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Water Science and Engineering 2013年第3期6卷 250-261页

作者： Zu-lin HUA Wei JI ning-ning shan Wei WU Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of Education Hohai University College of Environment Hohai University National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai University

A multi-anabranch river with three braid bars is a typical river pattern in nature, but no studies have been conducted to describe mixing characteristics of pollutants in the river. In this study, a physical model of a typical multi-anabranch river with three braid bars was established to explore the pollutant mixing characteristics in different branches. The multi-anabranch reach was separated into seven branches, B1, B2, B3, B4, B5, B6, and BT, by three braid bars. Five tracer release positions located 2.9 m upstream from the inlet section of the multi-anabranch reach were adopted, and the distances from the five positions to the left bank of the upstream main channel were 1/6B, 1/3B, 1/2B, 2/3B, and 5/6B （B is the width of the upstream main channel）, respectively. The longitudinal velocities and pollutant concentrations in the seven branches were measured. The planar flow field and mixing characteristics of pollutants from the bottom to the surface in the multi-anabranch river were obtained and analyzed. The results show that the pollutant release positions are the main influencing factors in the pollutant transport process, and the diversion points and pollutant release positions jointly influence the percentage ratios of the pollutant fluxes in branches B 1, B2, and B3 to the pollutant flux in the upstream main channel.

关键词： multi-anabranch river braid bar, pollutant mixing characteristic pollutanttransport process

Research Progress on Artemisinin and Its Derivatives against Hematological Malignancies

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Chinese Journal of Integrative Medicine 2020年第12期26卷 947-955页

作者： LI Ying shan ning-ning SUI Xiao-hui Department of Hematology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan(250021)China

Although current therapeutic methods against hematological malignancies are effective in the early stage,they usually lose their effectiveness because of the development of drug *** new drugs with significant therapeutic effects is one of the current research ***,an extract from the plant Artemisia annua Linne,and its derivatives have excellent antimalarial effects in clinical applications as well as excellent *** studies have documented that artemisinin and its derivatives(ARTs)also have significant effects against multiple types of tumours,including hematological *** review focuses on the latest research achievements of ARTs in the treatment of hematological malignancies as well as its mechanisms and future *** mechanisms of ARTs against different types of hematological malignancies mainly include cell cycle arrest,induction autophagy and apoptosis,inhibition of angiogenesis,production of reactive oxygen species,and induction of ***,the review also summarizes the anticancer effects of ARTs in many drug-resistant hematological malignancies and its synergistic effects with other drugs.

关键词： artemisinin artesunate dihydroartemisinin hematological malignancies review

基于CiteSpaceⅡ的信息素养教育领域可视化分析

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农业图书情报学刊 2016年第10期28卷 67-71页

作者：赵艳丽董宏伟孙宁宁张桂山吉林农业大学图书馆吉林长春130118 吉林省农业广播电视学校吉林长春130021

为了探知信息素养教育研究领域发展态势,研究应用Cite SpaceⅡ软件绘制信息素养教育研究领域的国家机构分布、著者分布、文献共被引可视化知识图谱,探测该领域的演进路径和研究热点。

关键词：信息素养教育 CiteSpaceⅡ 知识图谱可视化

Spectral Synthesis via Mean Field approach to Independent Component Analysis

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Research in Astronomy and Astrophysics 2016年第3期16卷 51-62页

作者： ning Hu shan-shan Su Xu Kong CAS Key Laboratory for Research in Galaxies and Cosmology Department of Astronomy University of Science and Technology of China

We apply a new statistical analysis technique, the Mean Field approach to Independent Component Analysis（MF-ICA） in a Bayseian framework, to galaxy spectral analysis. This algorithm can compress a stellar spectral library into a few Independent Components（ICs）, and the galaxy spectrum can be reconstructed by these ICs. Compared to other algorithms which decompose a galaxy spectrum into a combination of several simple stellar populations, the MF-ICA approach offers a large improvement in efficiency. To check the reliability of this spectral analysis method, three different methods are used：（1） parameter recovery for simulated galaxies,（2） comparison with parameters estimated by other methods, and（3） consistency test of parameters derived with galaxies from the Sloan Digital Sky Survey. We find that our MF-ICA method can not only fit the observed galaxy spectra efficiently, but can also accurately recover the physical parameters of galaxies. We also apply our spectral analysis method to the DEEP2 spectroscopic data, and find it can provide excellent fitting results for low signal-to-noise spectra.

