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Flexible piezoelectret film sensor for noncontact mechanical signal capture by multiple transmission media

Nano Research 2024年第8期17卷 7643-7657页

作者： Xingchen Ma Qianqian Hu Lian Zhou Xinhao Xiang Yi Qin Ke Zhang Pengfei He Ying Dai wenxin niu Xiaoqing Zhang Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghai 201619China Department of Rehabilitation Sciences Tongji University School of MedicineShanghai 200092China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Mechanical signal capture without physical contact has emerged as a highly promising research field and attracted tremendous attention due to its prosperous applications in household medical care,lifestyle monitoring and remote operation,offering users high level of safety,convenience and ***,noncontact sensing is ideal to maximize the immersive user experience in the human–machine interaction(HMI),eliminating interference to human activities and mechanical fatigue to the sensor,***,we report a self-powered flexible sensor integrated with irradiation cross-linked polypropylene(IXPP)piezoelectret film for noncontact sensing,featuring multi-functions to detect mechanical signals transmitted through solid,liquid and gaseous media and would facilitate their versatile practical *** folded-structure configuration of the sensor facilitates the improvement of the noncontact sensing *** solid media,such as the rectangular wooden stick used in this study,the sensor can detect mechanical stimulus exerted at a distance of 100 cm.A system detection sensitivity up to 57 pC/kPa with a low detection limit of 0.6 kPa is achieved at a noncontact distance of 10 *** when partly or completely immersed in water,the sensor effectively traces movement signals of human bodies underwater,demonstrating great advantages for non-inductive aquatic fitness training ***,due to the low acoustic impedance of piezoelectret film,speech recognition through gaseous medium is also *** further introduce application demonstrations of the developed film sensors to monitor exercise postures and physiological signals without direct contact between human body and the sensor,displaying great potential to be incorporated into future smart *** study commendably expands the application scope of piezoelectret materials,which will have profound implications for exploring novel intelligent human–machine interactions.

关键词： noncontact sensing piezoelectret multiple transmission media mechanical signal capture

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The expanded application of CAR-T cell therapy for the treatment of multiple non-tumoral diseases

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PROTEIN & CELL 2024年第9期15卷 633-641页

作者： Liu, Zhuoqun Xiao, Yuchen Lyu, Jianjun Jing, Duohui Liu, Liu Fu, Yanbin niu, wenxin Jin, Lingjing Zhang, Chao Tongji Univ Shanghai Yangzhi Rehabil Hosp Fundamental Res Ctr Shanghai Sunshine Rehabil CtrSch Med Shanghai 201619 Peoples R China East Lake High Tech Dev Zone Hubei Topgene Res Inst Hubei Topgene Biotechnol Co Wuhan 430205 Peoples R China Shanghai Jiao Tong Univ Shanghai Inst Hematol Natl Res Ctr Translat Med Shanghai State Key Lab Med GenomRuijin HospSch Med Shanghai 200025 Peoples R China Shanghai Yuhui Pharmaceut Technol Grp Co Ltd Shanghai 201203 Peoples R China Shanghai Ruishen Technol Dev Co Ltd Shanghai 201203 Peoples R China Shanghai Jiao Tong Univ Shanghai Canc Inst Dept Biliary Pancreat Surg Sch MedRenji Hosp Shanghai 200127 Peoples R China

As a powerful cell-based therapeutic approach,CAR-T therapy was originally designed for treating acquired immunodeficiency syndrome(AIDS)(Baker et al.,2023),but had been strikingly successful in curing hematologic malignancies and multiple solid *** evidence has expanded the medical application of CAR-T therapy for the treatment of many other human diseases beyond *** this article,we discuss the principle of CAR-T and enumerate the current application and limitation in ***,we provide a comprehensive perspective of current advance and future directions of CAR-T in treating multiple non-tumoral diseases.

