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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing chen Shuyuan bai Qiong Wu Yushan chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin Peng Yu bai Hang Li Meixiu Qu Zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei Tang Shulin bai Xiaodong Li Peng Ai Wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

New exploration on pathogenesis and early diagnosis of gestational diabetes

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World Journal of Clinical Cases 2025年第1期13卷 1-5页

作者： Hua bai Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina

Gestational diabetes mellitus(GDM)refers to varying degrees of abnormal glucose metabolism that occur during pregnancy and excludes patients pre-viously diagnosed with *** is a unique among the four subtypes of diabetes classified by the international World Health Organization *** GDM patients constitute a small proportion of the total number of diabetes cases,the incidence of GDM has risen significantly over the past decade,posing substantial risk to pregnant women and ***,it warrants considerable *** pathogenesis of GDM is generally considered to resemble that of type II diabetes,though it may have distinct *** blood biochemical proteins in the context of GDM can help elucidate its pathogenesis,thereby facilitating more effective prevention and management *** article reviews this critical clinical issue to enhance the medical community's sufficient understanding of GDM.

关键词： Gestational diabetes mellitus Pathogenesis Proteomics RBP4 ANGPTL8

腹腔镜辅助经肛门全直肠系膜切除术治疗中低位直肠癌的临床疗效

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中华消化外科杂志 2017年第7期16卷 695-700页

作者：张志鹏姚宏伟陈宁白洋田茂霖王德臣袁炯修典荣北京大学第三医院普通外科 100191 首都医科大学附属北京友谊医院普通外科国家消化系统疾病临床医学研究中心 100050

目的：探讨腹腔镜辅助经肛门全直肠系膜切除术（LaTaTME）治疗中低位直肠癌的临床疗效。方法：采用回顾性横断面研究方法。收集2015年8月至2016年8月北京大学第三医院收治的16例行LaTaTME中低位直肠癌患者的临床资料。同一组医师序贯完... 详细信息

目的：探讨腹腔镜辅助经肛门全直肠系膜切除术（LaTaTME）治疗中低位直肠癌的临床疗效。方法：采用回顾性横断面研究方法。收集2015年8月至2016年8月北京大学第三医院收治的16例行LaTaTME中低位直肠癌患者的临床资料。同一组医师序贯完成LaTaTME，先行腹腔镜手术，再行经肛门手术。观察指标：（1）手术及术后恢复情况：中转开腹情况、吻合方式、手术时间、术中出血量、术中并发症情况、术后首次下床活动时间、术后进流质食物时间、术后并发症情况、术后住院时间。（2）术后病理学检查情况：手术切除标本长度、肿瘤直径、肿瘤远端肠管切除距离、直肠系膜完整程度、环周切缘、病理学T分期、病理学N分期、淋巴结检出数目、肿瘤细胞分化程度。（3）随访结果。TNM Ⅲ～Ⅳ期的直肠癌患者，术后接受辅助化疗。术后每3个月门诊随访1次，随访内容为患者生存情况和肿瘤复发情况，随访时间截至2016年12月。计量资料采用M（范围）表示。结果：（1）手术资料及术后恢复情况：16例患者顺利完成手术，无中转开腹患者，其中结肠直肠吻合10例，结肠肛管吻合3例，结肠单腔永久性造瘘3例。16例患者手术时间为290 min（215～420 min），术中出血量为50 mL（30～100 mL）。术中1例患者出现并发症，该患者在直肠切除标本并经肛门拖出后，发现乙状结肠断端缺血，经腹腔进一步游离脾曲结肠，切除缺血的乙状结肠约5 cm，再行降结肠直肠吻合术。术后首次下床活动时间为1 d（1～3 d），术后进食流质食物时间为2 d（1～9 d）。术后3例患者出现并发症（ClavienDindo分级均为2级），其中2例为不完全性小肠梗阻，经过胃肠减压及静脉营养支持治疗后缓解；1例为骶前感染，经过引流以及抗生素治疗后缓解。术后住院时间为7 d（5～21 d）。（2）术后病理学检查情况：16例患者手术切除标本长度为18.0 cm（12.0～ 24.0 cm），肿瘤直径为3.5 cm（0.5～6.8 cm），肿瘤远端肠管切除距离为2.5 cm（1.0～5.0 cm）；手术切除标本的直肠系膜质量评估：完整14例，近乎完整2例；环周切缘及远近断端无肿瘤残留。16例患者病理学 T分期：0期（新辅助治疗后病理学完全缓解）1例，1期1例，2期4例，3期10例。病理学N分期：0期 12例，1期2例，2期2例。淋巴结检出数目为16枚（6～32枚）。肿瘤细胞分化程度：未见肿瘤细胞（新辅助治疗后病理学完全缓解）1例，高分化2例，中分化7例，低分化6例。（3）随访结果：16例患者均获得术后随访，中位随访时间为12个月（4～16个月），无局部复发及远处转移患者，无死亡患者。结论：LaTaTME为中低位直肠癌患者提供了一种新的、较为安全和有效的手术入路和切除方式，近期疗效较好。

关键词：直肠肿瘤,中低位全直肠系膜切除术经肛门腹腔镜检查

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NIR photothermal enhancement to achieve high-efficiency nitrogen reduction to ammonia by polyoxometalates@Fe-polydopamine

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Nano Research 2025年第1期18卷 118-128页

作者： Xiaofei chen Lixin Wu Feng bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Nanoscience and Materials EngineeringHenan UniversityKaifeng 475004China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

The development of atmospheric pressure N_(2)reduction to NH_(3)is attracting much attention in green chemistry,yet it is still a challenge to obtain satisfactory activity under mild ***,an efficient near-infrared(NIR)photothermal catalysis reduction of N_(2)constitutes an occurrence is *** or without V-substitute polyoxometalates(POMs)loaded on the surface of Fechelated polydopamine(Fe-PDA)photothermal support through the electrostatic interactions,NIR photothermal catalysts POMs@Fe-PDA are *** induction of“FeV”cofactor facilitates electron transfer between V(V)/V(IV)&Fe(III)/Fe(II)and N_(2),thereby activating N_(2)*** synergy between the catalytic activity of V-POMs and the local NIR photothermal effect of Fe-PDA dramatically enhances N_(2)***,PMo_(10)V_(2)@Fe-PDA exhibits a significantly enhanced NH_(3)production rate of 181.1μmol·LN^(-1)with a turnover frequency of 1006.1 mmol·MN^(-1)·hN^(-1)under 808 nm NIR laser radiation,being the highest values reported at atmospheric *** expect that this work could provide an alternative approach for photothermal catalysis N_(2)reduction under mild conditions.

关键词： polyoxometalate near-infrared photothermal catalysis N_(2)reduction mild condition

Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

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NANO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： bai, Yunzhao Zhou, Yunlei Wu, Xuanyu Yin, Mengfei Yin, Liting Qu, Shiyuan Zhang, Fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： Hua bai Xiao-Feng Feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： bai, Jie Jia, Jian Hui Wang, Yu Yang, Chun cheng Jiang, Qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries