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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of general Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-hua Wang Yi-Xin Liu Lu Xu Lin Fu ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKgROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for gFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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ON ENTROPY CONDITIONS OF HIgH RESOLUTION SCHEMES FOR SCALAR CONSERVATION LAWS

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Journal of Computational Mathematics 2001年第4期19卷 371-384页

作者： ning Zhao hua-mu Wu Department of Aerodynamics Nanjing University of Aeronautics and AstronauticsNanjing 210016China LSEC ICMSECAcademy of Mathematics and Systems SciencesChinese Acaderny of SciencesBeijing 100080China

Presents a method of proof which improves the estimates of entropy production for general total variation diminishing (TVD) schemes. Elements of the general theory of TVD schemes; Basis for obtaining the entropy inequality of a class of second order resolution-TVD schemes for strict convex conservation laws; Definition of discrete entropy inequality.

关键词： entropy condition high resolution schemes conservation laws

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Adaptive Control for a Class of Nonlinear Time-Delay System Based on the Fully Actuated System Approaches

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Journal of Systems Science & Complexity 2022年第2期35卷 522-534页

作者： ning Pengju hua Changchun MENg Rui School of Electrical Engineering Yanshan UniversityQinhuangdao 066004China

This paper focuses on the problem of adaptive control for a class of time-delay ***,the strict feedback nonlinear time-delay system is transformed into a fully actuated system by utilizing the fully actuated system ***,the uncertain time-delay terms of the system are bounded by the product of the absolute value of the system state and the non-linear function with the unknown *** following the high order fully actuated system approaches,a continuous adaptive controller is designed for the *** is proved that the controller can render the system achieve asymptotically ***,two numerical examples are provided to illustrate the effectiveness of the theoretical results.

关键词： Adaptive control fully actuated system approaches nonlinear systems time-delay systems

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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-ning Song Shua.g Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-hua Wan Hong-Wei Zhang Xiao guo hua.guo Shou-Feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKgROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of genes and genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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Equilibrium dynamics of the sub-ohmic spin-boson model at finite temperature

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Chinese Physics B 2021年第4期30卷 159-165页

作者： Ke Yang ning-hua Tong Department of Physics Renmin University of ChinaBeijing 100072China

We use the full-density matrix numerical renormalization group method to calculate the equilibrium dynamical correlation function C(ω) of the spin operator σ_(z) at finite temperature for the sub-ohmic spin-boson model.A peak is observed at the frequency ω_(T)~T in the curve of C(ω).The curve merges with the zero-temperature C(ω) in ω>>ω_(T) and deviates significantly from the zero-temperature curve in ω<<ω_(T).

关键词： spin-boson model full-density matrix renormalization group quantum phase transition dynamical correlation function finite temperature

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Controllable precision of the projective truncation approximation for green's functions

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Chinese Physics B 2019年第4期28卷 317-325页

作者： Peng Fan ning-hua Tong Department of Physics Renmin University of China

Recently, we developed the projective truncation approximation for the equation of motion of two-time green's functions(Fan et al., Phys. Rev. B 97, 165140(2018)). In that approximation, the precision of results depends on the selection of operator basis. Here, for three successively larger operator bases, we calculate the local static averages and the impurity density of states of the single-band Anderson impurity model. The results converge systematically towards those of numerical renormalization group as the basis size is enlarged. We also propose a quantitative gauge of the truncation error within this method and demonstrate its usefulness using the Hubbard-I basis. We thus confirm that the projective truncation approximation is a method of controllable precision for quantum many-body systems.

关键词： projective truncation approximation two-time green’s functions single-band Anderson impurity model numerical renormalization group

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Solar flare prediction using highly stressed longitudinal magnetic field parameters

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Research in Astronomy and Astrophysics 2013年第3期13卷 351-358页

作者： Xin hua.g hua-ning Wang Key Laboratory of Solar Activity National Astronomical Observatories Chinese Academy of Sciences

Three new longitudinal magnetic field parameters are extracted from SOHO/MDI magnetograms to characterize properties of the stressed magnetic field in active regions, and their flare productivities are calculated for 1055 active regions. We find that the proposed parameters can be used to distinguish flaring samples from non-flaring samples. Using the long-term accumulated MDI data, we build the solar flare prediction model by using a data mining method. Furthermore, the decision boundary, which is used to divide flaring from non-flaring samples, is determined by the decision tree algorithm. Finally, the performance of the prediction model is evaluated by 10-fold cross validation technology. We conclude that an efficient solar flare prediction model can be built by the proposed longitudinal magnetic field parameters with the data mining method.

关键词： Sun: magnetic fields -- Sun: flares -- methods: statistical

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Dirichlet characters, gauss sums and arithmetic Fourier transforms

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Applied Mathematics(A Journal of Chinese Universities) 2014年第3期29卷 307-316页

作者： gAO Jing LIU hua-ning School of Mathematics and Statistics Xi’an Jiaotong University School of Mathematics Northwest University

In this paper, a general algorithm for the computation of the Fourier coefficients of 2π-periodic （continuous） functions is developed based on Dirichlet characters, gauss sums and the generalized MSbius transform. It permits the direct extraction of the Fourier cosine and sine coefficients. Three special cases of our algorithm are presented. A VLSI architecture is presented and the error estimates are given.

关键词： Dirichlet characters gauss sums arithmetic Fourier transforms generalized MSbius transform

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Equation of Motion of a Mass Point in gravitational Field and Classical Tests of gauge Theory of gravity

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Communications in Theoretical Physics 2007年第3期47卷 503-511页

作者： WU ning ZHANg Da-hua Institute of High Energy Physics P.O. Box 918-1 Beijing 100039 China

A systematic method is developed to studY the classical motion of a mass point in gravitational gauge field. First, by using Mathematica, a spherical symmetric solution of the field equation of gravitational gauge field is obtained, which is just the traditional Schwarzschild solution. Combining the principle of gauge covariance and Newton＇s second law of motion, the equation of motion of a mass point in gravitational field is deduced. Based on the spherical symmetric solution of the field equation and the equation of motion of a mass point in gravitational field, we can discuss classical tests of gauge theory of gravity, including the deflection of light by the sun, the precession of the perihelia of the orbits of the inner planets and the time delay of radar echoes passing the sun. It is found that the theoretical predictions of these classical tests given by gauge theory of gravity are completely the same as those given by general relativity.

关键词： classical tests of gauge theory of gravity gauge theory of gravity classical solution of field equation Newton's second law of motion

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