关键词： CHIMERIC ANTIGEN RECEPTORS POTENCY CANCER

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A Musculoskeletal Modeling of Hand-foot Crawling with Different Heights

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Journal of Bionic Engineering 2020年第3期17卷 591-599页

作者： Meng Li Kuan Wang wenxin niu Shengnian Zhang Key Laboratory of Exercise and Health Sciences of Ministry of Education Shanghai University of SportsShanghai 200438China Yangzi Rehabilitation Hospital Tongji University School of MedicineShanghai 201619China Department of Rehabilitation Sciences Tongji University School of MedicineShanghai 20092China

As a bionic therapy,hand-foot crawling has been reported to be used for the rehabilitation of low back ***,there have been few relevant biomechanical studies about this type of *** purpose of this study was to calculate muscle activation and lumbar spinal load based on the examined limb kinematics and kinetics,which associated with hand-foot crawling at the different Centre of Mass(CoM)heights.A total of 14 men performed hand-foot crawling at three CoM *** kinematics and kinetics data were ***-way repeated measure analysis of variance was used to analyze the efFect of the CoM height on crawling *** crawling data from one subject at the three heights were used to calculate the muscle activation and compressive lumbar load with an OpenSim musculoskeletal *** CoM heights had no significant effect on kinematics,kinetics or muscle *** spinal load was larger at higher ***-foot crawling was associated with lower trunk muscle *** study helps us to understand hand-foot crawling from the perspective of *** findings from this study may help physical therapists choose hand-foot crawling as an appropriate exercise for patients with low back pain during early rehabilitation.

关键词： biomechanics crawling OpenSim muscle activity spinal load

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Seed-mediated growth method for high-quality noble metal nanocrystals

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Science China Chemistry 2012年第11期55卷 2311-2317页

作者： niu wenxin ZHANG Ling XU GuoBao State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Graduate University of the Chinese Academy of Sciences Beijing 100039China

This review highlights work from the authors' laboratory on the recent development of seed-mediated growth method for noble metal nanocrystals. The seed-mediated growth method has become one of the most efficient and versatile methods for synthe-sizing high-quality noble metal nanocrystals. The seed-mediated growth method can separate the nucleation and growth stages of metal nanocrystals, and thus provide better control over the size, size distribution, and crystallographic evolution of metal nanocrystals. Because of its high controllability, the seed-mediated growth method is especially promising in providing mechanistic insights into the growth mechanisms of noble metal nanocrystals. In this review, the thermodynamic and kinetic parameters for the nucleation and growth of noble metal nanocrystals are systematically summarized. Mechanistic understanding of these parameters is provided. These studies provide useful guidelines for the rational design and synthesis of novel noble metal nanocrystals with high quality.

关键词： crystal growth nanocrystal noble metal shape control seed-mediated growth method

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灵长类运动功能形态学研究进展

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广西师范大学学报（自然科学版） 2024年第4期42卷 22-31页

作者：孙涛牛文鑫李兆元周岐海黄乘明珍稀濒危动植物生态与环境保护教育部重点实验室(广西师范大学) 广西桂林541006 广西珍稀濒危动物生态学重点实验室(广西师范大学) 广西桂林541006 崇左白头叶猴野外科学观测研究站广西崇左532204 同济大学附属养志康复医院上海201619 同济大学医学院康复工程与生物力学实验室上海200092 西南林业大学地理与生态旅游学院云南昆明650224 中国科学院动物研究所动物生态与保护生物学重点实验室北京100101

功能形态学是研究功能和形态相互适应的学科。灵长类(包括非人灵长类和人类)在动物界是一个极其特殊的类群,其在形态、生理、行为上表现出很强的环境适应能力,使它们常常成为生态学问题研究的模式动物。为适应多样化栖息环境,灵长类发... 详细信息

功能形态学是研究功能和形态相互适应的学科。灵长类(包括非人灵长类和人类)在动物界是一个极其特殊的类群,其在形态、生理、行为上表现出很强的环境适应能力,使它们常常成为生态学问题研究的模式动物。为适应多样化栖息环境,灵长类发展形成不同的运动模式,其骨骼和肌肉系统也相应进化以适应不同的运动模式。非人灵长类与人类在生态位、社会结构、地理分布以及进化上密切相关,开展其运动功能形态学研究不仅有助于了解灵长类的生态与适应,而且对深入了解运动功能进化在人类进化中所发挥的作用也具有重要参考价值。本文总结灵长类运动功能形态学的发展历史,深入探讨灵长类的运动模式及与之相适应的骨骼、肌肉系统的特征和功能。未来,新技术和新方法不断融入灵长类的运动功能形态学研究,将进一步丰富人们对灵长类的了解,揭示其结构和功能的适应与进化规律。

关键词：灵长类运动功能形态学适应

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超声导入对酮洛芬凝胶药物经皮促透效果的研究

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中国现代应用药学 2024年第11期41卷 1508-1514页

