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Chronic Infusion of Urotensin Ⅱ Promote Diet-Induced Atherosclerosis in Rabbits

中国动脉硬化杂志 2013年第9期21卷 I0079-I0080页

作者： Ya-Feng Li Yan-Li Wang Si-Hai Zhao Rui-Han Liu Yu-Long Chen Yan Lin ning-hong zhu Liang Bai Jiang-Lin Fan En-Qi Liu Research Institute of Atherosclerotic Disease Xi ' an Jiaotong University Cardiovascular Research Center Xi ' an Shaanxi 710061 China Laboratory Animal Center School of Medicine of Xi'an Jiaotong University Xi ' an Shaanxi 710061 China Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi 409-3898 Japan

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Excitatory effect of histamine on neuronal activity of rat cerebellar fastigial nucleus by activation of H2 receptors in vitro

Excitatory effect of histamine on neuronal activity of rat c...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Biao TANG,Jun ZHANG,Jing-ning zhu,hong-Zhao LI,Jian-Jun WANG~* Department of Biological Science and Technology,School of Life Sciences,Nanjing University,Nanjing 210093,China

The cerebellar fastigial nucleus(FN) holds an important role in motor control and regulating body *** studies have revealed that the nucleus is innervated by direct hypothalamocerebellar histaminergic fibers arose from the tuberomammillary nucleus of the ***,the functional role of histaminergic projection on cerebellar FN has never been *** this study,we investigated the effect of histamine on neuronal firing of cerebellar FN by using slice ***-seven cells were recorded from 56 cerebellar slices,and vast majority of the cells responded to histamine stimulation with an excitatory response(84.4%,65/77).Perfusing slices with low-Ca～(2+)/high-Mg medium did not block the histamine-induced excitation(n = 10),supporting a direct postsynaptic action of histamine on the ***,the excitatory effect of histamine on FN neurons was not blocked by selective histamine H receptor antagonist triprolidine(n = 20) or chlorpheniramine(n = 10),but was effectively suppressed by ranitidine(n = 15),a highly selective histamine H receptor *** the other hand,highly selective histamine H receptor agonist dimaprit (n = 30) instead of histamine H receptor agonist 2-pyridylethylamine(n = 20) mimicked the excitatory effect of histamine on FN *** dimaprit-induced FN neuronal excitation was effectively antagonized by selective histamine H receptor antagonist ranitidine(n = 13) but not influenced by selective histamine H receptor antagonist triprolidine(n = 15). These results demonstrate that histamine excites cerebellar FN cells via the histamine H receptors and suggest that the hypothalamocerebellar histaminergic fibers may modulate cerebellar FN-mediated sensorimotor integration through their excitatory innervations on FN neurons.

关键词： histamine histamine receptors cerebellar fastigial nucleus hypothalamocerebellar histaminergic projections

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Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye zhu Yongjiang Sun hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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532nm激光光凝治疗视网膜前出血的临床观察

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眼科新进展 2014年第5期34卷 480-483页

作者：陈芳宁红珠曾琼英余青松肇庆医学高等专科学校广东省肇庆市526000

目的探讨532nm激光光凝治疗视网膜前出血的临床疗效。方法收集我院2010年1月至2013年10月确诊为视网膜前出血的患者13例（13眼），对其临床资料进行回顾性分析。8眼行激光爆破模式引流失败，改行激光光凝模式治疗；5眼视网膜前出血病程... 详细信息

