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R21 vaccine:A ray of hope for malaria elimination

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 243-244页

作者： nitika nitika Shrikant Nema Praveen Kumar Bharti ICMR-National Institute of Malaria Research Sector 8DwarkaNew DelhiIndia

The steady decline in malaria cases and deaths in recent years is a step ahead toward elimination;however,an increasing number of reports of antimalarial and insecticide resistance highlight the importance of having newer approaches to achieve the goal in the stipulated time ***,having an effective and durable malaria vaccine is extremely crucial,which can complement the tools currently in *** the malaria vaccine development efforts initiated in the 1910’s with the first attempts to develop a malaria vaccine involved inoculating humans with live,attenuated strains of the malaria parasite but the efforts have been intensified over the previous decade,resulting in several significant developments.

关键词： malaria vaccine elimination

Malaria slide bank plays a crucial role in achieving and sustaining malaria elimination in India

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Asian Pacific Journal of Tropical Medicine 2023年第10期16卷 431-433页

作者： Shrikant Nema nitika nitika Anup R Anvikar Praveen K Bharti ICMR-National Institute of Malaria Research Sector 8Dwarka 110077New DelhiIndia

India's healthcare system continues to place the highest priority on the fight against malaria[1].Malaria elimination program has received considerable attention from both the public and private sectors,resulting in a significant drop in malaria cases[2].In 2022,a total of 176000 million cases of malaria were reported in India,in which Plasmodium(P.)falciparum has contributed 57.0%and 42.3%were *** cases and limited cases of *** and ***.

关键词： malaria Malaria elimination

Synthesis and characterization of the nanostructured solid solution with extended solubility of graphite in nickel by mechanical alloying

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International Journal of Minerals,Metallurgy and Materials 2019年第8期26卷 1031-1037页

作者： nitika Kundan Biswajit Parida Anup Kumar Keshri Prathvi Raj Soni Department of Metallurgical and Materials Engineering Malaviya National Institute of TechnologyJaipurRajasthan 302017India Department of Materials Science and Engineering Indian Institute of Technology PatnaBihar 801106India

In the present work,mechanical alloying of a powder mixture of nickel and graphite(up to 15wt%)was carried out in an attrition mill under a nitrogen *** as-milled powders were characterized by scanning electron microscopy(SEM),X-ray diffraction(XRD),and transmission electron microscopy(TEM).The 15wt%graphite dissolved into the nickel(exceeding the negligible solid solubility in the nickel–carbon system),thereby forming a supersaturated solid solution of graphite in a nickel *** dissolved graphite occupied interstitial positions along the dislocation edges and at the grain-boundary regions.A three-step graphite dissolution mechanism has been *** associated changes in the nickel lattice,such as changes in the crystallite size(62 to 43 nm),lattice strain(0.12%to 0.3%),and lattice parameter(0.3533 to 0.3586 nm),which led to the formation of the supersaturated solid solution,were also evaluated and discussed.

关键词： Ni-C system mechanical alloying supersaturated solid solution nanostructured powder

Mental health promotion for elderly populations in World Health Organization South-East Asia Region:Needs and resource gaps

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World Journal of Psychiatry 2022年第1期12卷 117-127页

作者： Nisha Mani Pandey Rakesh Kumar Tripathi Sujita Kumar Kar K L Vidya nitika Singh Department of Geriatric Mental Health King George's Medical UniversityLucknow 226003Uttar PradeshIndia Department of Psychiatry King George's Medical UniversityLucknow 226003Uttar PradeshIndia

The accelerated population growth of the elderly(individuals aged 60 years or more)across the globe has many indications,including changes in demography,health,the psycho-social milieu,and economic *** transition has given rise to varied challenges;significant changes have been observed in regard to developing strategies for health care systems across the *** World Health Organization(WHO)is also engaging in initiatives and mediating ***,advocacy is being conducted regarding a shift toward the salutogenic model from the pathogenic *** concept behind this move was to shift from disablement to enablement and from illness to wellness,with the notion of mental health promotion(MHP)being *** article attempts to discuss the MHP of elderly individuals,with special reference to the need to disseminate knowledge and awareness in the community by utilizing the resources of the health sector available in the WHO South-East Asia Region *** have tried to present the current knowledge gap by exploring the existing infrastructure,human resources,and financial *** is much to do to promote the mental health of the elderly,but inadequate facilities are *** on available resources,a roadmap for MHP in elderly individuals is discussed.

