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Ineffective esophageal motility is associated with acute rejection after lung transplantation independent of gastroesophageal reflux

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World Journal of Gastroenterology 2023年第21期29卷 3292-3301页

作者： Wai-Kit Lo Brent Hiramoto Hilary J Goldberg nirmal sharma Walter W Chan Division of Gastroenterology Hepatology and EndoscopyBrigham and Women's HospitalBostonMA 02115United States Division of Pulmonary and Critical Care Medicine Brigham and Women's HospitalBostonMA 02115United States

BACKGROUND Gastroesophageal reflux is associated with poorer outcomes after lung transplant,likely through recurrent aspiration and allograft *** prior studies have demonstrated a relationship between impedance-pH results and transplant outcomes,the role of esophageal manometry in the assessment of lung transplant patients remains debated,and the impact of esophageal dysmotility on transplant outcomes is *** particular interest is ineffective esophageal motility(IEM)and its associated impact on esophageal *** To assess the relationship between pre-transplant IEM diagnosis and acute rejection after lung *** This was a retrospective cohort study of lung transplant recipients at a tertiary care center between 2007 and *** with pre-transplant anti-reflux surgery were *** and reflux diagnoses were recorded from pre-transplant esophageal function ***-to-event analysis using Cox proportional hazards model was applied to evaluate outcome of first episode of acute cellular rejection,defined histologically per International Society of Heart and Lung Transplantation *** not meeting this endpoint were censored at time of post-transplant anti-reflux surgery,last clinic visit,or ***’s exact test for binary variables and student’s t-test for continuous variables were performed to assess for differences between *** Of 184 subjects(54%men,mean age:58,follow-up:443 person-years)met criteria for *** pulmonary fibrosis represented the predominant pulmonary diagnosis(41%).During the follow-up period,60 subjects(33.5%)developed acute *** all-cause mortality was 16.3%.Time-to-event univariate analyses demonstrated significant association between IEM and acute rejection[hazard ratio(HR):1.984,95%CI:1.03-3.30,P=0.04],confirmed on Kaplan-Meier *** multivariable analysis,IEM remained independently associated with acute rejection,even after c

关键词： Ineffective esophageal motility Esophageal hypomotility Esophageal manometry Gastroesophageal reflux disease Lung transplantation Acute rejection

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Pre-Lung transplant reflux testing demonstrates high prevalence of gastroesophageal reflux in cystic fibrosis and reduces chronic rejection risk

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World Journal of Transplantation 2023年第4期13卷 138-146页

作者： Wai-Kit Lo Ryan Flanagan nirmal sharma Hilary J Goldberg Walter W Chan Division of Gastroenterology Hepatology and EndoscopyBrigham and Women's HospitalHarvard Medical SchoolBostonMA Division of Pulmonary and Critical Care Medicine Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115United States

BACKGROUND Gastroesophageal reflux(GER)has been associated with poor outcomes after lung transplantation for chronic lung disease,including increased risk of chronic *** is common in cystic fibrosis(CF),but factors influencing the likelihood of pre-transplant pH testing,and the impact of testing on clinical management and transplant outcomes in patients with CF are *** To evaluate the role of pre-transplant reflux testing in the evaluation of lung transplant candidates with *** This was a retrospective study from 2007-2019 at a tertiary medical center that included all patients with CF undergoing lung *** with pretransplant anti-reflux surgery were *** characteristics(age at transplantation,gender,race,body mass index),self-reported GER symptoms prior to transplantation,and pre-transplant cardiopulmonary testing results,were *** testing consisted of either 24-h pH-or combined multichannel intraluminal impedance and pH ***-transplant care included a standard immunosuppressive regimen,and regular surveillance bronchoscopy and pulmonary spirometry in accordance with institutional practice as well as in symptomatic *** primary outcome of chronic lung allograft dysfunction(CLAD)was defined clinically and histologically per International Society of Heart and Lung Transplantation *** analysis was performed with Fisher’s exact test to assess differences between cohorts,and time-to-event Cox proportional hazards *** After applying inclusion and exclusion criteria,a total of 60 patients were included in the *** all CF patients,41(68.3%)completed reflux monitoring as part of pre-lung transplant *** evidence of pathologic reflux,defined as acid exposure time>4%,was found in 24 subjects,representing 58%of the tested *** patients with pre-transplant reflux testing were older(35.8 vs 30.1 years,P=0.01)and more commonly reported typical

