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A knowledge integration strategy for the selection of a robust multi-stress biomarkers panel for Bacillus subtilis

Synthetic and Systems Biotechnology 2023年第1期8卷 97-106页

作者： Yiming Huang nishant sinha Anil Wipat Jaume Bacardit Interdisciplinary Computing and Complex BioSystems(ICOS)Group School of ComputingNewcastle UniversityUK Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaUSA

One challenge in the engineering of biological systems is to be able to recognise the cellular stress states of bacterial hosts,as these stress states can lead to suboptimal growth and lower yields of target *** enable the design of genetic circuits for reporting or mitigating the stress states,it is important to identify a relatively reduced set of gene biomarkers that can reliably indicate relevant cellular growth states in *** advances in high-throughput omics technologies have enhanced the identification of molecular biomarkers specific states in bacteria,motivating computational methods that can identify robust biomarkers for experimental characterisation and *** on identifying gene expression biomarkers to sense various stress states in Bacillus subtilis,this study aimed to design a knowledge integration strategy for the selection of a robust biomarker panel that generalises on external datasets and *** developed a recommendation system that ranks the candidate biomarker panels based on complementary information from machine learning model,gene regulatory network and co-expression *** identified a recommended biomarker panel showing high stress sensing power for a variety of conditions both in the dataset used for biomarker identification(mean f1-score achieved at 0.99),as well as in a range of independent datasets(mean f1-score achieved at 0.98).We discovered a significant correlation between stress sensing power and evaluation metrics such as the number of associated regulators in a *** gene regulatory network(GRN)and the number of associated modules in a *** co-expression network(CEN).GRNs and CENs provide information relevant to the diversity of biological processes encoded by biomarker *** demonstrate that quantitatively relating meaningful evaluation metrics with stress sensing power has the potential for recognising biomarkers that show better sensitivity and robustness to an exte

关键词： Transcriptomics analysis System biology Biomarker discovery Machine learning

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Assessment of long-term climate variability and its impact on the decadal growth of horticultural crops in central India

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Ecological Processes 2022年第1期11卷 862-889页

作者： Gaurav Sharma Amita Sharma nishant Kumar sinha Om Prakash Sharma Ashutosh Singh Ajai Kumar Pandey Abhishek Kumar Sudhir Kumar Trivedi Bharti Sao Mukesh Kumar Sahu College of Horticulture and Forestry Rani Lakshmi Bai Central Agricultural UniversityJhansiUttar Pradesh 284003India Department of Environmental Science Rajmata Vijayaraje Scindia Krishi VishwavidyalayaGwaliorMadhya Pradesh 474002India Division of Soil Physics Indian Institute of Soil ScienceBhopalMadhya Pradesh 462038India Department of Floriculture and Landscape Architecture Indira Gandhi Krishi VishwavidyalayaRaipurChhattisgarh 492012India

Background:The impact of climate change on horticultural production is of utmost concern *** such vulnerable region of horticultural importance is the Madhya Pradesh state in the central part of *** is crucial to analyse the long-term trend in climatic variations and its effect on horticultural crop ***,this study focuses on detecting trends in mean annual precipitation and temperature of 115 years for the 15 districts covering all the regions of the state as well as projections of all the Representative Concentration Pathway(RCP)climatic scenarios for 2050 and 2080 of Madhya Pradesh *** decadal(2010–2020)insight into the area and production of horticultural crops is undertaken which will help forecasting the future growth *** a better insight,case study on four horticultural crops is undertaken to assess their decadal growth trend vis-à-vis climate parameters in these 15 ***:The Mann–Kendall test for 1901–2016 and Sen’s slope indicated a non-significant change in long-term trend for precipitation except for increasing change in Khargone and decreasing change in Rewa ***-cant increasing trend of average temperature is obtained for Hoshangabad,Jabalpur,Sagar and Rewa *** Sen’s slope indicated an increase of 0.005 to 0.009℃for maximum temperature and 0.005 to 0.012℃for minimum temperature *** projections of all the RCP climate scenarios for the years 2050 and 2080 indicated non-significant variation in precipitation but an increase in maximum(1.4 to 4.1℃)and minimum(1.45 to 4.65℃)annual *** increasing trend in area and production for horticultural crops is also observed in central India for the study *** is yield increase in all the crops selected in case study except for potato,which recorded a decreased yield between the years 2010–***:The Mann–Kendall test and projections indicate towards climate change with a temperature *** the decad

