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A549/DDP derived exosomes can affect cisplatin chemosensitivity via transporting CXCR4 to A549 cells

BIOCELL 2022年第3期46卷 711-720页

作者： MINGMING FANG ning ge JIANFANG LIU YAYUN CUI Department of Radiation Oncology Changzhou Cancer Hospital Affiliated to Soochow UniversityChangzhou213032China Department of Cancer Radiotherapy The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China(Anhui Provincial Cancer Hospital)Hefei230031China Department of Neurology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou213001China

The resistance of cancer cells to the anti-cancer drugs is the most important reason that affecting the efficacy of the non-small cell lung cancer(NSCLC)chemotherapy;thus,to explore the underlyingmechanismof drug resistance ofNSCLC medications is urgently needed for improving the therapeutic efficacy of current anti-NSCLC *** aim of the present study is to explore the roles of exosomes in the chemosensitivity of A549 cells and the related mechanism.A549 cells and cisplatin resistant cell line A549/DDP derived exosomes were isolated,and the expressions of CXCR4 were ***,after cisplatin treatment,A549 cells were treated with exosomes,and the proliferation,apoptosis,migration,and invasion of the cells were ***,the tumorigenic effect of A549/DDP derived exosomes were also evaluated by cisplatin treated xenograft tumor mice models in *** found that A549/DDP derived exosomes increased the proliferation,migration,and invasion,and inhibited the apoptosis and cisplatin sensitivity of A549 ***4 was also significantly increased in cells treated with A549/DDP derived ***,A549/DDP derived exosomes may also decrease the chemosensitivity of NSCLC cells to cisplatin in *** data suggested that A549/DDP derived exosomes can affect the chemosensitivity of A549 cells to cisplatin,possibly by transporting CXCR4 to A549 *** data may provide novel evidence for the investigation of drug resistance of NSCLC.

关键词： Exosome Drug resistance CXCR4 NSCLC cells

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Discrete-time charge analysis for a digital RF charge sampling mixer

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第4期11卷 307-314页

作者： Yun PAN ning ge Xiao-lang YAN Xiao-peng YU Institute of VLS1 Design Zhejiang University Hangzhou 310027 China Department of Electronic Engineering Tsinghua University Beijing 100084 China

This paper presents an approach for analyzing the key parts of a general digital radio frequency(RF) charge sampling mixer based on discrete-time charge *** cascade sampling and filtering stages are analyzed and expressed in theoretical *** effects of a pseudo-differential structure and CMOS switch-on resistances on the transfer function are addressed in *** DC-gain is restrained by using the pseudo-differential *** transfer gain is reduced because of the charge-sharing time constant when taking CMOS switch-on resistances into *** unfolded transfer gains of a typical digital RF charge sampling mixer are analyzed in different cases using this approach.A circuit-level model of the typical mixer is then constructed and simulated in Cadence SpectreRF to verify the *** work informs the design of charge-sampling,infinite impulse response(ⅡR) filtering,and finite impulse response(FIR) filtering *** discrete-time approach can also be applied to other multi-rate receiver systems based on charge sampling techniques.

关键词： Digital RF Charge sampling Discrete-time Pseudo-differential Switch-on resistance

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Two-Phase Rate Adaptation Strategy for Improving Real-Time Video QoE in Mobile Networks

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China Communications 2018年第10期15卷 12-24页

作者： Ailing Xiao Jie Liu Yizhe Li Qiwei Song ning ge Department of Electronic Engineering Tsinghua University Beijing 100084 China Beijing National Research Center for Information Science and Technology Beijing 100084 China Network Technology Research Institute China Unicom Beijing 100052 China

With the popularity of smart handheld devices, mobile streaming video has multiplied the global network traffic in recent years. A huge concern of users' quality of experience(Qo E) has made rate adaptation methods very attractive. In this paper, we propose a two-phase rate adaptation strategy to improve users' real-time video Qo E. First, to measure and assess video Qo E, we provide a continuous Qo E prediction engine modeled by RNN recurrent neural network. Different from traditional Qo E models which consider the Qo E-aware factors separately or incompletely, our RNN-Qo E model accounts for three descriptive factors(video quality, rebuffering, and rate change) and reflects the impact of cognitive memory and recency. Besides, the video playing is separated into the initial startup phase and the steady playback phase, and we takes different optimization goals for each phase: the former aims at shortening the startup delay while the latter ameliorates the video quality and the rebufferings. Simulation results have shown that RNN-Qo E can follow the subjective Qo E quite well, and the proposed strategy can effectively reduce the occurrence of rebufferings caused by the mismatch between the requested video rates and the fluctuated throughput and attains standout performance on real-time Qo E compared with classical rate adaption methods.

