检索结果-南通市图书馆

Yes-associated protein-1 may serve as a diagnostic marker and therapeutic target for residual/recurrent hepatocellular carcinoma post-transarterial chemoembolization

引用

Liver Research 2020年第4期4卷 212-217页

作者： Xia Qian Wei Zhang Alireza Shams Kahee Mohammed Alex S.Befeler ningling kang Jinping Lai Department of Pathology Saint Louis University School of MedicineSaint LouisMOUSA Division of Gastroenterology Hepatology and NutritionDepartment of MedicineUniversity of FloridaGainesvilleFLUSA Department of Internal Medicine Saint Louis University School of MedicineSaint LouisMOUSA Division of Gastroenterology and Hepatology Saint Louis University School of MedicineSaint LouisMOUSA The Hormel Institute University of Minnesota and Mayo ClinicAustinMNUSA Department of Pathology Immunology and Laboratory MedicineUniversity of Florida College of MedicineGainesvilleFLUSA Department of Pathology and Laboratory Medicine Kaiser Permanente Sacramento Medical CenterSacramentoCAUSA

Background and aim:The transcriptional co-activator Yes-associated protein-1(YAP1)has been impli-cated as an oncogene and is overexpressed in different kinds of human cancers,especially hepatocellular carcinoma(HCC).However,the role of YAP1 has not been reported in residual/recurrent HCC after transarterial chemoembolization(TACE).Our aim is to determine whether YAP1 is overexpressed in the residual/recurrent HCC after ***:A total of 105 tumor tissues from 71 patients including 30 cases of primary HCC without prior treatment,35 cases of residual/recurrent HCC post TACE,and 6 cases of hepatoblastoma were included in the immunohistochemical ***1 immunoreactivity was blindly scored as 0,1+,2+or 3+in density and percentages of positive ***:About 33.3%(10/30)of primary HCC without prior treatment showed 2+of YAP1 *** 82.8%(29/35)of residual/recurrent HCCs after TACE treatment displayed 2-3+of YAP1 immunoreactivity,which was significantly higher compared to primary HCC without prior treatment(P=0.0002).YAP1 immunoreactivity was moderately to strongly positive(2-3+)in 100%of the hep-atoblastoma,particularly in the embryonal components(3+in 100%cases).Conclusions:YAP1 is significantly upregulated in the residual/recurrent HCCs post TACE treatment,suggesting that YAP1 may serve as a sensitive diagnostic marker and a treatment target for residual/recurrent HCC post TACE.

关键词： Yes-associated protein-1(YAP1) Residual/recurrent hepatocellular carcinoma Hepatoblastoma Cancer stem cell(CSC) Immunohistochemistry Transarterial chemoembolization(TACE)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical modelling and simulation analysis of wind blades:a critical review

引用

Clean Energy 2024年第1期8卷 261-279页

作者： Ibrahim Alrowwad Xiaojia Wang ningling Zhou Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Wind energy has emerged as a promising renewable energy source and wind turbine technology has developed rapidly in recent *** wind turbine performance depends heavily on the design and optimization of wind *** work offers a critical evaluation of the state of the art in the field of numerical modelling and simulation analysis,which have become crucial for the design and optimization of wind *** evaluation of the literature includes considerable research on the application of numerical methods for the structural and aerodynamic performance of wind blades under various operating situations,as well as for analysis and optimization of wind *** article illustrates how numerical techniques can be used to analyse wind blade performance and maximize design *** study of blade performance under various wind conditions has also been made possible through the use of simulation analysis,thus enhancing the efficiency and dependability of wind *** in wind turbine efficiency and dependability,and ultimately the move towards a more sustainable energy future,will be greatly helpful for the development of numerical modelling and simulation techniques.

关键词： wind blades simulations optimization numerical analysis mathematical modelling performance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Heart Rate on Major Adverse Cardiovascular Events in Hypertensive Patients with Different Ages and Genders

引用

China CDC weekly 2021年第15期3卷 320-322,I0001页

作者： Yang Xi ningling Sun Department of hypertension Heart CenterPeking University People’s HospitalBeijingChina

Summary What is already known on this topic?The increase of heart rate will increase blood pressure,and the cardiovascular risk will increase when heart rate>80 beats/min(bpm)in patients with *** is added by this report?Compared with patients who were female,<65 years old,and with hypertension,patients who were male,≥65 years old.

