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Effects of urea,metal ions and surfactants on the binding of baicalein with bovine serum albumin

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Journal of Pharmaceutical Analysis 2016年第4期6卷 256-267页

作者： Atanu Singha Roy Amit kumar Dinda nitin kumar Pandey Swagata Dasgupta Department of Chemistry Indian Institute of Technology

The interaction of baicalein with bovine serum albumin（BSA） was investigated with the help of spectroscopic and molecular docking *** binding affinity of baicalein towards BSA was estimated to be in order of 10~5 M^（-1） from fluorescence quenching *** ΔH°（-5.66 ＋ 0.14 kJ/mol） and positive（ΔS°）（＋ 79.96 ＋ 0.65J/mol k） indicate the presence of electrostatic interactions along with the hydrophobic forces that result in a positive ΔS°.The hydrophobic association of baicalein with BSA diminishes in the presence of sodium dodecyl sulfate（SDS） due to probable hydrophobic association of baicalein with SDS,resulting in a negative ΔS°（-40.65 ＋ 0.87 J/mol k）.matrix-assisted laser desorption ionization/time of flight（maLDI-TOF） experiments indicate a 1：1 complexation between baicalein and *** unfolding and refolding phenomena of BSA were investigated in the absence and presence of baicalein using steady-state and fluorescence lifetime *** was observed that the presence of urea ruptured the non-covalent interaction between baicalein and *** presence of metal ions（Ag~＋,Mg^（2＋）,Ni^（2＋）,Mn^（2＋）,Co^（2＋） and Zn^（2＋）） increased the binding affinity of ligand towards *** changes in conformational aspects of BSA after ligand binding were also investigated using circular dichroism（CD） and Fourier transform infrared（FT-IR） spectroscopic *** selectivity studies following molecular docking analyses indicated the binding of baicalein to site 1（subdomain ma） of BSA.

关键词： Bovine serum albumin(BSA) Baicalein Binding constant Fluorescence spectroscopy Molecular docking

Tale of fat and fib-cardiac lipoma managed with radiofrequency ablation: A case report

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World Journal of Cardiology 2020年第6期12卷 285-290页

作者： Swarna Sri Nalluru Srinivas Nadadur nitin Trivedi Sunita Trivedi Sanjeev Goyal Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01604United States Department of Cardiology Saint Vincent HospitalWorcesterMA 01604United States

BACkGROUND Cardiac lipoma and lipomatous hypertrophy of interatrial septum(LHIS)are very rare disorders with distinct pathological *** cardiac lipoma is a well-circumscribed encapsulated tumor of mature adipocytes,LHIS is due to entrapment of fat cells in the interatrial septum during *** a biopsy is the definitive diagnostic test,these disorders can be differentiated by a cardiac magnetic resonance imaging(MRI).Treatment of LHIS is not warranted in asymptomatic *** symptomatic patients,surgical resection is the only recommended treatment,which has shown to improve good long-term *** SUMmaRY A 63-year-old Caucasian woman with past medical history significant for hypertension,hypothyroidism,right breast ductal cell carcinoma treated with mastectomy and breast implant,platelet granule disorder,asthma requiring chronic intermittent prednisone use,presented to the outpatient cardiology office with recent onset exertional dyspnea,palpitations,weight gain and *** workup with electrocardiogram and holter monitor did not reveal significant *** the subsequent hospitalization for community acquired pneumonia,the patient developed symptomatic paroxysmal atrial *** echocardiogram showed a right ventricular mass.A biopsy was not pursued given the high risk of bleeding due to platelet granule *** MRI showed characteristic features consistent with cardiac lipoma and *** was *** testing for arrhythmogenic right ventricular dysplasia and 24-h urine cortisol test was *** multiple attempts at rhythm control failed with sotalol and flecainide,pulmonary vein isolation and right atrial isthmus radiofrequency ablation were *** is in follow-up with symptomatic relief and no recurrence of atrial fibrillation for 10 *** Benign fatty lesions in heart include solitary lipoma,lipomatous infiltration and lipomatous hypertrophy of intera

