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中国化学快报：英文版 2023年第2期34卷 372-375页

作者： Yue Zhang Wei Zhou ning xu Guangying Wang Jin Li Kai An Wenchao Jiang xuelian Zhou Qinglong Qiao Xindong Jiang Zhaochao xu Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment Shenyang University of Chemical TechnologyShenyang 110142China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

The unique structure of fluorescent proteins in which the fluorophore is encapsulated by the protein shell to restrict rotation and emit light inspired the screening of chromophores that selectively bind to biomolecules to generate fluorescence. In this paper, we report a curcuminoid-BF2-like fluorescent dye NBF2containing 4-dimethylaniline as an electron-donating group. When this dye is combined with HSA or BSA, the fluorescence is enhanced 90/112-fold, and the fluorescence quantum yield increases from ning in cells.

关键词： Fluorogen Aniline TICT HSA Methine dyes

A Plant Lectin Receptor-like Kinase Phosphorylates the Bacterial Effector AvrPtoB to Dampen Its Virulence in Arabidopsis

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Molecular Plant 2020年第10期13卷 1499-1512页

作者： ning xu xuming Luo Wei Wu Yingying Xing Yingbo Liang Yanzhi Liu Huasong Zou Hai-Lei Wei Jun Liu State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Plant Protection Fujian Agriculture and Forestry UniversityFuzhou 350002China Key Laboratory of Microbial Resources Collection and Preservation Ministry of Agriculture and Rural AffairsInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China

Plasma membrane-localized receptor-like kinases(RLKs)perceive conserved pathogen-associated molecular pattems(PAMPs)in plants,leading to PAMP-triggered immunity(PTI).TheArabidopsis thaliana lectin RLK LecRK-Ⅸ.2 has been shown to regulate the bacterial flagellin-derived peptide flg22-induced PTI.Here,we discover that Pseudomonas syringae effector AvrPtoB targets LecRK-Ⅸ.2 for degradation,which subsequently suppresses LecRK-Ⅸ.2-mediated PTI and disease resistance.However,LecRK-Ⅸ.2 can interact with and phosphorylate AvrPtoB at serine site 335(S335).AvrPtoB self-associates in vitro and in vivo,and the association appears to be essential for its E3 ligase activity in ubiquitinating substrate in plants.Phosphorylation of S335 disrupts the self-association and as a result,phosphomimetic AvrPtoBS335D cannot ubiquitinate LecRK-Ⅸ.2 efficiently,leading to the compromised virulence of AvrPtoB in suppressing PTI responses.fig22 enhances AvrPtoB S335 phosphorylation by inducing the expression and activating of LecRK-Ⅸ.2.Our study demonstrates that host RLKs can modify pathogen effectors to dampen their virulence and undermine their ability in suppressing PTI.

关键词： Arabidopsis AvrPtoB LecRK-Ⅸ.2 Pseudomonas syringae ubiquitination

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眼眶小细胞神经内分泌癌1例

中华眼视光学与视觉科学杂志 2024年第3期26卷 226-228页

作者：王霞贾刚诒徐宁王静远济南明水眼科医院济南250200 济南市章丘区人民医院放射科济南250200

患者,男,77岁,因"右眼眼胀,双眼视物重影半年余"于2022年12月就诊于济南明水眼科医院。既往无肿瘤病史,慢性胃炎史20余年、慢性支气管炎史20余年、肝囊肿病史11年、冠心病史10余年、结肠息肉切除术后11年余、小肠疝气术后3年余,无传染... 详细信息

患者,男,77岁,因"右眼眼胀,双眼视物重影半年余"于2022年12月就诊于济南明水眼科医院。既往无肿瘤病史,慢性胃炎史20余年、慢性支气管炎史20余年、肝囊肿病史11年、冠心病史10余年、结肠息肉切除术后11年余、小肠疝气术后3年余,无传染病史。眼部检查:视力:右眼0.6,左眼0.8,双眼视力矫正无助;眼压:右眼10 mmHg(1 mmHg=0.133 kPa),左眼10 mmHg;双眼位正,眼球各方向运动未见明显异常;眶压:右眼(++);右眼上睑下垂,遮挡瞳孔上缘,瞳孔圆,直径约3 mm,光反射正常,晶状体混浊(++),玻璃体轻度混浊;裂隙灯显微镜下眼底检查:右眼视盘颞侧萎缩弧,黄斑中心凹反光不明,鼻下方及颞侧周边视网膜见出血点。

关键词：上睑下垂眼部检查眼底检查眼科医院冠心病史传染病史鼻下方慢性支气管炎

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膜联蛋白A11在肿瘤中的研究进展

现代医药卫生 2024年第3期40卷 472-476,481页

作者：徐宁(综述) 李勇(审校) 重庆医科大学附属口腔医院/口腔疾病与生物学重庆市重点实验室/重庆市高校市级口腔生物医学工程重点实验重庆401147

膜联蛋白(ANX)是以钙离子(Ca^(2+))浓度依赖性方式结合膜磷脂的细胞内蛋白质家族,在各种细胞类型中广泛表达。ANXA11是Ca^(2+)调节的磷脂依赖性和膜结合ANX多基因家族成员之一。既往研究表明,ANXA11在细胞分裂、Ca^(2+)信号传导、囊泡... 详细信息

