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Effects of proton pump inhibitor on gastroesophageal varices in patients with cirrhosis:A randomized controlled trial from China

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Portal Hypertension & Cirrhosis 2023年第1期2卷 1-8页

作者： Xiaoning Chen Tao Zhou Ting Zhou Yueyue Li Xin Sun Baoquan Cheng ning zhong Xuefeng Lu Yanjing Gao Department of Gastroenterology Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandongChina Department of Geriatric Medicine Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandongChina

Aims:Proton pump inhibitors(PPI)are widely used for gastroesophageal varices in patients with cirrhosis after endoscopic therapy,although the effect of PPI on these patients remains controversial.This study aimed to evaluate the effect of PPI on gastroesophageal varices in patients with cirrhosis after endoscopic therapy,including variceal bleeding and adverse events.Methods:Cirrhotic patients with endoscopically confirmed gastroesophageal varices were enrolled in this study between May 2017 and June 2019.Eligible patients were randomized into two groups:one group received PPI for 14 days and the other group did not receive PPI treatment(n=53 in each group).All patients were followed for 8 weeks.Results:During the follow‐up period,three patients(5.66%)in the PPI group experienced variceal bleeding on days 9,16,and 25 after endoscopic therapy,including two patients with acute bleeding and one with primary prophylaxis.In the non‐PPI group,three patients(5.66%)experienced variceal bleeding on days 7,42,and 56 after endoscopic therapy,including one patient with acute bleeding and two with secondary prophylaxis(p=0.990).The incidence of adverse events was similar between the two groups(37.74%vs.28.30%,p=0.30).Conclusions:PPI did not appear to reduce variceal bleeding and adverse events in patients with cirrhosis after endoscopic therapy.

关键词： endoscopic therapy gastroesophageal varices liver cirrhosis proton pump inhibitor

Comprehensive Design of the High-Sulfur-Loading Li–S Battery Based on MXene Nanosheets

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Nano-Micro Letters 2020年第9期12卷 70-82页

作者： Shouzheng Zhang ning zhong Xing Zhou Mingjie Zhang Xiangping Huang Xuelin Yang Ruijin Meng Xiao Liang College of Materials and Chemical Engineering China Three Gorges University8 Daxue RoadYichang 443002HubeiPeople’s Republic of China State Key Laboratory of Chem/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082People’s Republic of China College of Science China Three Gorges University8 Daxue RoadYichang 443002HubeiPeople’s Republic of China

The lithium-sulfur battery is the subject of much recent attention due to the high theoretical energy density,but practical applications are challenged by fast decay owing to polysulfide shuttle and electrode architecture degradation.A comprehensive study of the sulfur host microstructure design and the cell architecture construction based on the MXene phase(Ti3C2Tx nanosheets) is performed,aiming at realize stable cycling performance of Li-S battery with high sulfur areal loading.The interwoven KB@Ti3C2Tx composite formed by self-assembly of MXene and Ktej en black,not only provides superior conductivity and maintains the electrode integrality bearing the volume expansion/shrinkage when used as the sulfur host,but also functions as an interlayer on separator to further retard the polysulfide cross-diffusion that possibly escaped from the cathode.The KB@Ti3C2Tx interlayer is only 0.28 mg cm-2 in areal loading and 3 μm in thickness,which accounts a little contribution to the thick sulfur electrode;thus,the impacts on the energy density is minimal.By coupling the robust KB@Ti3C2Tx cathode and the effective KB@Ti3C2Tx modified separator,a stable Li-S battery with high sulfur areal loading(5.6 mg cm-2) and high areal capacity(6.4 mAh cm-2) at relatively lean electrolyte is achieved.