关键词： methods: data analysis -- methods: statistical -- galaxies: evolution -- galaxies: fundamentalparameters -- galaxies: stellar content

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Molecular basis for the selective recognition and ubiquitination of centromeric histone H3 by yeast E3 ligase Psh1

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Journal of Genetics and Genomics 2021年第6期48卷 463-472页

作者： ning Zhou Liuxin Shi shan shan Zheng Zhou National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100089China

Centromeres are chromosomal loci marked by histone variant Cen H3(centromeric histone H3)and essential for genomic stability and cell *** budding yeast E3 ubiquitin ligase Psh1 selectively recognizes the yeast Cen H3(Cse4)for ubiquitination and controls the cellular level of Cse4 for proteolysis,but the underlying mechanism remains largely ***,we show that Psh1 uses a Cse4-binding domain(CBD,residues 1-211)to interact with Cse4-H4 instead of H3-H4,yielding a dissociation constant(Kd)of 27 ***1 recognizes Cse4-specific residues in the L1 loop and a2 helix to ensure Cse4 binding and *** map the Psh1-binding region of Cse4-H4 and identify a wide range of Cse4-specific residues required for the Psh1-mediated Cse4 recognition and *** analyses reveal that histone chaperone Scm3 can impair Cse4 ubiquitination by abrogating Psh1-Cse4 ***,our study reveals a novel Cse4-binding mode distinct from those of known Cen H3 chaperones and elucidates the mechanism by which Scm3 competes with Psh1 for Cse4 binding.

关键词： Cse4 CENP-A Psh1 Scm3 Selective recognition Ubiquitination

Indirect approach for predicting cutting force coefficients and power consumption in milling process

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Advances in Manufacturing 2022年第1期10卷 101-113页

作者： Kai-ning Shi ning Liu Cong-Le Liu Jun-Xue Ren shan-shan Yang Wei Chit Tan Key Laboratory of High Performance Manufacturing for Aero Engine Department of Mechanical EngineeringMinistry of Industry and Information TechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China Engineering Research Centre of Advanced Manufacturing Technology for Aero Engine Department of Mechanical EngineeringMinistry of EducationNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China Virtual Manufacturing Group Smart Manufacturing DivisionAdvanced Remanufacturing and Technology Centre3 Cleantech Loop#01-01CleanTech TwoSingapore 637143Singapore

Accurate energy consumption modeling is an essential prerequisite for sustainable ***,cutting-power-based models have garnered significant attention,as they can provide more comprehensive information regarding the machining energy consumption ***,their implementation is challenging because new cutting force coefficients are typically required to address new workpiece ***,cutting force coefficients are calculated at a high operation cost as a dynamometer must be ***,a novel indirect approach for estimating the cutting force coefficients of a new tool-workpiece pair is proposed *** key idea is to convert the cutting force coefficient calculation problem into an optimization problem,whose solution can be effectively obtained using the proposed simulated annealing ***,the cutting force coefficients for a new tool-workpiece pair can be estimated from a pre-calibrated energy consumption *** experiments performed using different machine tools clearly demonstrate the effectiveness of the developed *** studies with measured cutting force coefficients reveal the decent accuracy of the approach in terms of both energy consumption prediction and instantaneous cutting force *** proposed approach can provide an accurate and reliable estimation of cutting force coefficients for new workpiece materials while avoiding operational or economic problems encountered in traditional force monitoring methods involving ***,this study may significantly advance the development of sustainable manufacturing.