关键词： Climate change Horticulture Madhya Pradesh Precipitation Temperature Trend analysis

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Telemedicine and public health–pearls and pitfalls

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World Journal of Methodology 2025年第2期15卷 177-179页

作者： Ranjeet Kumar sinha Sony sinha Prateek nishant Arvind Kumar Morya Arshi Singh Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology Guru Nanak Eye CenterNew Delhi 110001India

We hereby comment on the interesting systematic review by Grewal et al where they have provided an overall picture of the current status of available tele-health programs in the United States with emphasis on the Amazon *** analysis is an appreciable effort in discovering the features available and features lacking in these tele-health *** concept of tele-health originated to curtail the need for physical attendance of patients at health clinics,and has been beneficial during the coronavirus disease 2019 *** implore that the pearls and pitfalls of these programs have to be understood by policymakers prior to forming a consensus regarding the availability,accessibility and affordability of these programs as methods of healthcare *** proliferation of tele-health programs in their current form may pose threats to patient and provider safety and medicolegal ***,patients and providers must work together to improve them to meet their expectations and enable them to provide the best care for the ailing public.

关键词： Telemedicine Remote Access Availability Accessibility Affordability Ethics Privacy Medicolegal liability

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Bidirectional link between periodontitis and systemic inflammation in diabetic retinopathy

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World Journal of Diabetes 2024年第7期15卷 1651-1653页

作者： Prateek nishant Sony sinha Ranjeet Kumar sinha Arvind Kumar Morya Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

Periodontitis is independently associated with numerous lifestyle *** patients have approximately threefold increased odds of periodontitis,which in turn increases the risk of systemic *** study by Thazhe Poyil et al is an effort to establish the inflammatory link between diabetic retinopathy(DR)and periodontitis based on the periodontal inflamed surface area in diabetic patients with and without *** further advance the study,we suggest refining the eligibility criteria to explicitly state the clinical correlates of periodontitis and DR,larger sample size and improved sampling methodology,matching of baseline characteristics of the two groups,as well as improved statistical approach and interpretation of the study *** of hemoglobin A1c(HbA1c)in studies comparing type 2 diabetes mellitus patients with DR of matched severity with and without periodontitis could provide a clearer picture of whether HbA1c level is indeed influenced by periodontitis.

关键词： Glucose intolerance Hyperglycemia Inflammation Research methodology Vision

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Nutrition interventions and clinical outcomes of pregnant women with gestational diabetes mellitus: More than meets the eye

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World Journal of Diabetes 2024年第1期15卷 126-128页

作者： Sony sinha Prateek nishant Ranjeet Kumar sinha Arvind Kumar Morya Ripunjay Prasad Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Ophthalmology ESIC Medical CollegePatnaPatna 801103BiharIndia Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001DelhiIndia

In the retrospective study by Luo et al regarding clinical outcomes in gestational diabetes mellitus(GDM),the results are statistically significant in favour of the benefits of individualized nutrition interventions enumerated *** study has provided important evidence to improve maternal and child health in the Asian *** methods,however,appear to have considerable limi-tations,wherein the time point of diagnosis of GDM,severity of GDM,selection bias,compliance to therapy,important maternal covariates,observable microvascular abnormalities and the confounding effect of added insulin have not been *** have provided suggestions to improve the external validity of the study,including the use of Equator Network reporting guidelines and inclusion of overweight and obese patients in future studies.

