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Progression on canaloplasty for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1629-1633页

作者： Jun Zhang ning-li wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Dalian Aier Eye Hospital Dalian 116031Liaoning ProvinceChina

As a non-penetrating glaucoma surgery(NPGS), canaloplasty aims to reconstruct the physiological outflow of aqueous humor by dilating the Schlemm’s canal. Ab interno canaloplasty(ABiC), which can reconstruct the natural outflow pathways of aqueous humor in mild-tomoderate primary open angle glaucoma(POAG) patients, is a new minimally invasive glaucoma surgery(MIGS) procedure improving from traditional canaloplasty. Canaloplasty can reduce intraocular pressure(IOP) with high efficiency and security. There are no complications such as scar formation and encapsulation for this no-bleb canaloplasty.

关键词： glaucoma canaloplasty ab-interno canaloplasty

Predicting the prognosis of primary orbital lymphoma by clinical characteristics and imaging features

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International Journal of Ophthalmology(English edition) 2023年第5期16卷 705-711页

作者： Jian-Bo Zhu Bin li Hong-Mei Zhang ning-li wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual ScienceBeijing 100730China Department of Diagnostic Radiology Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China

AIM: To analyze the 5-year disease-free survival(DFS) of primary orbital lymphoma(POL) by clinical characteristics and imaging ***: A total of 72 patients, 43 males and 29 females, with histologically confirmed POL, were retrospectively recruited between January 2012 and May 2017. The information on clinical characteristics, imaging features, and 5-year DFS was obtained. Univariate and multivariate forward logistic regression analyses were used to identify the variables significantly associated with 5-year DFS. Kaplan-Meier was applied for survival analysis. RESULTS: Univariate analysis revealed that uni-or bilateral orbital involvement, single or multiple lesions, treatment methods, and contrast enhancement pattern on images were significant for 5-year DFS(P=0.022, 0.042, <0.001, and 0.028, respectively), while in multivariate logistic regression analysis, only uni-or bilateral orbital involvement, treatment methods and contrast enhancement pattern on images were significant(r=0.453, 0.897, and 0.556, P=0.038, <0.001 and 0.022, respectively). The survival curves for DFS were obtained. CONCLUSION: The majority of POL are B-cell lymphomas. Unilateral orbital involvement, homogeneous contrast enhancement on images, and the appropriate treatment schemes result to be significant factors for a good prognosis for POL.

关键词： lymphoma orbital primary prognosis

Sulforaphane modulates TGFβ2-induced conjunctival fibroblasts activation and fibrosis by inhibiting PI3K/Akt signaling

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1505-1511页

作者： Han-Ruo liu Zi-Yao Xia ning-li wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren Hospital of Capital Medical UniversityBeijing Key Laboratory of Ophthalmology&Visual SciencesBeijing 100005China

AIM:To examine the effects of sulforaphane on fibrotic changes of transforming growth factor(TGFβ2)induced human conjunctival fibroblast(HCon Fs).METHODS:HCon Fs were cultured and divided into control,TGFβ2(1 ng/m L),sulforaphane and TGFβ2+sulforaphane *** viability and apoptosis were detected using the MTT and Apo Tox-Glo Triplex *** migration was detected using scratch and Transwell ***-time quantitative PCR method was used to evaluate m RNA expression of TGFβ2,matrix metalloproteinase-2(MMP2),myosin light chain kinase(MYLK),integrinαV,integrinα5,fibronectin 1 andα-smooth muscle actin(α-SMA).The protein expression ofα-SMA,p-PI3 K,PI3 K,p-Akt,and Akt were detected by Western ***:The proliferation of HCon Fs was significantly(Pliferation after 48 h incubation was significantly reduced with 100μmol/L sulforaphane treatment by 17.53%(Pliferation,migration,and synthesis of the extracellular matrix in HCon Fs,and inhibiting the PI3 K/Akt signaling *** could be a potential therapeutic drug for prevention of scar formation in filtering bleb after trabeculectomy.

关键词： human conjunctival fibroblasts sulforaphane transforming growth factorβ2 PI3K/Akt signaling

Spillover of international crude oil prices on China's refined oil wholesale prices and price forecasting:Daily-frequency data of private enterprises and local refineries

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Petroleum Science 2022年第3期19卷 1433-1442页

作者： Xun-Zhang Pan Xi-Ran Ma li-ning wang Ya-Chen Lu Jia-Quan Dai Xiang li School of Economics and Management China University of PetroleumBeijing 102249China Economics&Technology Research Institute China National Petroleum CorporationBeijing 100724China Key Laboratory of Oil and Gas Market Simulation and Price Forecasting China National Petroleum CorporationBeijing 100724China Institue of Energy Peking UniversityBeijing 100080China

Compared with retail prices of state-owned companies used in almost all existing studies,China’s refined oil wholesale prices of private enterprises and local refineries are more affected by the market and better reflect the real supply-demand *** the first time,this paper applies own-monitored dailyfrequency wholesale prices of China’s private enterprises and local refineries during 2013-2020 to derive spillover effects of international crude oil prices on China’s refined oil prices through the VAR-BEKKGARCH(vector autoregression-Baba,Engle,Kraft,and Kroner-generalized autoregressive conditional heteroscedasticity)model,and then tries to forecast wholesale prices through the PCA-BP(principal component analysis-back propagation)neural network *** show that international crude oil prices have significant mean spillover and volatility spillover effects on China’s refined oil wholesale *** in crude oil prices are the Granger cause of changes in refined oil wholesale *** the improvement of China’s oil-pricing mechanism in 2016,the volatility spillover from the international crude oil market to China’s refined oil market gradually increases,and the BRENT price variation has an increasing impact on the refined oil wholesale price *** PCA-BP model could serve as a candidate tool for forecasting China’s refined oil wholesale prices.

关键词： Own-monitored daily-frequency data Refined oil wholesale prices Spillover effects VAR-BEKK-GARCH PCA-BP neural Network

Development of gene and stem cell therapy for ocular neurodegeneration

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 622-630页

作者： Jing-Xue Zhang ning-li wang Qing-Jun Lu Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University

Retinal degenerative diseases pose a serious threat to eye health, but there is currently no effective treatment available. Recent years have witnessed rapid development of several cutting-edge technologies, such as gene therapy, stem cell therapy, and tissue engineering. Due to the special features of ocular structure, some of these technologies have been translated into ophthalmological clinic practice with fruitful achievements, setting a good example for other fields. This paper reviews the development of the gene and stem cell therapies in ophthalmology.

关键词： stem cell gene therapy retina translational medicine

A Running Average Method for Predicting the Size and Length of a Solar Cycle

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Chinese Journal of Astronomy and Astrophysics 2008年第4期8卷 477-488页

作者： Zhan-Le Du Hua-ning wang li-Yun Zhang National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

The running correlation coefficient between the solar cycle amplitudes and the max-max cycle lengths at a given cycle lag is found to vary roughly in a cyclical wave with the cycle number, based on the smoothed monthly mean Group sunspot numbers available since 1610. A running average method is proposed to predict the size and length of a solar cycle by the use of the varying trend of the coefficients. It is found that, when a condition （that the correlation becomes stronger） is satisfied, the mean prediction error （16.1） is much smaller than when the condition is not satisfied （38.7）. This result can be explained by the fact that the prediction must fall on the regression line and increase the strength of the correlation. The method itself can also indicate whether the prediction is reasonable or not. To obtain a reasonable prediction, it is more important to search for a running correlation coefficient whose varying trend satisfies the proposed condition, and the result does not depend so much on the size of the correlation coefficient. As an application, the peak sunspot number of cycle 24 is estimated as 140.4 ± 15.7, and the peak as May 2012 ±11 months.

关键词： Sun activity -- Sun sunspots - Sun general

Human podocyte injury in the early course of hypertensive renal injury

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World Journal of Clinical Cases 2019年第22期7卷 3698-3710页

作者： Da Sun Jiao-Jiao wang Wei wang Juan wang li-ning wang li Yao Ying-Hui Sun Zi-Long li Department of Nephrology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Experimental Medicine General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina

BACKGROUND Hypertension is prevalent in the general population and is regarded as the second leading cause of renal damage and dysfunction,outnumbered only by ***,the mechanisms remain *** To investigate podocyte injury induced by hypertension in the early course without massive proteinuria or renal *** The hypertension group comprised 18 patients with hypertension accompanied by microalbuminuria,diagnosed with hypertensive renal injury according to biopsy *** a comparison of pathological changes in renal tissue,control group 1 comprised 10 healthy volunteers,and control group 2 comprised 16 patients who underwent surgery for renal *** The hypertension group had significantly higher blood pressure(P=0.000)and microalbuminuria(P=0.000)compared with control group *** the hypertension group,urinary podocytes were detected following positive staining of podocytespecific nephrin and/or CD2-associated protein(CD2AP)in urine *** foot process fusion and a significant decrease in nephrin and/or CD2AP expression in glomeruli were observed in the hypertension group compared with control group *** indicated that hypertension caused podocyte injury and detachment from the glomerular basement membrane,which was consistent with urinary detection of *** Our results suggest that podocyturia appears early in the course of hypertensive renal injury,and may be a sensitive marker for early prediction of hypertensive renal injury.

关键词： Podocyte Hypertension Hypertensive renal injury Microalbuminuria Nephrin CD2-associated protein

Dedifferentiated orbital liposarcoma: a case report

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 452-453页

作者： Jing-Xue Zhang Jian-Min Ma and ning-li wang Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 100730 China

AIM: To report the abnormal type of the orbital liposarcoma-dedifferentiated subtype in a patient. METHODS: A case report. RESULTS: A 23 years old Chinese woman with a recurrence of right-sided proptosis was evaluated. Ocular examination revealed proptosis of the right eye with chemosis, hyperemia and limitation of eye movements. Magnetic resonance imaging scanning showed an irregular shaped tumor in the right orbit. The tumor resection was done with a clinical diagnosis of malignant tumor. Histopathological findings revealed the diagnosis of dedifferentiated liposarcoma. CONCLUSION: The rare occurrence of this tumour should be kept in mind while dealing with orbital tumours.

关键词： orbit liposarcoma tumour

Neurodegeneration in Diabetic Retinopathy： Current Concepts and Therapeutic Implications

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Chinese Medical Journal 2016年第24期129卷 3001-3003页

作者： ning-li wang Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing 100005 China

The prevalence of diabetes mellitus （DM） has increased significantly in recent decades in China. Recently, it has been reported that the estimated prevalence of DM among a representative sample of Chinese adults was 11.6% and the prevalence of prediabetes was 50.1%. Furthermore, the awareness, treatment, and control rates of DM in the general Chinese population are disproportionately low, raising concerns for future high rates of diabetes-related morbidity and mortality.

关键词： Diabetic Retinopathy Neurodegeneration Neuroprotection