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Antiulcerogenic Effect of Brazilian Propolis Formulation in Mice

Pharmacology & Pharmacy 2015年第12期6卷 580-588页

作者： niraldo paulino Lucas Amorim Coutinho Jose Reinaldo Coutinho Giselle Cunha Vilela Veroneide Pio da Silva Leandro Amarilis Scremin paulino Universidade Anhanguera de Sao Paulo Sao PauloBrasil Medical Lex Gestao de Informacoes & Cursos Ltda FlorianopolisBrasil

Propolis is a natural resin used around the world to treatment of several diseases. We evaluated the effect of Brazilian propolis (P1) in guinea pig isolated trachea in vitro contracted with hista-mine, in paw oedema induced by histamine in mice and anti-ulcerogenic effect of propolis formulation in mice. We used a P1 extract from South of Brazil to produce a formulation containing sodium bicarbonate and propolis dry extract (2%). In the guinea pig trachea Brazilian propolis extract (10 μg/mL) produced a non-significant inhibition in the cumulative response curve for histamine. However, the dose of 100 μg/mL shown had a significant inhibitory effect on the contraction induced by histamine (51% ± 5%). In the mouse paw oedema induced by intraplantar injection of histamine (50 μg/paw), the results showed that the treatment of the mice with P1 (10 or 100 mg/Kg (p.o) or 1 or 10 mg/Kg (i.p)), 0.5 h beforehand, significantly inhibited the paw oedema with maximal inhibition (MI) of 25% or 42% by p.o. route or 22% or 37% by i.p. route, respectively. Finally we have pre-treated mice with P1 formulation (20 mg/Kg or 40 mg/Kg, p.o, one time) or vehicle (powder) in animals submitted to diclofenac-induced ulcer, after 8 h P1 formulation inhibited of 43% or 83% of ulcers scores, respectively. Results showed that P1 formulation inhibited the ulcerogenic effect induced by diclofenac. Results suggested also, at least in part, the antiulcerogenic effect of formulation containing standardized extract of propolis can be due to the antagonistic action on the histaminergic system.

关键词： Propolis Formulation Ulcer Stomach Mice Palavras Chaves: Própolis Formula??o Oral úlcera Est?mago Camundongo

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Evaluation of Antinociceptive and Anti-Inflammatory Effects of Synthetic O-Prenylated Phenolic Derivatives

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Pharmacology & Pharmacy 2012年第3期3卷 348-357页

作者： niraldo paulino Amarilis Scremin paulino Priscila Vautier Laura Pisco Carolina Passarelli Jose Matheus de Freitas Costa Dirk Michalik Paulo Celso Pardi Jose Agustín Quincoces Suarez Grupo de Pesquisa e Desenvolvimento de Biomedicamentos(BIOMED) Programa de Mestrado Profissional em FarmaciaUniversidade Bandeirante de Sao PauloSao PauloBrasil Programa de Pos-Graduacao em Farmacia Universidade Federal de Santa CatarinaFlorianopolisBrasil Laboratorio de Síntese Organica Universidade Bandeirante de Sao PauloSao PauloBrasil Leibniz-Institut für Katalyse an der Universitat Rostock RostockGermany

This work describes the synthesis, antinociceptive and anti-inflammatory effect of O-prenyl derivatives: O-prenyl derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) and 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (V1). Treatment with L1- or V1-produced antinociceptive effect on classical pain models: acetic acid abdominal contortions and formalin test (first and second phases), and in hot plate or tale flick models in mice without changing the locomotors performance, and anti-oedematogenic or anti-inflammatory effect in vivo: carrageenan-induced paw oedema and peritonitis in mice. In addition, L1 and V1 derivatives reduced nitric oxide production on RAW 264.7 cells stimulated with lipopolysaccharide without changing the cell viability. Taken together, our results show for the first time that L1 and V1 can produce antinociception and modulate inflammatory response when administered in mice.

关键词： Anti-Inflammatory Antinociception Synthesis O-Prenyl Compounds

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