关键词： MXene nanosheet High sulfur areal loading Interlayer Lithium–sulfur battery

Intergranular corrosion behavior and mechanism of the stabilized ultra-pure 430LX ferritic stainless steel

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Journal of Materials Science & Technology 2019年第8期35卷 1787-1796页

作者： Peize Cheng ning zhong Nianwei Dai Xuan Wu Jin Li Yiming Jiang Department of Materials Science Fudan University Shanghai 200433 China Institute of Marine Materials Science and Engineering Shanghai Maritime University Shanghai 201306 China

Intergranular corrosion(IGC) behavior of the stabilized ultra-pure 430 LX ferritic stainless steel(FSS) was investigated by using double loop electrochemical potentiokinetic reactivation(DL-EPR) and oxalic acid etch tests to measure the susceptibility of specimens given a two-step heat treatment. The results reveal that IGC occurs in the specimens aged at the temperature range of 600–750℃ for a short time. The aging time that is required to cause IGC decreases with the increase of aging temperature. A longer aging treatment can reduce the susceptibility to IGC. The microstructural observation shows that M(23)C6 precipitates form along the grain boundaries, leading to the formation of Cr-depleted zones. The presence of Cr-depleted zones results in the susceptibility to IGC. However, the atoms of stabilizing elements replace chromium atoms to form MC precipitates after long-time aging treatment, resulting in the chromium replenishment of Cr-depleted zones and the reduction of the susceptibility to IGC.

关键词： Intergranular corrosion Ferritic stainless steel Double loop electrochemical potentiokinetic reactivation (DL-EPR) TEM Cr-depleted zone

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骨关节炎软骨细胞衰老潜在生物标志物的筛选

中国矫形外科杂志 2024年第10期32卷 916-923页

作者：白贵文许世林王胜张仲宁郑州大学第二附属医院河南郑州450000

[目的]采用生物信息分析学方法,筛选骨关节炎(osteoarthritis,OA)软骨细胞衰老潜在生物标志物,为揭示OA的发生机制及探索新的治疗方法提供理论依据。[方法]从基因表达综合数据库(gene expression omnibus,GEO)获取OA软骨组织数据集,使用... 详细信息

[目的]采用生物信息分析学方法,筛选骨关节炎(osteoarthritis,OA)软骨细胞衰老潜在生物标志物,为揭示OA的发生机制及探索新的治疗方法提供理论依据。[方法]从基因表达综合数据库(gene expression omnibus,GEO)获取OA软骨组织数据集,使用RStudio软件筛选出差异表达基因(differentially expressed genes,DEGs),并进行富集分析,再将DEGs与SenMayo衰老基因集取交集获得Hub基因,并进行验证,最后用miRNet在线平台及Cytoscape软件构建竞争性内源性RNA(competing endogenous RNA,ceRNA)网络。[结果]数据集GSE169077和GSE114007经差异分析并取交集后共得到DEGs 272个;对DEGs行基因本体论(Gene Ontology,GO)分析,发现其主要富集在细胞外基质组织、细胞外结构组织等条目中;行京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)分析,发现其主要富集在PI3K-Akt信号通路,黏着斑信号通路等;经筛选及验证,得到了2个Hub基因:IGF1和MMP2;构建ceRNA网络并筛选出3组RNA调控途径:KCNQ1OT1/XIST-hsa-mir-16-5p-IGF1,KCNQ1OT1/XIST-hsa-mir-424-5p-MMP2,KCNQ1OT1/XIST-hsa-mir-377-3p-IGF1/MMP2。[结论]IGF1和MMP2可作为OA软骨细胞衰老的Hub基因,KCNQ1OT1/XIST-hsa-mir-16-5p-IGF1,KCNQ1OT1/XIST-hsa-mir-424-5p-MMP2,KCNQ1OT1/XIST-hsa-mir-377-3p-IGF1/MMP2可能是调节OA软骨细胞衰老的潜在RNA调控途径。

关键词：骨关节炎软骨细胞衰老 SenMayo衰老基因集生物标志物 RNA调控途径生物信息学

积石山Ms 6.2级地震诱发的次生泥流灾害再现喇家遗址史前灾难场景

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科学通报 2024年第10期69卷 1320-1326页

作者：张玉柱沈铭健郭永强孟兴民李亚军钟宁陈发虎西北大学城市与环境学院陕西省地表系统与环境承载力重点实验室西安710127 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101 中国科学院大学资源与环境学院北京100049 中国科学院、水利部成都山地灾害与环境研究所成都610041 兰州大学西部环境教育部重点实验室兰州730000 兰州大学地质科学与矿产资源学院兰州730000 中国地质科学院地质力学研究所自然资源部活动构造与地质安全重点实验室北京100081

