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Journal of Semiconductors 2024年第8期45卷 59-66页

作者： Danrui Wan Jianping Zhou Guoyun Meng ning su Dongdong Zhang Lian Duan Junqiao Ding School of Chemical Science and Technology Yunnan UniversityKunming 650091China Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Southwest United Graduate School Kunming 650092China

Boron−nitrogen doped multiple resonance(BN-MR)emitters,characterized by B−N covalent bonds,offer distinctive advantages as pivotal building blocks for facile access to novel MR emitters featuring narrowband spectra and high ***,there remains a scarcity of exploration concerning synthetic methods and structural derivations to expand the library of novel BN-MR ***,we present the synthesis of a BN-MR emitter,tCz[B−N]N,through a one-pot borylation reaction directed by the amine group,achieving an impressive yield of 94%.The emitter is decorated by incorporating two 3,6-di-tbutylcarbazole(tCz)units into a B−N covalent bond doped BN-MR parent molecule via para-C−π−D and para-N−π−D *** peripheral decoration strategy enhances the reverse intersystem crossing process and shifts the emission band towards the pure green region,peaking at 526 nm with a narrowband full-width at half maximum(FWHM)of 41 ***,organic light emitting diodes(OLEDs)employing this emitter achieved a maximum external quantum efficiency(EQEmax)value of 27.7%,with minimal efficiency *** at a practical luminance of 1000 cd·m^(−2),the device maintains a high EQE value of 24.6%.

关键词： multi-resonance narrowband emission B−N covalent bond organic light emitting diodes

Primary ovarian cancer combined with primary fallopian tube cancer:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3188-3193页

作者： su-ning Bai Qi Wu Li-Yun Song Department of Gynecology Hebei General HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Low grade serous carcinoma of the ovary(LGSOC)is a rare type of epithelial ovarian cancer with a low incidence *** origin of ovarian cancer has always been a hot topic in gynecological oncology research,and some scholars believe that the origin of ovarian malignant tumors is the fallopian *** fallopian tube cancer is the lowest incidence of malignant tumors in the female reproductive *** are only a few reports in the literature,but the mortality rate is very *** in clinical practice,fallopian tube cancer is very common,but in most cases,it is classified as ovarian *** suMMARY We report a 54 years old postmenopausal woman who was hospitalized with a lower abdominal mass and underwent surgical *** final pathological confirmation was low-grade serous carcinoma of the right ovary and low-grade serous carcinoma of the left fallopian *** special treatment was performed after the surgery,and the patient was instructed to undergo regular follow-up without any signs of disease *** The prognosis of LGSOC is relatively good,over 80%of patients still experience disease recurrence.

关键词： Low grade serous carcinoma of the ovary Primary fallopian tube cancer Ovarian cancer Epithelial ovarian cancer Case report

Mouse KL2 is a unique MTSE involved in chromosome-based spindle organization and regulated by multiple kinases during female meiosis

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The Journal of Biomedical Research 2024年第05期 485-499+403-405页

作者： Shiya Xie Yanjie Yang Zhen Jin Xiaocong Liu Shuping Zhang ning su Jiaqi Liu Congrong Li Dong Zhang Leilei Gao Zhixia Yang State Key Lab of Reproductive Medicine and Offspring Health Nanjing Medical University Central Laboratory the First Affiliated Hospital of Anhui Medical University Department of Gynaecology and Obstetrics the First Affiliated Hospital of Anhui Medical University Center for Reproductive Medicine Department of Gynecology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Center for Reproductive Medicine Department of Reproductive Endocrinology Zhejiang Provincial People's Hospital(Affiliated People's Hospital) Hangzhou Medical College Laboratory Department of Shihezi People's Hospital

