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常压质谱用于脂质识别的研究进展

色谱 2025年第1期43卷 22-32页

作者：王晓蓉尹伊颜欧阳津那娜北京师范大学化学学院放射性药物化学教育部重点实验室北京100875 北京师范大学文理学院化学系广东珠海519087

脂质是生物体的重要组成成分,参与细胞膜流动、神经递质传递和运输以及能量供应等多个过程。研究表明,癌细胞为了适应不断变化的生物微环境和快速增殖的需求,其脂质代谢过程不同于正常细胞。因而,对脂质组分进行快速检测、识别及监测研... 详细信息

脂质是生物体的重要组成成分,参与细胞膜流动、神经递质传递和运输以及能量供应等多个过程。研究表明,癌细胞为了适应不断变化的生物微环境和快速增殖的需求,其脂质代谢过程不同于正常细胞。因而,对脂质组分进行快速检测、识别及监测研究,对了解生命过程、监测诊疗过程变化、提升诊疗效率等具有重要意义。质谱是直接获取分子结构最有效的手段之一,在生物分子及脂质鉴定中具有独特优势。近年来,常压质谱技术(ambient mass spectrometry,AMS)不断涌现,该技术无需样品预处理,为直接快速脂质识别及监测提供了有效手段。软电离技术的不断发展也为复杂多样的脂质分子检测提供了广阔的发展空间。电喷雾离子化(ESI)作为主要的软电离技术之一,易于离子化中高极性的生物样品,能够满足生物体内大多数脂质的检测需求。因此,研究人员基于ESI技术,开展了广泛的癌症脂质代谢研究,实现了不同脂质的鉴定和相对定量研究。由于脂质存在丰富的异构体,人们又创新性地将各种化学衍生法和其他技术与AMS结合起来,实现了对复杂脂质结构异构体的准确识别和相对定量研究。基于此,本文综述了近5年用于脂质检测的主要常压质谱技术及应用进展,并汇总了质谱解析脂质精细结构的典型策略。

关键词：常压质谱离子化技术脂质脂质精细结构串联质谱

Physical characteristics of detonation noise from multi-tube pulse detonation engine

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Chinese Journal of Acoustics 2021年第3期40卷 378-388页

作者： HUANG Xiaolong LI ning weng Chunsheng national Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing210094

An experimental system of multi-tube pulse detonation engine with single tube to four tubes is set up to study the formation of detonation noise and acoustic characteristics of multi-tube pulse detonation *** physical parameters of multi-tube detonation noise,including waveform,attenuation of sound pressure,radiation characteristics,duration and acoustic spectrum characteristics are *** results show that the peak sound pressure of detonation noise attenuates faster in the area near the tube exit,and the attenuation speed in the area far away from the tube exit is inversely proportional to the radius *** the increase of the number of detonation tubes,the peak sound pressure level of detonation noise at each directivity angle increases *** the far-fiekl region,the directivity of the detonation noise is *** the number of detonation tubes increases,the A and B durations of detonation noise *** acoustic spectrum of detonation noise is a broadband signal,and the acoustic energy mainly concentrates in the range of middle and low *** dominant spectrum peak and sound pressure level of the acoustic spectrum vary with the increase of the number of detonation *** results are of great significance for studying the propagation of acoustic wave in detonation process and will be useful for application of pulse detonation engine in aircraft power systems.

关键词： characteristics pulse tube

Oxidation behavior of Nb–24Ti–18Si–2Al–2Hf–4Cr and Nb–24Ti–18Si–2Al–2Hf–8Cr hypereutectic alloys at 1250°C

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Rare Metals 2017年第3期36卷 168-173页