喇家遗址位于青海省民和县官亭盆地黄河北岸的第二级阶地之上,是一处以大型的齐家文化(4200~3600 a BP)为主的聚落遗址[1].在遗址区8处房址中发现了32具非正常死亡人骨遗骸和惨烈灾难场景,被称为“东方庞贝”,并出土了已知世界上最早的... 详细信息

喇家遗址位于青海省民和县官亭盆地黄河北岸的第二级阶地之上,是一处以大型的齐家文化(4200~3600 a BP)为主的聚落遗址[1].在遗址区8处房址中发现了32具非正常死亡人骨遗骸和惨烈灾难场景,被称为“东方庞贝”,并出土了已知世界上最早的面条.凭借其罕见的史前灾难遗迹和诸多突破性的新发现,喇家遗址入选2001年度“全国十大考古新发现”[1~4].近年来,对于造成喇家遗址齐家文化时期人群突然死亡和聚落毁灭废弃的灾难问题,学术界提出了各种观点和见解,引发了激烈的学术争议[4~9].其中,基于观察到的史前地震现象、毁灭喇家遗址齐家文化聚落的堆积物、全新世地层沉积特征和区域地貌演化,学术界提出了3种不同的观点.

关键词：喇家遗址齐家文化史前灾难考古新发现聚落遗址积石山非正常死亡庞贝

Effects of Local Application of Adipose-Derived Stromal Vascular Fraction on Tendon-Bone Healing after Rotator Cuff Tear in Rabbits

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Chinese Medical Journal 2018年第21期131卷 2620-2622页

作者： Liang-Yu Lu Min Ma Jun-Feng Cai Feng Yuan Wei Zhou Shu-Lin Luo Zhang-Yi Pan Wen Zeng ning zhong Feng Yin Department of Joint and Sports Medicine East Hospital Tongji University School of Medicine Shanghai 200120 China Department of Operation Theater East Hospital Tongji University School of Medicine Shanghai 200120 China

To the Editor： Previous studies showed that the rate of retears after repair of rotator cuffinjury was 38-94%, owing to the low healing capability of tendon-bone and the long duration. Adipose-derived mesenchymal stein cells （ADSCs） have been adopted to repair the tendon and ligament tears, which acquired effective repair improvement.

关键词： STEM-CELLS REPAIR

Paired-Pd(Ⅱ) centers embedded in HKUST-1 framework: Tuning the selectivity from dimethyl carbonate to dimethyl oxalate

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Journal of Energy Chemistry 2022年第4期31卷 233-240页

作者： Hong-Zi Tan Zhe-ning Chen Kai-Qiang Jing Jing Sun Yu-Ping Xu ning-ning Zhang zhong-ning Xu Guo-Cong Guo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina School of Chemistry&Chemical Engineering Shandong University of TechnologyZibo 255049ShandongChina School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252000ShandongChina

CO oxidative coupling to dimethyl oxalate(DMO) is the most crucial step in coal to ethylene glycol. Pdbased supported catalysts have been verified effective for generating DMO, but concomitant generation of dimethyl carbonate(DMC) is always unavoidable. It is generally accepted that Pd(0) is the active species for producing DMO, while Pd(II) for DMC. However, density functional theory calculations have proposed that the selectivity to DMO or DMC highly depends on the space state of Pd species rather than its oxidative state. It is thus urgently desired to develop high-efficient catalysts with well-defined structure,and further to elucidate the structure-performance relationship. In this work, HKUST-1 with unique structure of paired-Cu(Ⅱ) centers was chosen as ideal support to construct the catalysts with respective paired-Pd(Ⅱ) centers and isolated-Pd(Ⅱ) centers via in situ Pd species doping. In despite of featuring Pdδ+(δ≈2) oxidation state, the synthesized paired-Pd(Ⅱ)/HKUST-1 catalyst still exhibited DMO as dominant product(90.8% of DMO selectivity). For isolated-Pd(Ⅱ)/HKUST-1 catalyst, however, the main product was DMC(84.8% of DMC selectivity). Based on catalyst characterizations, the structures of paired-Pd(Ⅱ) centers and isolated-Pd(Ⅱ) centers were determined. DMO was generated from the coupling of adjacent *COOCH;intermediates adsorbed on paired-Pd(Ⅱ) centers, while DMC was produced from the reaction between methyl nitrite and the *COOCH;intermediates formed on isolated-Pd(Ⅱ) centers. Current work is the first MOFs-based catalyst with well-defined structure being applied in CO oxidative coupling reaction, which not only sheds light on the structure-performance relationship, but also inspires the potential of using MOFs as tunable platform to design high-efficient catalysts in heterogeneous catalysis.