Microtubule-severing enzymes(MTSEs) play important roles in mitosis and meiosis of the primitive organisms. However, their roles in mammalian female meiosis, which accounts for over 80% of gameteoriginated human reproductive diseases, remain unexplored. In the current study, we reported that katanin-like 2(KL2) was the only MTSE concentrating at chromosomes. Furthermore, the knockdown of KL2 significantly reduced the chromosome-based increase in the microtubule(MT) polymer, increased aberrant kinetochore-MT(K-MT) attachment, delayed meiosis, and severely affected normal fertility. We demonstrated that the inhibition of aurora B, a key kinase for correcting aberrant K-MT attachment, significantly eliminated KL2 expression from chromosomes. Additionally, KL2 interacted with phosphorylated eukaryotic elongation factor-2 kinase, and they competed for chromosome binding. Phosphorylated KL2 was also localized at spindle poles, with its phosphorylation regulated by extracellular signal-regulated kinase 1/2. In summary, the current study reveals a novel function of MTSEs in mammalian female meiosis and demonstrates that multiple kinases coordinate to regulate the levels of KL2 at chromosomes.

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“土著”还是“移民”?利用新的巨行星分类方法与相对出现率探索温木星和热木星的起源

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科学通报 2024年第23期69卷 3342-3345页

作者：苏湘宁张辉海南大学物理与光电工程学院海口570228 中国科学院上海天文台上海200030

热木星(hot Jupiter, HJ)和温木星(warm Jupiter, WJ)的起源,一直是系外行星研究领域的未解之谜.尽管有科学家认为热木星可能在本地形成^([1~3]),但也有学者认为这些轨道周期很短的“大个子”,应该像太阳系的木星一样只能在远离恒星的... 详细信息

热木星(hot Jupiter, HJ)和温木星(warm Jupiter, WJ)的起源,一直是系外行星研究领域的未解之谜.尽管有科学家认为热木星可能在本地形成^([1~3]),但也有学者认为这些轨道周期很短的“大个子”,应该像太阳系的木星一样只能在远离恒星的偏远之地形成——只有在那里,才有足够的“粮食”供它们生长.但与木星不同的是,它们获得了宿主恒星的某种“眷顾”——经历了某种轨道迁移过程——从而进入了“人生的上升通道”,最终来到了靠近宿主恒星的中心地带.

关键词：系外行星轨道周期 Jupiter 巨行星迁移过程木星太阳系分类方法

Mouse KL2 is a unique MTSE involved in chromosome-based spindle organization and regulated by multiple kinases during female meiosis

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Journal of biomedical research 2024年第5期38卷 1-15页

作者： Shi-Ya Xie Yan-Jie Yang Zhen Jin Xiao-Cong Liu Shu-Ping Zhang ning su Jia-Qi Liu Cong-Rong Li Dong Zhang Lei-Lei Gao Zhi-Xia Yang State Key Lab of Reproductive Medicine and Offspring Health Nanjing Medical University Nanjing Jiangsu 211166 China. Central Laboratory the First Affiliated Hospital of Anhui Medical University No 218 Jixi Road Hefei Anhui 230022 China. Department of Gynaecology and Obstetrics the First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China. Center for Reproductive Medicine Department of Gynecology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang 310014 China. Center for Reproductive Medicine Department of Reproductive Endocrinology Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou Zhejiang 310014 China. Laboratory Department of Shihezi People's Hospital Xinjiang 832099 China.

Microtubule-severing enzymes (MTSEs) play important roles in mitosis and meiosis of the primitive organisms. However, no studies have assessed their roles in mammalian meiosis of females, whose abnormality accounts for over 80% of the cases of gamete-originated human reproductive disease. In the current study, we reported that katanin-like 2 (KL2) was the only MTSE concentrating at chromosomes. Furthermore, the knockdown of significantly reduced chromosome-based increase in the microtubule (MT) polymer, increased aberrant kinetochore-MT (K-MT) attachment, delayed meiosis, and severely affected normal fertility. Importantly, we demonstrated that the inhibition of aurora B, a key kinase for correcting aberrant K-MT attachment, eliminated KL2 from chromosomes completely. KL2 also interacted with phosphorylated eukaryotic elongation factor-2 kinase; they competed for chromosome binding. We also observed that the phosphorylated KL2 was localized at spindle poles, and that KL2 phosphorylation was regulated by extracellular signal-regulated kinase 1/2. In summary, our study reveals a novel function of MTSEs in mammalian female meiosis and demonstrates that multiple kinases coordinate to regulate the levels of KL2 at chromosomes.

