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Experimentally-Induced Inhibition of Growth in Melanoma Cell Cultures Separated by ~2 Kilometers When Both Share Excess Correlation Magnetic Fields: Macroscopic Evidence of Free-Space Quantum Teleportation?

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j.urnal of Signal and Information Processing 2015年第1期6卷 39-48页

作者： Lukasz M. Karbowski nirosha j. murugan Michael A. Persinger Behavioural Neuroscience and Biomolecular Sciences Programs Laurentian University Sudbury Canada

In multiple experiments plates of melanoma cells separated by either 3 m or 1.7 km were placed in the centers of toroids. A specific protocol of changing, angular velocity, pulsed magnetic fields that has been shown to produce excess correlation in photon durations and shift in proton concentrations (pH) in spring water were generated around both plates of cells. Serial inj.ctions of 50 μL of standard concentrations of hydrogen peroxide into the “local” plates of cells during the 12 min of field activation produced conspicuous cell death (reduction of viable cells by about 50%) with comparable diminishments of cell numbers in the non-local plates of cells within 24 hr but only if both loci separated by either 3 m or 1.7 km had shared the “excess correlation” magnetic field sequence. The non-local effect did not occur if the magnetic fields had not been present. Higher or lower concentrations of peroxide or concentrations that eliminated all of the cells or very few cells in the local dishes were associated with no significant diminishment of non-local cell growth. The data indicate that there must be a critical number of cells remaining viable following the local chemical reaction for the excess correlation to be manifested in the non-local cells. We suggest that this specific spatial-temporal pattern of fields generated within the paired toroidal geometries promotes transposition of virtual chemical reactions as an information field. Calculations of the energy available per cell and per volume of the quantity of reactants inj.cted into the local space from the intensity of the changing velocity toroidal magnetic field support previous measurements and derivations that the units of information transposition may involve discrete quantities that represent equivalents of photons, electrons and protons.

关键词： Excess Correlation Entanglement Malignant Cell Death Melanoma Cells Magnetic Fields Changing Angular Velocities Biophoton Emissions 10-20 j

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Cosic’s Resonance Recognition Model for Protein Sequences and Photon Emission Differentiates Lethal and Non-Lethal Ebola Strains: Implications for Treatment

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Open j.urnal of Biophysics 2015年第1期5卷 35-43页

作者： nirosha j. murugan Lukasz M. Karbowski Michael A. Persinger Bioquantum Laboratory Biomolecular Sciences and Behavioural Neuroscience Programs Laurentian University Sudbury Canada

The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or minimal numbers of human fatalities. The results clearly differentiated highly lethal and non-lethal strains. Solutions for the two lethal strains exhibited near ultraviolet (~230 nm) photon values while the two asymptomatic forms displayed near infrared (~1000 nm) values. Cross-correlations of spectral densities of the RRM values of the different classes of proteins associated with the genome of the viruses supported this dichotomy. The strongest coefficient occurred only between Sudan-Zaire strains but not for any of the other pairs of strains for sGP, the small glycoprotein that intercalated with the plasma cell membrane to promote insertion of viral contents into cellular space. A surprising, statistically significant cross-spectral correlation occurred between the “spike” glycoprotein component (GP1) of the virus that associated the anchoring of the virus to the mammalian cell plasma membrane and the Schumann resonance of the earth whose intensities were determined by the incidence of equatorial thunderstorms. Previous applications of the RRM to shifting photon wavelengths emitted by melanoma cells adapting to reduced ambient temperature have validated Cosic’s model and have demonstrated very narrowwave-length (about 10 nm) specificity. One possible ancillary and non-invasive treatment of people within which the fatal Ebola strains are residing would be whole body application of narrow band near-infrared light pulsed as specific physiologically-patterned sequences with sufficient radiant flux density to perfuse the entire body volume.

关键词： Cosic Resonance Recognition Model Ebola Virus Fatal vs Asymptomatic Forms Ultraviolet vs Infrared Photon Equivalents Schumann Resonance Cross-Spectral Analyses of Viral Proteins

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Seeking the Source of Transience for a Unique Magnetic Field Pattern That Completely Dissolves Cancer Cells <i>in Vitro</i>

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j.urnal of Biomedical Science and Engineering 2015年第8期8卷 531-543页

作者： Lukasz M. Karbowski nirosha j. murugan Stanley A. Koren Michael A. Persinger Behavioural Neuroscience and Biomolecular Sciences Programs Laurentian University Sudbury Canada

Purpose: Exposure to a particular pattern of weak (~3 to 5 μT) magnetic fields produced by computer-generated point durations within three-dimensions completely dissolved malignant cancer cells but not healthy cells. Biomolecular analyses and confocal microscopy indicated excessive expansion followed by contraction contributed to the “explosion” of the cell. However, after months of replicable effects, the phenomenon slowly ceased. Considering the potency of the complete dissolution of cancer cell lines after 5 days of 6.5-hour daily exposures and the implications for human treatment, the potential source of the disappearance of the effect was pursued by summarizing all of the 50 experiments and assessing the likely etiologies. Materials and Methods: B16-BL6, MDAMB 231 and MCF7 malignant cells and HSG, a non-malignant cell line, were exposed to a sham-field condition or to a specific pattern of computer-generated magnetic fields produced from converting different voltages, each with point durations of 3 ms to 3-D magnetic fields. Conclusion: The specific serial presentation of the two field patterns (one frequency modulated;the other amplitude and frequency modulated) completely dissolved malignant cells but not normal cells within a “zone” within the exposure volume at the conj.nction of the three planes of the applied magnetic fields. The affected cells underwent massive melanin production, expansion, contraction and “beading” of submembrane actin structures before fragmentation within this zone. However, this powerful all-or-none phenomenon may have been disrupted by moving the cells, excess mechanical agitation during exposure, or non-optimal point durations of the field parameters. Indirect effects from communication signals (WIFI) through line currents that operated the incubators could not be excluded.

