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Anneal-free ultra-low loss silicon nitride integrated photonics

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Light(Science & Applications) 2024年第8期13卷 1565-1577页

作者： Debapam Bose Mark W.Harrington Andrei Isichenko Kaikai Liu Jiawei Wang nitesh Chauhan Zachary L.Newman Daniel J.Blumenthal Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octave Photonics LouisvilleCO 80027USA

Heterogeneous and monolithic integration of the versatile low-loss silicon nitride platform with low-temperature materials such as silicon electronics and photonics,III–v compound semiconductors,lithium niobate,organics,and glasses has been inhibited by the need for high-temperature annealing as well as the need for different process flows for thin and thick *** techniques are needed to maintain the state-of-the-art losses,nonlinear properties,and CMOS-compatible processes while enabling this next generation of 3D silicon nitride *** report a significant advance in silicon nitride integrated photonics,demonstrating the lowest losses to date for an anneal-free process at a maximum temperature 250℃,with the same deuterated silane based fabrication flow,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record low anneal-free losses for both nitride core and oxide cladding,enabling 1.77 dBm^(-1) loss and 14.9 million Q for 80 nm nitride core waveguides,more than half an order magnitude lower loss than previously reported sub 300℃ *** 800 nm-thick nitride,we achieve as good as 8.66 dBm^(-1) loss and 4.03 million Q,the highest reported Q for a low temperature processed resonator with equivalent device area,with a median of loss and Q of 13.9 dBm^(-1) and 2.59 million each *** demonstrate laser stabilization with over 4 orders of magnitude frequency noise reduction using a thin nitride reference cavity,and using a thick nitride micro-resonator we demonstrate OPO,over two octave supercontinuum generation,and four-wave mixing and parametric gain with the lowest reported optical parametric oscillation threshold per unit resonator *** results represent a significant step towards a uniform ultra-low loss silicon nitride homogeneous and heterogeneous platform for both thin and thick waveguides capable of linear and nonlinear photonic circuits and

关键词： resonator thick free

Ketosis-prone diabetes mellitus:A phenotype that hospitalists need to understand

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World Journal of Clinical Cases 2022年第30期10卷 10867-10872页

作者： Sydney Boike Mikael Mir Ibtisam Rauf Abbas B Jama Shaleen Sunesara Hisham Mushtaq Anwar Khedr Jain nitesh Salim Surani Syed A Khan Medicine University of Minnesota Medical SchoolMinneapolisMN 55455United States Medicine St.George’s School of MedicineGrenada FZ818West Indies Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Medicine University of Southern CaliforniaLos AngelesCA 90007United States Medicine St.Vincent’s Medical CenterBridgeportCT 06606United States Medicine BronxCare Health SystemBronxNY 10457United States Medicine Texas A&M UniversityBryanTX 77843United States Anesthesiology Mayo ClinicRochesterMN 55905United States

Diabetes has been classified mainly into types 1 and *** type 2 diabetes patients,when developing ketosis,have been labeled as having atypical ***,syndromes of ketosis-prone diabetes,primarily in patients who we previously classified as type 2 diabetics,have emerged,and calls are being made to even reclassify *** mini-review will extensively deal with the historical,molecular,phenotypical,and clinical basis of why ketosis-prone diabetes is different than the traditional principles of type 1 and 2 diabetes and should be classified as ***,especially those who are not diabetologists or endocrinologists,as well as hospitalists,intensivists,and primary care providers,will greatly benefit from this review.

关键词： Diabetic ketoacidosis Diabetes Diabetes prone ketosis Ketosis Acidosis

What we learned in the past year in managing our COvID-19 patients in intensive care units?

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World Journal of Critical Care Medicine 2021年第4期10卷 81-101页

作者： Jain nitesh Rahul Kashyap Salim R Surani Department of Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Department of Medicine Texas A&M UniversityCorpus ChristiTX 78404United States

Coronavirus disease 2019 is a pandemic,was first recognized at Wuhan province,China in December *** disease spread quickly across the globe,spreading stealthily from human to human through both symptomatic and asymptomatic individuals.A multisystem disease which appears to primarily spread via bio aerosols,it has exhibited a wide clinical spectrum involving multiple organ systems with the respiratory system pathology being the prime cause of morbidity and *** unleashing a huge destructive trail at Wuhan China,Lombardy Italy and New York City,it has now spread to all parts of the globe and has actively thrived and mutated into new *** care systems and Governments responded initially with panic,with containment measures giving way to mitigation *** global medical and scientific community has come together and responded to this huge *** medical societies quickly laid out“expert”guidelines which were conservative in their *** drugs were re formulated and tested quickly with the help of national and international collaborative groups,helping carve out effective treatment strategies and help build a good scientific foundation for evidencebased *** of the darkness of chaos,we now have an orderly approach to manage this disease both from a public health preventive and therapeutic *** preventive measures such as masking and social distancing to the development of highly effective and potent vaccines,the public health success of such measures has been tempered by behavioral responses and resource *** a therapy standpoint,we now have drugs that were promising but now proven ineffective,and those that are effective when given early during viral pathogenesis or later when immune dysregulation has established,and the goal is to help reign in the destructive *** has been a fascinating journey for mankind and our work here recapitulates the evolution of various aspects of