关键词： KL2 MTSE female meiosis kinase mouse

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沿空留巷非对称底鼓机理及控制技术研究

能源技术与管理 2024年第3期49卷 160-163页

作者：苏宁山西省朔州市平鲁区应急管理局山西朔州036800

为研究受重复采动影响下沿空留巷巷道剧烈的底鼓发生机理及治理方法,以芦家窑煤矿二采区84206工作面运输顺槽为工程案例,通过理论分析、数值模拟等方式分析了该矿84206运输顺槽底鼓特征及影响因素。结果表明:工作面回采后,沿空留巷顶板... 详细信息

为研究受重复采动影响下沿空留巷巷道剧烈的底鼓发生机理及治理方法,以芦家窑煤矿二采区84206工作面运输顺槽为工程案例,通过理论分析、数值模拟等方式分析了该矿84206运输顺槽底鼓特征及影响因素。结果表明:工作面回采后,沿空留巷顶板应力经过2次应力分流,在煤体和充填体上形成非对称分布的应力双峰现象;基于朗肯土压力理论和数值模拟,非对称应力分布是造成沿空留巷非对称底鼓的主要原因,最大底鼓量靠近垂直应力低的采空区一侧;提出了巷道底板注浆锚索+喷浆密闭的支护方案,现场试验表明该技术有效地控制了沿空留巷巷道底鼓的变形。

关键词：非对称底鼓注浆锚索沿空留巷数值模拟

TP53等位基因状态对骨髓增生异常综合征患者临床表现和预后的影响

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中国实验血液学杂志 2024年第3期32卷 811-818页

作者：沈凯胡德媛陈苏宁苏州大学附属第一医院血液科江苏苏州215006

目的:探讨TP53等位基因状态在骨髓增生异常综合征(MDS)患者中的临床意义。方法:回顾性分析2019年1月至2021年12月在苏州大学附属第一医院进行二代测序的858例MDS患者的临床资料。结果:患者中位年龄为52岁,中位随访时间为23.8(0.4-109.6... 详细信息

目的:探讨TP53等位基因状态在骨髓增生异常综合征(MDS)患者中的临床意义。方法:回顾性分析2019年1月至2021年12月在苏州大学附属第一医院进行二代测序的858例MDS患者的临床资料。结果:患者中位年龄为52岁,中位随访时间为23.8(0.4-109.6)个月。401例患者(46.7%)至少有一个染色体异常,其中,复杂核型106例,单体核型78例。共发现103例TP53突变,突变率为12%。与TP53野生型患者相比,各种类型的染色体异常情况明显更多见于TP53突变型患者(均P0.05)。TP53野生型患者的中位OS未达到,野生型、单等位基因和双等位基因TP53突变患者中位OS比较存在明显差异(P<0.001)。多因素Cox回归分析结果显示,双等位基因TP53突变为患者不良预后的独立预测因子(HR=2.808,95%CI:1.487-5.003,P=0.001),而单等位基因TP53突变与野生型TP53不是。结论:伴TP53突变的患者预后不良,双等位基因TP53突变相比单等位基因TP53突变预后更差,并且独立地影响MDS患者的预后。

关键词：骨髓增生异常综合征 TP53突变等位基因状态预后

矩形平面投影气膜结构风振响应特性及风振系数研究

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振动工程学报 2024年第7期37卷 1115-1125页

作者：陈昭庆魏超王爽赵军宾武岳苏宁东北电力大学建筑工程学院吉林吉林132012 东北电力大学吉林省电力基础设施安全评估与灾害防治重点实验室吉林吉林132012 中国电力工程顾问集团东北电力设计院有限公司吉林长春130021 哈尔滨工业大学结构工程灾变与控制教育部重点实验室黑龙江哈尔滨150090 交通运输部天津水运工程科学研究院天津300456

