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Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma

Science China(Life Sciences) 2023年第12期66卷 2837-2850页

作者： Jian Wu Caixia Lin Chenlong Yang Lijie Pan Hongyi Liu Sirui Zhu Shuwen Wei Xu Jia Qi zhang Ziyu Yu Xiaofang Zhao Weihai Liu Yehong Zhuo ningli Wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Neurosurgery Peking University Third HospitalCenter for Precision Neurosurgery and Oncology of Peking University Health Science CenterBeijing 100191China North America Medical Education Foundation Union City CA 94539USA State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Spencer Center for Vision Research Byers Eye InstituteSchool of MedicineStanford UniversityPalo Alto CA 94304USA

Primary open-angle glaucoma(POAG)is a prevalent cause of blindness worldwide,resulting in degeneration of retinal ganglion cells and permanent damage to the optic ***,the underlying pathogenetic mechanisms of POAG are currently indistinct,and there has been no effective nonsurgical treatment *** objective of this study is to identify novel biomarkers and potential therapeutic targets for *** mRNA expression microarray datasets GSE27276 and GSE138125,as well as the single-cell high-throughput RNA sequencing(sc RNA-seq)dataset GSE148371 were utilized to screen POAGrelated differentially expressed genes(DEGs).Functional enrichment analyses,protein-protein interaction(PPI)analysis,and weighted gene co-expression network analysis(WGCNA)of the DEGs were ***,the hub genes were validated at a single-cell level,where trabecular cells were annotated,and the mRNA expression levels of target genes in different cell clusters were *** and quantitative real-time PCR(q PCR)were performed for further *** analysis identified 43 downregulated and 32 upregulated genes in POAG,which were mainly enriched in immune-related pathways,oxidative stress,and endoplasmic reticulum(ER)*** networks showed that FN1 and DUSP1 were the central hub nodes,while GPX3 and VAV3 were screened out as hub genes through WGCNA and subsequently validated by q ***,FN1,GPX3,and VAV3 were determined to be pivotal core genes via single-cell *** relevant biomarkers involved in the pathogenesis of POAG,may serve as potential therapeutic *** studies are necessary to unveil the mechanisms underlying the expression variations of these genes in POAG.

关键词： primary open-angle glaucoma biomarkers immune response oxidative stress endoplasmic reticulum stress

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CCN1 participates in the pathogenesis of Psoriasis by promoting IL-36γ expression

CCN1 participates in the pathogenesis of Psoriasis by promot...

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第十一届全国免疫学学术大会

作者： zhang Jie He Jun Li ningli Center for Clinical Laboratory the First Affiliated Hospital of Soochow Hospital Shanghai Institute of Immunology & Department of Immunology and Microbiology Shanghai Jiao Tong University School of Medicine

Objective: Psoriasis is a common chronic inflammatory skin disease characterized by epidermal hyperplasia and inflammation. The pathogenesis of psoriasis is multifactorial and is not fully understood. Method: We have demonstrated that CCN1(also called Cyr61, which is short for cysteine-rich 61), an extra-cellular matrix protein that is also considered a pro-inflammatory factor, is highly expressed in the lesional skin of psoriasis patients, as well as in that of imiquimod(IMQ)- and IL-23-treated psoriasis-like ***: We found that the high expression of CCN1 is prior to that of IL-36γ during the process of imiquimod(IMQ)-and IL-23- treated psoriasis-like mice. Further, in Ha Ca T(human keratinocyte cell line) cells, CCN1, as an upstream stimulator, can promote IL-36γ expression, which was confirmed to be expressed in psoriasis lesions only as a biomarker. Finally, we observe that CCN1 stimulation activates the downstream phosphoinositide-3kinase/Akt/ NF- κB and ERK/AP1 signaling pathways through integrin receptor α6β***: CCN1 has a critical role in psoriasis pathogenesis. Moreover, as CCN1 is a secreted extracellular matrix(ECM) protein. Our study also provides evidence that ECM, which is involved in psoriatic pathogenesis, could be a potent and upstream target for psoriasis treatment.

关键词： Psoriasis CCN1 IL-36γ inflammation

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青海省居民中藏医药利用程度及满意度调查

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西部中医药 2024年第9期37卷 72-77页

作者：王树林洒玉萍吴萍普措多杰扎西东主张广梅赵协慧曹宁丽徐超青海大学医学部青海西宁810001

目的:了解青海省居民中藏医药利用程度、满意度情况及其影响因素。方法:采用入户问卷调查方式对青海省居民中藏医药利用程度及满意度情况进行调查。结果:近5年青海省居民中藏医药利用最多占11.8%(94/797),较多占25.0%(199/797);利用程... 详细信息

