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Journal of Biosciences and Medicines 2024年第1期12卷 161-172页

作者： Naveen Vithanage Cyrill James nirojan karunanathan Amandip Singh Rakkar General Medicine Tauranga Hospital Bay of Plenty Tauranga New Zealand Cardiology Department Wexford General Hospital Ireland Wexford Ireland School of Medicine University College Dublin Ireland Dublin Ireland

Central nervous system (CNS) vasculitis encompasses a broad range of diseases characterized by inflammation of blood vessels within the brain, spinal cord, and meninges. This review focuses on Primary Angiitis of the CNS (PACNS), a unique form affecting only the CNS without other organ involvement. PACNS primarily affects the small- and medium-sized arteries in the brain, leading to neurological symptoms. Early recognition and intervention are essential for optimal management. This case report of a 25-year-old male highlights the diagnostic challenges, where a multidisciplinary approach was necessary to diagnose PACNS, given initial negative results. The paper also explores the etiology and pathogenesis of PACNS and discusses the diagnostic criteria proposed by researchers. Medical professionals primarily base management strategies on induction and maintenance therapies, utilizing a combination of glucocorticoids and immunosuppressants as the standard treatment. However, the exact dosages and administration methods need further research due to the absence of randomized clinical trials. The review underscores the need for continued research to enhance diagnostic and treatment protocols, given the severity of PACNS.

关键词： Primary Angitis of Central Nervous System

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Atypical Manifestations of Systemic Lupus Erythematosus (SLE) in Elderly Men

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Journal of Biosciences and Medicines 2023年第6期11卷 135-139页

作者： Naveen Vithanage Ihsan Ul Haq nirojan karunanathan Colm Quigley Aidan Buckley Jabran Hasan Khan Internal Medicine Department Wexford General Hospital Wexford Ireland

This case report highlights the rare occurrence of SLE in an elderly male patient. Despite the unusual presentation, the team was able to make a diagnosis of SLE using a combination of an atypical clinical picture, with initial signs and symptoms of weight loss, anemia, leucopenia and arthlagia, in combination with investigation results, including a positive test for anti-dsDNA antibodies. A more indolent disease course, combined with non-specific initial manifestations and low prevalence within the elderly population, often leads to delayed diagnosis. This case underscores the importance of considering SLE in the differential diagnosis of elderly patients, even in those who do not fit the typical epidemiological profile.

关键词： SLE ANA Anti-dsDNA Antibodies C3

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