关键词： Cancer Cells Normal Cells Point Duration Magnetic Fields Dissolution Effect MicroTesla Intensities Melanoma M16 cells Three-Dimensional Conj.nctive Fields

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Proteasome regulators in pancreatic cancer

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World j.urnal of Gastrointestinal Oncology 2022年第1期14卷 38-54页

作者： nirosha j.murugan Ioannis A Voutsadakis Department of Biology Algoma UniversitySault Sainte Marie P6A3T6ONCanada Department of Medical Oncology Sault Area HospitalSault Sainte Marie P6A3T6ONCanada

Pancreatic adenocarcinoma is one of the most lethal cancers with rising *** progress in its treatment,with the introduction of more effective chemotherapy regimens in the last decade,prognosis of metastatic disease remains inferior to other cancers with long term survival being the *** characterization of pancreatic cancer has elucidated the landscape of the disease and has revealed common lesions that contribute to pancreatic *** of proteostasis is critical in cancers due to increased protein turnover required to support the intense metabolism of cancer *** proteasome is an integral part of this regulation and is regulated,in its turn,by key transcription factors,which induce transcription of proteasome structural *** include FOXO family transcription factors,NFE2L2,hHSF1 and hHSF2,and *** that encompass proteasome regulators and transduction pathways dysregulated in pancreatic cancer such as the KRAS/BRAF/MAPK and the Transforming growth factor beta/SMAD pathway contribute to pancreatic cancer *** review discusses the proteasome and its transcription factors within the pancreatic cancer cellular *** also consider the role of stemness in carcinogenesis and the use of proteasome inhibitors as therapeutic agents.

关键词： Pancreatic adenocarcinoma Proteasome Transcription factors Regulation Unfolded protein response Cancer stem cells

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AcWRKY28 mediated activation of AcCPK genes confers salt tolerance in pineapple(Ananas comosus)

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Horticultural Plant j.urnal 2024年第2期10卷 398-412页

作者： Qiao Zhou Samaranayaka Vidana Gamage nirosha Priyadarshani Rongj.an Qin Han Cheng Tiantian Luo Myat Hnin Wai Mohammad Aqa Mohammadi Yanhui Liu Chang Liu Hanyang Cai Xiaomei Wang Yeqiang Liu Yuan Qin Lulu Wang Guangxi Key Lab of Sugarcane Biology State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of AgricultureGuangxi UniversityNanningGuangxi 530004China State Key Laboratory of Ecological Pest Control for Fuj.an and Taiwan Crops College of Life ScienceCollege of Plant ProtectionCollege of AgricultureCollege of HorticultureFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCenter for Genomics and BiotechnologyFujian Agriculture and Forestry UniversityFuzhouFujian 350002China Pingtan Science and Technology Research Institute of Fuj.an Agriculture and Forestry University PingtanFujian 350400China National Education Commission BMICHColombo00700Sri Lanka Fishery Multiplication Management Station of Lij.ang River Water Supply Hub Proj.ct GuilinGuangxi 541001China Horticulture Research Institute Guangxi Academy of Agricultural SciencesNanning Investigation Station of South Subtropical Fruit TreesMinistry of AgricultureNanningGuangxi 530007China

Unfavorable environmental cues severely affect crop productivity resulting in significant economic losses to farmers. In plants, multiple regulatory genes, such as the WRKY transcription factor (TF) family, modulate the expression of defense genes. However, the role of the pineapple WRKY genes is poorly understood. Here, we studied the pineapple WRKY gene, AcWRKY28, by generating AcWRKY28 over-expressing transgenic pineapple plants. Overexpression of AcWRKY28 enhanced the salt stress resistance in transgenic pineapple lines. Comparative transcriptome analysis of transgenic and wild-type pineapple plants showed that “plant-pathogen interaction” pathway genes, including 9calcium-dependent protein kinases (CPKs), were up-regulated in AcWRKY28 over-expressing plants. Furthermore, chromatin immunoprecipitation and yeast one-hybrid assays revealed AcCPK12, AcCPK3, AcCPK8, AcCPK1, and AcCPK15 as direct targets of AcWRKY28. Consistently, the study of AcCPK12 over-expressing Arabidopsis lines showed that AcCPK12 enhances salt, drought, and disease resistance. This study shows that AcWRKY28 plays a crucial role in promoting salt stress resistance by activating the expression of AcCPK genes.

关键词： Pineapple AcWRKY AcCPK Transcription factor Salt stress ChIP

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