目的:了解青海省居民中藏医药利用程度、满意度情况及其影响因素。方法:采用入户问卷调查方式对青海省居民中藏医药利用程度及满意度情况进行调查。结果:近5年青海省居民中藏医药利用最多占11.8%(94/797),较多占25.0%(199/797);利用程度有序logistic回归分析显示:文化程度、收入、地区和中藏药熟悉程度是居民中藏药利用程度的影响因素(P<0.05);对中藏医药利用非常满意占23.5%(175/745),比较满意占41.9%(312/745),整体满意度为65.4%(487/745);满意度二元logistic回归分析显示:户籍、地区和对中医药了解程度是满意度的影响因素(P<0.05)。结论:青海省居民对中藏医药的利用程度不高,整体满意度一般,应该加大对居民中藏医药文化知识的宣传和项目的体验力度,提升居民对中藏医药的利用程度和满意度。

关键词：中医药藏医药居民利用程度满意度

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An Effcient Trap Passivator for Perovskite Solar Cells: Poly(propylene glycol) bis(2-aminopropyl ether)

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Nano-Micro Letters 2020年第12期12卷 255-267页

作者： ningli Chen Xiaohui Yi Jing Zhuang Yuanzhi Wei Yanyan zhang Fuyi Wang Shaokui Cao Cheng Li Jizheng Wang CAS Key Laboratory of Organic Solids Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Physics Xiamen University CAS Key Laboratory of Analytical Chemistry for Living Biosystems Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences School of Materials Science and Engineering Zhengzhou University

Perovskite solar cells(PSCs) are regarded as promising candidates for future renewable energy production. High-density defects in the perovskite films, however, lead to unsatisfactory device performances. Here, poly(propylene glycol) bis(2-aminopropyl ether)(PEA) additive is utilized to passivate the trap states in perovskite. The PEA molecules chemically interact with lead ions in perovskite, considerably passivate surface and bulk defects, which is in favor of charge transfer and extraction. Furthermore, the PEA additive can e ciently block moisture and oxygen to prolong the device lifetime. As a result, PEA-treated MAPb I3(MA: CH3NH3) solar cells show increased power conversion e ciency(PCE)(from 17.18 to 18.87%) and good longterm stability. When PEA is introduced to(FAPb I3)1-x(MAPb Br3)x(FA: HC(NH2)2) solar cells, the PCEffis enhanced from 19.66 to 21.60%. For both perovskites, their severe device hysteresis is e ciently relieved by PEA.

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卵巢癌患者DCE-MRI联合高b值DWI检查的表现分析

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国际医药卫生导报 2024年第10期30卷 1703-1707页

作者：唐敏丽张涛蔡雷刘连锋白江涛任召杨宁丽马旭阳唐海利延安大学咸阳医院CT/MRI室咸阳712000 中国人民解放军空军军医大学第二附属医院普通外科西安710038

目的分析卵巢癌患者磁共振动态增强(DCE-MRI)联合高b值弥散加权成像(DWI)检查的表现。方法回顾性分析延安大学咸阳医院在2020年6月至2023年6月收治的50例确诊为卵巢癌患者的临床资料,作为观察组,并选取同期体检健康者50例为对照组。对... 详细信息

目的分析卵巢癌患者磁共振动态增强(DCE-MRI)联合高b值弥散加权成像(DWI)检查的表现。方法回顾性分析延安大学咸阳医院在2020年6月至2023年6月收治的50例确诊为卵巢癌患者的临床资料,作为观察组,并选取同期体检健康者50例为对照组。对照组年龄(33.58±5.47)岁;观察组年龄(33.37±5.53)岁,国际妇产科联盟(FIGO)分期Ⅰ期8例、Ⅱ期25例、Ⅲ期12例、Ⅳ期5例。两组受试者均接受DCE-MRI及高b值DWI检查,比较两组受试者的DCE-MRI定量参数,包括容量转移常数(Ktrans)、速率常数(Kep)、血管外细胞外容积分数(Ve);观察并比较两组DWI表观弥散系数(ADC)情况;绘制受试者操作特征曲线(ROC),计算曲线下面积(AUC)评估DCE-MRI联合高b值DWI检查对卵巢癌患者的诊断效能。采用F检验。结果观察组Ktrans、Kep、Ve分别为(0.43±0.05)min、(0.85±0.13)min、(0.75±0.25),均高于对照组的(0.07±0.06)min、(0.27±0.12)min、(0.26±0.16),观察组ADC值为(0.93±0.13)×10^(-3) mm^(2)/s,低于对照组的(1.53±0.23)×10^(-3) mm^(2)/s,差异均有统计学意义(均P<0.05);Ⅳ期患者Ktrans、Kep、Ve高于Ⅲ期,Ⅲ期高于Ⅱ期,Ⅱ期高于Ⅰ期,Ⅳ期患者ADC值低于Ⅲ期,Ⅲ期低于Ⅱ期,Ⅱ期低于Ⅰ期,差异均有统计学意义(均P<0.05)。经ROC分析,DCE-MRI对卵巢癌不同分期的诊断灵敏度为85.35%,特异度为90.14%,高b值DWI对卵巢癌不同分期的诊断灵敏度为82.45%,特异度为87.14%,DCE-MRI联合高b值DWI对卵巢癌不同分期的诊断灵敏度为94.14%,特异度为95.85%。结论DCE-MRI联合高b值DWI检查应用于卵巢癌患者具有更高效能,显著优于单项检测;当b值为1600 s•mm^(-2)时,结合DCE-MRI对卵巢癌的临床分期诊断具有更高的灵敏度和特异度;作为临床无创诊断辅助手段,两种检查方式可互为补充,避免卵巢癌的误诊,对患者治疗和预后具有重要临床价值。

