检索结果-南通市图书馆

Chinese Medical Journal 2024年第4期137卷 484-486页

作者： Jian Wu Qi Zhang Xu Jia Yingting Zhu Zhidong Li Shu Tu Ling Zhao Yifan Du Wei Liu Jiaoyan Ren Liangzhi Xu Hanxiang Yu Fagao Luo Wenru Su ningli wang Yehong Zhuo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-sen UniversityGuangzhouGuangdong 510060China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China School of Food Sciences and Engineering South China University of TechnologyGuangzhouGuangdong 510641China Guangzhou Huazhen Biosciences GuangzhouGuangdong 510920China

To the Editor:Normal-tension glaucoma(NTG)is a progressive optic neuropathy characterized by irreversible blindness with statistically normal intraocular pressure(IOP)(≤21 mmHg),^([1,2])which makes early-stage diagnosis in the clinical practice difficult.Pathophysiological pathways underlying NTG include vascular dysregulation,toxic metabolite accumulation,and elevated translaminar cribrosa pressure difference(TLCPD).^([3])Although various small animal models have provided evidence of different pathophysiological mechanisms,the complicated clinical phenotype cannot be fully imitated by secondary disease models,and the gap between rodents and humans weakens their translational potential.Thus,the pathological changes associated with NTG remain unclear.

关键词： elevated glaucoma diagnosis

Fabrication of CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2) photocatalyst with intrinsic p-n junction for highly efficient bisphenol A degradation

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 547-558页

作者： Yong wang Cheng Liu Haoyun Hu Qiujun Lu Haiyan wang Chenxi Zhao Fuyou Du ningli Tang Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China College of Biological and Environmental Engineering Changsha UniversityChangsha 410022China

The construction and application of novel highly efficient photocatalysts have been the focus in the field of environmental pollutant removal.In this work,a novel CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)photocatalysts were synthesized by simple hydrothermal and chemical precipitation method.The fabricated CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)composite exhibited much higher photocatalytic activity than pristine CuFe_(2)O_(4)and Bi_(12)O_(17)Cl_(2)in the removal of bisphenol A(BPA)under visible-light illumination,which ascribed to the intrinsic p-n junction of CuFe_(2)O_(4)and Bi_(12)O_(17)Cl_(2).The photocatalytic degradation rate of BPA on CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)with an optimized CuFe_(2)O_(4)content(1.0 wt.%)reached 93.0%within 30 min.The capture experiments of active species confirmed that the hydroxyl radicals(·OH)and superoxide radicals(·O_(2)^(-))played crucial roles in photocatalytic BPA degradation process.Furthermore,the possible degradation mechanism and pathways of BPA was proposed according to the detected intermediates in photocatalytic reaction process.

关键词： Bi_(12)O_(17)Cl_(2) CuFe_(2)O_(4) Heterojunction Bisphenol A Photocatalytic degradation

The new criteria for differential diagnosis of indeterminate biliary stricture under super minimally invasive peroral cholangioscopy

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第3期137卷 255-256页

作者： Wengang Zhang ningli Chai Qingzhen Wu Enqiang Linghu Department of Gastroenterology Chinese PLA General HospitalBeijing 100853China

Indeterminate biliary stricture(IBS)refers to biliary stricture with an uncertain histological diagnosis^([1])and can be classified as non-neoplastic stricture or neoplastic stricture.The former is mainly caused by various inflammatory biliopancreatic diseases,congenital malformations,or postoperative bile duct injury,while the latter exists in neoplastic lesions such as cholangiocarcinoma,invasion from pancreatic cancer,and adenomas in the bile duct.Most non-neoplastic strictures can be relieved by endoscopic or conservative medical treatment,and only a few require surgical intervention.Nevertheless,radical surgery or palliative biliary drainage should be applied for neoplastic strictures according to the progression of the disease.Therefore,it is essential to obtain an accurate diagnosis for IBS in clinical work.