关键词： Cystic fibrosis Gastroesophageal reflux Lung transplantation pH monitoring

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Low-cost high entropy alloy(HEA)for high-efficiency oxygen evolution reaction(OER)

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Nano Research 2022年第6期15卷 4799-4806页

作者： Lalita sharma nirmal Kumar Katiyar Arko Parui Rakesh Das Ritesh Kumar Chandra Sekhar Tiwary Abhisek K.Singh Aditi Halder Krishanu Biswas School of Basic Sciences Advanced Materials Research Centre(AMRC)Indian Institute of Technology Mandi(H.P)KamandMandi 175005India Department of Materials Science and Engineering Indian Institute of Technology KanpurKanpur 208016India School of Engineering London South Bank UniversityLondonSE10 AAUK Materials Research Centre Indian Institute of ScienceBangalore 560012India Metallurgical and Materials Engineering Indian Institute of Technology KharagpurKharagpur 382355India

Oxygen evolution reaction(OER)is the key step involved both in water splitting devices and rechargeable metal-air batteries,and hence,there is an urgent need for a stable and low-cost material for efficient *** the present investigation,Co-Fe-Ga-NiZn(CFGNZ)high entropy alloy(HEA)has been utilized as a low-cost electrocatalyst for ***,after cyclic voltammetry activation,CFGNZ-nanoparticles(NPs)are covered with oxidized surface and form high entropy(oxy)hydroxides(HEOs),exhibiting a low overpotential of 370 mV to achieve a current density of 10 mA/cm^(2)with a small Tafel slope of 71 mV/*** alloy has higher electrochemical stability in comparison to state-of-the art RuO2 electrocatalyst as no degradation has been observed up to 10 h of *** electron microscopy(TEM)studies after 10 h of long-term chronoamperometry test showed no change in the crystal structure,which confirmed the high stability of *** density functional theory(DFT)based calculations show that the closeness of d(p)-band centers to the Fermi level(EF)plays a major role in determining active *** work highlights the tremendous potential of CFGNZ HEA for OER,which is the primary reaction involved in water splitting.

关键词： high entropy alloy cyclic voltammetry activation oxygen evolution reaction electrocatalyst nanocrystalline catalyst

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Thermo-Protective Role of 28-Homobrassinolide in <i>Brassica juncea</i>Plants

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American Journal of Plant Sciences 2014年第15期5卷 2431-2439页

作者： Sirhindi Geetika Kaur Harpreet Bhardwaj Renu Kaur nirmal Spal sharma Poonam Department of Botanical and Environmental Sciences GNDU Amritsar India Department of Botany Punjabi University Patiala India

The present work was undertaken to study the effects of 28-homobrassinolide on growth, stress markers, antioxidative enzyme [superoxide dismutase (EC 1.***.1.1), guaiacol peroxidase (EC 1.***.1.7), catalase (EC 1.***.1.6) ] activities and protein content in 10 days old seedlings of Brassica juncea L. treated with different degrees (4°C, 44°C) of temperature. 28-homobrassinolide at 10-9 M concentration lowered temperature stress. Different degrees of temperature treatment alone decreased the enzyme activities and protein concentration of seedlings. However, pre-sowing treatments of 28-homobrassinolide lowered the temperature stress and enhanced the contents of MDA and proline, activities of enzymes and protein concentration of seedlings.

关键词： Antioxidative Enzymes 28-Homobrassinolide Brassinosteroids Temperature Stress Lipid Peroxidation Guaiacol Peroxidase Catalase

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