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Relativistic Quantum Mechanical Condition for Expansion of the Universe

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Journal of High Energy Physics, Gravitation and Cosmology 2021年第3期7卷 1049-1088页

作者： nishant Kumar sharma S.B. SGOVT.P G College Kumaun University Nainital India

In this manuscript, we will discuss about the quantum mechanical system for the movement of non-intractable particle, non-intractable particle which attends every mass state in the universe, the form of a non-intractable particle is n = -m, this manuscript defines the stable cross system for the movement of n-i particles and elementary particles with a perfect black body at centre with proofs of picture of super massive black hole, the linear hamiltonian of the cross quantum mechanical system and with this, it’s co-related matrixes, then by the use of cross system of Non-Intractable Particles defining a new right angel theorem. Then the new black body relation free from plank constant depends on non interactive mechanics and m, which has already mentioned in non-interactive mechanics and it’s relation with galaxies. The unique property of cross system is that it is surrounded by the energy of 10e + e always, and at last the relation between zero point energy and dark energy.

关键词： Riemannian Geometry Euclidean Geometry Right Angel Theorem Factors for the Expansion of Universe Black Body Radiation Cosmic Form of the nishant Effect

Assessment of long-term climate variability and its impact on the decadal growth of horticultural crops in central India

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Ecological Processes 2022年第1期11卷 862-889页

作者： Gaurav sharma Amita sharma nishant Kumar Sinha Om Prakash sharma Ashutosh Singh Ajai Kumar Pandey Abhishek Kumar Sudhir Kumar Trivedi Bharti Sao Mukesh Kumar Sahu College of Horticulture and Forestry Rani Lakshmi Bai Central Agricultural UniversityJhansiUttar Pradesh 284003India Department of Environmental Science Rajmata Vijayaraje Scindia Krishi VishwavidyalayaGwaliorMadhya Pradesh 474002India Division of Soil Physics Indian Institute of Soil ScienceBhopalMadhya Pradesh 462038India Department of Floriculture and Landscape Architecture Indira Gandhi Krishi VishwavidyalayaRaipurChhattisgarh 492012India

Background:The impact of climate change on horticultural production is of utmost concern *** such vulnerable region of horticultural importance is the Madhya Pradesh state in the central part of *** is crucial to analyse the long-term trend in climatic variations and its effect on horticultural crop ***,this study focuses on detecting trends in mean annual precipitation and temperature of 115 years for the 15 districts covering all the regions of the state as well as projections of all the Representative Concentration Pathway(RCP)climatic scenarios for 2050 and 2080 of Madhya Pradesh *** decadal(2010–2020)insight into the area and production of horticultural crops is undertaken which will help forecasting the future growth *** a better insight,case study on four horticultural crops is undertaken to assess their decadal growth trend vis-à-vis climate parameters in these 15 ***:The Mann–Kendall test for 1901–2016 and Sen’s slope indicated a non-significant change in long-term trend for precipitation except for increasing change in Khargone and decreasing change in Rewa ***-cant increasing trend of average temperature is obtained for Hoshangabad,Jabalpur,Sagar and Rewa *** Sen’s slope indicated an increase of 0.005 to 0.009℃for maximum temperature and 0.005 to 0.012℃for minimum temperature *** projections of all the RCP climate scenarios for the years 2050 and 2080 indicated non-significant variation in precipitation but an increase in maximum(1.4 to 4.1℃)and minimum(1.45 to 4.65℃)annual *** increasing trend in area and production for horticultural crops is also observed in central India for the study *** is yield increase in all the crops selected in case study except for potato,which recorded a decreased yield between the years 2010–***:The Mann–Kendall test and projections indicate towards climate change with a temperature *** the decad

关键词： Climate change Horticulture Madhya Pradesh Precipitation Temperature Trend analysis

Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations

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Journal of Pharmaceutical Analysis 2015年第1期5卷 18-26页

作者： nishant A.Dafale Uttam P.Semwal Piyush K.Agarwal Pradeep sharma G.N.Singh Microbiology Division Indian Pharmacopoeia Commission

The aim of this study was to develop and validate a simple,sensitive,precise and cost-effective onelevel agar diffusion（5＋1） bioassay for estimation of potency and bioactivity of Levofioxacin in pharmaceutical preparation which has not yet been reported in any *** 16 microbial *** pumilus ATCC-14884 was selected as the most significant strain against *** was optimized by investigating several factors such as buffer pH,inoculums concentration and reference standard *** of Levofioxacin in commercial sample Levoflox tablet was done by FTIR *** potency recovery value for Levofioxacin in Levoflox tablet was estimated as 100.90%.A validated bioassay method showed linearity（r^2 = 0.988）,precision（Interday RSD=1.05%,between analyst RSD=1.02%） and accuracy（101.23%,RSD=0.72%）.Bioassay was correlated with HPLC using same sample and estimated potencies were 100.90% and 99.37%.*** show that bioassay is a suitable method for estimation of potency and bioactivity of Levofioxacin pharmaceutical preparations.

