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Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

Genes & Diseases 2024年第1期11卷 413-429页

作者： Dongsheng Zhang Wenjuan Tang haitao niu William Tse Hai-Bin Ruan Helmut Dolznig Thomas Knosel Friedrich Karl-Heinz Madeleine Themanns Jiang Wang Mingquan Song Lee Denson Lukas Kenner Richard Moriggl Yi Zheng Xiaonan Han Division of Hematology and Oncology Division of Cancer BiologyDepartment of MedicineMetroHealth Medical Center(MHMC)Case Western Reserve University(CWRU)School of MedicineClevelandOH 44109USA Cancer Genomics and Epigenomics Program Case Comprehensive Cancer CenterCase Western Reserve University(CWRU)ClevelandOH 44106USA Division of Gastroenterology Hepatology and NutritionCincinnati Children’s Hospital Medical Center(CCHMC)CincinnatiOH 45229USA Children’s Hospital of Fudan University Shanghai 201102China School of Medicine Jinan UniversityGuangzhouGuangdong 510632China Laboratory Animal Science(ILAS) Chinese Academy of Medical Science(CAMS)and Peking Union Medical College(PUMC)Beijing 100006China Department of Integrative Biology and Physiology University of Minnesota Medical SchoolMinneapolisMI 55455USA Institute of Medical Genetics Medical University of ViennaVienna 1040Austria Institute of Pathology Ludwig-Maximilians-University MunichMunich 80539Germany Institute of Biochemistry II University Hospital JenaJena 07743Germany Laboratory Animal Pathology University of Veterinary Medicine ViennaVienna 1210Austria Department of Pathology University of CincinnatiCincinnatiOH 45221USA Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266005China Department of Pathology Medical University of ViennaVienna 1040Austria Ludwig Boltzmann Institute for Cancer Research Vienna 1090Austria Medical University of Vienna Vienna 1040Austria Institute of Animal Breeding and Genetics University of Veterinary Medicine ViennaVienna 1210Austria Division of Experimental Hematology CCHMCCincinnatiOH 45229USA

CDC42 controls intestinal epithelial(IEC)stem cell(IESC)*** aberrant CDC42 initiates intestinal inflammation or neoplasia is *** utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and *** specimens were collected to determine the levels of CDC42 in IBD or colorectal ***42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient ***,colitis,aging,and intestinal organoid were used to evaluate CDC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC *** studies revealed that increased CDC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CDC42 were found in the inflamed IBD *** Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt *** Cdc42 depletion markedly enhanced irra-diation-or chemical-induced *** or inhibition of Cdc42 reduced colonic Lgr5+IESC *** conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal *** monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging.

关键词： Cell divisioncycle 42(CDC42) Colitis Colorectal cancer(CRC) Inflammatory bowel diseases(IBD) Intestinal epithelial cell(IEC) Intestinal epithelial stem cell(IESC) Irradiation

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Applications of electrospun nanofibers

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Chinese Science Bulletin 2008年第15期53卷 2265-2286页

作者： FANG Jian niu haitao LIN Tong WANG XunGai Centre for Material and Fibre Innovation Deakin University Geelong VIC 3217 Australia

Polymeric nanofiber non-woven materials produced by electrospinning have extremely high sur-face-to-mass (or volume) ratio and a porous structure with excellent pore-interconnectivity. These characteristics plus the functionalities and surface chemistry of the polymer itself impart the nanofi-bers with desirable properties for a range of advanced applications. This review summarizes the recent progress in electrospun nanofibers, with an emphasis on their applications.

