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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Construction and Analysis of an Adapted Spectral Finite Element Method to Convective Acoustic Equations

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Communications in Computational Physics 2016年第6期20卷 1-22页

作者： Andreas Huppe Gary cohen Sebastien Imperiale Manfred Kaltenbacher TU Wien Institute of Mechanics and MechatronicsGetreidemarkt 9/E3251060WienAustria Inria-CNRS-ENSTA Saclay Ile-de-France91120 PalaiseauFrance Inria Saclay Ile-de-France91120 PalaiseauFrance

The paper addresses the construction of a non spuriousmixed spectral finiteelement(FE)method to problems in the field of computational *** a computational scheme for the conservation equations of linear acoustics,the extensiontowards convected wave propagation is *** aeroacoustic applications,the mean flow effects can have a significant impact on the generated soundfield even for smaller Mach *** those convective terms,the initial spectralFE discretization leads to non-physical,spurious ***,a regularizationprocedure is proposed and qualitatively investigated bymeans of discrete eigenvaluesanalysis of the discrete operator in space.A study of convergence and an applicationof the proposed scheme to simulate the flow induced sound generation in the processof human phonation underlines stability and validity.

关键词： Spectral finite elements aeroacoustics perturbation equations

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Israeli High School Graduates＇ Knowledge of the Holocaust： A Case Study

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Journal of Philosophy Study 2017年第4期7卷 169-183页

作者： nitza Davidovitch Amir Haskel Esther Wagner Shaked Jacobson-Meyzles Liraz Bahamam

In November 2015, the Israeli Ministry of Education declared that the matriculation exam in history would no longer include the Holocaust, and instead students would be required to write a research paper. Following this decision, we wished to test the level of knowledge concerning the Holocaust among undergraduate students （excluding those who study contemporary history, which includes Holocaust studies）. For this purpose, 145 participants were sampled, students at four Israeli academic institutions： two universities and two colleges. The research question referred to remembering information about the Holocaust and the study took into account students＇ different personal, family, and academic background （having participated in the journey to Poland or not, having relatives who had died or survived the Holocaust, being religious or secular）. The knowledge survey refers to terms from four areas： people, historical events during the Holocaust era, organizations that operated in that period, and places and methods of killing. In general, the level of knowledge was found to be very low （general knowledge score： 42.6 of 100）. No significant differences were found in scores by religion or participation in the journey to Poland, aside from knowledge about places and methods of killing, where we found a significant difference between those who participated in the journey to Poland and those who did not. In addition, no significant differences were found between participants whose relatives had died in or had survived the Holocaust, or by either the number of years since high school graduation or gender. From the respondents＇ answers, it appears that high school studies play an essential role as the main perceived source of knowledge （90.4% referred to school as a main or additional knowledge source）. When asked about the new exam format, the majority （52.1%） replied that they would prefer writing a research paper to taking an exam. The low level of knowledge that we found ra

关键词： Holocaust undergraduate students knowledge Israel high school graduates

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Temporal trends in inflammatory bowel disease publications over a 19-years period

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World Journal of Gastroenterology 2014年第44期20卷 16745-16749页

作者： Yael Weintraub Francis B Mimouni Shlomi cohen Pediatric Gastroenterology and Nutrition Unit "Dana-Dwek" Children’s Hospital Tel Aviv Medical Center Sackler Faculty of Medicine Tel Aviv University Department of Pediatrics "Dana-Dwek" Children’s Hospital Tel Aviv Medical Center and Sackler Faculty of Medicine Tel Aviv University Division of Neonatology Shaare Zedek Medical Center

AIM: To determine whether temporal changes occurred in the pediatric vs adult inflammatory bowel disease(IBD), both in terms of number and type of yearly published ***:We aimed to evaluate all Pub Med-registered articles related to the field of IBD from January1,1993 and until December 31,*** searched for articles using the key words"inflammatory bowel disease"or"Crohn’s disease"or"ulcerative colitis"or"undetermined colitis",using the age filters of"child"or"adult".We repeated the search according to the total number per year of articles per type of article,for each year of the specified *** studied randomized controlled trials,clinical trials,case reports,meta-analyses,letters to the editor,reviews,systematic reviews,practice guidelines,and ***:We identified 44645 articles over the *** were 8687 pediatric-tagged articles vs 19750 adult-tagged *** 16208 articles were unaccounted and not assigned a"pediatric"or"adult"tag by Pub *** was an approximately3-fold significant increase in all articles recorded both in pediatric and adult *** significant increase was true for nearly every category of article but the number of clinical trials,meta-analysis,and randomized controlled trials increased proportionally more than the number of"lower quality"articles such as editorials or letters to the *** few guidelines were published every ***:There is a yearly linear increase in publications related to ***,there are more and more clinical trials and higher quality articles.

