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Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 673-678页

作者： Apurba Sarker Apu Mahmuda Sultana Liza A.T.M.Jamaluddin Md.Amran Howlader Repon Kumer Saha Farhana Rizwan nishat nasrin Department of Pharmacy East West University

Objective:To investigate the bioactivities of crude n-hexane,ethyl acetate and methanol extracts of aerial part of Boerhavia diffusa Linn.(***) and its phytochemical ***: the identification of phyloconstituents and assay of antioxidant,thrombolytic,cytotoxic, antimicrobial activities were conducted using specific standard in vitro ***:The results showed that the plant extracts were a rich source of *** extract showed higher antioxidant,thrombolytic activity and less cytotoxic activity than those of n-hexane and ethyl acetate extracts of A *** the bioactivities,antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of natural *** case of antimicrobial screening,crude extracts of the plant showed remarkable antibacterial activity against tested *** the extracts showed significant inhibitory activity against Candida albicuns,at a concentration of 1000 μg/***:The present findings suggest that,the plant widely available in Bangladesh,could be a prominent source of medicinally important natural compounds.

关键词： Boerhavia diffusa Antioxidant Cytotoxic Thrombolytic Antimicrobial DPPH NO

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A Comparative Phytochemical and Biological Study between Different Solvent Extracts of <i>Bombax ceiba </i>Roots Available in Bangladesh

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Pharmacology & Pharmacy 2018年第2期9卷 53-66页

作者： Nazia Hoque Sabera Rahman Ishrat Jahan Meena Afroze Shanta Nigar Sultana Tithi nishat nasrin Department of Pharmacy East West University Dhaka Bangladesh

Use of different solvent systems for extraction of plant materials may cause variation in their bioactivities. The present study was conducted to evaluate the presence of different phytoconstituents and to compare in vitro bioactivities of petroleum ether, dichloromethane (DCM) and methanol extracts of Bombax ceiba (B. ceiba) roots available in Bangladesh. Preliminary phytochemical screening was conducted using specific standard procedure. Antioxidant activity of the extracts was evaluated using DPPH radical scavenging assay. Determination of total phenolic and flavonoid content was also carried out. Antibacterial and cytotoxic activities were investigated using disc diffusion method and brine shrimp lethality bioassay, respectively. All the experiments were carried out from February 2016 to September 2016. Phytochemical evaluation revealed the presence of alkaloids, terpenoids, carbohydrates, tannins, flavonoids, saponins and steroids. The methanol extract showed the highest DPPH radical scavenging activity and had the highest phenolic (187.42 ± 3.77 mg/g, GAE) and flavonoid content (74.67 ± 4 mg/g, QE) followed by the DCM and petroleum ether extracts. The extracts showed positive correlation between DPPH radical scavenging activity with the phenolic and flavonoid content. All the extracts showed mild to moderate in vitro antibacterial activity with zone of inhibition ranging from 7 mm to 13 mm. In brine shrimp lethality bioassay, the observed LC50 values for petroleum ether, DCM and methanol extracts were 70.72 μg/ml, 37.72 μg/ml and 22.58 μg/ml, respectively which revealed strong cytotoxic potential of the extracts compared to the positive control. The results indicated that B. ceiba roots could be a very potent source of natural radical scavenger and cytotoxic agent.

关键词： Bombax ceiba antioxidant activity DPPH antibacterial activity cytotoxic effect

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