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Fragility of statistically significant findings from randomized clinical trials of surgical treatment of humeral shaft fractures:A systematic review

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World Journal of Orthopedics 2022年第9期13卷 825-836页

作者： Stephen Craig Morris Anirudh K Gowd Avinesh Agarwalla Wesley P Phipatanakul nirav h amin Joseph N Liu Department of Orthopaedic Surgery Loma Linda UniversityLoma LindaCA 92354United States Department of Orthopaedic Surgery Wake Forest University Baptist Medical CenterWinston-SalemNC 27157United States Department of Orthopaedic Surgery Westchester Medical CenterValhallaNY 10595United States Department of Orthopaedic Surgery Premier Orthopaedic and Trauma SpecialistsPomonaCA 91767United States Department of Orthopedic Surgery USC Epstein Family Center for Sports MedicineLos AngelesCA 90089United States

BACKGROUND Despite recent meta-analyses of randomized controlled trials(RCTs),there remains no consensus regarding the preferred surgical treatment for humeral shaft *** fragility index(FI)is an emerging tool used to evaluate the robustness of RCTs by quantifying the number of participants in a study group that would need to switch outcomes in order to reverse the study *** To investigate the fragility index of randomized control trials assessing outcomes of operative fixation in proximal humerus *** We completed a systematic review of RCTs evaluating the surgical treatment of humeral shaft *** criteria included:articles published in English;patients randomized and allotted in 1:1 ratio to 2 parallel arms;and dichotomous outcome *** FI was calculated for total complications,each complication individually,and secondary surgeries using the Fisher exact test,as previously *** Fifteen RCTs were included in the analysis comparing open reduction plate osteosynthesis with dynamic compression plate or locking compression plate,intramedullary nail,and minimally invasive plate *** median FI was 0 for all parameters *** individual outcomes,the FI was 0 for 81/91(89%)of *** FI exceeded the number lost to follow up in only 2/91(2%)*** The FI shows that data from RCTs regarding operative treatment of humeral shaft fractures are fragile and does not demonstrate superiority of any particular surgical technique.

关键词： humerus fracture Open reduction internal fixation Intramedullary nail Fragility index Complications Fragility index

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Analysis of stress and failure in rock specimens with closed and open flaws on the surface

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Frontiers of Structural and Civil Engineering 2021年第5期15卷 1222-1237页

作者： amin MANOUChEhRIAN Pinnaduwa h.S.W.KULATILAKE School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

The influence of closed and open surface flaws on the stress distribution and failure in rock specimens is *** finite element models are developed to simulate the compression tests on flawed rock *** simulated specimens include those with closed flaws and those with open flaws on the *** analyses are conducted to investigate the influences of the flaw inclination,friction coefficient and the confining stress on failure *** results show significant differences in the stress,displacement,and failure behavior of the closed and open flaws when they are subjected to pure compression;however,their behaviors under shear and tensile loads are *** to the results,when compression is the dominant mode of stress applied to the flaw surface,an open flaw may play a destressing role in the rock and relocate the stress concentration and failure *** presented results in this article suggest that failure at the rock surface may be managed in a favorable manner by fabricating open flaws on the rock *** insights gained from this research can be helpful in managing failure at the boundaries of rock structures.

关键词： surface flaw heterogeneity circular hole numerical modeling relative displacement

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Calculation of hildebrand Solubility Parameters of Some Polymers Using QSPR Methods Based on LS-SVM Technique and Theoretical Molecular Descriptors

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Chinese Journal of Polymer Science 2014年第5期32卷 587-594页

作者： Nasser Goudarzi M.Arab Chamjangali A.h.amin Faculty of Chemistry Shahrood University of Technology

In this work, some chemometrics methods are applied for the modeling and prediction of the hildebrand solubility parameter of some polymers. A genetic algorithm （GA） method is designed for the selection of variables to construct two models using the multiple linear regression （MLR） and least square-support vector machine （LS-SVM） methods in order to predict the hildebrand solubility parameter. The MLR method is used to build a linear relationship between the molecular descriptors and the hildebrand solubility parameter for these compounds. Then the LS-SVM method is utilized to construct the non-linear quantitative structure-activity relationship （QSAR） models. The results obtained using the LS-SVM method are then compared with those obtained for the MLR method; it was revealed that the LS-SVM model was much better than the MLR one. The root-mean-square errors of the training set and the test set for the LS-SVM model were 0.2912 and 0.2427, and the correlation coefficients were 0.9662 and 0.9518, respectively. This paper provides a new and effective method for predicting the hildebrand solubility parameter for some polymers, and also reveals that the LS-SVM method can be used as a powerful chemometrics tool for the quantitative structure-property relationship （QSPR） studies.

关键词： hildebrand solubility parameter Least square-support vector machine (LS-SVM) Quantitative structure- property relationship (QSPR) Multiple linear regression (MLR) Genetic algorithm (GA).

