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Integrated Manufacturing Cell Formation Technology Orienting Multi-product Type and Variant Volume Production

Chinese Journal of Mechanical Engineering 2011年第1期24卷 12-22页

作者： CHEN Huawei WANG Aimin ning Ruxin shao Canxia Digital Design and Manufacturing Laboratory Beijing Institute of Technology Beijing 100081 China

What is pursued by multi-product type and variant volume（MPTVV） production is rapid response and quick switching,so that structure of transferring line in manufacturing system is no longer *** formation（CF） algorithm is the key technology of cellular manufacturing system（CMS）.Currently,CF methods are mainly extended on the idea of group technology（GT） that covers a lot on analysis of resource capability matching and its *** constraints are considered,but seldom utilized *** to the problem of manufacturing cell（MC） formation under MPTVV production mode,integrated formation technologies for typical MC as group type of cell（GC）,flow type of cell（FC） and inherited cell（IC） are presented based on technical analysis of *** to practical production constraints like delivery time,product batch,equipment ability,key machine,key part and machine sharing,etc,an integrated formation model is constructed and internal interrelations of these constraints are analyzed ***,formation goals of types of MCs and their formation procedures under joint effect of formation constraints and rules are *** case study,three highly balanced GC are formed first;then FC formation are implemented based on the same data which indicate good balancing effect of cell load and flow-style production for key tasks;When task is adjusted,a new scheme is constructed on the result of FC configuration by using IC formation method,and more optimal performance of flow-style production is *** proposed comparative study of different type of cells strongly explains the validation of integrated MC formation in support of rapid manufacturing resource transformation under MPTVV production mode.

关键词： multi-product type and variant volume production cell formation flow style manufacturing cell inheriting manufacturing cell

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Effect of precipitates on high-temperature strength and irradiation behavior of vanadium-based alloys

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Journal of Iron and Steel Research International 2018年第12期25卷 1270-1277页

作者： shao-ning Jiang Li-qun Xu Fa-rong Wan School of Mechanical and Automotive Engineering Qilu University of Technology (Shandong Academy of Science) Jinan 250353ShandongChina School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

The formation of precipitates and their effect on mechanical properties and irradiation damage in V-4CraTi alloys have been investigated using transmission electron microscope,high-temperature tensile tests and high-voltage electron microscope (HVEM).V-4Cr-4Ti alloys were aged for 20-40 h at 873 K,and extremely fine precipitates were produced during the aging process,which coarsened with aging *** results of high-temperature (773,873 and 973 K)tensile tests showed an increase in strength with increasing aging time (i.e:,increasing size of precipitates)while a decrease in the uniform *** was evidence that presence of precipitates strengthened V-4Cr-4Ti *** situ HVEM observations showed that the precipitates restricted the growth rate of dislocation loops induced during electron irradiation at 773 *** interactions between precipitates and irradiation-induced dislocation loops were *** presence of particles alleviated the increase in irradiation hardening up to an irradiation dose of 3.42 dpa (displacement per atom).The precipitates shrank in size during electron irradiation,which was due to the dissolution of constituent atoms of the precipitates into the alloy matrix.

关键词： Aging Precipitate strengthening Electron irradiation Irradiation defect Dislocation loop

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Identification of seven long noncoding RNAs signature for prediction of biochemical recurrence in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 618-622页

作者： ning shao Wo Zhu Fang-ning Wan Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China.

Accumulating evidenee suggested that long noncoding RNAs(IncRNAs)possess a potential role in prostate cancer(PCa)diagnosis and *** biochemical recurrence(BCR)is considered as a sign for clinical recurrence metastasis and PCa-specific ***,the aim of the present study was to identify a IncRNA signature that can predict BCR of PCa *** analysis,Kaplan-Meier analyses,Cox regression analyses,and Gene Set Enrichment Analysis(GSEA)were performed in a publicly available database with 499 PCa tissues and 52 matched normal tissues.A signature was *** these IncRNAs were differentially expressed between tumor and normal tissues and differentially expressed between high Gleason score and low Gleason score ***,we developed a seven IncRNAs signature that can predict PCa *** classified into low-risk group showed better BCR survival significantly than the patients in the high-risk group(hazard ratio=0.32,95%Cl:0.20-0.52,concordance index=0.63).The area under the curve was 0.68 for *** signature also had good discrimination for BCR in men with Gleason 7 *** conclusion,our results suggest that the seven IncRNAs signature is a new biomarker of BCR and high risk in *** addition,the in dividual In cRNA warrants further study to un cover the associated mechanisms of PCa progression and the signature could be used to design direct clinical trials for adjuvant therapy.

