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Genes & Diseases 2024年第2期11卷 535-538页

作者： Xi Kong Peng Lu Jinyue Zhang Zheng Bao Chenghao Kuang Bingqing Xie Jianhua Peng ning ma Yong Jiang Shigang Yin Laboratory of Neurological Diseases and Brain Function The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Institute of Epigenetics and Brain Science Southwest Medical UniversityLuzhouSichuan 646000China Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Inflammation and Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following *** is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal ***,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.

关键词： invasion homeostasis maintain

Combined Effect of Outdoor Time and Other Modifiable Factors on Myopia Incidence Among Children and Adolescents—9 PLADs,China,2020

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China CDC weekly 2024年第9期6卷 151-156,I0001,I0002页

作者： Panliang Zhong Yunfei Liu ning ma Jiajia Dang Di Shi Shan Cai Ziyue Chen Yanhui Dong Peijin Hu Jun ma Patrick W.C Lau Randall S.Stafford Yi Song Institute of Child and Adolescent Health School of Public HealthPeking UniversityNational Health Commission Key Laboratory of Reproductive HealthBeijingChina Department of Sport Physical Education&HealthHong Kong Baptist UniversityKowloon TongHong Kong Special Administrative RegionChina Department of Medicine Stanford Prevention Research CenterStanford University School of MedicineStanfordCAUnited States

Summary What is already known about this topic?Myopia has been identified as a significant emerging challenge and policy priority among children and adolescents in China by the Ministry of Education and seven other *** research has been conducted to investigate the collective impact of outdoor time and other modifiable factors on the incidence of myopia.

关键词： Incidence collective policy

超声心动图用于诊断及治疗儿童心脏瓣膜病进展

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中国医学影像技术 2024年第7期40卷 961-963页

作者：马宁国家儿童医学中心首都医科大学附属北京儿童医院心脏中心心脏超声科北京100045

儿童心脏瓣膜病的诊断思路和治疗方案均与成人有所不同.超声心动图是诊断和评估儿童心脏瓣膜疾病的首选影像学方法.本文就超声心动图技术用于诊断及治疗儿童心脏瓣膜病进展进行述评.

关键词：儿童心脏瓣膜疾病超声心动描记术

Identification of overlay differentially expressed genes in both rats and goats with blast lung injury through comparative transcriptomics

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Chinese Journal of Traumatology 2024年第1期27卷 34-41页

作者： Hong Wang Jun-Hong Gao Xiao-Lin Fan Qing Lu Liang Li ning ma Qi Wang Yu-Hao Zhang Xi'an Key Laboratory of Toxicology and Biological Effects Research Center for Toxicological and Biological EffectsInstitute for Hygiene of Ordnance IndustryXi'an710065China

Purpose:To identify the potential target genes of blast lung injury(BLI)for the diagnosis and ***:This is an experimental *** BLI models in rats and goats were established by conducting a fuel-air explosive power test in an unobstructed environment,which was subsequently validated through hematoxylin-eosin *** sequencing was performed on lung tissues from both goats and *** expressed genes were identified using the criteria ofq≤0.05 and|log2 fold change|≥*** that,enrichment analyses were conducted for gene ontology and the Kyoto Encyclopedia of Genes and Genomes *** potential target genes were further confirmed through quantitative real-time polymerase chain reaction and enzyme linked immunosorbent ***:Observations through microscopy unveiled the presence of reddish edema fluid,erythrocytes,and instances of focal or patchy bleeding within the alveolar *** sequencing analysis identified a total of 83 differentially expressed genes in both rats and ***,49 genes exhibited a consistent expression pattern,with 38 genes displaying up-regulation and 11 genes demonstrating *** analysis highlighted the potential involvement of the interleukin-17 signaling pathway and vascular smooth muscle contraction pathway in the underlying mechanism of ***,the experimental findings in both goats and rats demonstrated a strong association between BLI and several key genes,including anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4,which exhibited ***:Anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4 hold potential as target genes

关键词： Blast lung injury Transcriptomic Target genes Differentially expressed genes

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第36届中国电影金鸡奖评选侧记

电影艺术 2024年第1期 42-51页

作者：马宁中国电影家协会行风建设与维权处

第36届中国电影金鸡奖共产生93项提名和20个获奖奖项,一定程度上体现出本评奖年度内中国电影在艺术审美、类型创作、思想表达、科技创新等方面取得的成就。从评奖结果来看,本届影片在高扬人民性和反映时代性上有突出表现,更多的优秀影... 详细信息

第36届中国电影金鸡奖共产生93项提名和20个获奖奖项,一定程度上体现出本评奖年度内中国电影在艺术审美、类型创作、思想表达、科技创新等方面取得的成就。从评奖结果来看,本届影片在高扬人民性和反映时代性上有突出表现,更多的优秀影片聚焦当下百姓的精神和审美需求,用细腻的平实视角贴近生活日常,用鲜活的镜头语言描摹生活纹理,用真挚的情感共情生活冷暖,在光影中刻下生动的时代烙印,体现出中国电影在现实主义美学上的追求和探索。

关键词：中国电影金鸡奖评选侧记专家奖

保险法解除权与民法撤销权制度竞合的体系规整

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法学 2024年第2期 102-117页

作者：马宁西安交通大学法学院

在投保人违反如实告知义务时可能发生保险法上解除权与民法上撤销权的适用选择问题。两者之间并非特别法与一般法的关系,其构成要件部分交叉,属于两类法律制度的竞合,此时应通过体系解释与价值权衡划定各自的适用空间。其一,当投保人一... 详细信息

