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Iridoid Glycosides from Pedicularis dolichocymba Hand.-Mazz.

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Journal of Integrative Plant Biology 2006年第10期48卷 1250-1253页

作者： Hong-Biao Chu ning-Hua tan State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

During investigation of the chemical constituents of the whole plant ethanol extract of Pedlcularis dollchocymba Hand.-Mazz. （Scrophularlaceae）, four new irldold glycosides, dolichocymbosides A （compound 1）, B （compound 2）, C （compound 3） and D （compound 4）, were Isolated. Their structures were determined based on spectral data Including 1D and 2D-nuclear magnetic resonance spectroscopy （^1H-^1H COSY, HSQC, HMBC, ROESY） and FAB-MS.

关键词： dolichocymboside A-D iridoid glycosides Pedicularis dolichocymba Scrophulariaceae

New Minor Cyclopeptides from Arenaria oreophila (Caryophyllaceae)

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Chinese Chemical Letters 2006年第4期17卷 477-480页

作者： Ai Qun JIA ning Hua tan Jun ZHOU State Key Laboratory of Phytochemistry and Plant Resources in West China Kuning Institute of Botany Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Kunming 650204

New minor cyclic peptides, named arenariphilin C 1 and arenariphilin D 2, were isolated from the whole plants of Arenaria oreophila （Caryophyllaceae）. Their structures were determined as cyclo（Pro^1-Pro2-Leu^1-Leu2-Phe-Ser-Gly-Thr） and cyclo （Ser-Cys） on the basis of spectroscopic data, especially by two-dimension NMR （2D NMR） technologies.

关键词： Arenaria oreophila Caryophyllaceae cyclopeptide arenariphilin C arenariphilin D.

Cyclopeptidic Constituents from Arenaria oreophila J.D,Hooker(Caryophyllaceae)

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Journal of Integrative Plant Biology 2006年第6期48卷 740-744页

作者： Ai-Qun Jia ning-Hua tan Jun Zhou State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 Yunnan China

To further investigate the cyclopeptldes of the Caryophyllaceae family, two new cyclopeptldes, named Arenarlphilin E （compound 1） and Arenariphilin F （compound 2）, were obtained from Arenaria oreophUe J. D. Hooker using some Isolation methods, e. g. normal and reverse silica gel. By detailed spectroscopic analysis, such as FAB^＋-MS, 1 D NMR, 2D NMR, the structures of Arenariphilin E （compound 1） and Arenariphilln F （compound 2） were determined as cyclo（lle^1-Gly-Val^1-Ala-Leu-lle^3-lle^2-Val^2-Pro） and cyclo（Pro^2-Pro^1-Gly^2-lle-Val-Leu-Gly^1-AiaThr- Gly^3）, respectively.

关键词： Arenaria oreophila Arenariphilin E Arenariphilin F Caryophyllaceae Cyclopeptide.

Simulation of the T-jump triggered unfolding and thermal unfolding vibrational spectroscopy related to polypeptides conformation fluctuation

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Science China Chemistry 2017年第8期60卷 1115-1129页

作者： Xian Chen Tianmin Wu Zhe-ning Chen tan Jin Wei Zhuang Yisong Zheng State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matte~ Chinese Academy of Sciences Fuzhou 350002. China

We review in this article our recent simulation works on modeling peptide T-jump and thermal unfolding Fourier transform infrared spectroscopy(FTIR) and two-dimensional infrared(2DIR) spectra. The theoretical and computational techniques used,including Markov state model(MSM), integrated tempering sampling(ITS) and nonlinear exciton propagation(NEP), are first briefly introduced. The protocols for simulating the thermal unfolding as well as T-jump unfolding are then summarized in details. The simulated spectral features, such as the intensity and ellipticity, are demonstrated to agree well with the experimental observations.

关键词： polypeptides amide vibration nonlinear response MSMs T-jump implicit solvent model ITS 2DIR folding landscape

Three New Saikosaponin-like Compounds from Polycarpon prostratum

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Chinese Chemical Letters 2001年第8期12卷 705-708页

作者： Zhong Tao DING Jun ZHOU ning Hua tan Shi Ming DENG Laboratory of Phytochemistry Kunming Institute of BotanyAcademia SinicaKunming 650204 Department of Chemistry Yunnan UniversityKunming 650091

Three new saikosaponin-like compounds (named prostratoside F-H) were isolated from the whole plants of Polycarpon prostratum (Forssk.) Aschers. et Schwein. ex Aschers. By detailed spectroscopic analysis, their structures were determined as 13 beta, 28-epoxy-16-keto-22 alpha, 23-dihydroxyolean-11-en-3 beta -yl-alpha -L-arabinopyranoside, 13 beta, 28-epoxy-16-keto-23-hydroxy-olean-11-en-3 beta -yl-alpha -L-arabinopyranoside and 13 beta, 28-epoxy-16-keto-22 alpha -hydroxyolean-11-en-3 beta -yl-alpha -L-arabinopyranoside, respectively.

关键词： Polycarpon prostratum Caryophyllaceae saikosaponin-like compound

A New Steroidal Glycoside from Ophiopogon japonicus （Thunb.） Ker-Gawl.