关键词： Glucose intolerance Hyperglycemia Obesity Pregnancy Research methodology

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Relationship between age and subfoveal choroidal thickness and its clinical implications

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World Journal of Diabetes 2024年第11期15卷 2251-2254页

作者： Sony sinha Prateek nishant Arvind K Morya Arshi Singh Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology Guru Nanak Eye CentreNew Delhi 110001New DelhiIndia

The retrospective study by Lei et al is an investigation of the relationship between age and subfoveal choroidal thickness(SFCT)in Chinese patients with proliferative diabetic *** of the study design prevent the generalizability of the study findings,limiting their clinical *** recommend consideration of stricter eligibility criteria,other variables like duration of diabetes,interpretation of gender-differences in SFCT,longitudinal follow-up,use of newer choroidal flow indices,comparison of values with normal controls,subgroup analysis to determine the effect of prior treatment,as well as consideration of various real-world scenarios in future studies.

关键词： Diabetic retinopathy Optical coherence tomography Phenotypic sex Research design Visual acuity

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Intraocular lens selection in diabetic patients:How to increase the odds for success

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World Journal of Diabetes 2024年第6期15卷 1199-1211页

作者： Arvind Kumar Morya Prateek nishant Prasanna Venkatesh Ramesh Sony sinha Aarti Heda Sarika Salodia Ripunjay Prasad Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology ESIC Medical CollegePatna 801113BiharIndia Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Ophthalmology National Institute of OphthalmologyPune 411000MaharashtraIndia Department of Safety Global Medical SafetyLundbeckSingapore 307591Singapore Department of Ophthalmology RP Eye InstituteDelhi 110001India

The incidence of cataracts is significantly higher in diabetic individuals,particularly in younger age groups,with rates quadrupled in those under 65 and doubled in those over 65 compared to *** surgery in diabetic patients poses many challenges:Poor epithelial healing,decreased corneal sensitivity,increased central corneal thickness,decreased endothelial cell count,variable topography,poor pupillary dilatation,anterior capsular phimosis,posterior capsular opacification(PCO),chances of progression of diabetic retinopathy(DR),zonular weakness,and vitreous prolapse and diabetic macular *** of an appropriate intraocular lens(IOL)is crucial for visual rehabilitation and monitoring *** choice of IOL in diabetic cataract patients is a challenging ***-edge IOLs are favored for their capacity to mitigate PCO,whereas hydrophilic counterparts may incur calcification in the setting of proliferative *** advisability of premium IOLs for achieving spectacle independence warrants judicious evaluation,particularly in the presence of advanced *** IOL placement within the capsular bag is advocated to minimize postoperative *** preoperative assessment and informed patient counseling regarding IOL options are indispensable for optimizing surgical *** review article covers various aspects regarding the choice of IOLs in different case scenarios and complications in the diabetic population.

关键词： Diabetics Cataract Intraocular lens Diabetic retinopathy Diabetes mellitus

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Axenfeld-Reiger syndrome: A search for the missing links

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World Journal of Clinical Cases 2023年第29期11卷 7034-7042页

作者： Arvind Kumar Morya Prasanna Venkatesh Ramesh Sony sinha Prateek nishant Nazia Nain Ravi NaikRamavath Chetana Gone Ripunjay Prasad Department of Ophthalmology All India Institute of Medical SciencesBibi NagarHyderabad 508126TelanganaIndia Glaucoma Medical Officer Mahathma Eye Hospital Private LimitedThennurTrichy 620017Tamil NaduIndia Department of Ophthalmology-Vitreo-Retina and Oculoplasty All India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Ophthalmology All India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Ophthalmology RP Eye InstituteDelhi 110001DelhiIndia