关键词： biochemical recurrence biomarker high risk Iong noncoding RNA prostate cancer

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An unprecedented one-arrow-two-hawks strategy achieves high yield with early flowering in rice

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Molecular Plant 2022年第9期15卷 1412-1414页

作者： Hong Yu ning shao Jiayang Li State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing) Institute of Genetics and Developmental BiologyThe Innovative Academy for Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

By 2021,nearly 9%of the global population was still suffering from *** has estimated that the world population will reach 9.7 billion in 2050(United Nations,2019;Tian et al.,2021),which requires a 2.4%increase per year for the yields of major ***,current growth rates are only half of this,imposing serious challenges in increasing grain yield by crop *** growth and development mainly require energy and nutrients,and thus it is generally considered that the crop yield could be increased by elevating photosynthetic efficiency and higher nitrogen-use ***,the uptake and transport of nitrogen must be coordinated with carbon fixation and production of carbohydrates by ***,effective strategies for optimizing the carbon/nitrogen status in crops are still relatively limited and therefore require new promising targets.

关键词： crops yield suffering

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Effect of SiO_2/Na_2O mole ratio on the properties of foam geopolymers fabricated from circulating fluidized bed fly ash

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International Journal of Minerals,Metallurgy and Materials 2014年第6期21卷 620-626页

作者： Ze Liu ning-ning shao Tian-yong Huang Jun-feng Qin Dong-min Wang Yu Yang School of Chemical and Environmental Engineering China University of Mining and Technology

Geopolymers are three-dimensional aluminosilicates formed in a short time at low temperature by geopolymerization. In this pa-per, alkali-activated foam geopolymers were fabricated from circulating fluidized bed fly ash （CFA）, and the effect of SiO2/Na2O mole ratio （0.91-1.68） on their properties was studied. Geopolymerization products were characterized by mechanical testing, scanning electron mi-croscopy （SEM）, energy-dispersive X-ray spectroscopy （EDX）, and X-ray diffraction （XRD）. The results show that SiO2/Na2O mole ratio plays an important role in the mechanical and morphological characteristics of geopolymers. Foam samples prepared in 28 d with a SiO2/Na2O mole ratio of 1.42 exhibit the greatest compressive strength of 2.52 MPa. Morphological analysis reveals that these foam geo-polymers appear the relatively optimized pore structure and distribution, which are beneficial to the structure stability. Moreover, a combina-tion of the Si/Al atomic ratio ranging between 1.47 and 1.94 with the Na/Al atomic ratio of about 1 produces the samples with high strength.

关键词： foamed products geopolyrners fly ash strength of materials morphology silicon oxide sodium oxide

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Synergistic extraction and separation of Am(III) and Ln(III) with HBMPPT-sulfoxide-HNO_3-toluene system

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Nuclear Science and Techniques 2000年第3期11卷 192-196页

作者： YU shao-ning Naval Medical Research Institute, Shanghai 200433 解放军海军医学所上海 200423

Some sulfoxides (petroleum sulfoxide - PSO, di-n-octyl sulfoxide - DOSO, etc.) were chosen as synergists to study the synergistic effect on the extraction reaction with HBMPPT (4-benzoy1-2,4-dihydro-5-menthy1-2-pheny1-3H-pyrazol1-3-thione) for Am(III), and the synergistic separation for Am(III) and Ln(III). The synergistic extraction ability of PSO is greater than that of DOSO for Am(III). The synergistic complexes may be presented as ***3.(BMPPT)***.S2 (S indicates PSO or DOSO).

关键词：镅(Ⅲ) 镧子元素 HBMPPT 萃取体系萃取剂核燃料增效作用分离硝酸亚砜甲苯

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Synergistic Combination of Biodegradable Peptide Polymer and Curcumin as Promising Antibiotic Substitution in Aquaculture to Alleviate the Global Challenge of Antimicrobial Resistance

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Chinese Journal of Chemistry 2022年第24期40卷 2947-2955页

作者： Pengcheng Ma Yuan Chen ning shao Junyu Zhang Yueming Wu Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237 China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237 China

