者： Ping Zheng Feng-li niu Wen-Zhong liu Yao Shi Lun-Gen Lu Shanghai Institute of Digestive Disease Renji Hospital Shanghai Second Medical University Shanghai 200127 China

AIM： To investigate the anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium （DSS）-induced colitis of rats. METHODS： Acute colitis was induced by giving 2% DSS orally in drinking water for 8 d. Twenty-six male rats were randomized into oxymatrine-treated group （group A, 10 rats）, DSS control （group B, 10 rats） and normal control （group C, 6 rats）. The rats in group A were injected muscularly with oxymatrine at the dosage of 63 mg/（kg·d） from d 1 to 11 and drank 2% DSS solution from d 4 to 11. The rats in group B were treated with 0.9% saline in an equal volume as group A and drank 2% DSS solution from d 4 to 11. The rats in group C were treated with 0.9% saline as group B from d 1 to 11 and drank water normally. Diarrhea and bloody stool as well as colonic histology were observed. The levels of serum tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were determined by EliSA, and nuclear factor-κB （NF-κB） activity and the expression of inter-cellular adhesion molecule-1 （ICAM-1） in colonic mucosa were detected by immunohistochemistry method. RESULTS： Compared with DSS control group, the inflammatory symptoms and histological damages of colonic mucosa in oxymatrine-treated group were significantly improved, the serum levels of TNF-α, IL-6, and the expression of NF-κB, ICAM-1 in colonic mucosa were significantly reduced. CONCLUSION： The fact that oxymatrine can reduce the serum levels of TNF-α, IL-6, and the expression of NF-κB and ICAM-1 in colonic mucosa in DSS-induced colitis of rats indicates that oxymatrine may ameliorate the colonic inflammation and thus alleviate diarrhea and bloody stool.

关键词： Oxymatrine Colitis Colonic mucosa

鄂尔多斯盆地陆相页岩油藏天然裂缝刻画与储层改造对策

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中国石油勘探 2024年第3期29卷 131-145页

作者：雷启鸿马福建何右安王书宇牛利罗引叶坡黄天镜黄哲远刘原冯张斌中国石油长庆油田公司斯伦贝谢中国公司

鄂尔多斯盆地陇东地区三叠系延长组长7段页岩油储层主要为深湖相泥页岩和重力流砂体的交互沉积,储层的分布在纵向和横向上均复杂多变,单砂体厚度薄,同时又受到天然裂缝的影响,对该区科学压裂、生产提出了一系列挑战,压窜、砂堵等工程问... 详细信息

鄂尔多斯盆地陇东地区三叠系延长组长7段页岩油储层主要为深湖相泥页岩和重力流砂体的交互沉积,储层的分布在纵向和横向上均复杂多变,单砂体厚度薄,同时又受到天然裂缝的影响,对该区科学压裂、生产提出了一系列挑战,压窜、砂堵等工程问题与降本增产成为目前重要攻关方向。文章总结了近两年来针对该区天然裂缝刻画方面的工作和认识,以及在压裂改造方面的最新理念和对策。在综合地质研究的基础上,建立三维精细地质、油藏和地质力学模型,进行合理的压裂设计、施工、压裂后分析和计算机模拟,更好地了解天然裂缝和水力裂缝之间的相互作用和水力缝的扩展规律,达到定制化的压裂设计和施工优化。最终实现施工井与同平台邻井在产量相当的情况下,支撑剂的用量减少20%左右、压裂液用量减少10%左右。这种地质工程一体化工作流程使“一井一策”和“一段一法”真正落到实处,从长远来看,这将成为鄂尔多斯盆地陆相页岩油达到单井和井场EUR最佳效果的基础性技术保障。

关键词：页岩油地质工程一体化三叠系延长组长7段天然裂缝井间干扰

Characterization of Domeless receptors and the role of Bd Domeless3 in anti-symbiont-like virus defense in Bactrocera dorsalis

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Journal of Integrative Agriculture 2024年第4期23卷 1274-1284页

作者： Wei Zhang Shaoyang li Rong li Jinzhi niu Jinjun Wang Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River Ministry of Education/International Joint Laboratory of China-Belgium on Sustainable Crop Pest ControlAcademy of Agricultural SciencesSouthwest UniversityChongqing 400715China

The Janus kinase/signal transducers and activators of transcription(JAK/STAT)signaling pathway play a pivotal role in innate *** invertebrates,Domeless receptors serve as the key upstream regulators of this *** our study on Bactrocera dorsalis,we identified three cytokine receptors:BdDomeless1,BdDomeless2,and *** receptor encompasses five fibronectin-type-III-like(FN III)extracellular domains and a transmembrane ***,these receptors exhibit the increased responsiveness to diverse pathogenic ***,only BdDomeless3 is upregulated during symbiont-like viral ***,silencing BdDomeless3 enhanced the infectivity of Bactrocera dorsalis cripavirus(BdCV)and *** picorna-like virus(BdPLV),underscoring BdDomeless3’s crucial role in antiviral defense of *** the suppression of Domeless3 expression,six antimicrobial peptide genes displayed decreased expression,potentially correlating with the rise in viral *** our knowledge,this is the first study identifying cytokine receptors associated with the JAK/STAT pathway in tephritid flies,shedding light on the immune mechanisms of ***.