关键词： CO Methyl nitrite Oxidative coupling Dimethyl oxalate Paired-Pd(Ⅱ)centers HKUST-1

Morphology Engineering toward Highly Emissive Mn^(2+)Doped PEA_(2)PbBr_(4) Perovskite with Their LED Application via Phosphonium Passivation

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Chinese Journal of Structural Chemistry 2022年第5期41卷 70-76页

作者： Yu-Feng Sang Liang-Jin Xu zhong-ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

Mn^(2+)-doped lead halide perovskites either in 3D or 2D have been extensively explored due to their rich energy-transfer behaviors.While their application on LED is still lagging behind in comparison to non-doped 3D perovskite due to inferior film-formation and low luminescent efficiency.Here we report an in-situ-formed Mn^(2+)doped 2D perovskite nanocrystal(NCs)film by introducing quaternary phosphonium salt during the crystallizing process.The as-formed film shows improved luminescent efficiency with emission peaked at 600 nm and photo-luminescence quantum yield(PLQY)of as high as 73.37%,which is about 1.3 times higher than that of pristine film.Further characterizations confirm the enhanced confinement effect from smaller size particle is responsible for the improved luminescent efficiency.The perovskite LEDs based on pristine and phosphonium passivated thin films were fabricated,and a great improvement in the external quantum efficiency of these LEDs(from 0.0017%to 0.12%)is observed due to the improved morphology and enhanced luminescent efficiency.

关键词： 2D perovskite Mn^(2+)doped energy transfer perovskite LED

血清视黄醇结合蛋白、胱抑素C及载脂蛋白B/载脂蛋白A1联合检测对高血压早期肾损伤的诊断价值

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川北医学院学报 2024年第1期39卷 51-54页

作者：毛辉黄洁群欧志强宁亮忠钟敏贺州市中医医院医学检验科广西贺州542800

目的:探讨视黄醇结合蛋白(RBP)、胱抑素C(Cys-C)及载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)检测对高血压早期肾损伤的诊断价值。方法:选取80例高血压患者为研究对象,根据早期肾损伤诊断标准将其分为单纯高血压组(n=47)及高血压合并早期肾损伤... 详细信息

目的:探讨视黄醇结合蛋白(RBP)、胱抑素C(Cys-C)及载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)检测对高血压早期肾损伤的诊断价值。方法:选取80例高血压患者为研究对象,根据早期肾损伤诊断标准将其分为单纯高血压组(n=47)及高血压合并早期肾损伤组(n=33)。比较两组患者一般资料、血脂、RBP、Cys-C、ApoB/ApoA1水平,采用Logistic回归分析高血压患者早期肾损伤的危险因素。采用ROC曲线评估RBP、Cys-C、ApoB/ApoA1及其联合对高血压患者早期肾损伤的诊断效能。结果:早期肾损伤组患者RBP、Cys-C、ApoB/ApoA1水平均高于单纯高血压组,ApoA1水平低于单纯高血压组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,RBP、Cys-C、ApoB/ApoA1是原发性高血压患者合并早期肾损伤的危险因素(P<0.05)。ROC分析显示,当RBP≥3.475 mg/L时,诊断原发性高血压患者合并早期肾损伤的曲线下面积(AUC)为0.729,灵敏度为69.7%,特异度为72.3%;当Cys-C≥2.525 mg/L时,AUC为0.768,灵敏度为72.7%,特异度为74.5%;当ApoB/ApoA1≥0.870时,AUC为0.656,灵敏度为63.6%,特异度为68.1%;三者联合诊断的AUC为0.870,灵敏度为81.8%,特异度为80.9%。结论:高血压合并早期肾损伤患者RBP、Cys-C、ApoB/ApoA1水平升高,可将其联合用于高血压合并早期肾损伤的辅助诊断。

关键词：高血压早期肾损伤视黄醇结合蛋白胱抑素C 载脂蛋白B 载脂蛋白A1