作者： Zhen Hong Hu Zhang Jun-Fei weng Lin-Fen Su Zhen Li Li-na Jia School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Nb-24Ti-18Si-2Al-2Hf-4Cr and Nb-24Ti-18Si-2Al-2Hf-8Cr alloys were prepared by arc melting in a water-cooled crucible under argon *** characteristics and oxidation resistance of the alloys at 1250 ℃ were *** results show that,when the Cr content is 4 at%,the microstructures consist of （Nb,Ti）ss and Nb5Si3;as Cr content increases to 8 at%,C14 Laves phase Cr2Nb is *** isothermal oxidation tests show that the oxidation kinetics of the two alloys follow similar *** weight gains of the two alloys after oxidation at 1250 ℃ for 100 h are 235.61 and 198.50 ***-2,*** oxidation,SiO2,TiO2,Nb2O5 and CrNbO4 are formed at ***,Ti2Nb10O29 is formed after oxidation for 20 min and begins to change into TiNb2O7 as the oxidation ***2 is formed as solid state at first but later evolves into glassy state to improve the cohesion of the *** oxidation for 100 h,oxidation products consist of SiO2,TiNb2O7,Nb2O5 and CrNbO4.

关键词： Nb-Si-based alloy lntermetallics Microstructural characteristics Oxidation

Microstructures and high-temperature oxidation behavior of directionally solidified Nb-Si-based alloys with Re additions

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Rare Metals 2023年第1期42卷 273-280页

作者： Jie-Chao Zhang Li-na Jia Jun-Fei weng Lin-Fen Su Bin Kong Hu Zhang School of Materials Science and Engineering Beihang UniversityBeijing100191China

High-temperature oxidation behavior of directionally solidified(DS) Nb-Si-based alloys with Re additions was investigated at 1200 and 1250℃,*** and high-temperature oxidation behavior of the alloys were *** show that the microstructures in vertical section of Nb-24Ti-15Si-4Cr-2Al-2Hf-xRe(x=0,1,3;at%) alloys grow parallel to the withdrawal direction and the cross section exhibits bud-like *** bud-like structures become finer with more Re *** weight gain of the Nb-24Ti-15Si-4Cr-2Al-2Hf-3Re alloy after oxidation at 1200℃ for 100 h is 198.1 mg·cm^(-2),and it is a bit higher at 1250℃.The other two alloys perform somewhat *** influence of Re addition on the oxidation resistance at 1250℃ is more significant than that at 1200 ℃.Although Re addition does not benefit obviously the high-temperature oxidation resistance of the DS samples,it does not compromise the oxidation resistance with a certain amount of Re additions in contrast with the alloy without Re addition.

关键词： Nb-Si alloys Directional solidification Rhenium addition Oxidation behavior Microstructure

Effect of adenovirus-mediated brain derived neurotrophic factor in early retinal neuropathy of diabetes in rats

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 145-148页

作者： Chao Wan ning-ning Liu Li-Min Liu na Cai and Lei Chen Department of Ophthalmology the First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIMTo observe effect of adenovirus-mediated brain derived neurotrophic factor in early retinal neuropathy of diabetes in rats.

关键词： diabetic retinopathy tyrosine hydroxylase brain derived neurotrophic factor adenovirus

On Loss Spillover Mechanism

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学术界 2015年第6期 307-311页

作者： Yang Yuhong Ni ning Ni na School of Business Administration Shanghai Lixin University of Commerce Department of human resource management Shanghai Normal University Department of Management and Marketing Hong Kong Polytechnic University

Negative events not only result in losses for the target organization,but also a spillover effect which harms innocent organization in addition. This research will focus on the mechanism behind the spillover effect and attempts to build a sound loss- spillover model,aiming to benefit whoever use it to enhance an organization’s ability on coping with accidental events,improving an organization’s capability on identity building and its ability to properly choose institutional environments and helping leaders of organizations and administrators better understand the industry and promote a self- constraining culture within the industry.