关键词： Bactrocera dorsalis JAK/STAT pathway Domeless receptors antiviral immunity symbiont-like virus

Sustainable Intensification and Large-scale Operation of Cultivated Land Use at the Farmers’ Scale:A Case Study of Shandong Province,China

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Chinese Geographical Science 2024年第1期34卷 149-167页

作者： li li LYU Xiao ZHANG Anlu niu Shandong PENG Wenlong School of Public Administration Huazhong Agricultural UniversityWuhan430070China Department of Geography University of ZurichZurich8057Switzerland School of Humanities and Law Northeastern UniversityShenyang110169China School of Geography and Tourism Qufu Normal UniversityRizhao276800China

Sustainable intensification of cultivated land use(SICLU) and large-scale operations(LSO) are widely acknowledged strategies for enhancing agricultural ***,the existing literature has faced challenges in precisely defining SICLU and constructing comprehensive indicators,which has hindered the exploration of factors influencing LSO within the SICLU *** address this gap,we integrated self-efficacy theory into the design of an index framework for evaluating *** subsequently employed econometric models to analyze the significant factors that impact *** findings reveal that SICLU can be divided into four key dimensions:intensive management,efficient output,resource conservation,and ecological environment ***,it is crucial to incorporate belief-based cognitive factors into the index system,as farmers’ understanding of fertilizer and pesticide application significantly influences their willingness to engage in ***,we identify grain market turnover as the most influential factor in promoting LSO,with single-factor contribution rates reaching 70.9% for cultivated land transfer willingness and 62.5% for the total planting ***,unlike irrigation and agricultural machinery inputs,increased labor inputs correspond to larger planting areas for *** trend may be attributed to reduced labor availability because of rural labor migration,whereas the reduction in irrigation and agricultural input is contingent on innovations in production practices and the transfer of cultivated land management ***,SICLU dynamically influences LSO,with each index related to SICLU having an optimal range that fosters *** insights offer valuable guidance for policymakers,emphasizing farmers as their central focus,with the adjustment of input and output factors as a means to achieve LSO as the ultimate *** conclusion,we propose research avenues for further enriching the SICLU framework to ensur

关键词： sustainable intensification of cultivated land use(SICLU) self-efficacy status quo bias input and output Boosted Regression Tree willingness to transfer cultivated land cultivated land planting areas Shandong,China

'新郁'葡萄microRNA的鉴定及其高温胁迫响应分析

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农业生物技术学报 2024年第9期32卷 2009-2020页

作者：牛丽丽武云龙刘丽媛宋洋波曹红燕杜婷婷王胜杰郗琳杨清孟冬周慧何坤祖中国医学科学院北京协和医学院药用植物研究所吐鲁番市葡萄产业发展促进中心青海大学农牧学院北京林业大学林学院霍恩海姆大学吐鲁番丝路明珠农业生物科技有限公司

高温胁迫是制约果树生产的主要逆境胁迫之一。葡萄(Vitis vinifera)是世界范围内具有较高经济价值的栽培水果作物，其生长发育经常受到高温胁迫的影响。研究葡萄高温胁迫响应机制对了解葡萄对高温胁迫的驯化具有重要意义。本研究采集'新... 详细信息

高温胁迫是制约果树生产的主要逆境胁迫之一。葡萄(Vitis vinifera)是世界范围内具有较高经济价值的栽培水果作物，其生长发育经常受到高温胁迫的影响。研究葡萄高温胁迫响应机制对了解葡萄对高温胁迫的驯化具有重要意义。本研究采集'新郁'葡萄叶片进行高通量测序，分别构建了对照组和高温胁迫处理组的小RNA (small RNA, sRNA)文库，鉴定了一系列高温应激反应miRNA，并分析了其在高温耐受反应中的功能。共鉴定得到171个已知miRNA和251个新miRNA，其中6个已知miRNA和21个新鉴定miRNA在高温胁迫下差异表达，预测获得这些差异表达的miRNA靶基因共计297个。通过qRTPCR对筛选出的10个miRNA及其靶基因表达进行了验证，结果表明这些靶基因对高温胁迫有明显响应。基因功能和通路分析表明，这些基因可能在耐高温胁迫中起重要作用。本研究结果为进一步了解果树驯化过程中的高温胁迫反应以及选育耐高温胁迫葡萄品种提供了理论基础。

关键词：葡萄 miRNA 高温胁迫高通量测序

Effect of holding time on microstructure and mechanical properties of Al-40 wt.%Si alloys fabricated by combination of gas atomization and spark plasma sintering

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Journal of Central South University 2022年第3期29卷 860-870页

作者： AN Yu-jiao niu li-bin GAO Chong HU Yu-yang li Yu-hua liU Jin-song College of Materials Science and Engineering Xi'an University of Science and TechnologyXi’an 710054China Shaanxi Key Laboratory of Nano-materials and Technology Xi'an University of Architecture and TechnologyXi’an 710054China College of Mechanical Engineering Xi'an University of Science and TechnologyXi’an 710054China