关键词： Levofloxacin Antibiotic resistance Microbiological bioassay HPLC Pharmacopoeia

Biotransformation,multifunctional recycling mechanism of nanostructures,and evaluation of the safety of nanoscale materials

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Particuology 2023年第11期82卷 76-86页

作者： Debjyoti Talukdar Parveen Kumar Benu Chaudhary Deepak sharma nishant Yadav Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Waleed Hassan Almalki Sami IAlzarea Imran Kazmi Ashutosh Pareek Gaurav Gupta Madan Mohan Gupta Department of Medical Research Armenian Russian International University“Mkhitar Gosh”YerevanArmenia Shri Ram College of Pharmacy KarnalHaryanaIndia Guru Gobind Singh College of Pharmacy YamunanagarHaryanaIndia Department of Pharmaceutical Technology SOMSAdamas UniversityBarasat-Barracpore RoadKolkataWest BengalIndia B.S.Anangpuria Institute of Pharmacy FaridabadHaryanaIndia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl Kharj11942Saudi Arabia Department of Pharmacology College of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakaAl-JoufSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Banasthali VidyapithBanasthali-RajasthanIndia School of Pharmacy Suresh Gyan Vihar UniversityJagatpura302017Mahal RoadJaipurIndia Department of Pharmacology Saveetha Dental CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal UniversityDehradunIndia School of Pharmacy Faculty of Medical SciencesThe University of the West IndiesSt.AugustineTrinidad and Tobago

Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics;which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.

关键词： Nanostructure Nanoparticle Biotransformation Toxiceffect Environmental risk

Compatibility studies of the Thiocolchicoside with Eudragit RLPO,Eudragit E100 and Eudragit L100 using thermal and non-thermal methods

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Drug Combination Therapy 2022年第1期4卷 1-9页

作者： nishant Thakur Bhupinder Kaur Manish Goswami Chandan sharma University Institute of Pharma Sciences Chandigarh UniversityGharuanMohaliPunjab140413India Saraswati College of Pharmacy GharuanMohaliPunjab140413India

Aim:Thiocolchicoside is a sulfur derivative of the colchicine widely used as the skeletal muscle relaxant in variety of muscle related *** of the Thiocolchicoside is screened with the Eudragit RLPO,Eudragit L-100 and Eudragit E-100 for checking its suitability for formulating as transdermal drug delivery ***:The binary mixtures of the drug and polymers were placed in the Petri plates and the temperature and humidity were adjusted at 40℃±2℃ and 75%relative *** drug and polymer mixture were examined on the FTIR and DSC for detection of any possible physical and chemical ***:Eudragit E100 and L100showed no significant interaction with the Thiocolchicoside and that was justified with differential scanning calorimetryand Fourier transform ***,Eudragit RLPO showed a slight interaction with the drug during the compatibility studies.

关键词： Thiocolchicoside Relative humidity Eudragit Compatibility Fourier transform infrared Differential scanning calorimetry

Review of X-ray and computed tomography scan findings with a promising role of point of care ultrasound in COVID-19 pandemic

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World Journal of Radiology 2020年第9期12卷 195-203页

作者： Darshan Gandhi Kriti Ahuja Hemal Grover Pranav sharma Shantanu Solanki nishant Gupta Love Patel Department of Radiology Northwestern Memorial HospitalChicagoIL 60611United States Department of Internal Medicine John H Stroger Jr.Hospital of Cook CountyChicagoIL 60612United States Department of Diagnostic Radiology Icahn School of Medicine at Mount Sinai WestNew YorkNY 10029United States Department of Diagnostic Radiology Vascular and Interventional RadiologyUniversity of Minnesota Medical CenterMinneapolisMN 55455United States Department of Internal Medicine Guthrie Robert Packer HospitalSayrePA 18840United States Department of Radiology Bassett HealthcareCooperstownNY 13326United States Division of Hospital Medicine Abbott Northwestern HospitalAllina HealthMinneapolisMN 55407United States

As healthcare professionals continue to combat the coronavirus disease 2019(COVID-19)infection worldwide,there is an increasing interest in the role of imaging and the relevance of various *** imaging not only helps assess the disease at the time of diagnosis but also aids evaluation of response to management,it is critical to examine the role of different modalities currently in use,such as baseline X-rays and computed tomography scans *** this article,we will draw attention to the critical findings for the ***,we will look at point of care ultrasound,an increasingly a popular tool in diagnostic medicine,as a component of COVID-19 management.

关键词： X-ray Computed tomography Point of care ultrasound COVID-19 Coronavirus Wuhan

Ipsilateral simultaneous fracture of the trochlea involving the lateral end clavicle and distal end radius：a rare combination and a unique mechanism of injury

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Chinese Journal of Traumatology 2014年第4期17卷 246-248页

作者： RK Gupta Raj Singh Vinit Verma Amit Batra nishant Setia Paritosh Gogna Jeetesh Gawande Department of Orthopaedics Pt.BD Sharma Post Graduate Institute of Medical Sciences Department of Orthopaedics Civil Hospital Campus Rohtak Rohtak Haryana 124001 India

Isolated trochlea fracture in adults is a rare surgical entity as compared to its capitellar *** has been only mentioned sporadically in the literature as case *** of the trochlea is accompanied by other elbow injuries like elbow dislocation,capitellum fracture,ulnar fracture and extraarticular condylar *** we report a unique case of isolated displaced trochlea fracture associated with fractures of the lateral end clavicle and the distal end *** propose a unique mechanism for this rare combination of injuries：typical triad of injury,*** of the distal end radius with trochlea and fracture of the lateral end of the *** treatment is recommended for undisplaced humeral trochlea fractures;but for displaced ones,anatomical reduction and internal fixation are essential to maintain the congruous trochleacoronoid articulation and hence to maintain the intrinsic stability of the elbow.

关键词： Isolated trochlea fracture Clavicle Radius fractures