BACKGROUND Axenfeld-Rieger syndrome(ARS)is a rare cause of congenital glaucoma and may result in loss of *** is mostly autosomal dominant in nature characterized by developmental abnormalities in the angle of anterior chamber and iris of the eye,also associated with structural abnormalities in the *** To study and observe the demographics and clinical findings in a very rare ocular disease known as *** Case records of symptomatic patients attending Ophthalmology outpatient department and diagnosed to have ocular hypertension or glaucoma in 3 years from March 2017 to March 2020 were evaluated to search for cases diagnosed with *** of all patients diagnosed with ARS were then analysed for demographic and clinical characterization as well as management and success of *** Eight out of ten patients with positive clinical signs were symptomatic and had *** of these patients had limbal stem cell deficiency and another had vernal *** Clinical characterization of ARS is important for making a definitive diagnosis and determining prognosis.

关键词： Axenfeld-Reiger Syndrome Glaucoma Limbal stem cell deficiency Vernal keratoconjuctivitis

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Intensive care unit-acquired weakness and mechanical ventilation:A reciprocal relationship

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World Journal of Clinical Cases 2024年第18期12卷 3644-3647页

作者： Ranjeet Kumar sinha Sony sinha Prateek nishant Arvind Kumar Morya Department of Community Medicine Patna Medical CollegeBiharPatna 800004India Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesBiharPatna 801507India Department of Ophthalmology ESIC Medical CollegeBiharPatna 801113India Department of Ophthalmology All India Institute of Medical SciencesTelanganaHyderabad 508126India

Intensive care unit-acquired weakness(ICU-AW;ICD-10 Code:G72.81)is a syndrome of generalized weakness described as clinically detectable weakness in critically ill patients with no other credible *** risk factors for ICU-AW include hyperglycemia,parenteral nutrition,vasoactive drugs,neuromuscular blocking agents,corticosteroids,sedatives,some antibiotics,immobilization,the disease severity,septicemia and systemic inflammatory response syndrome,multiorgan failure,prolonged mechanical ventilation(MV),high lactate levels,older age,female sex,and pre-existing systemic *** is a definite association between the duration of ICU stay and MV with ***,the interpretation that these are modifiable risk factors influencing ICU-AW,appears to be flawed,because the relationship between longer ICU stays and MV with ICU-AW is reciprocal and cannot yield clinically meaningful strategies for the prevention of *** strategies must be based on other risk *** multicentric randomized controlled trials as well as meta-analysis of such studies can be a more useful approach towards determining the influence of these risk factors on the occurrence of ICU-AW in different populations.

关键词： Critical illness Meta-analysis Morbidity Myopathy Polyneuropathy Risk factors

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Ophthalmic complications of injectable facial fillers

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World Journal of Clinical Cases 2024年第34期12卷 6736-6739页

作者： Prateek nishant Arvind Kumar Morya Sony sinha Ranjeet Kumar sinha Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia

The recently published mini-review article by Miotti et al is an effort to clarify various aspects regarding the choice between fat grafts and fillers in facial aesthetic *** of the complications associated with the administration of fillers is the possibility of vascular injury and spread of the dermal filler into the orbit,causing unexpected effects at a site distant from that of the initial injection,including ophthalmoplegia,ptosis and even visual *** vision loss following filler injection is a devastating complication,occurring in up to 0.0008%of *** greatest risk of this complication occurs with nasal augmentation,followed by glabellar wrinkle *** injected autologous fat predominantly occludes the proximal portion of the ophthalmic artery,hyaluronic acid fillers obstruct the ophthalmic artery comparatively *** interventions include thrombolysis,hyperbaric oxygen therapy,oral aspirin,cobamamide and acetazolamide and administration of ***,most studies show a poor prognosis in the form of partial or no recovery of ***,prevention is of paramount importance.A high index of suspicion is also warranted on the part of both those administering as well as receiving injections of facial fillers to prevent potentially vision-threatening complications of this seemingly innocuous procedure.

关键词： Adverse effects Blindness Cosmetic techniques Dermal drug administration Hyaluronic acid Iatrogenic disease

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