关键词： diagnosis stricture biliary

The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2022年第6期65卷 1171-1180页

作者： Xiangxiang Liu Mohamed M.Khodeiry Danting Lin Yunxiao Sun Qing Zhang Jiawei wang Richard K.Lee ningli wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiami FL 33136USA Research institute of Ophthalmology Giza 12557Egypt Beijing Ophthalmology and Visual Science Key Laboratory Beijing Eye InstituteBeijing 100730China Department of Neurology and Medical Research Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The present study aims to investigate the effect of temporary cerebrospinal fluid pressure(CSFP) reduction on optic nerve head(ONH) and macular vessel density(VD) using optical coherence tomography angiography.Forty-four eyes of 44 adults with diagnostic lumbar puncture and CSFP reduction were recruited.Thirty-two eyes of 32 healthy volunteers were controls.ONH and macular VD images were evaluated differences between baseline and after CSFP reduction.The results showed that the mean CSFP decreased from(11.6±2.1) mm Hg to(8.2±3.4) mm Hg(P0.05).In the study group,decreased VD in the macular parainferior region was associated with CSFP reduction(R^(2)=0.192,P=0.003),the reduction of macular VD in parafoveal(R^(2)=0.098,P=0.018),parainferior(R^(2)=0.104,P=0.021),parasuperior(R^(2)=0.059,P=0.058),paranasal(R^(2)=0.057,P=0.042),paratemporal(R^(2)=0.079,P=0.026) was associated with mean ocular perfusion pressure decrease following CSFP reduction.ONH vessel density did not differ after CSFP reduction(all P>0.05).In conclusion,macular vessel density decreased in association with CSFP reduction.Retinal vessel density in the macular region is more sensitive than that in peripapillary region after CSFP reduction.

关键词： cerebrospinal fluid pressure reduction macular vessel density peripapillary vessel density blood pressure

Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第7期66卷 1693-1696页

作者： Shen Wu Chen Xin Wei Zhu Yue Wan Qing Sang Rong Du Jian Wu Jin wang ningli wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing100730China Beijing Institute of Brain Disorders Collaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijing100069China Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application Capital Medical UniversityBeijing100069China Department of Pharmacology School of PharmacyQingdao UniversityQingdao266021China

The blood circulatory system is the largest system of fluid flow in the human body,and it has been widely studied and well understood.Pulsation characterizes the blood circulatory system and results in three essentials,including(i)pressure fluctuations attributed to pumping of the heart,(ii)the self-regulatory,elastic cardiac muscle,which is sensitive to pressure variance and controls the output volume of the heart,and(iii)valves controlling the one-way flow.

关键词： glaucoma intraocular breakthrough

Enlightenment of blinding trachoma elimination in China

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2017年第12期60卷 1453-1456页

作者： Ailian Hu ningli wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&vision Science Key LabBeijing 100730China

Trachoma is a blinding eye disease caused by Chlamydia trachomatis infection.Trachoma was pandemic in the 19th century and rampant around the world,and was a widely prevalent infectious eye disease.Still prevalent in some countries and regions,it is an eye disease with the longest epidemic time.Trachoma is a blinding eye disease pandemic globally,having caused many people to lose their visions

关键词： Enlightenment of blinding trachoma elimination in China

Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第3期8卷 912-915页

作者： Xiao Liu Fei Hao Peng Hao Jingxue Zhang Liqiang wang Si-Wei You ningli wang Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical University100069 BeijingChina School of Engineering Medicine Beijing Key Laboratory for Biomaterials and Neural RegenerationBeihang University100083 BeijingChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key Laboratory100005 BeijingChina Department of Ophthalmology The Third Medical CenterChinese PLA General Hospital100089 BeijingChina Department of Ophthalmology Xijing HospitalThe Fourth Military Medical University710032 Xi’anShanxi ProvinceChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan University510632 GuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) 510530 GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong999077 Hong KongChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay Area510515 GuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong University226001 NantongJiangsu ProvinceChina Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang University100083 BeijingChina

Dear Editor,The optic nerve,which belongs to the central nervous system(CNS),cannot regenerate when injured in adult mammals.1 Up to now,no readily translatable measures are available for repairing a severely injured optic nerve.Herein we demonstrated that ciliary neurotrophic factor(CNTF)-chitosan enabled the reconstruction and functional recovery of the adult rat visual system,thus shedding light on the clinical potential for repairing the severely injured optic nerve.