关键词： loss spillover organizational legitimacy organizational reputation

The prognostic value of clinical and pathologic features in nonmetastatic operable male breast cancer

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Asian Journal of Andrology 2016年第1期18卷 90-95页

作者： Bo Sun Li-na Zhang Jun Zhang ning Zhang Lin Gu The Second Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical University Ministry of Education Key Laboratory of Cancer Prevention and Therapy Tianjin China Laboratory of Cancer Cell Biology fianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical University Ministry of Education Key Laboratory of Cancer Prevention and Therapy Tianjin China Laboratory of Translational Cancer Biology Research Center of Basic Medical Science Tianjin Medical University No. 22 Qixiangtai Road Heping District Tianjin China

Compared with female breast cancer, male breast cancer is a rare disease, and the relationship between clinical/pathologic features and prognosis is controversial, or even largely unknown. In this study, we performed a retrospective analysis using clinical and pathologic data from 109 nonmetastatic operable male breast cancer patients treated from January 1996 to December 2011 at Tianjin Medical University Cancer Institute and Hospital. Log-rank test showed that lower tumor stage, no lymph node involvement, and positive estrogen/progesterone receptor status were good predictors of both disease-free survival and overall survival on univariate analysis. However, hormonotherapy is only a good predictive factor of disease-free survival, and not of overall survival. In addition, based on a Cox proportional hazard regression model, only lymph node involvement, and estrogen/progesterone receptor status were statistically significant predictive factors on multivariate analysis. Our results demonstrated that although adjuvant systemic therapy is used extensively in male breast cancer patients and prognosis has improved over the last few decades, lymph node involvement, and estrogen/progesterone receptor status are still the most important prognostic factors. A prospective multi-center study with a larger sample size is urgently needed to further understand male breast cancer.

关键词： breast neoplasms clinical/pathologic features male prognosis

Prediction of Mechanical Properties of Hot Rolled Strip by Using Semi-Parametric Single-Index Model

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Journal of Iron and Steel Research International 2013年第7期20卷 9-15页

作者： ZHAO Yong-hong weng Yang PENG ning-qi TANG Guang-bo LIU Zheng-dong College of Mathematics Sichuan University Institute for Structural Materials Central Iron and Steel Research Institute

A semi-parametric single-index model based approach was proposed for prediction of mechanical properties of hot rolled strip. Based on industrial production data, a semi-parametric single-index model was developed by choo-sing the appropriate kernel function and window width to predict the yield strength, tensile strength and elongation. When data samples are limited, compared with regression method and neural network method, the prediction results show that the semi-parametric single-index model based method is more adaptive and the prediction performance is superior to those by both regression and neural network methods.

关键词： hot strip rolling mechanical property prediction regression analysis neural network~ semi-parametricsingle-index model

Detection and characterization of an isolate of Tomato mottle mosaic virus infecting tomato in China

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Journal of Integrative Agriculture 2018年第5期17卷 1207-1212页

作者： ZHAN Bin-hui CAO ning WANG Kai-na ZHOU Xue-ping State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChina Academy of Agricultural Sciences State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang University

Tomato（Solanum lycopersicum） plants exhibiting severe leaf distortion, mottle and systemic crinkling symptoms were identified in Hainan province in China in 2016. To survey and control the disease, it is necessary to identify and characterize the pathogen causing the disease. Dot enzyme-linked immunosorbent assay showed that the crude saps of the infected tomato samples reacted positively with the monoclonal antibody against Tobacco mosaic virus which indicated that one or more tobamoviruses are likely associated with the disease. RT-p CR and Dna sequence analysis results further elucidated that Tomato mottle mosaic virus（To MMV） in Tobamovirus was the pathogen causing the mottle disease in tomato. We amplified and sequenced the full-length sequence of the genome which showed the highest nucleotide identity with To MMV YYMLJ and To MMV Ti Lha LJ isolates. The putative virus isolate was named To MMV Hainan. Biological indexing studies showed that To MMV Hainan can infect Nicotiana benthamiana, Capsicum annuum and Solanum lycopersicum showing serious symptoms. This was the first identification and characterization of To MMV infecting tomato in Hainan of China.

关键词： Tomato mottle mosaic virus tomato Tobamovirus dot-ELISA biological characterization