膜联蛋白(ANX)是以钙离子(Ca^(2+))浓度依赖性方式结合膜磷脂的细胞内蛋白质家族,在各种细胞类型中广泛表达。ANXA11是Ca^(2+)调节的磷脂依赖性和膜结合ANX多基因家族成员之一。既往研究表明,ANXA11在细胞分裂、Ca^(2+)信号传导、囊泡运输、细胞凋亡中均具有重要作用。近年来,有研究表明,ANXA11的失调和突变与系统性自身免疫性疾病和癌症的发展、化疗耐药性和复发等有关。ANXA11在多种肿瘤中高表达,可作为促癌基因参与肿瘤的发生、发展,有望成为一个癌症诊断、治疗及预后的潜在分子标志物。该文就近年来ANXA11的生物学功能及在肿瘤中的研究进展进行了回顾和综述。

关键词：膜联蛋白A11 肿瘤肿瘤微环境综述

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顶管工程套管内供热管道允许布置长度分析

Progress of the technique of coal microwave desulfurization

建筑与装饰 2024年第3期 156-158页

作者：宣旭宁中国市政工程华北设计研究总院有限公司天津 300074

由于非开挖顶管工程中套管内供热管道在热膨胀后易拱起,为防止管道因拱起受到损坏,应对套管内管道允许布置长度进行校核分析.采用传统校核方法得到的计算结果较短,不满足实际工程的需要.本文为此提出了考虑供热管道自重与介质重量的改... 详细信息

由于非开挖顶管工程中套管内供热管道在热膨胀后易拱起,为防止管道因拱起受到损坏,应对套管内管道允许布置长度进行校核分析.采用传统校核方法得到的计算结果较短,不满足实际工程的需要.本文为此提出了考虑供热管道自重与介质重量的改进校核方法,得到的允许布置长度范围得以扩大,可满足工程实际需要.

关键词：非开挖顶管套管允许布置长度范围校核分析

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International Journal of Coal Science & Technology 2014年第1期1卷 113-128页

作者： Xiuxiang Tao ning xu Maohua Xie Longfei Tang Key Laboratory of Coal Processing and Efficient Utilization of Ministry of Education School of Chemical Engineering and TechnologyChina University of Mining and TechnologyXuzhou 221116China

With the advantages of its fast speed,effective and moderate controllable conditions,desulfurization of coal by microwave has become research focus in the field of clean coal technology.Coal is a homogeneous mixture which consists of various components with different dielectric properties,so their abilities to absorb microwaves are different,and the sulfur-containing components are better absorbers of microwave,which makes them can be selectively heated and reacted under microwave irradiation.There still remain controversies on the principle of microwave desulfurization at present,thermal effects or non-thermal effects.The point of thermal effects of microwave is mainly base on its characters of rapidly and selectly heating.While,in view of non-thermal effect,direct interactions between the microwave electromagnetic field and sulfur containing components are proposed.It is a fundamental problem to determine the dielectric properties of coal and the sulfur-containing components to reveal the interaction of microwave and sulfur-containing compounds.However,the test of dielectric property of coal is affected by many factors,which makes it difficult to measure dielectric properties accurately.In order to achieve better desulfurization effect,the researchers employ methods of adding chemical additives such as acid,alkali,oxidant,reductant,or changing the reaction atmosphere,or combining with other methods such as magnetic separation,ultrasonic and microorganism.Researchers in this field have also put forward several processes,and have obtained a number of patents.Obscurity of microwave desulfurization mechanism,uncertainties in qualitative and quantitative analysis of sulfur-containing functional groups in coal,and the lack of special microwave equipment have limited further development of microwave desulfurization technology.

关键词： Microwave desulfurization Dielectric properties Microwave effects Clean coal

Optimal amounts of coconut oil in diets improve the growth,antioxidant capacity and lipid metabolism of large yellow croaker(Larimichthys crocea)

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Marine Life Science & Technology 2020年第4期2卷 376-385页

作者： Tao Ding ning xu Yongtao Liu xueshan Li Xiaojun Xiang Dan xu Chuanwei Yao Qiangde Liu Zhaoyang Yin Kangsen Mai Qinghui Ai Key Laboratory of Aquaculture Nutrition and Feed Ministry of Agriculture and Rural Affairsand Key Laboratory of MaricultureMinistry of EducationOcean University of China.Qingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

The purpose of this study was to investigate the effect of different dietary coconut oil(CO)levels on growth,antioxidant capacity and lipid metabolism of juvenile large yellow croaker(Larimichthys crocea).Five iso-nitrogen(45%crude protein)and iso-lipid(13%crude lipid)experimental diets were prepared by replacing 0%(the control),25%,50%,75%and 100%fish oil with coconut oil.The results showed that dietary CO had no significant effect on survival rate(SR.P>0.05).However,the specific growth rate was increased significantly when compared with the control group when fish were fed the diet with 50%CO(P<0.05).The saturated fatty acids were increased significantly with increasing dietary CO in the liver and muscle,whereas the content of n-3 PUFA was decreased significantly(P<0.05).The highest activities of glutathione peroxidase and superoxide dismutase in the liver were recorded in fish-fed diet with 50%CO;conversely,the content of malondialdehyde was significantly decreased(P<0.05).The mRNA expression of peroxisome proliferator-activated receptor a,carnitine palmitoyl transferase 1 and acyl-CoA oxidase reached the highest levels in fish-fed diet with 50%CO.To some extent,this indicated that the rapid oxidation reaction of fatty acids to provide energy may be the reason for the rapid growth of large yellow croaker.In conclusion,fish-fed diet with 50%CO increased the growth rate and antioxidant capacity.Therefore,the optimal replacement level of CO to FO in the diet should be 50%.