关键词： continuous quality of experience (QoE) model recurrent neural network(RNN) real-time video QoE improving dynamic adaptive streaming over HTTP (DASH)

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Characterization and Performance Evaluation of Turbulent Plasma Sheath Channel

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China Communications 2016年第6期13卷 88-99页

作者： Jingzhuo Zhang Guolong He Peng Bai Jianhua Lu ning ge Department of Electronic Engineering Tsinghua University Synthetic Electronic Information System and Electronic Countermeasure Technology Research Department Air Force Engineering University

Radio waves are highly attenuated and distorted by turbulent plasma sheath around hypersonic vehicles in near space, leading to communication blackout. The purpose of the paper is to investigate the plasma channel characteristics and the communication performances over the channel. We treat the turbulent plasma medium as a fast fading wireless channel. The coherence time and the spectrum spread of the plasma sheath channel are obtained in terms of root-meansquare(RMS). Baseband simulation scheme is proposed based on a stratified model of the plasma flow field. Results indicate that the coherence time is on the order of milliseconds and decreases rapidly with the increasing electron density turbulence. The spectrum spread due to plasma turbulence is also significant. Extensive simulations have been carried out to make communication performance evaluations. Quantitative results show that error floor takes place for PSK and QAM, while FSK with noncoherent detection is a promising method to mitigate the blackout problem.

关键词： plasma sheath channel characteristics fast fading error performance

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MULTIPLE DIMENSION COLLABORATIVE OPERATION TECHNIQUES AND NETWORKING FOR AIR-SPACE-GROUND INTEGRATED SYSTEM:TECHNOLOGIES AND APPLICATIONS

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China Communications 2021年第9期18卷 I0003-I0004页

作者： Qinyu Zhang Xuejun Sha Fei Ji ning ge Harbin Institute of Technology(Shenzhen) system of MOE China communication research center Electronic Engineering South China University of Technology Department of Electronics Engineering at Tsinghua University

Along with the swift growth of communication services,various networks have undergone multidimensional technical evolution,*** transmission speed and large bandwidth for ground cellular network,high mobility for aviation network,and wide-area coverage for satellite *** the industry demands for joint operation arise,an integrated space-air-ground collaboration network will be formed.

关键词： network SPACE aviation

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Detecting While Accessing:A Semi-Supervised Learning-Based Approach for Malicious Traffic Detection in Internet of Things

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China Communications 2023年第4期20卷 302-314页

作者： Yantian Luo Hancun Sun Xu Chen ning ge Wei Feng Jianhua Lu Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Beijing 100084China Unit 91977 of PLA Beijing 100036China

In the upcoming large-scale Internet of Things(Io T),it is increasingly challenging to defend against malicious traffic,due to the heterogeneity of Io T devices and the diversity of Io T communication *** this paper,we propose a semi-supervised learning-based approach to detect malicious traffic at the access *** overcomes the resource-bottleneck problem of traditional malicious traffic defenders which are deployed at the victim side,and also is free of labeled traffic data in model ***,we design a coarse-grained behavior model of Io T devices by self-supervised learning with unlabeled traffic ***,we fine-tune this model to improve its accuracy in malicious traffic detection by adopting a transfer learning method using a small amount of labeled *** results show that our method can achieve the accuracy of 99.52%and the F1-score of 99.52%with only 1%of the labeled training data based on the CICDDoS2019 ***,our method outperforms the stateof-the-art supervised learning-based methods in terms of accuracy,precision,recall and F1-score with 1%of the training data.

关键词： malicious traffic detection semi-supervised learning Internet of Things(Io T) Transformer masked behavior model

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Improving Low Bitrate Video Coding via Computation Incorporating A Priori Information

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China Communications 2015年第9期12卷 22-34页

作者： Tao Xiaoming Dong Linhao Li Shaoyang Li Yang ge ning Lu Jianhua Department of Electronics Engineering Tsinghua University School of Aerospace Engineering Tsinghua University

The growing number of mobile users, as well as the diversification in types of services have resulted in increasing demands for wireless network bandwidth in recent years. Although evolving transmission techniques are able to enlarge the network capacity to some degree, they still cannot satisfy the requirements of mobile users. Meanwhile, following Moore's Law, the data processing capabilities of mobile user terminals are continuously improving. In this paper, we explore possible methods of trading strong computational power at wireless terminals for transmission efficiency of communications. Taking the specific scenario of wireless video conversation, we propose a model-based video coding scheme by learning the structures in multimedia contents. Benefiting from both strong computing capability and pre-learned model priors, only low-dimensional parameters need to be transmitted; and the intact multimedia contents can also be reconstructed at the receivers in real-time. Experiment results indicate that, compared to conventional video codecs, the proposed scheme significantly reduces the data rate with the aid of computational capability at wireless terminals.