关键词： COvID-19 Respiratory support Renal replacement therapy Extracorporeal membrane oxygenator Medications Therapeutics

Does a staged treatment of high energy tibial plateau fractures affect functional results and bony union?A case series

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Chinese Journal of Traumatology 2020年第4期23卷 238-242页

作者： Nilesh Barwar Abhay Elhence Sumit Banerjee nitesh gahlot Department of Trauma&Emergency Orthopedics All India Institute of Medical SciencesJodhpur 342005India Department of Orthopedics All India Institute of Medical SciencesJodhpur 342005India

Purpose:Tibial plateau fracture(TPF)is a devastating injury as it shatters lower articular surface of the largest *** from bony injury,TPF can lead to great soft tissue envelope compromise which affects the treatment plan and *** the present study,clinical results were assessed in cases of high energy TPFs treated in staged ***:Twenty-three(20 males and 3 females)patients of high energy communited TPFs(Schatzker typeⅤandⅥ)were consecutively treated.1 All the patient had compromise of overlying skin *** were all successively scheduled for staged treatment plan which comprised of application of bridging knee external fixator on the first day of admission and definitive internal fixation after skin and soft tissue overlying the fracture were *** typeⅠ,Ⅱ,ⅢandⅣwere excluded from the *** survey was done and patient who had head injury,chest and abdominal injury,pelvic injury and contralateral limb injury and open fractures were excluded from the *** patients were also evaluated in terms of wound complications,axial and rotary alignment of limb,fixation failure,articular congruity and range of motion of the knees and post injury *** analysis was done using SPSS ***:Maximum follow-up period was 13 *** the fractures were united at final *** evaluation was done with the Tegner Lysholm knee scoring scale.2 Excellent results were found in 78%cases and good and fair results in 22%*** was significant correlation between range of motion and the Tegner Lysholm knee score(pvelope,with avoidance of dreadful complications such as compartment syndrome and chronic *** addition,a staged treatment strategy do

关键词： High energy fracture Tibial plateau fractures Staged treatment

Sodium-glucose cotransporter-2 inhibitor-associated euglycemic diabetic ketoacidosis in COvID-19-infected patients: A systematic review of case reports

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World Journal of Clinical Cases 2023年第24期11卷 5700-5709页

作者： Anwar Khedr Hussam Al Hennawi Muhammed Khuzzaim Khan Aalaa Eissa Mikael Mir Ibtisam Rauf Jain nitesh Salim Surani Syed Anjum Khan Department of Medicine Bronx Care Health SystemBronxNY 10457United States Department of Internal Medicine Jefferson Abington HospitalAbingtonPA 19001United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200Pakistan Department of Medicine Kafrelsheikh UniversityKFS 33511Egypt Department of Medicine University of MinnesotaMinneapolisMN 55455United States Department of Medicine St.George’s UniversitySchool of MedicineSt.George SW170REGrenada Department of Critical Care Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States

BACKGROUND Diabetic ketoacidosis(DKA)manifests as hyperglycemia,metabolic acidosis,and ***,euglycemic DKA(eu-DKA)conceals severe DKA with glucose levels below 200 mg/***-glucose cotransporter-2(SGLT2)inhibitors can induce eu-DKA in diabetic ***,coronavirus disease 2019(COvID-19)-infected individuals with diabetes using SGLT2 inhibitors face an augmented risk of eu-DKA due to the direct toxic impact of the virus on pancreatic *** study aims to comprehensively investigate the association between SGLT2 inhibitors and eu-DKA in COvID-19 patients through meticulous case report ***,we endeavor to examine the outcomes and treatment approaches for COvID-19-infected diabetics receiving SGLT2 inhibitors,providing indispensable insights for healthcare professionals managing this specific patient *** To investigate the connection between SGLT2 inhibitors and euglycemic DKA in COvID-19 patients through a meticulous analysis of case *** We conducted an exhaustive search across prominent electronic databases,including PubMed,SCOPUS,Web of Science,and Google *** search encompassed the period from December 2019 to May 2022,incorporating published studies and *** search terms employed encompassed“SGLT2 inhibitors”,“euglycemic DKA”,“COvID-19”,and related *** incorporating these diverse sources,our objective was to ensure a thorough exploration of the existing literature on this subject,thereby augmenting the validity and robustness of our *** Our search yielded a total of seven case reports and one case series,collectively comprising a cohort of twelve *** reports detailed instances of eu-DKA in individuals with ***,all twelve patients were utilizing SGLT2 as their primary anti-diabetic *** admission,all oral medications were promptly discontinued,and the patients were initiated on intravenous insulin therapy to effectively ma