关键词： Inflammatory bowel disease Crohn's dis-ease Ulcerative colitis Randomized clinical trial Meta-analysis

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Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders

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Insect Science 2016年第1期23卷 59-67页

作者： Marina Katzman Ya'kobovitz Terry D. Butters Ephraim cohen Department of Entomology Robert H. Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem RehovotIsrael Department of Biochemistry University of Oxford Oxford OX1 3QU UK

Secondary metabolites and synthetic iminosugars that structurally resemble monosaccharides are potent inhibitors of a-glucosidase activity. The enzyme is core in cleaving sucrose in phloem feeding insects and it also plays a crucial role of reducing osmotic stress via the formation of oligosaccharides. Inhibition of hydrolysis by iminosug- ars should result in nutritional deficiencies and/or disruption of normal osmoregulation. Deoxynojirimycin （DNJ） and 2 N-alkylated analogs [N-butyl DNJ （NB-DNJ） and N-nonyl DNJ （NN-DNJ）] were the major iminosugars used throughout the study. The extensive experiments conducted with a-glucosidase of the whitefly Bemisia tabaci indicated the competitive nature of inhibition and that the hydrophilic DNJ is a potent inhibitor in com- parison to the more hydrophobic NB-DNJ and NN-DNJ compounds. The same inhibitory pattern was observed with the psyllid Cacopsylla bidens a-glucosidase. In contrast to the above pattern, enzymes of the aphids, Myzus persicae and Aphis gossypii were more sen- sitive to the hydrophobic iminosugars as compared to DNJ. In vivo experiments in which adult B. tabaci were fed dietary iminosugars, show that the hydrophilic DNJ was far less toxic than the lipophilic NB-DNJ and NN-DNJ. It is proposed that this pattern is attributed to the better accessibility of the hydrophobic NN-DNJ to the a-glucosidase membrane- bound compartment in the midgut. Based on the inhibitory effects of certain polyhydroxy N-alkylated iminosugars, a-glucosidase of phloem feeding hemipterans could serve as an attractive target site for developing novel pest control agents.

关键词： a-glucosidase inhibition Bemisia tabaci Cacopsylla bidens iminosugars Myzuspersicae osmoregulation phloem sap feeders

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Review and synthesis of the effects of climate change on amphibians

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Integrative Zoology 2013年第2期8卷 145-161页

作者： Yiming LI Jeremy M.cohen Jason R.ROHR Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Department of Integrative Biology University of South FloridaTampaFLUSA

Considerable progress has been made in understanding the responses of amphibians to climate change,with successful research carried out on climate change-associated shifts in amphibian phenology,elevational distributions and amphibian-parasite *** review and synthesize the literature on this topic,emphasizing acutely lethal,sublethal,indirect and positive effects of climate change on amphibians,and major research *** instance,evidence is lacking on poleward shifts in amphibian distributions and on changes in body sizes and morphologies of amphibians in response to climate *** have limited information on amphibian thermal tolerances,thermal preferences,dehydration breaths,opportunity costs of water conserving behaviors and actual temperature and moisture ranges amphibians *** when much of this information is available,there remains little evidence that climate change is acutely lethal to *** suggests that if climate change is contributing to declines,it might be through effects that are not acutely lethal,indirect,or both,but evidence in support of this suggestion is *** fact,evidence that climate change is directly contributing to amphibian declines is weak,partly because researchers have not often ruled out alternative hypotheses,such as chytrid fungus or climate-fungus ***,we recommend that amphibian-climate research shift from primarily inductive,correlational approach as to studies that evaluate alternative hypotheses for *** additional rigor will require interdisciplinary collaborations,estimates of costs and benefits of climate change to amphibian fitness and populations,and the integration of correlative field studies,experiments on‘model’amphibian species,and mathematical and functional,physiological models.