近年来,矩形平面投影气膜结构被广泛应用于大跨度气膜煤仓等设施中,但是规范中尚无该类结构的风振系数。本文通过风洞测压试验,测量了典型矢跨比矩形平面投影气膜结构的风荷载;运用非线性动力时程分析法分析了结构的风振响应。研究了风... 详细信息

近年来,矩形平面投影气膜结构被广泛应用于大跨度气膜煤仓等设施中,但是规范中尚无该类结构的风振系数。本文通过风洞测压试验,测量了典型矢跨比矩形平面投影气膜结构的风荷载;运用非线性动力时程分析法分析了结构的风振响应。研究了风速、风向、跨度、矢跨比和内压等参数对结构变形和响应极值的影响。结果表明:结构呈现迎风面及背风面凹陷、顶部和两侧向外凸的平均变形特征;极值响应的分布受结构参数和风向角的影响;响应的大小与跨度和矢跨比呈正相关;增大内压在一定程度上可以提高结构的抗风性,内压调控区间建议为400~500Pa;给出了可供抗风设计参考的位移风振系数及应力风振系数。

关键词：充气膜结构风洞试验风振响应风振系数

高强管道用1Cr16Ni4Mo2N不锈钢的热处理与组织性能研究

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锻压技术 2024年第6期49卷 215-220,254页

作者：苏宁刘凤军李月超中国石油管道局工程有限公司河南郑州451450 河南科技大学机电工程学院河南洛阳471000

为了提升高强管道用不锈钢的力学性能和耐腐蚀性能,对高强管道用1Cr16Ni4Mo2N不锈钢进行了固溶和时效处理,研究了时效温度对不锈钢显微组织、力学性能和耐腐蚀性能的影响,并分析了其作用机理。结果表明,1Cr16Ni4Mo2N不锈钢在350~625℃... 详细信息

为了提升高强管道用不锈钢的力学性能和耐腐蚀性能,对高强管道用1Cr16Ni4Mo2N不锈钢进行了固溶和时效处理,研究了时效温度对不锈钢显微组织、力学性能和耐腐蚀性能的影响,并分析了其作用机理。结果表明,1Cr16Ni4Mo2N不锈钢在350~625℃时效处理4 h后,基体组织均为马氏体和奥氏体,且随着时效温度升高,马氏体向奥氏体转变;不锈钢的屈服强度ReL和抗拉强度R_(m)随着时效温度的升高先增大后减小,在时效温度为350℃时具有较高的强塑性。FeCl_(3)溶液中浸泡腐蚀试验结果与电化学试验结果一致,1Cr16Ni4Mo2N不锈钢的腐蚀速率随着时效温度的升高先增大后减小,在时效温度为350℃时具有最佳的耐腐蚀性能。因此,高强管道用1Cr16Ni4Mo2N不锈钢最佳的时效温度为350℃,此时不锈钢具有良好的强塑性和耐腐蚀性能。

关键词：时效温度 1Cr16Ni4Mo2N不锈钢显微组织力学性能耐腐蚀性能

500kV高压输电线路运维中状态巡视应用研究

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电力设备管理 2024年第9期 32-34页

作者：余洋苏宁国网湖南省电力有限公司超高压输电公司

在电网中,500kV高压输电线路扮演着关键的角色,相关运维工作对电网运行的安全性、稳定性能够带来直接影响。然而由于受到多方面因素的影响,早期运维工作存在诸多问题,导致一些细节被忽视,运维效果没有达到预期。因此,工作人员必须加强... 详细信息

在电网中,500kV高压输电线路扮演着关键的角色,相关运维工作对电网运行的安全性、稳定性能够带来直接影响。然而由于受到多方面因素的影响,早期运维工作存在诸多问题,导致一些细节被忽视,运维效果没有达到预期。因此,工作人员必须加强状态巡视,了解设备的状况,根据各个线路的实际问题制定针对性方案,为线路的正常运行提供帮助。本文主要描述了状态巡视的概念,探讨了高压输电线路运维存在的问题,并对于线路状态巡视方案进行分析,以供同行参考。

关键词：高压输电线路运维工作状态巡视