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Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats

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Chinese Medical Journal 2013年第11期126卷 2157-2162页

作者： LIU Ran sun ning-ling yang Song-na GUO Jian-qiang Department of Cardiology Peking University People's HospitalBeijing 100044 China

Background Catestatin, a chromogranin A-derived peptide, is a potent antagonist of nicotine-evoked catecholamine release. We know that catecholamine plays an important role in cardiovascular remodeling induced by hypertension, therefore we hypothesized that catestatin would affect target-organ structure during hypertension. Methods Twelve spontaneously hypertensive rats （SHRs） were randomized to SHR control group and catestatin group, the normal control group was comprised of six healthy Wistar-Kyoto rats of the same age. Tail-cuff blood pressure and pulse rate were obtained at weeks 1, 4 and 8. At the end of the eight-week period, the heart, abdominal aorta and left kidney were excised and weighed, VG staining was done and the intima-media thickness of vessels and the collagen volume fraction were assessed by an image acquisition and analysis system. The proliferating cell nuclear antigen （PCNA） was observed by immunohistochemistry, and real time reverse transcription-polymerase chain reaction （RT-PCR） was used to detect the mRNA levels of proliferative genes including cyclin A, ki67 and PCNA in the abdominal aorta. Results All the parameters in SHR observed in the present study increased significantly compared to Wistar Kyoto rats （P 〈0.01 ）. With intervention with catestatin, the systolic blood pressure decreased slightly but it was not significantly different from the SHR control, the cardiac mass index and left ventricular mass index both decreased significantly, the collagen volume fraction decreased by nearly 30% in the heart, by 25% in vessels and by 10% in the kidney, and the intima-media thickness and expression of proliferative genes, including cyclin A, ki67 and PCNA, in the abdominal aorta also decreased significantly. Conclusions The present study indicated that catestatin could ameliorate proliferating changes of heart, kidney and vessels during hypertension, especially to the deposition of interstitial collagen. Blood pressure was not the main factor

关键词： catestatin spontaneously hypertensive rat target-organ structure interstitial collagen

Transcriptome and microRNA Profiling Analyses Reveal various Anti-metastatic Effect of Dihydrobenzofuran Lignan on Tumor-Associated Fibroblasts

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Transcriptome and microRNA Profiling Analyses Reveal various...

第十四届全国中药和天然药物学术研讨会

作者： Shu-Yi Yin ning-sun yang Academia Sinica

＜正＞Tumor-associated fibroblasts（TAFs）,are essential for tumor progression and metastasis by providing a functional supportive *** study was aimed to evaluate various regulatory effects of specific phytochemical on mammary TAFs.A synthetic dihydrobenzofuran lignan（Q2-3）,the dimerization product of caffeic acid methyl ester,was shown with specific

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Differential Effect of Shikonin-induced Immunogenic Cell Death Versus Autophagy:Mechanisms and Application for DC-based Cancer Vaccine

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Differential Effect of Shikonin-induced Immunogenic Cell Dea...

第十四届全国中药和天然药物学术研讨会

作者： Sheng-Yen Lin Wen-Chi Wei Pei-Wen Hsiao ning-sun yang Academia Sinica National Defense Medical Center

＜正＞Tumor immunogenicity can be characterized by the exposure of damage-associated molecular patterns（DAMPs）on cell surface,which can recruit dendritic cells（DCs）and enhance DC *** studies have demonstrated that chemotherapy-induced autophagy may positively regulate immunogenic cell death（ICD）.We recently showed that

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Oral Feeding with phytochemicais from Medicinal Plant TMP1 effectively Suppress Mammary Tumor Metastasis via Inhibition of Granulocytic Myeloid-derived Suppressor Cell Activities

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Oral Feeding with phytochemicais from Medicinal Plant TMP1 e...

第十四届全国中药和天然药物学术研讨会

作者： Wen-Chi Wei Sheng-Yen Lin Chun-Wen Lan Chen-Chen Liu Wen-Chin yang Yu-Chin yang Pei-Wen Hsiao ning-sun yang Academia Sinica National Defense Medical Center

＜正＞Myeloid-derived suppressor cells（MDSCs）consist of heterogeneous population of immature myeloid cells,including linages for granulocytes,macrophages,and dendritic cells,known for expanding extensively during tumorigenesis,inflammation and pathogen infections and playing a critical role in protecting tumor cells from immune *** previous study

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Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-based Vaccine against Mouse Mammary Tumor Metastasis

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Specific Medicinal Plant Polysaccharides Effectively Enhance...

第十四届全国中药和天然药物学术研讨会

作者： Wei-Ting Chang Tzung-Hsien Lai Yau-Jan Chyan Shu-Yi Yin Yung-Hsiang Chen Wen-Chi Wei ning-sun yang Academia Sinica

＜正＞Engineering and optimization of efficacious adjuvant formulation for dendritic cell（DC）-based vaccines have received increasing attention in recent *** this study,we developed a new ex vivo approach for DC vaccine *** evaluated the polysaccharides from two medicinal plants（denoted as Am,Cp and[Am+Cp]）for potential use on enhancing the

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen ning sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna sun Pei Cheng Zhaoyang Yao ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia ning Xu Wen sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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CF增强PEEK/Cu复合材料的制备与性能

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现代塑料加工应用 2017年第5期29卷 26-28页

作者：宁洋孙诗良曲敏杰吴立豪乔占凤大连工业大学纺织与材料工程学院辽宁大连116034 大连路阳科技开发有限公司辽宁大连116600

采用模压法制备碳纤维(CF)增强聚醚醚酮(PEEK)/Cu复合材料,研究了CF等离子处理时间、CF用量和热处理工艺对PEEK/Cu/CF复合材料力学性能的影响。结果表明:随着未处理CF用量增加,PEEK/Cu/CF复合材料的力学性能逐渐下降;当CF等离子处理时... 详细信息

采用模压法制备碳纤维(CF)增强聚醚醚酮(PEEK)/Cu复合材料,研究了CF等离子处理时间、CF用量和热处理工艺对PEEK/Cu/CF复合材料力学性能的影响。结果表明:随着未处理CF用量增加,PEEK/Cu/CF复合材料的力学性能逐渐下降;当CF等离子处理时间小于等于4 min时,PEEK/Cu/CF复合材料的拉伸强度和冲击强度随处理时间增加而提高;等离子处理4 min,随CF用量的增加,PEEK/Cu/CF复合材料的拉伸强度提高,但其冲击强度下降。与未处理的复合材料相比,热处理Ⅱ和Ⅲ这2种处理工艺的复合材料结晶度和熔点均提高,且热处理Ⅲ的提高幅度大于热处理Ⅱ的。

关键词：聚醚醚酮碳纤维热处理性能