关键词：电子纳米纤维电子针一维材料应用软件

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Applications of Next-generation Sequencing in Systemic Autoimmune Diseases

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Genomics, Proteomics & Bioinformatics 2015年第4期13卷 242-249页

作者： Yiyangzi Ma Na Shi Mengtao Li Fei Chen haitao niu Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical Collage Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical Collage CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences

Systemic autoimmune diseases are a genetic and environmental factors. Although group of heterogeneous disorders caused by both numerous causal genes have been identified by genome-wide association studies （GWAS）, these susceptibility genes are correlated to a relatively low disease risk, indicating that environmental factors also play an important role in the pathogen- esis of disease. The intestinal microbiome, as the main symbiotic ecosystem between the host and host-associated microorganisms, has been demonstrated to regulate the development of the body＇s immune system and is likely related to genetic mutations in systemic autoimmune diseases. Next-generation sequencing （NGS） technology, with high-throughput capacity and accuracy, provides a powerful tool to discover genomic mutations, abnormal transcription and intestinal microbiome identification for autoimmune diseases. In this review, we briefly outlined the applications of NGS in systemic autoimmune diseases. This review may provide a reference for future studies in the pathogenesis of systemic autoimmune diseases.

关键词： Next-generation sequencing Intestinal microbiome Susceptibility genes Systemic autoimmune diseases

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Recent Advances in Superhydrophobic and Antibacterial Cellulose‑Based Fibers and Fabrics:Bio‑inspiration,Strategies,and Applications

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Advanced Fiber Materials 2023年第5期5卷 1555-1591页

作者： Hua Zhou Qingshuo Li Zhong Zhang Xungai Wang haitao niu College of Textiles and Clothing Qingdao UniversityQingdao 266071China Collaborative Innovation Center for Eco‑Textiles of Shandong Province and the Ministry of Education Collaborative Qingdao UniversityQingdao 266071China JC STEM Lab of Sustainable Fibers and Textiles School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Cellulose-based fabrics are ubiquitous in our daily *** are the preferred choice for bedding materials,active sportswear,and next-to-skin ***,the hydrophilic and polysaccharide characteristics of cellulose materials make them vulnerable to bacterial attack and pathogen *** design of antibacterial cellulose fabrics has been a long-term and on-going *** strategies based on the construction of surface micro-/nanostructure,chemical modification,and the application of antibacterial agents have been extensively investigated by many research groups *** review systematically discusses recent research on super-hydrophobic and antibacterial cellulose fabrics,focusing on morphology construction and surface ***,natural surfaces showing liquid-repellent and antibacterial properties are introduced and the mechanisms behind are ***,the strategies for fabricating super-hydrophobic cellulose fabrics are summarized,and the contribution of the liquid-repellent function to reducing the adhesion of live bacteria and removing dead bacteria is *** studies on cellulose fabrics functionalized with super-hydrophobic and antibacterial properties are discussed in detail,and their potential applications are also ***,the challenges in achieving super-hydrophobic antibacterial cellulose fabrics are discussed,and the future research direction in this area is proposed.

关键词： Cellulose fiber Super-hydrophobic Antibacterial Fabrication strategies Applications

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A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer

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Chinese Journal of Cancer Research 2016年第6期28卷 598-605页

作者： haitao Zhou Yan Song Jun Jiang haitao niu Hong Zhao Jianwei Liang Hao Su Zheng Wang Zhixiang Zhou Jing Huang Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Imageology National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Abdominal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China

Objective： This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon ***： Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen（oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals） for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant ***： All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients（91.3%） had reductions in tumor volume after neoadjuvant treatment, and 13 patients（56.5%） had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete ***： Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer.

关键词： 5-Fluorouracil colon cancer irinotecan oxaliplatin neoadjuvant chemotherapy

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The status,limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies

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Chinese Journal of Cancer Research 2015年第2期27卷 128-137页

作者： Haoqing Shi Xiangjie Qi Bin Ma Yanwei Cao Lina Wang Lijiang Sun haitao niu Department of Urology Affiliated Hospital of Qingdao University Department of Urology People's Hospital of Linzi District Medical College of Qingdao University