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Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy,safety and cost-comparison

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World Journal of Gastroenterology 2013年第41期19卷 7106-7113页

作者： Atilla Ertan Irum Zaheer Arlene M Correa nirav Thosani Shanda h Blackmon Ertan Digestive Disease Center Memorial Hermann HospitalTexas Medical CenterHoustonTX 77030United States Division of Gastroenterology Hepatology and NutritionThe University of Texas Health Science Center at HoustonHoustonTX 77030United States Division of Gastroenterology The Methodist HospitalHoustonTX 77030United States Division of Thoracic and Cardiovascular Surgery The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Surgery The Methodist HospitalHoustonTX 77030United States

AIM:To compare effectiveness,safety,and cost of photodynamic therapy(PDT)and radiofrequency ablation(RFA)in treatment of Barrett’s dysplasia(BD).METhODS:Consecutive case series of patients undergoing either PDT or RFA treatment at single center by a single investigator were ***-three patients with high-grade dysplasia(hGD)had treatment with porfimer sodium photosensitzer and 630 nm laser(130 J/cm),with maximum of 3 treatment ***-three patients with BD(47 with low-grade dysplasia-LGD,6 with hGD)had step-wise circumferential and focal ablation using the hALO system with maximum of 4 treatment *** groups received proton pump inhibitors twice *** biopsies were acquired at 2 and 12 mo after enrollment,with 4-quadrant biopsies every 1 cm of the original BE extent.A complete histological resolution response of BD(CR-D)was defined as all biopsies at the last endoscopy session negative for ***’s exact test was used to assess differences between the two study groups for primary *** all outcomes,a two-sided P value of less than 0.05 was considered to indicate statistical ***:Thirty(91%)PDT patients and 39(74%)RFA were men(P=0.05).The mean age was 70.7±12.2 and 65.4±12.7(P=0.10)year and mean length of BE was 5.4±3.2 cm and 5.7±3.2 cm(P=0.53)for PDT and RFA patients,*** CR-D was(18/33)54.5%with PDT vs(47/53)88.7%with RFA(P=0.001).One patient with PDT had an esophageal perforation and was managed with non-surgical measures and no perforation was seen with *** was five times more costly than RFA at our *** two groups were not randomized and had different BD grading are the limitations of the ***:In our experience,RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of BD.

关键词： Barrett’s esophagus Dysplasia Photodynamic therapy Radiofrequency ablation Cost comparison

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Numerical study on rock failure around a tunnel destressed by a conceptualized notched technique

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Underground Space 2022年第6期7卷 1086-1097页

作者： amin Manouchehrian Pinnaduwa h.S.W.Kulatilake School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

A destressing method for reducing the strainburst risk in burst-prone grounds is *** this method,the rock is destressed by cutting notches at the excavation ***,the concept of the proposed method is described both analytically and ***,the method is applied to a tunneling *** numerical models are built to study the destressing process and the failure mechanism around a circular *** show that when the notch is added to the model,the rock at the tunnel wall is destressed,and the stress concentration zones shift to a farther distance away from the ***,the analysis of the failure zone around the tunnel and the velocity of the failed elements show that the failure in the notched tunnel is less violent compared to that in the tunnel without the ***,a parametric study is conducted to investigate the influences of the notch dimensions on the stress distribution,deformation,and failures around the tunnel.

关键词： Strainburst Destressing Deep excavation Notched tunnel Rock violent failure

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The fractional features of a harmonic oscillator with position-dependent mass

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Communications in Theoretical Physics 2020年第5期72卷 13-20页

作者： Dumitru Baleanu amin Jajarmi Samaneh Sadat Sajjadi h Asad Department of Mathematics Faculty of Arts and SciencesCankaya University06530 AnkaraTurkey Institute of Space Sciences PO Box MG–23R 76900Magurele–BucharestRomania Department of Electrical Engineering University of BojnordPO Box 94531–1339BojnordIran Department of Electrical and Computer Engineering Hakim Sabzevari UniversitySabzevarIran Palestine Technical University College of Arts and SciencesDepartment of PhysicsPO Box 7 TulkarmPalestine

In this study,a harmonic oscillator with position-dependent mass is ***,as an introduction,we give a full description of the system by constructing its classical Lagrangian;thereupon,we derive the related classical equations of motion such as the classical Euler–Lagrange ***,we fractionalize the classical Lagrangian of the system,and then we obtain the corresponding fractional Euler–Lagrange equations(FELEs).As a final step,we give the numerical simulations corresponding to the FELEs within different fractional *** results based on the Caputo and the Atangana-Baleanu-Caputo(ABC)fractional derivatives are given to verify the theoretical analysis.

关键词： position-dependent mass harmonic oscillator Euler–Lagrange equations fractional derivative

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Insecticidal efficacy of three vegetable oils as post-harvest grain protectants of stored wheat against Rhyzopertha dominica （F.）（Coleoptera： Bostrychidae）

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Insect Science 2007年第2期14卷 145-150页

作者： amin NIKPAY Department of Entomology College of Agriculture Urmia University Urmia Iran

The lesser grain borer, Rhyzopertha dominica is a major insect pests of stored grain in the tropics. Vegetable oils （chamomile, sweet almond and coconut） at 2.5, 3.5, 5.0, 7.0 and 10.0 mL/kg were tested against Rhyzopertha dominica （F.） in wheat grain. All bioassays were conductr, d at 30℃ and 65% ＋ 2% Rh. Treatments with vegetable oils at high dose （10.0 mL/kg） achieved over 95% control within 24 h of exposure to freshly treated grain, There was little difference between the three oils in their effect. Persistence of oils in grains was tested at short-term storage intervals （48, 72 and 96 h） and intermediate-term intervals （10, 20 and 30 days） after treatments. The activity of all products decreased with storage period. Seed viability was reduced by the high dose rate （10.0 mL/kg） of oil treatments. The potential use of vegetable oils as supplementary or alternative grain protectants against insect damage in traditional grain storage in developing countries is discussed.

