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Emergence of taurine as a therapeutic agent for neurological disorders

Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz kamal Punya Sachdeva Saurabh k.mar jha Shreesh Ojha Dinesh k.mar niraj k.mar jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UkM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

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Molecular basis of fluoride toxicities:Beyond benefits and implications in human disorders

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Genes & Diseases 2023年第4期10卷 1470-1493页

作者： Priyankar Pal niraj k.mar jha Debankur Pal Saurabh k.mar jha Uttpal Anand Abilash Valsala Gopalakrishnan Abhijit Dey Prabir k.mar Mukhopadhyay Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Department of Biotechnology School of Engineering and Technology(SET)Sharda UniversityGreater NoidaUttar Pradesh 201310India Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradun 248007India Department of Biotechnology Engineering and Food Technology Chandigarh UniversityMohali 140413India Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Biomedical Sciences School of Bio Sciences and TechnologyVellore Institute of Technology(VIT)VelloreTamil Nadu 632014India

Detrimental impacts of fluoride have become a global concern for several *** its beneficial role which is restricted only in skeletal tissues,deleterious effects are also observed in soft tissues and *** generation of enhanced oxidative stress is the commencement of excess fluoride exposure which may lead to cell *** causes cell death through autophagy via Beclin 1 and mTOR signaling *** these,several or-gan specific anomalies through different signaling pathways have been ***-drial dysfunction,DNA damage,autophagy and apoptosis are the damaging outcomes in case of hepatic *** concentration defects and cell cycle arrest have been reported in renal *** immune response has been characterized in the cardiac ***-tive dysfunction,neurodegenerative condition and learning impairment have also been *** steroidogenesis,gametogenic abnormalities,epigenetic alterations and birth defect are the major reprotoxic *** immune responses,altered immu-nogenic proliferation,differentiation as well as altered ratio of immune cells are well-defined anomalies in the immune *** the mechanistic approach of fluoride toxicity in phys-iological systems is common,it follows different signaling *** review emphasizes diverse signaling pathways which are the targets of overexposed fluoride.

关键词： Fluoride Autophagy Mitochondrial dysfunction Signaling cascades System disorders

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61例川崎病的临床分析

61例川崎病的临床分析

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作者： niraj jha 大理大学

学位级别：硕士

目的:通过临床前瞻性分析,了解川崎病(kawasakidisease kD)的发病率,临。比较典型和不完整的kD的临床特征。比较kD引起的静脉注射免疫球蛋白(intravenous immune globulin IVIG)和冠状动脉病变(Coronary artery lesion,CAL)不同剂量方... 详细信息

目的:通过临床前瞻性分析,了解川崎病(kawasakidisease kD)的发病率,临。比较典型和不完整的kD的临床特征。比较kD引起的静脉注射免疫球蛋白(intravenous immune globulin IVIG)和冠状动脉病变(Coronary artery lesion,CAL)不同剂量方法的治疗效果。方法:收集大理大学第一附属医院儿科2017年11月至2019年12月份期间确诊的61例川崎病住院患儿临床病历资料。记录患儿的发病时间、季节、年龄、性别、临床表现、超声心动图(UCG)、心电图(ECG)、胸部X线检查、血常规、C反应蛋白(CRP)、血沉(ESR)、谷草转氨酶(AST)、白蛋白(ALB)、肌酸磷酸激酶同工酶(Ck-MB)、血培养、肺炎支原体抗体(MP-Ig M)、尿常规等数据;通过统计分析:(1)总结61例kD患儿的临床特征;(2)比较典型(typical)kD与不完全kD(incomplete,kD)的临床特点;(3)kD合并CAL的危险因素;(4)比较三种不同剂量用法IVIG的疗效.结果:(1)61例kD病例在5岁以下儿童(77.04%)和3岁以下儿童(57.4%)更为常见更常见。男孩的发病率较高(男性:女性1.6:1),而且全年都有发现。但他们更多的是在夏季和秋季(占64%):(2)不完全kD在1岁以下的婴儿中更为常见,所有主要临床表现的患病率低于典型病例(P,0.05或0.01),在诊断前持续发热时间较长。与典型的kD相比,CAL(Pkgx1d和1g/kgx2d优于400mg/kgx5d,但1g/kgx1d和1g/kgx2d(P>0.05)之间没有差异:(5)年龄小,持续时间长是危险因素,IVIG的剂量和方法是保护因素。结论:(1)kD在5岁以下男孩中较为常见,夏季和秋季发病率较高:(2)婴儿易患的不完整kD,所有主要临床表现的发病率均低于典型kD,在诊断前持续发热时间较长,但CAL发病率明显较高:(3)年龄小于3岁是kD与CAL结合的危险因素:(4)在抗火药时间和治疗反应方面,1g/kg x1d是IVIG更经济有效的治疗方案:(5)IVIG的发热持续时间和剂量方法是独立相关因素,对IVIG的初始治疗没有反应。

关键词：川崎病冠状动脉损害静脉注射免疫球蛋白

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Epidemiological Study of Rapidly Emerging Uropathogens Isolated from Urinary Catheter and Its Influential Demographic Factors Responsible for Contamination

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Advances in Microbiology 2020年第12期10卷 713-729页

作者： Anjali A. Tiwari niraj Ghnawate Yogesh khalshinge Department of Microbiology Sant Gadge Baba Amravati University Amravati India

Urinary tract infections (UTI) are very common in all the developed as well as developing countries in which the majority of infections are catheter associated. Catheter associated urinary tract infections (CAUTI) is one of the major causes of hospital acquired infections. The aim of this study is to investigate influential demographic factors responsible for contamination associated with the rate of CAUTI, while taking into account type of urinary catheter used, the most common organisms found, patient diagnosis, age, gender, and comparison with other studies. During the study, 22 uropathogenic species were isolated from the different segments of urinary catheter samples of the patients collected from 12 different hospitals of Amravati city, Maharashtra, India from January 2015 to 2018. Gram negative organisms were the most frequent isolates, with Pseudomonas aeruginosa (16.08%) being the most common followed by Escherichia coli (10%) and Candida albicans accounted for almost 11% of all the uropathogens. It was found that the majority of uropathogens were isolated from the section A (Catheter segment inside the bladder) and section E (Catheter segment connected to drainage tube) of the urinary catheter. The duration of the catheterization plays the major role in the contamination and further infection to continue. It was observed that the female catheterized patients are more prone to the contamination and infection as compared to male catheterized patient. The antibiotic sensitivity pattern indicates that mar (Multiple Antibiotic Resistance) index was more than 0.2 for almost all the uropathogens tested concluding that there is antibiotic stress on uropathogens and rate of resistance increased rapidly. Also it was found that there was a statistically significant association between the duration of catheterization, type of disease, age of patient and type of catheter with respect to gender.

关键词： CAUTI Uropathogens Urinary Tract Infection Urinary Catheter Contamination

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