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Evaluation of atmospheric corrections on hyperspectral data with special reference to mineral mapping

Geoscience Frontiers 2017年第4期8卷 797-808页

作者： nisha rani Venkata Ravibabu Mandla Tejpal Singh Centre for Disaster Mitigation and Management(CDMM) VIT University OSGST-Lab Department of Environmental.Water Resources EngineeringSchool of Civil and Chemical EngineeringVIT University CSIR-Central Scientific Instruments Organisation

Hyperspectral images have wide applications in the fields of geology,mineral exploration,agriculture,forestry and environmental studies *** to their narrow band width with numerous ***,these images commonly suffer from atmospheric effects,thereby limiting their *** such a situation,atmospheric correction becomes a necessary pre-requisite for any further processing and accurate interpretation of spectra of different surface materials/*** the present study,two very advance atmospheric approaches *** and FLAASH have been applied on the hyperspectral remote sensing *** spectra of vegetation,man-made structure and different minerals from the Gadag area of Karnataka,were extracted from the raw image and also from the QUAC and FLAASH corrected *** spectra were compared among themselves and also with the existing USGS and JHU spectral *** is rigorous atmospheric algorithm and requires various parameters to perform but it has capability to compensate the effects of atmospheric *** absorption curves in any spectra play an important role in identification of the ***,the presence of unwanted absorption features can lead to wrong interpretation and identification of mineral *** also has an advantage of spectral polishing which provides smooth spectral curves which helps in accurate identification of composition of ***,this study recommends that FLAASH is better than QUAC for atmospheric correction and correct interpretation and identification of composition of any object or minerals.

关键词： Atmospheric correction Hyperspectral data Radiance Reflectance FLAASH QUAC

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Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3891-3904页

作者： Ping Bai Prasenjit Mondal Frederick A.Bagdasarian nisha rani Yan Liu Ashley Gomm Darcy R.Tocci Se Hoon Choi Hsiao-Ying Wey Rudolph E.Tanzi Can Zhang Changning Wang Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Genetics and Aging Research Unit McCance Center for Brain HealthMassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA

Although the epigenetic regulatory protein histone deacetylase 6(HDAC6)has been recently implicated in the etiology of Alzheimer’s disease(AD),little is known about the role of HDAC6 in the etiopathogenesis of AD and whether HDAC6 can be a potential therapeutic target for ***,we performed positron emission tomography(PET)imaging in combination with histopathological analysis to better understand the underlying pathomechanisms of HDAC6 in *** first developed[^(18)F]PB118 which was demonstrated as a valid HDAC6 radioligand with excellent brain penetration and high specificity to *** studies of[^(18)F]PB118 in 5xFAD mice showed significantly increased radioactivity in the brain compared to WT animals,with more pronounced changes identified in the cortex and *** translatability of this radiotracer for AD in a potential human use was supported by additional studies,including similar uptake profiles in non-human primates,an increase of HDAC6 in ADrelated human postmortem hippocampal tissues by Western blotting protein analysis,and our ex vivo histopathological analysis of HDAC6 in postmortem brain tissues of our ***,our findings show that HDAC6 may lead to AD by mechanisms that tend to affect brain regions particularly susceptible to AD through an association with amyloid pathology.

关键词： HDAC6 Alzheimer’s disease Radiotracer PET imaging Epigenetic

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