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Journal of Integrative Plant Biology 2005年第9期47卷 1148-1152页

作者： Hao-Fu DAI Shi-Ming DENG ning-Hua tan Jun ZHOU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany the Chinese Academy of Sciences Kunming 650204 China

To study the chemical constituents from traditional Chinese herb Ophiopogon japonicus （Thunb.） Ker-Gawl., a new steroidal glycoside, named ophiopojaponin C （1）, together with two known ones, was isolated by column chromatography. Spectroscopic and chemical evidence revealed the structures to be ophiopogenin 3-O-[α-L-rhamnopyranosyl（1→2）]-β-D-xylopyranosyl（1→4）-β-D-glucopyranoside （1）, diosgenin 3-O-[2-O-acetyl-α-L-rhamnopyranosyl（1→2）]-β-D-xylopyranosyl（1→3）-β-D-glucopyranoside （2）, and ruscogenin 1-O-[2-O-acetyl-α-L-rhamnopyranosyl（1→2）]-β-D-xylopyranosyl（1→3）-β-D-fucopyranoside （3）.

关键词： C27 steroidal glycosides Liliaceae Ophiopogonjaponicus.

Two New Steroidal Glycosides from Ophiopogon japonicus

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Chinese Chemical Letters 2000年第10期11卷 901-904页

作者： Hao Fu DAI Jun ZHOU Zhong Tao DING Jiang XIONG ning Hua tan Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 Department of Chemistry Yunnan UniversityKunming 650091

Two new C-27 steroidal: glycosides, named ophiopojaponin A(1)and B(2), were isolated from the tubers of famous traditional Chinese herb-Ophiopogon japonicus. The spectroscopic and chemical evidences revealed their structures to be Pennogenin 3-O-[2'-O-acetyl-alpha-L-rhamnopyranosyl (1-->2)]-beta-D-xylopyranosyl (1-->3)-beta-D-glucopyranoside (1) and 26-O-beta-D-glucopyranosyl-(22 xi, 25R)-3 beta, 14 alpha, 22 xi, 26-tetrahydroxyfurost-5-ene 3-O-alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranoside (2), respectively.

关键词： Liliaceae Ophiopogon jappnicus C-27 steroidal glycosides ophiopojaponin A and B

Genetic and logic networks with the signal-inhibitor-activator structure are dynamically robust

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Progress in Natural Science:Materials International 2006年第12期16卷 1329-1336页

作者： LI Fangting** and tan ning(School of Physics and Centre for Theoretical Biology, Peking University, Beijing 100871, China) [a]School of Physics and Centre for Theoritical Biology Peking University Beijing China

The proteins, DNA and RNA interaction networks govern various biological functions in living cells, these networks should be dynamically robust in the intracellular and environmental fluctuations. Here, we use Boolean network to study the robust structure of both genetic and logic networks. First, SOS network in bacteria E. coli, which regulates cell survival and repair after DNA damage, is shown to be dynamically robust. Comparing with cell cycle network in budding yeast and flagella network in E. coli, we find the signal-inhibitor-activator (SIA) structure in transcription regulatory networks. Second, under the dynamical rule that inhibition is much stronger than activation, we have searched 3-node non-self-loop logical networks that are dynamically robust, and that if the attractive basin of a final attractor is as large as seven, and the final attractor has only one active node, then the active node acts as inhibitor, and the SIA and signal-inhibitor (SI) structures are fundamental architectures of robust networks. SIA and SI networks with dynamic robustness against environment uncertainties may be selected and maintained over the course of evolution, rather than blind trial-error testing and being an accidental consequence of particular evolutionary history. SIA network can perform a more complex process than SI network, and SIA might be used to design robust artificial genetic network. Our results provide dynamical support for why the inhibitors and SIA/SI structures are frequently employed in cellular regulatory networks.

关键词： genetic network signal-inhibitor-activator (SIA) structure Boolean network model dynamical robust.

Early renal injury indicators can help evaluate renal injury in patients with chronic hepatitis B with long-term nucleos(t)ide therapy

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World Journal of Clinical Cases 2020年第24期8卷 6306-6314页

作者： Tong-Tong Ji ning tan Hai-Ying Lu Xiao-Yuan Xu Yan-Yan Yu Department of Infectious Diseases Peking University First HospitalBeijing 100034China

BACKGROUND Patients with chronic hepatitis B(CHB)with long-term nucleos(t)ide therapy may experience renal *** renal function indicators,such as urine protein,serum urea nitrogen(BUN),and serum creatinine,are normal when early mild lesions ***,more sensitive renal function indicators are *** To investigate the significance of early renal injury indicators in evaluating renal injury in patients with CHB with long-term nucleos(t)ide *** We collected the clinical data of 69 outpatients with CHB at Peking University First Hospital from March 2018 to January 2020 who had been treated with longterm nucleos(t)ide therapy and analyzed the results of early renal injury *** normal distribution data were analyzed by the t-test to determine the difference between two *** non-normally distributed data were analyzed by the Mann-Whitney U-test between two *** Kruskal-Wallis H test was used to determine the differences among multiple *** data were analyzed by the chi-square *** related factors of early renal injury indicators were analyzed by logistic regression *** The average treatment duration with nucleos(t)ide analogs of the 69 patients with CHB was 99.7±28.7 *** cases of patients with elevated BUN and hypophosphatemia were 6(8.7%)and 13(18.8%),respectively;31(44.9%)patients had abnormal early renal injury indicators,including 9 patients with abnormal urine microalbumin,7 patients with abnormal urine immunoglobulin,6 patients with abnormal urine transferrin,and 19 patients with abnormalα1 *** were no significant differences in the mean values of age,sex,BUN,estimated glomerular filtration rate(eGFR),serum uric acid,serum calcium,or serum phosphorus between the two groups of patients with and without early renal injury ***,the mean levels of serum creatinine and urine creatinine,N-acetyl-β-D-glucosidase enzyme,α1 microglo

关键词： Early renal injury Chronic hepatitis B Nucleos(t)ide analog N-acetyl-β-Dglucosidase enzyme α1 microglobulin Urine immunoglobulin