In recent years, immunotherapy has been gradually established as the fourth frequently adopted antitumor therapy, following surgery, chemotherapy and radiotherapy, for advanced urologic malignancies with an improved understanding of theoretical basis, such as molecular biology and immunology. Thereinto, adoptive cellular immunotherapy （ACI） has become one of the hotspots, which comprises a variety of treatment approaches, such as TIL, CIK cell, ~＇~ T cell, CAR-engineered T cell and Allogeneie stem cell transplantation （alloSCT）. Although preclinical efficacy has been demonstrated remarkably, clinical trials could not consistently show the benefit due to multi-factors in complex immnnosuppressive microenvironment in vivo compared to that of in vitro. Here we review some timely aspects of ACI for advanced urologic malignancies, and describe the current status and limitation of immunotherapy from the cellular level. It＇s our expectation to provide prompting consideration of novel combinatorial ACI strategies and a resurgence of interest in ACI for advanced urologic malignancies.

关键词： Adoptive cellular immunotherapy (ACI) limitation improvement urologic malignancies

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Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis

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Animal Models and Experimental Medicine 2019年第2期2卷 98-106页

作者： Na Shi Shuangyue Zhang Gregg Silverman Mengtao Li Jun Cai haitao niu NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences CAMS&PUMC) Key Laboratory of Human Diseases Animal Model State Administration of Traditional Chinese Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China Department of Rheumatology Langone Medical Center New York University New York City New York Peking Union Medical College Hospital Beijing China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China

Background: Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis. Methods: We created three groups of K/BxN female mice that were positive for the anti‐glucose‐6‐phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (TCHO), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), anti‐ GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing. Results: Relative to mice given the CD, those receiving the HFD had increased serum levels of LDL‐C, TCHO, and TG, decreased serum levels of HDL‐C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL‐C, TCHO, and TG, increased serum levels of HDL‐C, and decreased the atherosclerotic lesions in the aortic root. Mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups. Moreover, HCQ treatment significantly increased the abundance of Akkermansia and Parabacteroides, and decreased the abundance of Clostridium sensu stricto cluster 1, and therefore may be responsible for the reduced RA‐associated atherosclerosis and dyslipidemia. Conclusion: Our mouse model of RA indicated that HFD increased ankle width and aggravated a therosclerosis a nd d yslipidemia, a nd t hat H CQ a lleviated t he d yslipidemia and atherosclerosis, but had no effect on ankle width.

关键词： atherosclerosis autoimmunity hydroxychloroquine intestinal microbiota rheumatoid arthritis

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Mucin-Producing Urothelial-Type Adenocarcinoma of the Prostate (a Case Report and Review of the Literature)

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Chinese Journal of Clinical Oncology 2006年第5期3卷 370-372页

作者： haitao niu Guang Sun Jiwu Chang Yibing Zhang Department of Urology Second Hospital of Tianjin Medical University Institute of Urology Tianjin 300211 China.

OBJECTIVE To report clinical and pathologic findings of one case of mucin-producing urothelial-type adenocarcinoma of the prostate, and to discuss the diagnosis and prognosis of this disease. METHODS The patient was a 60-year-old man who had an 8-month history of urinary frequency and dysuria culminating in an aggravating condition for 10-days. Laboratory results were tPSA 3.0 and fPSA 0.4. An ultrasound and digital rectal exam showed no abnormal findings, so he was diagnosed as having benign prostatic hyperplasia, and underwent a transurethral prostate resection. RESULTS The findings during the operation resembled benign prostatic hyperplasia (BPH), whereas the pathological exam showed that the pro-static construction was deranged in the tumor infiltrating region, with many mucin lakes and signet ring cell in the cancer tissue. Immunohisto-chemical staining revealed that the cancer tissue was negative for prostate-specific antigen (PSA) and postive for carcinoembryonic antigen (CEA). Final diagnosis: mucin-producing urothelial-type adenocarcinoma of the prostate. After 50 Gy radiotherapy, the patient was free of recurrent signs and metastasis up to 8 months after operation. CONCLUSION Mucin-producing urothelial-type adenocarcinoma of the prostate is extremely rare. Its differential diagnosis mainly includes conventional prostatic adenocarcinoma with mucin production and secondary adenocarcinoma. The diagnosis and treatment of this disease should be further investigated.