关键词：磁共振动态增强高b值弥散加权成像卵巢癌速率常数

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重视《中国青光眼指南(2020年)》发布后的推广和评价

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中华眼科杂志 2021年第3期57卷 161-165页

作者：张纯王宁利北京大学第三医院眼科眼部神经损伤的重建保护与康复北京市重点实验室100191 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所北京市眼科学与视觉科学重点实验室100730

青光眼是全球首位不可逆性致盲眼病。《中国青光眼指南(2020年)》(以下简称《指南》)基于我国基本国情,结合了国内外最新研究进展,可为我国青光眼临床诊疗工作提供重要参考和建议。眼科界应对《指南》加大宣传和推广力度,拓展其传播渠... 详细信息

青光眼是全球首位不可逆性致盲眼病。《中国青光眼指南(2020年)》(以下简称《指南》)基于我国基本国情,结合了国内外最新研究进展,可为我国青光眼临床诊疗工作提供重要参考和建议。眼科界应对《指南》加大宣传和推广力度,拓展其传播渠道和覆盖范围,以期充分发挥《指南》对临床工作的指导作用;还应注重对《指南》进行质量评价和后效评价,在临床工作中检验《指南》的可靠性和适用性,推动青光眼循证实践;同时应不断积累和反馈证据,以促进《指南》更新和完善,从而构建良好的证据生态系统,以期不断有效助力我国青光眼临床诊疗水平提高。(中华眼科杂志,2021,57:161-165)

关键词：青光眼循证实践诊疗准则评价研究生态系统

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Long-term outcomes of peroral endoscopic myotomy with simultaneous submucosal and muscle dissection (POEM-SSMD) for achalasia with severe interlayer adhesions

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Chinese Medical Journal 2022年第6期135卷 724-726页

作者： Jiancong Feng ningli Chai Wengang zhang Longsong Li Xiaowei Tang Jiale Zou Lu Ye Enqiang Linghu Medical School of Chinese People's Liberation Army Beijing 100853China Department of Gastroenterology and Hepatology The First Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China

Many previous studies have confirmed the effectiveness and safety of peroral endoscopic myotomy(POEM)to treat ***,severe interlayer adhesions preclude the establishment of a submucosal tunnel and then result in aborted POEM *** address this challenge,we introduced POEM with simultaneous submucosal and muscle dissection(POEM-SSMD)in 2014.[1]During the short-term follow-up,the symptoms of the patient were significantly ***,for patients with esophageal interlayer adhesions,the relative indications of POEM may be ***,only a few case reports using this technique with a shorter follow-up have been published to ***,the present study aimed to further report the long-term outcomes of POEM-SSMD for achalasia with severe interlayer adhesions in a relatively larger population.

关键词： dissection interlayer simultaneous

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Long-term follow-up of optic neuropathy in chronic low cerebrospinal fluid pressure monkeys: the Beijing Intracranial and Intraocular Pressure(iCOP) Study

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Science China(Life Sciences) 2020年第11期63卷 1762-1765页

作者： Jing Li Diya Yang Jacky MKKwong Jidi Fu Ruowu Hou Jost BJonas Huaizhou Wang Zheng zhang Weiwei Chen Zhen Li Jinghong Sang Xiaobin Xie Ruojin Ren Robert NWeinreb ningli Wang Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Jules Stein Eye Institute David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCalifornia 90095United States Department of Neurosurgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University HeidelbergSeegartenklinikb Heidelberg 68167Germany Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Ophthalmology Eye Hospital of China Academy of Chinese Medical SciencesBeijing 100040China Devers Eye Institute Optic Nerve Head Research LaboratoryLegacy Research InstitutePortlandOregon 97232United States Hamilton Glaucoma Center and Department of Ophthalmology University of California-San DiegoLa JollaCalifornia 92093United States

Dear Editor,Clinical and anatomic investigations strongly suggest that a low orbital cerebrospinal fluid pressure (CSFP), parallel to an elevated intraocular pressure (IOP), may have a role in the pathogenesis of optic neuropathy (Ren et al., 2011, Wang et al., 2012). Optic neuropathy including glaucoma demonstrated structural alterations in the optic nerve head (ONH)and retinal nerve fiber layer (RNFL), as well as functional abnormalities such as visual field (VF) that eventually cause severe visual impairment and blindness.