关键词： Cardiac lipoma Lipomatous hypertrophy of interatrial septum Atrial fibrillation Radiofrequency ablation Case report

Hyperglycemia in COVID-19 infection without diabetes mellitus:Association with inflammatory markers

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World Journal of Clinical Cases 2023年第6期11卷 1287-1298页

作者： Harinivaas shanmugavel Geetha Garima Singh Abinesh Sekar maya Gogtay Yuvaraj Singh George mabraham nitin Trivedi Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Hospice and Palliative Medicine University of Texas HealthSan AntonioTX 78229United States Department of Internal Medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States

BACkGROUND New onset hyperglycemia is common in patients with severe coronavirus disease 2019(COVID-19)*** storm due to COVID-19 infection is an essential etiology for new-onset hyperglycemia,but factors like direct severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced pancreaticβ-cell failure have also been postulated to play a *** We plan to investigate further the mechanisms underlying SARS-CoV-2 infection-induced hyperglycemia,particularly the rationale of the cytokine-induced hyperglycemia hypothesis,by evaluating the association between inflammatory markers and new onset hyperglycemia in non-diabetic patients with COVID-19 *** We conducted a retrospective case-control study on adults without diabetes mellitus hospitalized for COVID-19 *** serum levels of glucose and inflammatory markers at presentation before initiation of corticosteroid were *** was defined as glucose levels≥140 mg/dL.C-Reactive protein(CRP)≥100 mg/L,ferritin≥530 ng/mL,lactate dehydrogenase(LDH)≥590 U/L,and D-dimer≥0.5 mg/L were considered *** used theχ2 test for categorical variables and the mann-Whitney U test for continuous variables and calculated the logistic regression for *** Of the 520 patients screened,248 met the inclusion *** demographics were equally distributed between patients with hyperglycemia and those who were *** inflammatory markers in patients with or without new-onset hyperglycemia were elevated as follows:CRP(58.1%vs 65.6%,P=0.29),ferritin(48.4%vs 34.9%,P=0.14),D-dimer(37.1%vs 37.1%,P=0.76)and LDH(19.4%vs 11.8%,P=0.02).Logistic regression analysis showed LDH odds ratio(OR)=1.623(P=0.256).We observed significantly higher mortality(24.2%vs 9.1%,P=0.001;OR=2.528,P=0.024)and length of stay(8.89 vs 6.69,P=0.026)in patients with *** Our study showed no association between CRP,ferritin,LDH,D-dimer levels,and new-onset hyperg

关键词： COVID-19 Inflammatory markers Hyperglycemia C-reactive protein Mortality Severity Mechanisms Diabetes mellitus

Assessment of compatibility of rhlGF-1/rhlGFBP-3 with neonatal intravenous medications

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World Journal of Pediatrics 2023年第1期19卷 58-67页

作者： Nazila Salamat-Miller mark A.Turner Amey Bandekar nitin Dixit Emily Jochim Barry mangum Christopher McPherson Srini Tenjarla Sukhjeet Singh You Seok Hwang Norman Barton Takeda 200 Shire WayLexingtonMA 02421USA Institute of Translational Medicine University of LiverpoolLiverpoolUK Paidion Research DurhamNCUSA Washington University St.LouisMOUSA