关键词： Regeneration functional CNTF

Retinal microvasculature is a potential biomarker for acute mountain sickness

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第6期66卷 1290-1302页

作者： Yuan Xie Diya Yang Alex S.Huang Yiquan Yang Ying Han Yunxiao Sun Kai Cao Huaizhou wang Shizheng Wu Qiang Zhu Guozhong wang Tianyi Wu ningli wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing100005China The Viterbi Family Department of Ophthalmology Shiley Eye InstituteUniversity of CaliforniaSan DiegoCA92121USA Department of Ophthalmology University of CaliforniaSan FranciscoCA94143USA Institution of Geriatric Qinghai Provincial Hospital Xining810007China Department of Ultrasound Beijing Tongren HospitalCapital Medical UniversityBeijing100730China Department of Hyperbaric and Hypobaric Chamber Civil Aviation General HospitalBeijing100025China National Key Laboratory of High Altitude Medicine China High Altitude Medical Research InstituteXining810012China

Increased cerebral blood flow resulting from altered capillary level autoregulation at high altitudes leads to capillary overperfusion and then vasogenic cerebral edema,which is the leading hypothesis of acute mountain sickness(AMS).However,studies on cerebral blood flow in AMS have been mostly restricted to gross cerebrovascular endpoints as opposed to the microvasculature.This study aimed to investigate ocular microcirculation alterations,the only visualized capillaries in the central neural system(CNS),during early-stage AMS using a hypobaric chamber.This study found that after high altitude simulation,the optic nerve showed retinal nerve fiber layer thickening(P=0.004–0.018)in some locations,and the area of the optic nerve subarachnoid space(P=0.004)enlarged.Optical coherence tomography angiography(OCTA)showed increased retinal radial peripapillary capillary(RPC)flow density(P=0.003–0.046),particularly on the nasal side of the nerve.The AMSpositive group had the largest increases in RPC flow density in the nasal sector(AMS-positive,?3.21±2.37;AMS-negative,?0.01±2.16,P=0.004).Among multiple ocular changes,OCTA increase in RPC flow density was associated with simulated early-stage AMS symptoms(beta=0.222,95%CI,0.009–0.435,P=0.042).The area under the receiver operating characteristics curve(AUC)for the changes in RPC flow density to predict early-stage AMS outcomes was 0.882(95%CI,0.746–0.998).The results further confirmed that overperfusion of microvascular beds is the key pathophysiologic change in early-stage AMS.RPC OCTA endpoints may serve as a rapid,noninvasive potential biomarker for CNS microvascular changes and AMS development during risk assessment of individuals at high altitudes.

关键词： optical coherence tomography angiography retinal microvasculature acute mountain sickness

Elimination of blinding trachoma in China: why is further study necessary?

在线全文

学校读者我要写书评

暂无评论

中国科学：生命科学英文版 2016年第6期59卷 539-540页

作者： ningli wang Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual Sciences

Sixty years ago,Prof.Feifan Tang and Xiaolou Zhang first discovered and isolated Chlamydia trachomatis,a finding that clarified the cause of trachoma and marked the beginning of a fresh chapter on trachoma research,pr... 详细信息

关键词：沙眼衣原体致盲中国

A review of trachoma history in China: research, prevention, and control

在线全文

学校读者我要写书评

暂无评论

中国科学：生命科学英文版 2016年第6期59卷 541-547页

作者： ningli wang Shijing Deng Lei Tian Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical UniversityBeijing Ophthalmology & Visual Sciences Key Laboratory

Trachoma is one of the most widespread blinding eye diseases, which is harmful to human visual health. The efforts to prevent and control trachoma in China can be divided into three periods, i.e., highly epidemic period, research on pathogenesis and control of trachoma, and blinding trachoma elimination and epidemiological evaluation. In 1956, Prof. Feifan Tang and Xiaolou Zhang first discovered and isolated Chlamydia trachomatis, which clarified the cause of trachoma, and kick-started a fresh chapter in trachoma research, prevention, and control around the world. Although, the prevalence of trachoma differed in different areas, the average prevalence once exceeded 50% and was as high as 90% in some areas before and at early liberation of China. Therefore, the government-led efforts were made to comprehensively prevent and control trachoma, including development of National Plan for the Prevention and Control of Trachoma, nationwide screening and treatment of trachoma, implementation of National Patriotic Health Campaign and improvement of water supply and lavatories. After decades of effort, China reached the goal of eliminating blinding trachoma in 2015. China has gained remarkable achievements in the prevention and treatment of trachoma, making outstanding contributions toward the goal of eliminating trachoma worldwide. The research, prevention, and control of trachoma in China were reviewed in this paper.

关键词：沙眼衣原体控制预防中国历史人类视觉发病机理流行病学