关键词： visual eventually fluid

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Outcomes of super minimally invasive surgery *** for superficial esophageal squamous cell carcinoma:a single-center study based on propensity score matching

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Chinese Medical Journal 2022年第20期135卷 2491-2493页

作者： Jiancong Feng ningli Chai Enqiang Linghu Xiuxue Feng Longsong Li Chen Du Wengang zhang Qingzhen Wu Medical School of Chinese People's Liberation Army Beijing 100853China Department of Gastroenterology and Hepatology The First Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China

Super minimally invasive surgery(SMIS)is a new concept proposed in 2016,which is defined as“curing the disease while preserving the integrity of human organ anatomy.”[1]Its concept has been accepted by the World Endoscopy Organization and Chinese Society of Digestive *** obvious advantage of SMIS is to cure diseases without damaging the structure and function of *** cancer patients,it can ensure a normal survival time and postoperative quality of life(QoL).

关键词： superficial anatomy surgery

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中药明视方干预儿童低度近视心阳不足证的多中心、随机双盲安慰剂对照临床研究

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中医杂志 2024年第6期65卷 587-593页

作者：王健全侯昕玥亢泽峰杨迎新刘新泉沈志华俞晓艺姚靖梁凤鸣张风梅喻京生王宁利宋曼孙宏睿晏鑫中国中医科学院眼科医院北京市100040 首都医科大学附属北京中医医院上海中医药大学附属龙华医院深圳市中医院广州中医药大学第一附属医院黑龙江中医药大学附属第一医院天津中医药大学第一附属医院河南省中医院湖南中医药大学第一附属医院首都医科大学附属北京同仁医院福建中医药大学附属福州中医院

目的观察中药明视方颗粒控制儿童心阳不足证低度近视的有效性和安全性。方法采用多中心、随机、双盲安慰剂对照的研究方法,将就诊于8家分中心的290例心阳不足证低度近视患儿随机分为治疗组和对照组各145例,治疗组给予宣教+配镜+中药明... 详细信息

目的观察中药明视方颗粒控制儿童心阳不足证低度近视的有效性和安全性。方法采用多中心、随机、双盲安慰剂对照的研究方法,将就诊于8家分中心的290例心阳不足证低度近视患儿随机分为治疗组和对照组各145例,治疗组给予宣教+配镜+中药明视方颗粒,对照组给予宣教+配镜+明视方安慰剂颗粒。明视方及安慰剂颗粒均口服,每次1袋(3 g),每日2次,口服4周休息2周为1个疗程,共治疗4个疗程(共24周)。分别在治疗前、治疗第12周、治疗第24周、36周随访时、48周随访时观察等效球镜、最佳裸眼远视力、眼轴、角膜曲率K1、调节幅度、中医证候评分、等效球镜进展量,并于治疗第24周判定近视进展控制率,治疗前后分别进行安全性指标检测。结果48周随访时治疗组等效球镜进展量低于对照组(P<0.05)。治疗组近视进展控制率(57.60%,72/125)高于对照组(44.63%,54/121)(P<0.05)。治疗组36周随访时最佳裸眼远视力高于对照组(P<0.05);两组各观察时点等效球镜与治疗前比较均明显降低(P<0.05),48周随访时治疗组高于对照组(P<0.05);两组眼轴治疗及随访各观察时点与治疗前比较均明显升高(P<0.05),治疗组眼轴增长量在治疗第24周及48周随访时均低于对照组(P<0.05);治疗组角膜曲率K1治疗第24周较治疗前明显降低(P<0.05);治疗组调节幅度在36周及48周随访时均较治疗前明显提高(P<0.05)。两组患儿在治疗第12周、第24周及36周、48周随访时面色淡白/晦滞、苔白脉细、神疲乏力评分及中医证候总积分均较治疗前明显降低(P<0.05);治疗第24周及36周随访时视物模糊评分均较治疗前明显降低(P<0.05);48周随访时治疗组视物模糊评分较治疗前明显降低(P<0.05)。治疗组36周随访时神疲乏力评分高于对照组,48周随访时视物模糊评分低于对照组(P<0.05)。两组治疗过程均未发现不良反应,治疗前后安全性指标未见明显异常。结论中药明视方具有控制低度近视度数进展、提高最佳裸眼远视力、减缓眼轴增长、改善部分中医症状等作用,且具有较好安全性。

关键词：低度近视儿童明视方精筋失衡心阳不足证

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