作者：蒋秀梅方任华牛文信王维青安悦杨晶王浩然江昌照叶金翠杭州医学院浙江省神经精神疾病药物研究重点实验室杭州310013 浙江工业大学长三角绿色制药协同创新中心浙江湖州313200 南通大学杏林学院江苏南通226001

目的研究物理经皮促透手段低频低功率超声对酮洛芬凝胶经皮吸收的促进作用。方法以酮洛芬凝胶为模型药物,比较超声处理和未处理组的离体经皮渗透量。并建立大鼠胶原蛋白致炎模型,评价2组药效学差异。最后通过药动学研究观察超声对酮洛... 详细信息

目的研究物理经皮促透手段低频低功率超声对酮洛芬凝胶经皮吸收的促进作用。方法以酮洛芬凝胶为模型药物,比较超声处理和未处理组的离体经皮渗透量。并建立大鼠胶原蛋白致炎模型,评价2组药效学差异。最后通过药动学研究观察超声对酮洛芬凝胶体内过程的影响。结果与未进行超声处理相比,超声处理可将酮洛芬凝胶在给药24 h的离体皮肤累积渗透量提高3.5倍;使药动学中的AUC_(0-t)从(4289.02±763.58)ng·h·mL^(-1)提高至(11301.10±3386.30)ng·h·mL^(-1),T_(max)从(6.0±1.4)h提前至(3.0±2.0)h;另外,超声处理4 h后能显著提高酮洛芬凝胶在大鼠炎症模型中的抗炎作用,快速有效地降低蛋清致炎后的肿胀程度。结论本研究从皮肤渗透试验、药效学评价和药动学等方面证实了低频低功率超声可显著提高酮洛芬凝胶的经皮吸收量和吸收速率,增强其药效强度,是酮洛芬凝胶经皮给药的有效促进手段。

关键词：酮洛芬凝胶超声导入离体渗透药效学药动学

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Biomechanical comparison of locking plate and crossing metallic and absorbable screws fixations for intra-articular calcaneal fractures

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Science China(Life Sciences) 2016年第9期59卷 958-964页

作者： Ming Ni Duo Wai-Chi Wong Jiong Mei wenxin niu Ming Zhang Tongji Hospital Tongji University School of Medicine Shanghai 200065 China Pudong New Area People's Hospital Shanghai 201299 China Interdisciplinary Division of Biomedical Engineering The Hong Kong Polytechnic University Hong Kong SAR China Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center) Shanghai 201619 China

The locking plate and percutaneous crossing metallic screws and crossing absorbable screws have been used clinically to treat intra-articular calcaneal fractures, but little is known about the biomechanical differences between them. This study compared the biomechanical stability of calcaneal fractures fixed using a locking plate and crossing screws. Three-dimensional finite-element models of intact and fractured calcanei were developed based on the CT images of a cadaveric sample. Surgeries were simulated on models of Sanders type III calcaneal fractures to produce accurate postoperative models fixed by the three implants. A vertical force was applied to the superior surface of the subtalar joint to simulate the stance phase of a walking gait. This model was validated by an in vitro experiment using the same calcaneal sample. The intact calcaneus showed greater stiffness than the fixation models. Of the three fixations, the locking plate produced the greatest stiffness and the highest von Mises stress peak. The micromotion of the fracture fixated with the locking plate was similar to that of the fracture fixated with the metallic screws but smaller than that fixated with the absorbable screws. Fixation with both plate and crossing screws can be used to treat intra-articular calcaneal fractures. In general, fixation with crossing metallic screws is preferable because it provides sufficient stability with less stress shielding.

关键词： finite-element analysis in vitro experiment calcaneal fracture plate fixation absorbable screw biomechanics

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微针材料的发展与应用

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中国医药工业杂志 2024年第2期55卷 196-202页

作者：陈杭江昌照陈朴牛文信叶金翠浙江工业大学长三角绿色制药协同创新中心浙江湖州313200 杭州医学院药学院浙江杭州310012

微针是一种无痛的透皮给药系统,因可避免首过效应、血药浓度平稳、生物利用度高、安全性好,以及患者依从性良好等优势,成为近年来药物制剂开发的热点,但仍存在生物相容性差、载药量小、药物释放不稳定,以及受限于针体机械性能等问题。... 详细信息