关键词： computational communications a priori information bandwidth-limited wireless communications model-based video coding

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Lactic Acid Inhibits NF-kB Activation by Lipopolysaccharide in Rat Intestinal Mucosa Microvascular Endothelial Cells

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Agricultural Sciences in China 2011年第6期10卷 954-959页

作者： LIU Jing XUE Jiu-zhou ZHU Zhi-ning HU ge REN Xiao-ming Animal Science and Technology College Beijing University of Agriculture Beijing 102206 P.R. China

To investigate whether lactic acid could inhibit the LPS-activation of NF-κB p65 in rat intestinal mucosa microvascular endothelial cells （RIMMVECs）, RIMMVECs, cultured in vitro, were pretreated with different concentrations of lactic acid and then exposed to lipopolysaccharide （LPS）. Cells and cell culture media were then collected at different time intervals. Production of tumor necrosis factor-a （TNF-a） and interleukin-6 （IL-6） was examined at the protein level by enzyme-linked immunosorbent assay. The influence of lactic acid on the LPS-activation of NF-κB was examined at mRNA and protein levels by real-time quantitative PCR and Western blot analysis, respectively. TNF-a and IL-6 protein levels were significantly decreased after pretreatment with lactic acid compared with cells exposed to LPS only. After pretreatment with 7.5, 5.0, and 2.5 μL mL-1 lactic acid, NF-κB mRNA levels were increased by 1.51-, 2.62- and 3.00-fold, respectively, compared with levels in control cells without LPS treatment. Western blot analysis indicated that the level of NF-κB p65 in the lactic acid-pretreated group was significantly lower than that in the group treated with LPS only （positive control） and was unchanged compared with the group without LPS treatment （blank control）. These results suggest that lactic acid may inhibit LPS-activation of NF-κB, leading to the down-regulation of TNF-a and IL-6.

关键词： lactic acid RMMIVECs LPS NF-κB

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Microstructure and properties of 35 kg large aluminum alloy flywheel housing components formed by squeeze casting with local pressure compensation

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China Foundry 2024年第5期21卷 563-576页

作者： Ju-fu Jiang Jing Yan Ying-ze Liu ning ge Ying Wang Chang-jie Ding De-chao Zou School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China Dalian Innovation Die-casting Co. Ltd.Dalian 116600LiaoningChina

The squeeze casting method with local pressure compensation was proposed to form a flywheel housing component with a weight of 35 *** numerical simulation,microstructure observation and phase characterization were performed,and the influence of local pressure compensation on feeding of thick-wall position,microstructure and mechanical properties of the formed components were *** show that the molten metal keeps a good fluidity and the filling is complete during the filling *** the solidification at thick-wall positions of the mounting ports is slow,the local pressure compensation effectively realizes the local forced feeding,significantly eliminating the shrinkage cavity *** the microstructure of AlSi9Mg alloy,α-Al primarily consists of fragmented dendrites and rosette grains,while eutectic Si predominantly comprises needles and short *** impact of local pressure compensation on strength is relatively minimal,yet its influence on elongation is *** local pressure compensation,the average elongation at the compensated areas is 9.18%,which represents a 44.90%higher than that before *** average tensile strength is 209.1 MPa,and the average yield strength is 100.6 *** local pressure compensation can significantly reduce or even eliminate the internal defects in the 35 kg large-weight components formed by squeeze casting.

关键词： squeeze casting local pressure compensation aluminum alloy microstructure mechanical properties large flywheel housing components

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Programmed cell death and its role in inflammation

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Journal of Medical Colleges of PLA(China) 2015年第2期30卷 96-109页

作者： Yong Yang ge-ning Jiang Peng Zhang Jie Fan Department of Surgery University of Pittsburgh School of Medicine Depar tment of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of Medicine Research and Development Veterans Af airs Pittsburgh Healthcare System

Cell death plays an important role in the regulation of inflammation and may be the result of inflammation. The maintenance of tissue homeostasis necessitates both the recognition and removal of invading microbial pathogens as well as the clearance of dying cells. In the past few decades, emerging knowledge on cell death and inflammation has enriched our molecular understanding of the signaling pathways that mediate various programs of cell death and multiple types of inflammatory responses. This review provides an overview of the major types of cell death related to inflammation. Modification of cell death pathways is likely to be a logical therapeutic target for inflammatory diseases.

关键词： Inflammation Necroptosis Apoptosis Pyroptosis Pyronecrosis NETosis Autophagy

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