关键词： Mental health promotion Elderly Mental healthcare needs Resource gaps World health organization

Knowledge, attitude, and practice of techniques of breastfeeding among new mothers: A survey across Delhi Region

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Journal of Integrative Nursing 2022年第1期4卷 26-29页

作者： Himanshu VERMA Sirshti SINGH nitika BAHUGUNA Mukul DAHIYA Jyoti SHAH Department of Otolaryngology Speech and Hearing UnitPGIMERChandigarhIndia Department of Swallowing Service Amrita Vishwa VidhyapeethamKollamKeralaIndia Department of Speech Pathology Sarthak Educational TrustNew DelhiIndia Ashtavakra Institute of Rehabilitation Sciences and Research DelhiIndia Speech-Swallowing and Hearing Care Clinic New DelhiIndia Department of Audiology and Speech-Pathology Saroj HospitalNew DelhiIndia

Objective:The present study aims to evaluate aims to assess the knowledge,attitude,and practice of primiparous mothers in the immediate postpartum period regarding breastfeeding techniques which will be helpful in forming awareness and training *** and Methods:A cross-sectional survey was used.A total of 120 primiparous mothers with a mean age of 24.92 years participated in the survey and filled the questionnaire related to the knowledge,attitude,and practice of techniques of ***:Results revealed that 48.3%of new mothers were not aware of the correct techniques to initiate breastfeeding,whereas 68.3%of subjects reported that during latching,the baby’s upper and lower lip should be *** majority of new mothers were aware of breastfeeding techniques with some misconceptions as in our culture,most of the breastfeeding information passed from generation to ***:The level of awareness about feeding skills among primiparous mothers can be further improved by antenatal counseling or training from health-care workers during the gestational *** will further help new mothers to educate and will provide adequate information which will decrease the myths.

关键词： Breastfeeding breastfeeding techniques lactation primiparous mother

Biological Management of Damping-Off, Buckeye Rot and Fusarial Wilt of Tomato (cv. Solan Lalima) under Mid-Hill Conditions of Himachal Pradesh

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Agricultural Sciences 2015年第5期6卷 535-544页

作者： nitika Thakur Astha Tripathi Department of Microbiology Shoolini University of Biotechnology and Management Sciences Bajhol Campus Solan (Himachal pradesh) India

Disease management is often complicated by the presence of multiple types of pathogens;in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the management of important disease of tomato is through the integrated approaches and very few organic approaches have been tried with various degree of success. Boiopriming of seeds with biocontrol agents (Trichoderma viridae, Trichoderma harzianum and Pseudomonas fluorescens) in combination with different biofertilizers (Azotobacter, Azospirillum and PSB) and organic manures (FYM and vermi-compost) were tested against disease incidence and health management of tomato seedling under nursery as well as field conditions. The studies were conducted during two successive years (2012-2013) at farmer’s field with the objective to combat with the increasing disease incidence of three major disease damping-off, fusarium wilt and buckeye rot from nursery stage to the final harvesting. The study focused on the use of biocontrol agents as the suitable alternative to chemical pesticides with sustainable disease management without pesticide residues in foodstuff. The bio priming of seeds with fungal antagonist Trichoderma viridae and harzianum and bacterial antagonist Pseudomonas fluorescens significantly improved the germination behavior of tomato seeds as compared to untreated control. Highest mean germination (93.1%) and seedling vigour (953.33) was recorded in Treatment 3 (FYM @ 200 q/ ha + Azospirillum + PSB + Trichoderma herzianum (4 kg/ha each) and lowest in control (60.3%) and (304.83), thus indicating a significant per cent increase in seedling emergence (54.4%) and seedling vigour (95.23%). A considerable reduction in disease incidence (pre and post) of damping off was observed in treatment T? and T? (VC @ 50 q/ha + Azospirillum + PSB + Trichoderma herzianum @ (4 kg/ha) with 45.6% and 35.4% respectively). Treatment T? proved highest in terms of yield (665 Kg/

关键词： Biocontrol Agents Biofertilizers Disease Incidence Organic Manure Tomato Yield

An HIV 1/2 point of care test on sputum for screening TB/HIV coinfection in central India-Will it work?