Hypereutectic Al-40 wt.%Si alloys were fabricated by the combination of gas atomization and spark plasma sintering(SPS) technology. The effects of holding time(15-60 min) on phase composition, microstructure, density,mechanical properties of Al-Si alloys were investigated by XRD, SEM, a hydrostatic balance, an automatic micro hardness tester and a universal tensile testing machine. The results showed that homogenous distribution of ultrafine primary Si and high density of alloys can be obtained at holding time of 30 min. Compared with primary Si(3.7 μm)fabricated by gas atomization, the average size increased from 5.17 to 7.72 μm with the increase of holding time during SPS process. Overall, the relative density, maximum tensile strength and Vickers hardness of 94.9%, 205 MPa and HV;196.86 were achieved at holding time of 30 min, respectively. In addition, all the diffraction peaks were corresponded to α-Al or β-Si and no other phase can be detected. Finally, the densification process of SPS was also discussed.

关键词： Al-40 wt.%Si spark plasma sintering primary Si holding time gas atomization

国防领域研究生科研素养的分析与提升对策——以西北工业大学航空发动机专业为例

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教育教学论坛 2024年第27期 5-8页

作者：苏越郝雨菡牛晓莉张婷婷西北工业大学动力与能源学院陕西西安710029

为了更好地承担高层次人才培养和创新创造的使命,科研素养养成已经成为研究生教育的重要环节。针对国防教育领域的研究生培养需求,研究了科研素养的内涵、培养途径与养成效果,分析了国内外科研素养的培养现状。同时,介绍了西北工业大学... 详细信息

为了更好地承担高层次人才培养和创新创造的使命,科研素养养成已经成为研究生教育的重要环节。针对国防教育领域的研究生培养需求,研究了科研素养的内涵、培养途径与养成效果,分析了国内外科研素养的培养现状。同时,介绍了西北工业大学动力与能源学院在科研素养提升方面的实践。研究表明,高校应该积极推进相关课程建设,促进科研素养提升与培养环节的深度融合。通过课程设计、资源建设、能力评价的具体实践,可以有效促进航空发动机专业研究生的科研素养,为国防事业发展培养高质量创新人才。

关键词：科研素养研究生教育国防军工领域培养质量课程建设

Self-assembling Process of Alkanethiol Monolayers on Gold Surface via Underpotential Deposition

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Chemical Research in Chinese Universities 2006年第6期22卷 783-786页

作者： HAN Dong-xue XU Xiao-yu HOU Peng YANG Gui-fu niu li ZHAO Jian-wei State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China College of Chemistry Jilin University Changchun 130021 P. R. China Department of Chemistry Nanjing University Nanjing 210093 P. R. China

It was demonstrated feasible that underpotential deposition（UPD） of copper on a monolayer-modified gold substrate can be used to determine the gold electrode area. The deposition and stripping of a Cu adlayer can take place reversibly and stably at a bared or a self-assembled monolayer modified gold electrode. The growth kinetics of decanethiol/Au was also investigated v/a Cu UPD. The difference between the assembling kinetics determined by UPD and that by quartz crystal microbalance measurements reveals the configuration transmutation of the assembled molecules from a disordered arrangement to an ordered arrangement durinr the self-assembling processes.

关键词： SAM Configuration transmutation UPD QCM

Highly Thermoconductive,Strong Graphene‑Based Composite Films by Eliminating Nanosheets Wrinkles

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Nano-Micro Letters 2024年第1期16卷 328-340页

作者： Guang Xiao Hao li Zhizhou Yu Haoting niu Yagang Yao College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNational Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China Institute of Laser Manufacturing Henan Academy of SciencesZhengzhou 450052People’s Republic of China Center for Quantum Transport and Thermal Energy Science School of Physics and TechnologyNanjing Normal UniversityNanjing 210023People’s Republic of China

Graphene-based thermally conductive composites have been proposed as effective thermal management materials for cooling high-power electronic ***,when flexible graphene nanosheets are assembled into macroscopic thermally conductive composites,capillary forces induce shrinkage of graphene nanosheets to form wrinkles during solution-based spontaneous drying,which greatly reduces the thermal conductivity of the ***,graphene nanosheets/aramid nanofiber(GNS/ANF)composite films with high thermal conductivity were prepared by in-plane stretching of GNS/ANF composite hydrogel networks with hydrogen bonds andπ-π*** in-plane mechanical stretching eliminates graphene nanosheets wrinkles by suppressing inward shrinkage due to capillary forces during drying and achieves a high in-plane orientation of graphene nanosheets,thereby creating a fast in-plane heat transfer *** composite films(GNS/ANF-60 wt%)with eliminated graphene nanosheets wrinkles showed a significant increase in thermal conductivity(146 W m^(−1)K^(−1))and tensile strength(207 MPa).The combination of these excellent properties enables the GNS/ANF composite films to be effectively used for cooling flexible LED chips and smartphones,showing promising applications in the thermal management of high-power electronic devices.

关键词： Graphene Aramid nanofiber Wrinkles elimination In-plane stretching Thermal conductivity