关键词： Sodium-glucose transporter 2 inhibitors COvID-19 SARS-Cov-2 Diabetic ketoacidosis Euglycemic diabetic ketoacidosis Diabetes mellitus

Leiomyoma Of Urinary Bladder a Rare Entity:Series Of 3 Cases And Review Of Literature

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Journal of Oncology Research 2019年第3期1卷 7-12页

作者： nitesh Kumar Karthik M Samyuktha K Sunil Palve Tushar Agrawal MS(General Surgery) MCH trainee UrologyOsmania Medical CollegeIndia

Introduction:Leiomyoma of urinary bladder is a rare entity and comprises 0.43%of all bladder *** we present our series of 3 cases and the related review of ***:3 cases of bladder leiomyoma presented over a period of 16 months in Osmania Medical College and *** history was taken,physical examination,routine blood,urine and radiological investigations were *** were treated by Trensurethral Resection(TUR)of the mass and histopathological analysis with Immunohistochemistry was done for all ***:All 3 cases were females with mean age of 31.6 *** cases were endovesical type,mass near bladder neck and presented with obstructive *** cases presented with acute retention of *** investigations in all patients suggested a possibility of leiomyoma and all cases had reduced urinary flow *** confirmed the diagnosis in all *** recurrence was found at one year of follow ***:Leiomyoma of urinary bladder is a rare disorder which frequently occurs in middle aged *** are related to its size and location,diagnosis is confirmed by histopathological *** is by surgery(mainly TUR).Prognosis of the disease is excellent.

关键词： Leiomyoma Benign tumor Bladder outlet obstruction Benign bladder tumor LUTS

Overlap of diabetic ketoacidosis and hyperosmolar hyperglycemic state

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World Journal of Clinical Cases 2022年第32期10卷 11702-11711页

作者： Esraa Mamdouh Hassan Hisham Mushtaq Esraa Elaraby Mahmoud Sherley Chhibber Shoaib Saleem Ahmed Issa Jain nitesh Abbas B Jama Anwar Khedr Sydney Boike Mikael Mir Noura Attallah Salim Surani Syed A Khan Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Medicine St.Vincent's Medical CenterBridgeportCT 06606United States Medicine College of MedicineUniversity of SharjahSharjah 27272United Arab Emirates Medicine Mercy Catholic Medical CenterDarbyPA 19025United States Medicine Mayo HospitalLahore 54000PunjabPakistan Medicine Medical University of the AmericasNevisWest Indies Medicine BronxCare Health SystemBronxNY 10457United States Medicine University of Minnesota Medical SchoolMinneapolisMN 55455United States Medicine&Pharmacology Texas A&M University Health Science CenterCollege StationTX 77843United States Anesthesiolgy Mayo ClinicRochesterMN 55905United States

Diabetic ketoacidosis(DKA)and hyperosmolar hyperglycemia state(HHS)are two life-threatening metabolic complications of diabetes that significantly increase mortality and *** major advances,reaching a uniform consensus regarding the diagnostic criteria and treatment of both conditions has been challenging.A significant overlap between these two extremes of the hyperglycemic crisis spectrum poses an additional *** has well been noted that a complete biochemical and clinical patient evaluation with timely diagnosis and treatment is vital for symptom ***,there is a lack of large-scale studies that help define how hyperglycemic crises should be *** article will provide a comprehensive review of the pathophysiology,diagnosis,and management of DKA-HHS overlap.