The massive use of antibiotics in aquaculture and resulted antibacterial resistance problem urgently need antibiotic substitutions. Herein, we report a promising substitution of aquaculture antibiotics using a synergistic combination of biodegradable peptide polymers and curcumin, a natural compound from plant. The synergistic combination shows strong antibacterial activity against V. fluvialis and some other common bacteria in aquaculture. The membrane-damaging antibacterial mechanism echoes our finding that the synergistic combination will not induce bacteria to develop resistance after continuous use. The synergistic combination also displays effective cure on V. fluvialis-infected zebrafish. The biodegradability of the peptide polymer enables the combination to lose antibacterial activity and will not cause selective pressure on bacterial in the environment. Our study indicates potential application of synergistic composition, biodegradable peptide polymer and curcumin, as promising antibiotic substitution in aquaculture, which represents a promising strategy to address the global challenge of antimicrobial resistance.

关键词： Antimicrobial polymer Aquaculture Peptides Antibiotics Biological activity

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Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1318-1325页

作者： ning shao Xueyang Ma Ying-Ying Zhang Donghui Yang Ming Ma Gong-Li Tang State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Dihydrofolate reductase(DHFR),a housekeeping enzyme in primary metabolism,has been extensively studied as a model of acid-base catalysis and a clinic drug ***,we investigated the enzymology of a DHFR-like protein SacH in safracin(SAC)biosynthesis,which reductively inactivates hemiaminal pharmacophore-containing biosynthetic intermediates and antibiotics for ***,based on the crystal structure of SacH−NADPH−SAC-A ternary complexes and mutagenesis,we proposed a catalytic mechanism that is distinct from the previously characterized short-chain dehydrogenases/reductases-mediated inactivation of hemiaminal *** findings expand the functions of DHFR family proteins,reveal that the common reaction can be catalyzed by distinct family of enzymes,and imply the possibility for the discovery of novel antibiotics with hemiaminal pharmacophore.

关键词： Catalytic mechanism Crystal structure Dihydrofolate reductase(DHFR) Hemiaminal pharmacophoreSacH Safracin biosynthesis Self-resistance Tetrahydroisoquinoline(THIQ)alkaloids

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Fabrication and properties of foam geopolymer using circulating fluidized bed combustion fly ash

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International Journal of Minerals,Metallurgy and Materials 2014年第1期21卷 89-94页

作者： Ze Liu ning-ning shao Dong-min Wang Jun-feng Qin Tian-yong Huang Wei Song Mu-xi Lin Jin-sha Yuan Zhen Wang School of Chemical and Environmental Engineering China University of Mining & Technology

In recent years, circulating fluidized bed combustion fly ash （CFA） is used as a raw material for geopolymer synthesis. Hydrogen peroxide was employed as a foaming agent to prepare CFA-based foam geopolymer. The particle distribution, mineral composition, and chemical composition of CFA were examined firstly. Geopolymerization products were characterized by mechanical testing, scanning elec- tron microscopy （SEM）, X-ray diffraction （XRD）, and X-ray fluorescence （XRF）. The CFA-based foam geopolymer was successfully fabri- cated with different contents of hydrogen peroxide and exhibited uncompleted alkali reaction and reasonable strength with relative low atomic ratios of Si/Al and Si/Na. Type-C CFA in this research could be recycled as an akernative source material for geopolymer production.

关键词： fly ash geopolymers foamed products microstructure hydrogen peroxide

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Stabilization and volume reduction of radioactive spent ion exchange resins

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Nuclear Science and Techniques 2001年第1期12卷 68-72页

作者： YE Yu-Cai YU shao-ning (Institute of Nuclear Anerpy Technology, Tsinghua University, Beijing 102201) Institute of Nuclear Energy Technology Tsinghua University

Stabilization and volume reduction Of spent radioactive ion-exchange resins (IERs) were studied. Stabilization technology includes volume reduction with wet Chemical oxidation process and immobilization of the residue into cement. Under suitable conditions, the exhaussted radioactive ion-exchange resins were dissolved successfully in a H2,O2-Fe2+/Cu2+ catalytic oxidation system (Fenton reagent). The analytical results indicated that the radioactive nuclides loaded in the resins were concentrated in decomposed solution and solid residues. The process parameters of wet chemical oxidation and solidification were also obtained. The decomposition ratios were 100% and more than 90% for canon and anion IERs respectively. The waste volume was decreased by 40% compared with that of original spent resins.

关键词：离子交换树脂水泥固化湿式化学氧化放射性废料处理

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