关键词： Sustainable manufacturing Cutting force coefficients Energy consumption Machining processSimulated annealing

Effects of the mid-air collision on sand saltation

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Science China(Physics,Mechanics & Astronomy) 2008年第9期51卷 1416-1426页

作者： HUANG ning REN shan ZHENG XiaoJing Key Laboratory of Mechanics on Western Disaster and Environment Ministry of EducationDepartment of MechanicsLanzhou UniversityLanzhou 730000China

As to the fact that the effects of saltating particles’ mid-air collision on the sand transport rate are often neglected in the current theoretical models describing sand saltation movement,expressions to calculate velocity diversity of saltating parti-cles after mid-air collision are presented through collision theory of hard ball in this paper. Then,the theoretical model of the wind blown sand movement at the steady state,taking account of coupled interaction between saltation particles and wind,is combined with the model of the mid-air collision probability to calculate the sal-tating particles’ mass flux at heights,the sand transport rate,and further,their changing rules. The comparison of the results with those when the mid-air collision is not considered suggests that the mass flux at heights and the sand transport rate in this paper are less,and much closer,respectively,to the corresponding experi-mental values. The difference between the sand mass fluxes without and with con-sideration of mid-air collision increases at first,and then decreases as the height increases,exhibiting the stratified characteristics.

关键词： mid-air collision sand transport rate saltation

Locomotion trajectory with cooperative metrics in wireless sensor networks

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The Journal of China Universities of Posts and Telecommunications 2007年第2期14卷 64-68,74页

作者： QIN ning-ning ZHANG Lin shan Xiu-ming XU Bao-guo The School of Communications and Control Engineering Jiangnan University Wuxi 214122 China The Electrical Engineering Department Tsinghua University Beijing 100084 China

Detection coverage control is one of the most important topics in the intrusion detection problem of wireless sensor networks （WSN）. However, its converse, i.e., to design an object locomotion trajectory in WSN, has not received enough attention. This article proposes a heuristic algorithm, namely, the security ＆ speed （SS） algorithm, to depict such a trajectory that takes into consideration both security and speed. The merit of the SS algorithm is its topology independency. When compared with traditional algorithms, the SS algorithm approaches the optimal trajectory better, and enjoys considerably lower computational load, and a better and adjustable tradeoff between trajectory security and speed.

关键词： WSN coverage control locomotion trajectory algorithm

Modified Bishop method for stability analysis of weakly sloped subgrade under centrifuge model test

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 727-741页

作者： Ke SHENG Bao-ning HONG Xin LIU Hao shan Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China Jiangsu Research Center for Geotechnical Engineering Technology Hohai UniversityNanjing210098China Geotechnical Research Institute Hohai UniversityNanjing210098China Research Institute of Tunnel and Underground Engineering Hohai UniversityNanjing 210098China School of Civil Engineering Xuzhou University of TechnologyXuzhou 221018China

The sliding forms of weak sloped and horizontal subgrades during the sliding process *** addition,the sliding form of weakly sloped subgrades exhibits considerable slippage and *** accuracy of traditional slice methods for computing the stability safety factor of weakly sloped subgrades is insufficient for a subgrade *** this study,a novel modified Bishop method was developed to improve the accuracy of the stability safety factor for different inclination *** instability mechanism of the weakly sloped subgrade was considered in the proposed method using the“influential force”and“additional force”***“additional force”reflected the weight effect of the embankment fill,whereas the“influential force”reflected the effect of the potential energy *** simulations and experimental tests were conducted to evaluate the advantages of the proposed modified Bishop *** with the traditional slice method,the error between the proposed method and the exact value is less than 32.3%in calculating the safety factor.

关键词： weakly sloped subgrade stability analysis additional force influential force modified Bishop method