关键词： Diabetic ketoacidosis Hyperosmolar Coma Diabetes Metabolic acidosis Hypernatremia Hyperosmolar hyperglycemia state

Choledochocele with pancreas divisum:A rare cooccurrence diagnosed on magnetic resonance cholangiopancreatography

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World Journal of Radiology 2013年第7期5卷 264-266页

作者： Yashwant Patidar nitesh Agarwal Shailesh Gupta Ankur Arora Amar Mukund S Rajesh Department of Radiology Institute of Liver and Biliary Sciences New Delhi 110070 India

We report a case of a 42-year-old male with symptomatic choledochocele and incidental pancreas divisum diagnosed with magnetic resonance cholangiopancreatography (MRCP). Small choledochocele is rare congenital malformation associated with non-specific symptoms and a delay in diagnosis. The coexistence of choledochocele and pancreas divisum is extremely rare with only two case reports published in literature. In both cases MRCP failed to diagnose any biliary or pancreatic abnormality. This case suggests that the patients with recurrent abdominal pain and pancreas divisum should not be presumed to be suffering from pancreatitis. Careful evaluated for additional anomalies in the biliary tree should be sought for refractory symptoms. MRCP is a useful one-stop-shop for diagnosing pancreatic and biliary ductal anomalies.

关键词： Choledochocele Pancreas divisum Magnetic resonance cholangiopan-creatography Pancreaticand biliary ductal anomalies Pancreatitis

Effect of fibrinolytic therapy on ST-elevation myocardial infarction clinical outcomes during the COvID-19 pandemic:A systematic review and meta-analysis

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World Journal of Cardiology 2023年第6期15卷 309-323页

作者： Anwar Khedr Hussam Al Hennawi Muhammed Khuzzaim Khan Mostafa Elbanna Abbas B Jama Ekaterina Proskuriakova Hisham Mushtaq Mikael Mir Sydney Boike Ibtisam Rauf Aalaa Eissa Meritxell Urtecho Thoyaja Koritala nitesh Jain Lokesh Goyal Salim Surani Syed A Khan Department of Internal Medicine BronxCare Health SystemBronxNY 10457United States Department of Internal Medicine Jefferson Abington HospitalAbingtonPA 19001United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200Pakistan Department of Internal Medicine Rochester Regional HealthRochesterNY 14621United States Department of Critical Care Mayo Clinic Health SystemMankatoMN 56001United States Department of Internal Medicine Mount Sinai HospitalChicagoIL 60608United States Department of Internal Medicine St.Vincent's Medical CenterBridgeportCT 06606United States Department of Medicine University of MinnesotaMinneapolisMN 55455United States Department of Medicine St.George's UniversitySchool of MedicineSt George SW170REGrenada Department of Medicine KFS UniversityKFS 33511Egypt Department of Medicine Robert D and Patricia E.Kern Center of Health Care DeliveryMayo ClinicRochesterMN 55905United States Department of Hospital Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Hospital Medicine Christus Sphon Hospital-shorelineCorpus ChristoTX 78404United States Department of Pulmonary Critical Care&Sleep MedicineTexas A&M UniversityCollege StationTX 77843United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States

BACKGROUND ST-elevation myocardial infarction(STEMI)is the result of transmural ischemia of the myocardium and is associated with a high mortality *** percutaneous coronary intervention(PPCI)is the recommended first-line treatment strategy for patients with *** timely delivery of PPCI became extremely challenging for STEMI patients during the coronavirus disease 2019(COvID-19)pandemic,leading to a projected steep rise in *** delays were overcome by the shift from first-line therapy and the development of modern fibrinolytic-based *** is unclear whether fibrinolytic-based reperfusion therapy is effective in improving STEMI *** To determine the incidence of fibrinolytic therapy during the COvID-19 pandemic and its effects on STEMI clinical *** PubMed,Google Scholar,Scopus,Web of Science,and Cochrane Central Register of Controlled Trials were queried from January 2020 up to February 2022 to identify studies investigating the effect of fibrinolytic therapy on the prognostic outcome of STEMI patients during the *** outcomes were the incidence of fibrinolysis and the risk of all-cause *** were meta-analyzed using the random effects model to derive odds ratios(OR)and 95%confidence *** assessment was carried out using the Newcastle-Ottawa *** Fourteen studies including 50136 STEMI patients(n=15142 in the pandemic arm;n=34994 in the pre-pandemic arm)were *** mean age was 61 years;79%were male,27%had type 2 diabetes,and 47%were *** with the pre-pandemic period,there was a significantly increased overall incidence of fibrinolysis during the pandemic period[OR:1.80(1.18 to 2.75);I2=78%;P=0.00;GRADE:very low].The incidence of fibrinolysis was not associated with the risk of all-cause mortality in any *** countries with a low-and middle-income status reported a higher incidence of fibrinolysis[OR:5.16(2.18 to 12.22);I2=81%;P=0.00;GRADE:very lo

关键词： ST-elevation myocardial infarction Myocardial infarction Thrombolytic therapy Fibrinolysis COvID-19 Pandemics