关键词： Rhyzopertha dominica seed viability traditional grain storage tropics,vegetable oils

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Robust half-Metallicity in a Chromium-Substituted AlN

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Chinese Physics Letters 2011年第10期28卷 270-273页

作者： S.Arif Iftikhar Ahmad B.amin h.A.Rahnamaye Aliabad Materials Modeling Laboratory Department of PhysicsHazara UniversityMansehraPakistan Department of Physics University of MalakandChakdaraPakistan Department of Physics Sabzevar Tarbiat Moallem UniversitySabzevarIran

We investigate half metallicity in a chromium(Cr)-substituted AlN dilute magnetic semiconductor using the full-potential linearized augmented plane-wave *** results show that Al_(0.75)Cr_(0.25)N is half metal and holds a net integer magnetic moment of 3μβwith lattice *** half−metallic nature is maintained from the relaxed lattice constant 4.36Åto 4.09Å.An abrupt change of the physical properties is observed at a robust transition lattice constant of 4.09Å,and the material transforms from half metal to *** find that up to 6%compression,the material maintains its half-metallic ***,we also confirm that the origin of ferromagnetism in Al_(0.75)Cr_(0.25)N is double exchange.

关键词： metallic lattice chromium

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Compressed Natural Gas(CNG)as a fuel and the associated risks:A quantitative analysis in the scenario of a developing country

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Journal of Safety Science and Resilience 2024年第3期5卷 306-316页

作者： Yousaf Ali Ahsan Younus amin Ullah Khan Ahmed h.Alrefai College of Business&Management Fahad Bin Sultan UniversityP.O.Box 15700Tabuk 71454Saudi Arabia Schoolof Management Sciences Ghulam Ishaq Khan(GIK)Instituteof Enginering Sciences and TechnologyTopSwabiPakisan Departnent of Economics and Law University of MacerataMacerataItaly Dean College of Business and Management Fahad Bin Sultan UniversitySaudi Arabia

Excessive dependence on fossil fuels has precipitated various challenges,including Greenhouse Gas(GhG)emissions,health hazards,and the depletion of natural *** perils underscore the importance of conducting requisite risk assessments for alternative fuel sources like Compressed Natural Gas(CNG)to ensure their safe *** study undertakes a quantitative risk assessment encompassing diverse facets of the CNG sector holistically,aiming to pinpoint,analyze,and appraise risks,thus empowering policymakers to devise targeted mitigation *** achieve this goal,the collected data undergoes analysis via an integrated approach combining the Fuzzy Analytic hierarchy Process(F-AhP)and Fuzzy Technique of Order Preference by Similarity to Ideal Solution(F-TOPSIS).The study's findings reveal a heightened risk of explosion within the CNG sector owing to its highly combustible ***,it computes an overall risk index of o0.266 for the CNG sector in a developing nation like Pakistan,indicating a relatively lower risk level compared to other fuel *** are thus advised to undertake requisite measures concerning infrastructure,customer safety,and environmental and economic stability to accrue both immediate and long-term *** appli-cation of hybrid techniques for the risk assessment of the CNG sector in the case of a developing country marks the novelty of this study and a study of the first of its kind.

关键词： Risk Safety CNG industry Fuzzy Pakistan

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MicroRNAs in pathogenesis of breast cancer:Implications in diagnosis and treatment

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World Journal of Clinical Oncology 2014年第2期5卷 48-60页

作者： nirav R Shah hexin Chen Department of Biological Science Center for Colon Cancer Research University of South Carolina

MicroR NAs(miR NAs) are small non-coding RNAs generated by a two-step complex process and are post transcriptional negative regulators of their target m RNAs. Dysregulation of many of these miR NAs has been associated with tumorigenesis in various cancers including breast cancer. Aberrantly high expression of specific mi RNAs in breast cancer cells is demonstrated to be linked with inhibition of tumor suppressor genes and promote tumorigenesis. They are classified as oncogenic miR NAs. however, the tumor suppressor miR NAs are downregulated in breast cancer cells, since their major targets are oncogenic m RNAs. Understanding mechanism of action of specific miR NAs in breast cancer cells can be utilized to develop newer anti-cancer therapies. Recently, newer techniques are also developed to detect abundance of specific miR NA in the blood plasma samples and can be used in early diagnosis or prognosis in breast cancer. In this review article, we have discussed several mi RNAs dysregulated in breast cancer and their therapeutic potential.

关键词： MicroRNAs Breast cancer Cancer stem cells Diagnostic markers Drug resistance

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