关键词： cardiovascular hypertension patients

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tempospacial energy-saving effect-based diagnosis in large coal-fired power units:Energy-saving benchmark state

引用

Science China(Technological Sciences) 2015年第12期58卷 2025-2037页

作者： FU Peng WANG ningling YANG Yong Ping XU Han LI XiaoEn ZHANG YuMeng National Thermal Power Engineering and Technology Research Center North China Electric Power University

The energy-saving analytics of coal-fired power units in China is confronting new challenges especially with even more complicated system structure, higher working medium parameters, time-dependent varying operation conditions and boundaries such as load rate, coal quality, ambient temperature and humidity. Compared with the traditional optimization of specific operating parameters, the idea of the energy-consumption benchmark state was proposed. The equivalent specific fuel consumption(ESFC) analytics was introduced to determine the energy-consumption benchmark state, with the minimum ESFC under varying operation boundaries. Models for the energy-consumption benchmark state were established, and the endogenous additional specific consumption(ASFC) and exogenous ASFC were calculated. By comparing the benchmark state with the actual state, the energy-saving tempospacial effect can be quantified. As a case study, the energy consumption model of a 1000 MW ultra supercritical power unit was built. The results show that system energy consumption can be mainly reduced by improving the performance of turbine subsystem. This nearly doubles the resultant by improving the boiler system. The energy saving effect of each component increases with the decrease of load and has a greater influence under a lower load rate. The heat and mass transfer process takes priority in energy saving diagnosis of related components and processes. This makes great reference for the design and operation optimization of coal-fired power units.

关键词： energy-saving diagnosis coal-fired power generation unit specific fuel consumption exergy thermodynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-resolution Imaging of Living Retina through Optic Adaptive Retinal Imaging System

引用

眼科学报 2002年第3期18卷 131-135页

作者： ChunhuiJiang ningling 等 EyeENTHospitalofFudanUniversity Shanghai200031China InstituteofOpticsandElectronics ChineseAcademyofSciencesChengdu610209China

Purpose: To evaluate the possibility as well as the usage of adaptive optics in high-resolution retinal ***:From March to November 2001, the fundus of 25 adults were checked by using Optic Adaptive Retinal Imaging System (OAS). The age of the subjects varied from 18～48 years. All had normal visual acuity from 0.9 to 1.0. No abnormality was found in the ocular examination, and their medical as well as ocular history was unremarkable. Results: High-resolution images of the retinal cells, photoreceptor and bipolar cell, were analysed. In these images, the cells are clearly resolved. The density of the photoreceptor at area 1.5 degree from the foveloa is around 40 000～50 000/mm2. At area 3 degree, it drops to less than 30 000/***:Optic Adaptive Retinal Imaging System (AOS) is able to get high-resolution image of retinal cells in living human eyes. It may be widely used in ophthalmology experimentally and clinically.

关键词：适应性光学系统视网膜高分辨率成像

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Green heating:Theory and practice

引用

Science China(Technological Sciences) 2015年第12期58卷 2003-2015页

作者： YANG YongPing LI PeiFeng GE ZhiHua TIAN Jia WANG ningling SONG ZhiPing School of Energy Power and Mechanical Engineering North China Electric Power University Beijing Municipal Institute of City Planning & Design

Energy conservation in heating systems has great influence on overall sustainable development strategy. Heating technology, especially combined heat and power(CHP, cogeneration), has been attracting increased interest and rapidly developing in recent years. However, the theoretical potential of heating from the perspective of thermodynamics has not been clearly illustrated. This paper presents a theoretical analysis of heating systems based on the 1st and 2nd laws of thermodynamics using the specific fuel consumption(SFC) analysis method, clarifies the theoretical potential limitation of heating systems and illustrates the process of reversible heating on the basis of the total energy system. A novel concept(green heating, GH) and a new indicator(green-heating index, GH Index) are scientifically defined to characterise different options for heating and to quantitatively evaluate their fuel consumption levels. Thereafter, the fuel consumptions of four typical space heating modes are compared and discussed to present the application of GH theory and validate the power of the proposed concept and index. Furthermore, two different CHP technologies are analyzed with an instantiation case, and a novel CHP system is recommended, which may scientifically support the development of heating technology and further improve the processes of energy-saving and CO2 reduction.