微针是一种无痛的透皮给药系统,因可避免首过效应、血药浓度平稳、生物利用度高、安全性好,以及患者依从性良好等优势,成为近年来药物制剂开发的热点,但仍存在生物相容性差、载药量小、药物释放不稳定,以及受限于针体机械性能等问题。微针材料对微针临床应用方向、载药能力和药物稳定性影响巨大。该综述归纳和整理了各类新型微针材料的研究进展以及应用方向和前景,以期为微针制剂开发提供参考。

关键词：微针材料透皮给药系统药物载体应用

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Deformation and stress distribution of the human foot after plantar ligaments release:A cadaveric study and finite element analysis

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Science China(Life Sciences) 2011年第3期54卷 267-271页

作者： LIANG Jun YANG YunFeng YU GuangRong niu wenxin WANG YuBin Sports Medicine Department of Shanghai East Hospital Tongji University Shanghai 200120 China Orthopaedic Department of Tongji Hospital Tongji University Shanghai 200065 China School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

The majority of foot deformities are related to arch collapse or instability,especially the longitudinal *** the relationship between the plantar fascia and arch height has been previously investigated,the stress distribution remains *** aim of this study was to explore the role of the plantar ligaments in foot arch *** constructed a geometrical detailed three-dimensional (3-D) finite element (FE) model of the human foot and ankle from computer tomography *** model comprised the majority of joints in the foot as well as bone segments,major ligaments,and plantar soft *** of the plantar fascia and other ligaments was simulated to evaluate the corresponding biomechanical effects on load distribution of the bony and ligamentous *** intrinsic ligaments of the foot arch were sectioned to simulate different pathologic situations of injury to the plantar ligaments,and to explore bone segment displacement and stress *** validity of the 3-D FE model was verified by comparing results with experimentally measured data via the displacement and von Mise stress of each bone *** fascia release decreased arch height,but did not cause total collapse of the foot *** longitudinal foot arch was lost when all the four major plantar ligaments were sectioned *** fascia release was compromised by increased strain applied to the plantar ligaments and intensified stress in the midfoot and metatarsal *** redistribution among the centralized metatarsal bones and focal stress relief at the calcaneal insertion were *** 3-D FE model indicated that plantar fascia release may provide relief of focal stress and associated heel ***,these operative procedures may pose a risk to arch stability and clinically may produce dorsolateral midfoot *** initial strategy for treating plantar fasciitis should be non-operative.

关键词： biomechanics finite element analysis foot arch ligament stress

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Gap engineering of sandwich plasmonic gap nanostructures for boosting plasmon-enhanced electrocatalysis

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Nano Research 2023年第7期16卷 8961-8969页

作者： Lu Cheng Fengxia Wu Yu Tian Xiali Lv Fenghua Li Guobao Xu Hsien-Yi Hsu Yongjun Zhang wenxin niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Yanshan Branch of Beijing Chemical Research Institute SinopecBeijing 102500China University of Science and Technology of China Hefei 230026Chin a 4 School of Energy and Environment Department of Materials Science and EngineeringCity University of Hong KongKowloon TongHong Kong 999077China Shenzhen Research Institute of City University of Hong Kong Shenzhen 518057China Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China

Plasmonic catalysis is emerging as a dynamic field in heterogeneous catalysis and holds great promise for the efficient utilization of solar *** to the development of plasmonic catalysis is the design of efficient plasmonic *** this report,plasmonic gap nanostructures(PGNs)on the basis of Au@poly(o-phenylenediamine)(POPD)@Pd sandwich nanostructures are synthesized as plasmonic nanocatalysts by an in-situ reduction synthetic strategy,which allows for the precise engineering of the POPD gap size between plasmonic Au and catalytic Pd *** introduction of conducting POPD nanogap in PGNs not only effectively enhances their light harvesting capability,but also provides an effective charge transfer channel for harnessing the photogenerated hot charge *** this respect,distinct gap-dependent performances in plasmon-enhanced electrocatalysis of ethanol oxidation reactions(EOR)are demonstrated with the PGN nanocatalysts and over 2.5 folds of enhancement can be achieved.A volcano plot is derived to describe the relationship between the catalytic activities and gap size of the PGN nanocatalysts,which is well explained by the interplay of their light harvesting and charge transport *** results highlight the importance of gap engineering in PGNs for plasmonic catalysis and offer the promise of developing efficient plasmonic nanocatalysts for other heterogeneous catalytic reactions.

关键词： plasmonic gap nanostructures electrocatalysis ethanol oxidation reactions light harvesting charge transport

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