Background Recombinant human(rh)IGF-1/IGFBP-3 protein complex,administered as a continuous intravenous infusion in preterm infants,is being studied for the prevention of complications of *** We conducted in vitro studies to evaluate the physical and chemical compatibility of rhIGF-1/IGFBP-3 with medications routinely administered to preterm *** vitro mixing of rhIGF-1/IGFBP-3 drug product with small-molecule test medications plus corresponding controls was *** compatibility was defined as no color change,precipitation,turbidity,gas evolution,no clinically relevant change in pH/osmolality or loss in medication *** compatibility of small molecules was assessed using liquid chromatography(e.g.,reverse-phase HPLC and ion chromatography),with incompatibility defined as loss of concentration of≥10%.A risk evaluation was conducted for each medication based on in vitro compatibility data and potential for chemical *** In vitro physical compatibility was established for 11/19 medications:caffeine citrate,fentanyl,fluconazole,gen-tamicin,insulin,intravenous fat emulsion,midazolam,morphine sulfate,custom-mixed parenteral nutrition solution(with/without electrolytes),parenteral nutrition solution+intravenous fat emulsion,and vancomycin(dosed from a 5 mg/mL solu-tion),but not for 8/19 medications:amikacin,ampicillin,dopamine,dobutamine,furosemide,meropenem,norepinephrine,and penicillin G,largely owing to changes in pH after ***-molecule compatibility was unaffected post-mixing,with no loss of small-molecule *** physically compatible medications,risk analyses confirmed low probability and severity of a risk *** Co-administration of rhIGF-1/rhIGFBP-3 drug product with various medications was assessed by in vitro studies using case-by-case risk analyses to determine the suitability of the products for co-administration.

关键词： Chemical compatibility Intravenous Neonatal Physical compatibility rhIGF-1/rhIGFBP-3

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曲轴系多柔体动力学与动力润滑耦合仿真分析

润滑与密封 2012年第3期37卷 37-41页

作者：马星国李想尤小梅沈阳理工大学机械工程学院辽宁沈阳110168

使用LMS ***软件建立曲轴系的多体系统动力学仿真模型,对曲轴系进行刚柔耦合多体动力学仿真,得到周期内曲轴系的动态载荷,为研究主轴承液体动力润滑提供边界条件;联合主轴承油膜润滑模型和多体动力学模型进行耦合仿真,得到最小油膜厚度... 详细信息

使用LMS ***软件建立曲轴系的多体系统动力学仿真模型,对曲轴系进行刚柔耦合多体动力学仿真,得到周期内曲轴系的动态载荷,为研究主轴承液体动力润滑提供边界条件;联合主轴承油膜润滑模型和多体动力学模型进行耦合仿真,得到最小油膜厚度和最大油膜压力曲线及主轴承工作周期内的油膜最大节点压力的变化规律。结果表明:在第三缸点火后,油膜节点压力急剧增大,油膜节点最大压力区呈现出从轴瓦中心向轴瓦边缘偏移的特性。

关键词：曲轴刚柔耦合动力学动力润滑 Craig—Bampton模态

基于BP神经网络模型的Ni-TiN镀层耐磨性预测研究

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人工晶体学报 2016年第6期45卷 1718-1721页

作者：彭绪山章晓敏马春阳宁波大红鹰学院信息工程学院宁波315175 东北石油大学机械科学与工程学院大庆163318

采用超声电沉积方法,在C470型压缩机阀片表面制备Ni-TiN镀层。利用扫描电镜、X射线衍射仪和摩擦磨损试验机研究Ni-TiN镀层表面形貌、组织结构及耐磨性,并采用BP神经网络模型预测Ni-TiN镀层的磨损量。结果表明,BP神经网络模型的最佳结构... 详细信息

采用超声电沉积方法,在C470型压缩机阀片表面制备Ni-TiN镀层。利用扫描电镜、X射线衍射仪和摩擦磨损试验机研究Ni-TiN镀层表面形貌、组织结构及耐磨性,并采用BP神经网络模型预测Ni-TiN镀层的磨损量。结果表明,BP神经网络模型的最佳结构组成为3×9×1,其预测值与实验值的拟合度R=0.99938,相对误差最大值与最小值分别为1.67%和0.63%。当TiN粒子浓度为8 g/L、超声波功率180 W、电流密度4 A/dm2时,Ni-TiN镀层表面犁沟较浅,磨损量较小。Ni-TiN镀层中存在Ni和TiN相,镍的衍射峰分别位于44.82°、52.22°和76.78°,TiN的衍射峰分别位于38.48°、42.82°和66.54°。

关键词： BP神经网络模型 Ni-TiN镀层耐磨性