关键词： amphibian decline Batrachochytrium dendrobatidis breeding date climate-linked epidemic hypothesis global warming

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RNA-binding proteins related to stress response and differentiation in protozoa

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World Journal of Biological Chemistry 2016年第1期7卷 78-87页

作者： Lysangela Ronalte Alves Samuel goldenberg Inst.Carlos Chagas Fiocruz-PR

RNA-binding proteins(RBPs) are key regulators of gene expression. There are several distinct families of RBPs and they are involved in the cellular response to environmental changes, cell differentiation and cell death. The RBPs can differentially combine with RNA molecules and form ribonucleoprotein(RNP) complexes, defining the function and fate of RNA molecules in the cell. RBPs display diverse domains that allow them to be categorized into distinct families. They play important roles in the cellular response to physiological stress, in cell differentiation, and, it is believed, in the cellular localization of certain mRNAs. In several protozoa, a physiological stress(nutritional, temperature or pH) triggers differentiation to a distinct developmental stage. Most of the RBPs characterized in protozoa arise from trypanosomatids. In these protozoa gene expression regulation is mostly post-transcriptional, which suggests that some RBPs might display regulatory functions distinct from those described for other eukaryotes. mRNA stability can be altered as a response to stress. Transcripts are sequestered to RNA granules that ultimately modulate their availability to the translation machinery, storage or degradation, depending on the associated proteins. These aggregates of mRNPs containing mRNAs that are not being translated colocalize in cytoplasmic foci, and their numbers and size vary according to cell conditions such as oxidative stress, nutritional status and treatment with drugs that inhibit translation.

关键词： Gene expression regulation RNA-binding proteins RNA-protein complexes RNA granules Protozoa Stress and cell differentiation

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VHDL Coding Styles and Methodologies 2nd ed.

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1000年

作者： cohen, Ben.

来源：畅想之星图书光盘版（南... 评论

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World Governance and Leadership Designs for the Future

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Fudan Journal of the Humanities and Social Sciences 2017年第3期10卷 355-380页

作者： S. I. cohen Erasmus School of Economics Rotterdam Netherlands

An expanding globalization causes global failures, similar to economy failures encountered in the national economic system. Global failures take other forms and are likely to be more severe in the future because of the entry in the world scene of leading countries that have distinctly different economic systems （for instance, China, India） from leading incumbents （US, EU）, and because the new competition （country cum system） is likely to be perceived by newcomers and incumbents as a zero sum game. It is crucial in such circumstances to have a design of world governance that can respond adequately to global failures. The G-20 is one such design, but this is handicapped by its narrow scope （i.e. GDP） and undemocratic composition （selection of individual countries and not regional representation, next to being inconsistent and out of date）. The paper formulates and applies an index of influence potential that combines population and GDP, and which is measurable at the region and country levels. The paper projects these applications for the near future, comes up with more representative participations by regions/countries in world governance and explores effects of the changing distribution of influence potential on global development and economic systems.

关键词： World governance Country dominance Regional power Economic growth Population size

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Implicit pairs for boosting unpaired image-to-image translation

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Visual Informatics 2020年第4期4卷 50-58页

作者： Yiftach Ginger Dov Danon Hadar Averbuch-Elor Daniel cohen-Or Tel Aviv University Israel

In image-to-image translation the goal is to learn a mapping from one image domain to *** the case of supervised approaches the mapping is learned from paired ***,collecting large sets of image pairs is often either prohibitively expensive or not *** a result,in recent years more attention has been given to techniques that learn the mapping from unpaired *** our work,we show that injecting implicit pairs into unpaired sets strengthens the mapping between the two domains,improves the compatibility of their distributions,and leads to performance boosting of unsupervised techniques by up to 12%across several *** competence of the implicit pairs is further displayed with the use of pseudo-pairs,i.e.,paired samples which only approximate a real *** demonstrate the effect of the approximated implicit samples on image-to-image translation problems,where such pseudo-pairs may be synthesized in one direction,but not in the *** further show that pseudo-pairs are significantly more effective as implicit pairs in an unpaired setting,than directly using them explicitly in a paired setting.

关键词： Generative adversarial networks Image-to-image translation Data augmentation Synthetic samples

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