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 216-219页

作者： Prabha Desikan Sajal De nitika Pant Pai Pradyumna K Mishra Kaushal Kumar Nikita Panwalkar Mayanka Verma Zia Ul Hasan Kewal K Maudar Department of Microbiology Bhopal Memorial Hospital and Research CentreBhopalIndia Department of Pulmonary Medicine Bhopal Memorial Hospital and Research CentreBhopalIndia Department of Medicine Division of Clinical EpidemiologyMcGill University Health CentreMontrealCanada Department of Research Bhopal Memorial Hospital and Research CentreBhopalIndia TB Hospital Idgah HillsBhopalIndia

Objective:To determine whether the OraQuick(?).HIV-1/2 Assay(OraSure Technologies, Inc.,Bethlehem,PA,USA) in sputum is a valid tool for HIV surveillance among TB patients. Methods:A cross sectional study was carried out on sputa of patients diagnosed with *** were tested for antibodies to HIV using OraQuick. HIV-1/2 Assay(OraSure Technologies,Inc.,Bethlehem,PA,USA).The results were compared with results of serum ***:Compared to serum ELISA,the OraQuick(?).HIV-1/2 Assay in sputum specimens reported 90%sensitivity(9/10)and 100%specificity(307/307),with a positive predictive value of 100%(95%CI:66.37%-100.00%)and a negative predictive value of 99.68%(95%CI:98.20%-99.99%). Conclusions:This testing method may provide a useful strategy for conducting HIV surveillance in possible co-infected TB patients at peripheral *** there is no investment on infrastructure,it may be possible for paramedical health professionals to carry out the test. particularly in areas with low HIV endemicity.

关键词： Oraquick HIV Tuberculosis Sputum

Diversity of Sodium Transporter HKT1;5 in Genus Oryza

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Rice science 2022年第1期29卷 31-46,I0002-I0017页

作者： Shalini PULIPATI Suji SOMASUNDARAM nitika RANA Kavitha KUMARESAN Mohamed SHAFI Peter CIVÁŇ Gothandapani SELLAMUTHU Deepa JAGANATHAN Prasanna Venkatesan RAMARAVI S.PUNITHA Kalaimani RAJU Shrikant S.MANTRI R.SOWDHAMINI Ajay PARIDA Gayatri VENKATARAMAN M.S.Swaminathan Research Foundation Chennai 600113India National Agri-Food Biotechnology Institute Punjab 140306India Krishi Vigyan Kendra Kanyakumari 629901India National Centre for Biological Sciences/Tata Institute of Fundamental Research Bangalore 560065India National Research Institute for Agriculture Food and Environment UniversityClermont-AuvergneClermont-Ferrand 63000France Forest Molecular Entomology Laboratory Faculty of Forestry and Wood SciencesCzech University of Life SciencesPraguePraha 16500Czech Republic Tamil Nadu Agricultural University Coimbatore 641003India International Business Machines India Chennai 600125India Institute of Life Sciences Bhubaneswar 751023India

Asian cultivated rice shows allelic variation in sodium transporter,OsHKT1;5,correlating with shoot sodium exclusion(salinity tolerance).These changes map to intra/extracellularly-oriented loops that occur between four transmembrane-P loop-transmembrane(MPM)motifs in OsHKT1;***1;5 sequences from more recently evolved Oryza species(***/*** complex species)contain two expansions that involve two intracellularly oriented loops/helical regions between MPM domains,potentially governing transport characteristics,while more ancestral HKT1;5 sequences have shorter intracellular *** compared homology models for homoeologous OcHKT 1;5-K and OcHKT1;5-L from halophytic *** to identify complementary amino acid residues in OcHKT1;5-L that potentially enhance affinity for Na+.Using haplotyping,we showed that Asian cultivated rice accessions only have a fraction of HKT1;5 diversity available in progenitor wild rice species(*** and ***).Progenitor HKT1;5 haplotypes can thus be used as novel potential donors for enhancing cultivated rice salinity *** Asian rice accessions,10 non-synonymous HKT1;5 haplotypic groups *** HKT1;5 haplotypic diversities occur in cultivated indica gene pool compared to *** Haplotypes 2 and 10 occur in mutually exclusive japonica and indica groups,corresponding to haplotypes in *** salt-sensitive and salt-tolerant landraces,*** distinct haplotype partitioning may have originated in separate ancestral gene pools of indica and japonica,or from different haplotypes selected during *** of specific HKT1;5 haplotypes within the 3000 rice dataset may relate to eco-physiological fitness in specific geo-climatic and/or edaphic contexts.

关键词： HKT1 5 diversity single nucleotide polymorphism haplotype bacterial artificial chromosome salinity tolerance sodium transporter Oryza species