关键词： Coconut oil Growth performance Antioxidant capacity Lipid metabolism Larimichthys crocea

中国渐进利率市场化改革的再探讨——基于LPR改革与利率完全市场化模拟的对比研究

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经济体制改革 2024年第3期 140-149页

作者：徐宁丁一兵刘文轩吉林大学经济学院吉林长春130012 吉林大学商学与管理学院吉林长春130012

以我国利率市场化改革实践路径为基础,通过DSGE模拟仿真以及TVP-VAR时变分析,重新考量了利率市场化进程中财政政策和货币政策的有效性。研究发现:LPR改革等市场化措施可以显著提高货币政策的传导效率及其有效性,但会降低财政政策效率。... 详细信息

以我国利率市场化改革实践路径为基础,通过DSGE模拟仿真以及TVP-VAR时变分析,重新考量了利率市场化进程中财政政策和货币政策的有效性。研究发现:LPR改革等市场化措施可以显著提高货币政策的传导效率及其有效性,但会降低财政政策效率。此外,基于现实数据的测算结果表明,货币政策和财政政策在向实体经济进行传导时会出现一定程度上的效率衰减,这再次表明推行利率市场化改革不应操之过急。LPR改革是在当下经济不确定性较强、经济复苏偏弱的背景下,中央银行稳健推进利率市场化改革的权宜选择。因此,应持续深化LPR改革,培育存款端的市场化基准利率,确保在稳定的经济环境下实现利率完全市场化。

关键词：利率市场化 LPR DSGE模型 TVP-VAR模型

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船用轴流压气机推力轴承特性计算及试验研究

热能动力工程 2024年第2期39卷 50-58页

作者：孙勇徐宁高思华于海涛中国船舶集团有限公司第七○三研究所黑龙江哈尔滨150078 船舶与海洋工程特种装备和动力系统国家工程研究中心-燃气轮机研发与检测试验室黑龙江哈尔滨150078

为获得某新型推力轴承在某船用轴流压气机中的工作特性并进行试验验证,基于ARMD-Bearings软件及自编程序对推力轴承特性进行了模拟计算,在全尺寸高速大推力滑动轴承试验台上进行了轴承特性试验研究,并在实机台架试验中对轴瓦温度进行了... 详细信息

为获得某新型推力轴承在某船用轴流压气机中的工作特性并进行试验验证,基于ARMD-Bearings软件及自编程序对推力轴承特性进行了模拟计算,在全尺寸高速大推力滑动轴承试验台上进行了轴承特性试验研究,并在实机台架试验中对轴瓦温度进行了监测。计算分析了15种工作条件下油膜的压力、厚度、温度、刚度、阻尼及能量损失与推力和转速关系。轴承特性试验主要包括9种稳定工况下的性能试验,以及轴承超载、超速试验中每块轴瓦表面温度及油膜压力的测量。结果表明:模拟计算结果及试验测试得到的油膜温度、压力随推力及转速变化规律基本一致;轴瓦表面最大油膜压力位于支承块背部附近,与推力基本呈线性关系;转子转速越低、推力越大,则油膜厚度越小、油膜刚度及阻尼越大;转子转速越高、推力越大,则油膜温度越高、能量损失越大;在设计点轴承运行参数均有一定安全裕度,该推力轴承可以满足机组使用要求。

关键词：推力轴承特性计算试验研究油膜压力油膜温度

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热连轧高效工艺控制技术及应用

山东冶金 2024年第1期46卷 77-79页

作者：徐宁韩陶然天津市新天钢联合特钢有限公司天津301500

针对热轧600 mm以下带钢普遍还存在配置差、工艺落后、轧速低、污染重、能耗高等问题,开展了一些列的技改工作,包括高效除磷及控温控轧技术、粗轧过程的组织控制技术、中间坯保温技术、精轧组织控制和轧制节奏优化、轧辊涡流探伤技术、... 详细信息

针对热轧600 mm以下带钢普遍还存在配置差、工艺落后、轧速低、污染重、能耗高等问题,开展了一些列的技改工作,包括高效除磷及控温控轧技术、粗轧过程的组织控制技术、中间坯保温技术、精轧组织控制和轧制节奏优化、轧辊涡流探伤技术、ACC层流冷却的优化控制技术等。技术的应用,使带钢生产效率得到大幅提高,产品质量得到明显提升。

关键词：热连轧高效轧制工艺控制生产效率