目的探讨532nm激光光凝治疗视网膜前出血的临床疗效。方法收集我院2010年1月至2013年10月确诊为视网膜前出血的患者13例（13眼），对其临床资料进行回顾性分析。8眼行激光爆破模式引流失败，改行激光光凝模式治疗；5眼视网膜前出血病程超过2周者直接行激光光凝模式治疗。所有患者均接受视网膜激光光凝模式治疗1～2次，术后随访1个月，观察视力、眼底彩照及并发症情况。结果接受激光治疗的13眼患者，6眼（46．2％）行1次视网膜激光光凝术、7眼（53．8％）行2次视网膜激光光凝术。所有病例经治疗后出血均明显吸收，平均吸收时间18．92d；视力都有不同程度提高，1个月后随访视力平均提高6．0行。视网膜前出血吸收后激光光凝处未遗留激光斑痕迹，亦无色素增生，所有病例无其他激光并发症发生。结论532nm激光光凝模式治疗视网膜前出血简单实用、安全有效，且可重复实施，在激光引流视网膜前出血失败后或对于病程较长者可作为有效治疗手段。

关键词：视网膜前出血激光光凝术糖尿病视网膜病变

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Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu Wang Xiao-Hui Yu Shan-hong Tang hong-Wu zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-Han Guo Xiao-Mei Zhang Yun-Sheng Yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第01期 14-19页

作者： Song Jiang Congwen zhu ning Jiang State Key Laboratory of Severe Weather (LASW) Chinese Academy of Meteorological Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

基于1982–2022年资料分析,本文发现,热带太平洋海温年循环的主导模态为反对称模式,是ENSO发展的背景场.然而,其对ENSO相位和振幅的异常影响尚未可知.反对称模态异常可以通过Bjerknes反馈影响ENSO的年际变化,其正(负)异常可以通过更早(... 详细信息

基于1982–2022年资料分析,本文发现,热带太平洋海温年循环的主导模态为反对称模式,是ENSO发展的背景场.然而,其对ENSO相位和振幅的异常影响尚未可知.反对称模态异常可以通过Bjerknes反馈影响ENSO的年际变化,其正(负)异常可以通过更早(更晚)的季节循环转变时间和更大(更小)的年平均值增强冬季El Ni?o (La Ni?a)的强度.根据随机敏感性实验分析,与反对称模态变化有关的赤道中东太平洋海温异常可达±0.3℃以上.研究结果为背景海温年循环对ENSO的影响提供了新的见解,这可能对ENSO的预测具有重要意义.

关键词：年循环海表面温度异常反对称模态 ENSO

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Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-Jing Jiang Lu Wu Xiao Yang Yu Pu Bing-Jie ning Na Peng Xiao-Ju zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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Evaluation of the Visible and Shortwave Infrared Drought Index in China

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International Journal of Disaster Risk Science 2013年第2期4卷 68-76页

作者： ning Zhang Yang hong Qiming Qin Lin zhu Institute of Remote Sensing and GIS Peking UniversityBeijing 100871China School of Civil Engineering and Environmental Sciences University of OklahomaOK 73072USA National Satellite Meteorological Center of China Meteorological Administration Beijing 100081China

In this article, the performance of the Visible and Shortwave infrared Drought Index(VSDI), a drought index recently developed and validated in Oklahoma, United States, is further explored and validated in China. The in-situ measured soil moisture from 585 weather stations across China are used as ground-truth data, and five commonly used drought indices are compared with VSDI for surface drought monitoring. The results reveal that VSDI is robust and reliable in the estimation of surface dryness—it has the highest correlation with soil moisture among the six indices when computed using both the original and cloud removed data. All six indices show the highest correlation with soil moisture at the 10 cm layer and the averaged 10–50 cm layer. The spatiotemporal patterns of surface moisture indicated by the MODIS-based VSDI are further compared with the precipitation-based drought maps and the Global Land Data Assimilation System(GLDAS) simulated surface soil moisture maps over five provinces located in the Middle-Lower Yangtze Plain of China. The results indicate that despite the difference between the spatial and temporal resolutions of the three products, the VSDI maps still show good agreement with the other two drought products through the rapidly alternating drought and flood events in 2011 in this region. Therefore, VSDI can be used as an effective surface wetness indicator at both the provincial and the national scales in China.

关键词： China. drought moisture

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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