关键词： green heating combined heat and power space heating specific fuel consumption exergy thermodynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cell cycle regulator geminin is dispensable for the proliferation of vascular smooth muscle cells

引用

Science China(Life Sciences) 2013年第9期56卷 731-738页

作者： GUO JianQiang SUN ningling Department of Cardiology Peking University People's Hospital

The proliferation of vascular smooth muscle cells(VSMCs) plays a major role in the pathogenesis of many cardiovascular *** regulates DNA replication and cell cycle progression and plays a key role in the proliferation of cancer *** therefore hypothesized that geminin regulates the proliferation of *** present study demonstrates that the level of geminin expression was low in quiescent VSMCs(approximately 90% and 10% of cells in the G1 and in S/G2/M phases of the cell cycle,respectively),increased as more cells entered in S/G2/M,and then decreased as cells exited S/G2/***,angiotensin II and norepinephrine stimulated expression of geminin in ***,the DNA content,nuclear morphology,percentage of cells at different stages of the cell cycle,and rate of proliferation of VSMCs from which geminin was either depleted or overexpressed were all *** findings indicate geminin functions differently in VSMCs than it does in cancer cell lines and that it may provide a target for treating cancers without affecting normal cells.

关键词： geminin DNA replication cell cycle proliferation vascular smooth muscle cell

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Situation and Prospect of Energy Consumption for China＇s Thermal Power Generation

引用

中国电机工程学报 2013年第23期33卷 I0001-I0016页

作者： YANG Yongping YANG Zhiping XU Gang WANG ningling North China Electric Power University

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress and prospects of innovative coal-fired power plants within the energy internet

引用

Global Energy Interconnection 2019年第2期2卷 160-179页

作者： Yongping Yang Chengzhou Li ningling Wang Zhiping Yang National Research Center for Thermal Power Engineering and Technology North China Electric Power University

The development of electrical engineering and electronic, communications, smart power grid, and ultra-high voltage transmission technologies have driven the energy system revolution to the next generation: the energy internet. Progressive penetration of intermittent renewable energy sources into the energy system has led to unprecedented challenges to the currently wide use of coal-fired power generation technologies. Here, the applications and prospects of advanced coal-fired power generation technologies are analyzed. These technologies can be summarized into three categories:(1) large-scale and higher parameters coal-fired power generation technologies, including 620/650/700 oC ultra-supercritical thermal power and double reheat ultra-supercritical coal-fired power generation technologies;(2) system innovation and specific, highefficiency thermal cycles, which consist of renewable energy-aided coal-fired power generation technologies, a supercritical CO_2 Brayton cycle for coal-fired power plants, large-scale air-cooling coal-fired power plant technologies, and innovative layouts for waste heat utilization and enhanced energy cascade utilization;(3) coal-fired power generation combined with poly-generation technologies, which are represented by integrated gasification combined cycle(IGCC) and integrated gasification fuel cell(IGFC) technologies. Concerning the existing coal-fired power units, which are responsible for peak shaving, possible strategies for enhancing flexibility and operational stability are discussed. Furthermore, future trends for coal-fired power plants coupled with cyber-physical system(CPS) technologies are introduced. The development of advanced, coal-fired power generation technologies demonstrates the progress of science and is suitable for the sustainable development of human society.

关键词： En ergy In ternet Coal-fired Power Gen eration Flexibility Cyber-physical system Smart power plant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New Problems of Boiler Corrosion after Coupling Combustion of Coal and Biomass and Anti-Corrosion Technologies

引用

Journal of Renewable Materials 2024年第4期12卷 799-814页

作者： Lei Wang Ziran Ma Chunlin Zhao Jiali Zhou Hongyan Wang Ge Li ningling Zhou National Institute of Clean-and-Low-Carbon Energy Beijing102211China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy&EnvironmentSoutheast UniversityNanjing210096China

This study explores the corrosion issues arising from the coupled combustion of coal and biomass and proposes potential ***,as a renewable energy source,offers advantages in energy-saving and carbon ***,the corrosive effects of alkali metal compounds,sulfur(S)and chlorine(Cl)elements in the ash after combustion cannot be underestimated due to the high volatile content of biomass *** investigate the corrosion mechanisms,as well as the transfer of Cl and alkali metal elements during this *** corrosion analyses are conducted among coal-fired boilers,pure biomass boilers and boilers with coupled *** biomass types in co-firing are studied to understand different corrosion *** main factors influencing corrosion include the physicochemical properties of biomass feedstock,furnace temperature and heating surface materials,with the chemical composition and ash content of biomass playing a dominant ***,the methods used for anti-corrosion include water washing pretreatment of biomass feedstock,application of novel alloys and coatings and the development of additives to inhibit fouling,ash deposition and *** inhibitors are economical and easy to ***,biomass can be converted into biomass gasification gas,although challenges related to tar still need to be addressed.

关键词： Biomass coupled combustion corrosion mechanism anti-corrosion measures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：