在投保人违反如实告知义务时可能发生保险法上解除权与民法上撤销权的适用选择问题。两者之间并非特别法与一般法的关系,其构成要件部分交叉,属于两类法律制度的竞合,此时应通过体系解释与价值权衡划定各自的适用空间。其一,当投保人一方故意违反如实吿知义务时,保险人除了可以依据保险法解除合同之外,还可以根据民法上的欺诈规定撤销合同,这是遏制投保人一方道德风险的必要举措,以及维持风险共同体存续与内含了私法全部价值的诚信原则的当然要求。况且,禁止保险人于此时行使撤销权亦无法阻止其通过缔约过失责任、纯粹经济损失赔偿等路径寻求救济。其二,当投保人一方因重大过失违反如实吿知义务时,保险人仅可解除合同,而不得依民法上的重大误解规定撤销合同。这是因为彼时投保人的行为能否同时构成重大误解并不确定,且此种解释能适配投保人故意违反如实告知义务时的撤销权适用规则,有利于保险法和民法的体系规整,亦不会导致部门法之间的冲突。

关键词：保险法解除权民法撤销权制度竞合规制路径体系化

Development of a competitive array for discriminative determination of amphenicols in egg based on ribosomal protein L16

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Food Quality and Safety 2024年第1期8卷 105-114页

作者：才艺马宁吴宁鹏王建平 College of Veterinary Medicine Hebei Agricultural UniversityBaodingChina Henan Institute of Veterinary Drug and Feed Control ZhengzhouChina

Objective:Amphenicols(chloramphenicol,thiamphenicol and forfenicol)can cause aplastic anaemia and other severe side effects to consumers;therefore,it is necessary to inspect their residues in foods of animal ***,there has been no report on the use of amphenicols receptor for the determination of their residues,and none of the previously reported immunoassays for amphenicols can differentiate the specifc *** and Methods:In this study,the ribosomal protein L16 of Escherichia coli was frst expressed,and its intermolecular interaction mechanisms with the three amphenicols was studied using the molecular docking *** protein was then combined with three enzymelabelled conjugates to develop a direct competitive array on microplate for determination of the three drugs in ***:Due to the use of principal component analysis to analyse the data,this method could discriminate the three drugs in the range 0.1–10 ng/mL,and the limits of detection for the three drugs were in the range of 0.0002–0.0009 ng/*** analysis results for the unknown egg samples were consistent with a liquid chromatography–tandem mass spectrometry method,and the method performances were superior to the previous immunoassays for ***:This is the frst paper reporting the use of ribosomal protein L16 to develop a competitive array for discriminative determination of amphenicols in food samples.

关键词： Amphenicols ribosomal protein L16 recognition mechanism competitive array discriminative determination egg.

Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan Sun Ming Yang Dapeng Sun Guangge Peng Yiming Deng Xingquan Zhao Liping Liu ning ma Feng Gao Dapeng Mo Wengui Yu Yongjun Wang Yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 *** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

面向无人机自主着陆的视觉感知与位姿估计方法综述

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自动化学报 2024年第7期50卷 1284-1304页

作者：马宁曹云峰南京航空航天大学航天学院南京211106

自主着陆技术是制约无人机(Unmanned aerial vehicle,UAV)自主性等级提升中极具挑战性的一项技术.立足于未来基于视觉的无人机自主着陆技术的发展需求,围绕其中的核心问题——着陆场检测与位姿估计,对近十年来国内外无人机自主着陆领域... 详细信息

自主着陆技术是制约无人机(Unmanned aerial vehicle,UAV)自主性等级提升中极具挑战性的一项技术.立足于未来基于视觉的无人机自主着陆技术的发展需求,围绕其中的核心问题——着陆场检测与位姿估计,对近十年来国内外无人机自主着陆领域中基于视觉的着陆场检测与位姿估计方法研究进展进行总结.首先,在分析无人机自主着陆应用需求的基础上,指出机器视觉在无人机自主着陆领域的应用优势,并凝练出存在的科学问题;其次,按不同应用场景划分对着陆场检测算法进行梳理;然后,分别对纯视觉、多源信息融合的位姿估计技术研究成果进行归纳;最后,总结该领域有待进一步解决的难点,并对未来的技术发展趋势进行展望.

关键词：自主着陆无人机机器视觉着陆场检测位姿估计信息融合

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珞巴族“阿巴达尼始祖传说”国家级非物质文化遗产代表性传承人林东访谈

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文化遗产 2024年第4期 152-158,F0002,I0001页

作者：马宁西藏民族大学民族研究院陕西咸阳712082

传承人简介:林东(1948-2021),男,珞巴族,西藏自治区林芝市米林县才召村村民,既是一名优秀的猎人,又是珞巴族“阿巴达尼始祖传说”国家级“非遗”代表性传承人,他的一生见证了珞巴族民众翻身解放的全过程,也全身心参与到国家为保护珞巴... 详细信息

传承人简介:林东(1948-2021),男,珞巴族,西藏自治区林芝市米林县才召村村民,既是一名优秀的猎人,又是珞巴族“阿巴达尼始祖传说”国家级“非遗”代表性传承人,他的一生见证了珞巴族民众翻身解放的全过程,也全身心参与到国家为保护珞巴族非物质文化遗产的工作中,为传承珞巴族文化做出了自己的贡献。

关键词：始祖传说珞巴族代表性传承人非物质文化遗产阿巴达尼米林县西藏自治区林芝市