关键词： mucin-producing urothelial-type adenocarcinoma prostate diagnosis.

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高防护舒适性Janus聚氨酯纳米纤维复合膜制备及其性能

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纺织工程学报 2024年第4期2卷 1-11页

作者：邢小伟周华吴大伟姜露李鹏柳永杰牛海涛青岛大学纺织服装学院生态纺织省部共建协同创新中心山东青岛266071 联润翔(青岛)纺织科技有限公司山东青岛266071 国家先进印染技术创新中心山东泰安271000

具有抗液性和透湿性的类皮肤功能纤维膜在各种应用领域的需求日益增长。然而,这种纤维膜在平衡高防水性/静水压和透湿/气性等方面仍然面临着巨大的挑战。基于此,成功开发了一种具有不对称润湿性Janus聚氨酯(TPU)基静电纺纳米纤维膜。该... 详细信息

具有抗液性和透湿性的类皮肤功能纤维膜在各种应用领域的需求日益增长。然而,这种纤维膜在平衡高防水性/静水压和透湿/气性等方面仍然面临着巨大的挑战。基于此,成功开发了一种具有不对称润湿性Janus聚氨酯(TPU)基静电纺纳米纤维膜。该复合膜外层为疏水改性TPU纳米纤维,具有良好疏水性,水接触角为136.8°;内层为亲水改性TPU纳米纤维,水滴可以在1 s内完全铺展。研究了亲/疏水改性对静电纺丝及TPU纳米纤维影响,以及亲/疏水层厚度对复合膜性能影响。当疏水层/亲水层厚度比为2/1时,复合TPU纳米纤维膜展现优异的防护性及舒适性能(静水压HP为85.3 kPa,透湿率为9.16 kg m^(-2) d^(-1))。这种不对称润湿性Janus纳米纤维膜可为先进防护纺织品的设计和发展提供新的思路。

关键词：静电纺纳米纤维 Janus,防水透湿聚氨酯(TPU) 非对称润湿性

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Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

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Bioactive Materials 2021年第2期6卷 433-446页

作者： Ye Liang Yonghua Wang Liping Wang Zhijuan Liang Dan Li Xiaoyu Xu Yuanbin Chen Xuecheng Yang Hongbo Zhang haitao niu Key Laboratory of Urology and Andrology Medical Research CentreAffiliated Hospital of Qingdao UniversityQingdao266003China Department of Urology Affiliated Hospital of Qingdao UniversityQingdao266003China Pharmaceutical Sciences Laboratory and Turku Bioscience Centre Åbo Akademi UniversityTurku20520Finland

Bladder cancer is one of the concerning malignancies worldwide,which is lacking effective targeted *** therapy is a potential approach for bladder cancer ***,a safe and effective targeted gene delivery system is urgently needed for prompting the bladder cancer treatment in *** this study,we confirmed that the bladder cancer had CD44 overexpression and small interfering RNAs(siRNA)with high interfere to Bcl2 oncogene were designed and *** hyaluronic acid dialdehyde(HAD)was prepared in an ethanol-water mixture and covalently conjugated to the chitosan nanoparticles(CS-HAD NPs)to achieve CD44 targeted siRNA *** in vitro and in vivo evaluations indicated that the siRNA-loaded CS-HAD NPs(siRNA@CS-HAD NPs)were approximately 100 nm in size,with improved stability,high siRNA encapsulation efficiency and low ***-HAD NPs could target to CD44 receptor and deliver the therapeutic siRNA into T24 bladder cancer cells through a ligand-receptor-mediated targeting mechanism and had a specific accumulation capacity in vivo to interfere the targeted oncogene Bcl2 in bladder ***,a CD44 targeted gene delivery system based on natural macromolecules was developed for effective bladder cancer treatment,which could be more conducive to clinical application due to its simple preparation and high biological safety.

关键词： siRNA delivery Chitosan Hyaluronic acid dialdehyde CD44 targeting Bladder cancer

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